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1. 发明授权

US07588785B2 Methods and kits for reducing cellular damage, inhibiting free radical production and scavenging free radicals 有权
标题翻译：用于减少细胞损伤，抑制自由基产生和清除自由基的方法和试剂盒
公开(公告)号：US07588785B2
公开(公告)日：2009-09-15
申请号：US11624687
申请日：2007-01-18
申请人： Gregory S. Evans , Gregory Grochoski , Russell K. Randolph , Lynne M. Connor , John V. Scimeca , Kevin W. Gellenbeck , James R. Mayne , Haeri Roh-Schmidt , Thomas J. Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
发明人： Gregory S. Evans , Gregory Grochoski , Russell K. Randolph , Lynne M. Connor , John V. Scimeca , Kevin W. Gellenbeck , James R. Mayne , Haeri Roh-Schmidt , Thomas J. Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
IPC分类号： A61K36/82 , A61K36/736 , A61K36/752 , A61K36/906 , A61K36/00
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

2. 发明授权

US5561160A Formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferative disorders 失效
标题翻译：用于预防和治疗高胆固醇血症和细胞过度增殖性疾病的方法和方法
公开(公告)号：US5561160A
公开(公告)日：1996-10-01
申请号：US317790
申请日：1994-10-04
申请人： Zbigniew Walaszek , Thomas J. Slaga , Margaret Hanauek
发明人： Zbigniew Walaszek , Thomas J. Slaga , Margaret Hanauek
IPC分类号： A61K31/045 , A23L1/03 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A61K31/07 , A61K31/12 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/28 , A61K31/30 , A61K31/355 , A61K31/375 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/455 , A61K31/505 , A61K31/51 , A61K31/714 , A61K33/00 , A61K33/42 , A61K45/06 , A61P3/00 , A61P3/06 , A61P3/14
CPC分类号： A61K45/06 , A23L29/035 , A23L33/12 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/19 , A61K31/194 , A61K33/42 , A23V2002/00
摘要： The present invention provides a formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation. More specifically, the present invention provides a method for administering a formula including glucaric acid or a pharmaceutically acceptable salt thereof for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation in humans and animals. It has been determined that glucaric acid and pharmaceutically acceptable salts thereof significantly lower the total and LDL level of serum cholesterol and inhibit cellular hyperproliferation when administered in therapeutic amounts. It is intended that glucaric acid or a pharmaceutically acceptable salt thereof is employed alone or in combination with other medicinal agents for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation.
摘要翻译：本发明提供了预防和治疗高胆固醇血症和细胞过度增殖的方法和方法。更具体地，本发明提供了一种给予包括葡糖二酸或其药学上可接受的盐的配方用于预防和治疗人和动物中的高胆固醇血症和细胞过度增殖的方法。已经确定，当以治疗量施用时，葡糖二酸及其药学上可接受的盐显着降低血清胆固醇的总和LDL水平并抑制细胞过度增殖。意图是葡糖二酸或其药学上可接受的盐单独使用或与其它药物组合使用以预防和治疗高胆固醇血症和细胞过度增殖。

3. 发明申请

US20070243270A1 METHODS AND KITS FOR REDUCING CELLULAR DAMAGE, INHIBITING FREE RADICAL PRODUCTION, AND SCAVENGING FREE RADICALS IN MAMMALS 有权
标题翻译：用于减少细胞损伤，抑制自由放射生产的方法和工具，以及在哺乳动物中自由放射自由基
公开(公告)号：US20070243270A1
公开(公告)日：2007-10-18
申请号：US11624687
申请日：2007-01-18
申请人： Gregory Evans , Gregory Grochoski , Russell Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margareth Hanausek-Walaszek , Zbigniew Walaszek
发明人： Gregory Evans , Gregory Grochoski , Russell Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margareth Hanausek-Walaszek , Zbigniew Walaszek
IPC分类号： A61K36/736 , A61K36/82 , A61P17/18
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

4. 发明授权

US4871661A Process for testing the carcinogenicity of a material or the presence of cancer-inducing factors in an environment 失效
标题翻译：检测材料的致癌性或在环境中存在致癌因子的过程
公开(公告)号：US4871661A
公开(公告)日：1989-10-03
申请号：US745924
申请日：1985-06-18
申请人： Thomas E. Webb , Dorothy E. Schumm , Margaret Hanausek-Walaszek , Zbigniew Walaszek , Raymond W. Lang
发明人： Thomas E. Webb , Dorothy E. Schumm , Margaret Hanausek-Walaszek , Zbigniew Walaszek , Raymond W. Lang
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , Y10S530/806
摘要： Materials can be screened for carcinogenic properties by administering them to test animals and assaying biological tissue, preferably plasma, for the presence of a 60K cancer-associated phosphoprotein. The test is applicable to a wide range of chemically-diverse carcinogens and is not restricted to carcinogens having one particular mode of action.
摘要翻译：可以通过施用它们来测试动物并测定生物组织，优选血浆，以存在60K癌症相关磷蛋白，筛选出致癌性质的材料。该测试适用于各种各样的化学不同的致癌物质，并不限于具有一种特定作用模式的致癌物质。

