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1. 发明申请

US20060254588A1 Determination of mask fitting pressure and correct mask fit 有权
标题翻译：确定面罩配合压力和正确的面罩配合
公开(公告)号：US20060254588A1
公开(公告)日：2006-11-16
申请号：US11488130
申请日：2006-07-18
申请人： Gregory Brewer , Gregory Colla , Steven Farrugia , Chinmayee Somaiya
发明人： Gregory Brewer , Gregory Colla , Steven Farrugia , Chinmayee Somaiya
IPC分类号： A61M16/00 , A62B27/00
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0605 , A61M2016/0021 , A61M2016/0036 , A61M2205/13 , A61M2205/15 , A62B27/00
摘要： CPAP treatment apparatus (10), as one form of positive pressure ventilatory assistance, is disclosed. A turbine/blower (14), operated by a mechanically coupled electrical motor (16), receives air or breathable gas at an inlet (18) thereof, and supplies the breathable gas at a delivery pressure to a delivery tube/hose (20) having connection at the other end thereof with a nose mask (12). A microcontroller (38) has an operational “Mask-Fit” mode. An initial constant pressure level is applied by the blower (14) to the mask (12). If the functional mode is a Manual mode, then the mask-fit test pressure is the current ‘set’ pressure. If the functional mode is the Automatic Titration mode, the mask-fit test pressure is the 95th percentile pressure of the previous session, otherwise it is the base treatment pressure, e.g. 10-12 cm H2O. This constant pressure is applied for a period of time, typically 1-3 minutes. The microcontroller (38) continuously determines mask leak as the value, fLEAK, from a flow sensor (32), comparing this to a threshold, and providing the patient with a visual indication of degree of leak. In this way the patient can manipulate the mask to ensure correct fitting as indicated by the appropriate message or indication.
摘要翻译：公开了作为一种形式的正压通气辅助的CPAP治疗装置（10）。由机械联接的电动机（16）操作的涡轮/鼓风机（14）在其入口（18）处接收空气或可呼吸气体，并将输送压力下的可呼吸气体供应到输送管/软管（20）在其另一端具有与鼻罩（12）的连接。微控制器（38）具有可操作的“掩码拟合”模式。初始恒定压力水平由鼓风机（14）施加到面罩（12）。如果功能模式是手动模式，则掩模配合测试压力是当前的“设置”压力。如果功能模式是自动滴定模式，掩模拟合测试压力是上一届会议的第95百分位数压力，否则为基础处理压力。 10-12厘米H 2 O。施加该恒定压力一段时间，通常为1-3分钟。微控制器（38）从流量传感器（32）连续地将掩模泄漏确定为值泄漏，将其与阈值进行比较，并为患者提供渗透程度的视觉指示。以这种方式，患者可以操纵面罩，以确保正确的配合，如适当的消息或指示所示。

2. 发明授权

US08978643B2 Modification of sympathetic activation and/or respiratory function 有权
标题翻译：改善交感神经激活和/或呼吸功能
公开(公告)号：US08978643B2
公开(公告)日：2015-03-17
申请号：US13501700
申请日：2010-10-14
申请人： Steven Farrugia , Klaus Schindhelm
发明人： Steven Farrugia , Klaus Schindhelm
IPC分类号： A61M16/00 , A62B7/00 , F16K31/02 , A61B5/00 , A61B5/08 , A61B5/087 , A61B5/145
CPC分类号： A61M16/0069 , A61B5/0002 , A61B5/0816 , A61B5/087 , A61B5/145 , A61B5/4818 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/20 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2016/1025 , A61M2205/18 , A61M2205/3334 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/18 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61M2230/005
摘要： Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.
摘要翻译：公开了用于通过改变呼吸功能来改善患者的交感神经激活的装置，系统和方法。在一种形式中，确定用于呼吸机的子呼吸暂停通气目标，以减轻患者的慢性交感神经激活。

3. 发明申请

US20070142741A1 Macro-control of treatment for sleep disordered breathing 有权
标题翻译：治疗睡眠呼吸障碍的宏观控制
公开(公告)号：US20070142741A1
公开(公告)日：2007-06-21
申请号：US10595917
申请日：2004-11-25
申请人： Michael Berthon-Jones , Gordon Malouf , Peter Bateman , David Bassin , Robert Frater , Steven Farrugia
发明人： Michael Berthon-Jones , Gordon Malouf , Peter Bateman , David Bassin , Robert Frater , Steven Farrugia
IPC分类号： A61B5/08
CPC分类号： A61B5/087 , A61B5/4809 , A61B5/4818 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0858 , A61M2016/0039
摘要： A method and apparatus for treating sleep disordered breathing. An arousal index is determined for use in an outer loop of a control algorithm, the arousal index being a measure of the frequency of sleep arousals. The respiratory airflow signal in an inner loop of the control algorithm is monitored to detect an airway obstruction. If the arousal index is high, then the sensitivity of obstruction detection and/or the aggressiveness of the treatment is increased, and if the arousal index is low, then the sensitivity of the obstruction detection and/or the aggressiveness of the treatment is decreased
摘要翻译：一种治疗睡眠呼吸紊乱的方法和装置。确定唤醒指数用于控制算法的外环，唤醒指数是睡眠觉醒频率的量度。监控控制算法内循