5. 发明授权

US5773215A Tumor marker protein for cancer risk assessment 失效
标题翻译：用于癌症风险评估的肿瘤标志物蛋白
公开(公告)号：US5773215A
公开(公告)日：1998-06-30
申请号：US405648
申请日：1995-03-17
申请人： Margaret Hanausek-Walaszek , Thomas J. Slaga , Zbigniew Walaszek
发明人： Margaret Hanausek-Walaszek , Thomas J. Slaga , Zbigniew Walaszek
IPC分类号： C12N15/09 , C07K14/82 , C12N1/21 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/574
CPC分类号： C07K14/82 , C12Q1/6886 , Y10S530/828
摘要： This invention relates to the isolation, identification and sequencing of a cancer associated protein, preparation of hybridization probes therefrom, preparation of antibodies thereto, and methods of cancer risk assessment and diagnosis.
摘要翻译：本发明涉及癌相关蛋白的分离，鉴定和测序，其中杂交探针的制备，抗体的制备以及癌症风险评估和诊断方法。

6. 发明申请

US20050100537A1 Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals 审中-公开
标题翻译：用于减少细胞损伤，抑制自由基产生和清除哺乳动物自由基的方法和试剂盒
公开(公告)号：US20050100537A1
公开(公告)日：2005-05-12
申请号：US10705081
申请日：2003-11-10
申请人： Gregory Evans , Gregory Grochoski , Keith Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
发明人： Gregory Evans , Gregory Grochoski , Keith Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
IPC分类号： A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K45/06 , A61K38/43 , A61K35/78
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

7. 发明授权

US5364644A Formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferative disorders 失效
标题翻译：用于预防和治疗高胆固醇血症和细胞过度增殖性疾病的方法和方法
公开(公告)号：US5364644A
公开(公告)日：1994-11-15
申请号：US12145
申请日：1993-01-28
申请人： Zbigniew Walaszek , Thomas J. Slaga , Margaret Hanausek
发明人： Zbigniew Walaszek , Thomas J. Slaga , Margaret Hanausek
IPC分类号： A61K31/045 , A23L1/03 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A61K31/07 , A61K31/12 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/28 , A61K31/30 , A61K31/355 , A61K31/375 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/455 , A61K31/505 , A61K31/51 , A61K31/714 , A61K33/00 , A61K33/42 , A61K45/06 , A61P3/00 , A61P3/06 , A61P3/14
CPC分类号： A61K45/06 , A23L29/035 , A23L33/12 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/19 , A61K31/194 , A61K33/42 , A23V2002/00
摘要： The present invention provides a formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation. More specifically, the present invention provides a method for administering a formula including glucaric acid or a pharmaceutically acceptable salt thereof for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation in humans and animals. It has been determined that glucaric acid and pharmaceutically acceptable salts thereof significantly lower the total and LDL level of serum cholesterol and inhibit cellular hyperproliferation when administered in therapeutic amounts. It is intended that glucaric acid or a pharmaceutically acceptable salt thereof is employed alone or in combination with other medicinal agents for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation.
摘要翻译：本发明提供了预防和治疗高胆固醇血症和细胞过度增殖的方法和方法。更具体地，本发明提供了一种给予包括葡糖二酸或其药学上可接受的盐的配方用于预防和治疗人和动物中的高胆固醇血症和细胞过度增殖的方法。已经确定，当以治疗量施用时，葡糖二酸及其药学上可接受的盐显着降低血清胆固醇的总和LDL水平并抑制细胞过度增殖。意图是葡糖二酸或其药学上可接受的盐单独使用或与其它药物组合使用以预防和治疗高胆固醇血症和细胞过度增殖。

8. 发明授权

US5310653A Tumor marker protein and antibodies thereto for cancer risk assessment or diagnosis 失效
标题翻译：肿瘤标志物蛋白及其抗体用于癌症风险评估或诊断
公开(公告)号：US5310653A
公开(公告)日：1994-05-10
申请号：US12972
申请日：1993-02-02
申请人： Margaret Hanausek-Walaszek , Thomas J. Slaga , Zbigniew Walaszek
发明人： Margaret Hanausek-Walaszek , Thomas J. Slaga , Zbigniew Walaszek
IPC分类号： C07K14/47 , C07K16/18 , G01N33/574 , A61K37/08 , A61K39/00 , C07K15/18
CPC分类号： G01N33/57476 , C07K14/47 , C07K16/18 , G01N33/5743 , G01N33/57438 , G01N33/57496
摘要： A tumor-associated marker protein was purified and antibodies thereto developed for cancer diagnosis and assessment of cancer risk associated with the long-term use of synthetic steroid hormones, both contraceptive and non-contraceptive, and other drugs that exhibit tumor promotional properties. The marker protein and antibodies thereto provided are interspecies immunologically cross-reactive.In summary, the marker p65 tumor-associated factor of the present invention has the following characteristics:(a) binds substantially completely to a phenyl hydrophobic interaction column in a buffer containing 20% ammonium sulfate and eluted at ca. 16% ammonium sulfate;(b) localized primarily in the nuclear envelopes with only small amounts present in the cytoplasm from where is released to the blood circulation in vivo or cell culture medium in vitro;(c) induced in normal, adult tissues by chemical carcinogens (initiators) but not by tumor promoters, the carcinogen-induced production being enhanced by the latter.Also disclosed herein are processes for purifying the 65 kDa tumor marker from plasma, tumor cytosol or ascitic fluid of carcinoma bearing animals; processes for producing antisera and purified antibody preparations to the 65 kDa tumor marker; and methods using antibody to the 65 kDa to diagnose or assess the likelihood of cancer.
摘要翻译：纯化了与肿瘤相关的标记蛋白，并且其抗体开发用于癌症诊断和评估与长期使用合成类固醇激素（避孕和非避孕药）以及其它展现肿瘤促进性质的药物相关的癌症风险。标记蛋白及其提供的抗体是免疫交叉反应性的种间。总之，本发明的标记p65肿瘤相关因子具有以下特征：（a）基本上完全与含有20％硫酸铵的缓冲液中的苯基疏水相互作用柱结合并在约5℃下洗脱。 16％硫酸铵; （b）主要在核包膜中定位，其中只有少量存在于细胞质中，其体内释放到体内血液循环或体外细胞培养基; （c）通过化学致癌物（引发剂）而不是由肿瘤启动子在正常的成年组织中诱导，致癌物诱导的生产由后者增强。本文还公开了从承载动物的血浆，肿瘤细胞质或腹水中纯化65kDa肿瘤标志物的方法; 制备抗血清和纯化抗体制剂至65kDa肿瘤标志物的方法; 以及使用65kDa抗体诊断或评估癌症可能性的方法。

9. 发明授权

US4845123A Reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by sustained-release inhibitors of .beta.- g 失效
标题翻译：通过β-葡萄糖醛酸酶的缓释抑制剂减少内源和环境衍生化合物的不适当水平的体内
公开(公告)号：US4845123A
公开(公告)日：1989-07-04
申请号：US762339
申请日：1985-08-05
申请人： Zbigniew Walaszek , Malgorzata Hanausek-Walaszek , Thomas E. Webb , John P. Minton
发明人： Zbigniew Walaszek , Malgorzata Hanausek-Walaszek , Thomas E. Webb , John P. Minton
IPC分类号： A61K31/19 , A61K31/365
CPC分类号： A61K31/19 , A61K31/365
摘要： A method for the reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by inhibiting the activity of .beta.-glucuronidase in a mammal which comprises the administration to the mammal of an effective amount of a water insoluble, or sparingly soluble, sustained release precursor of glucarolactone or its analog is disclosed. The sustained release precursor of glucarolactone compound is selected from the group consisting of D-glucaric acid, D-galactaric acid, and L-idaric acid or derivatives or analogs. An orally administrable preparation of the sustained release precursor of glucarolactone compound is provided in the form of a capsule tablet, such that the glucarolactone or its analog is slowly released in the stomach of the treated animal or human.
摘要翻译：一种通过抑制哺乳动物中β-葡糖醛酸糖苷酶的活性来减少内源和环境衍生化合物的不适当水平的方法，其包括向哺乳动物施用有效量的不溶于水的或微溶的持续的公开了葡萄糖内酯或其类似物的释放前体。葡萄糖内酯化合物的持续释放前体选自D-葡糖二酸，D-半乳糖酸，L-赖氨酸或其衍生物或类似物。提供了可口服给药的葡萄糖内酯化合物的缓释前体，其形式为胶囊片剂，使得葡萄内酯酮或其类似物在经处理的动物或人的胃中缓慢释放。

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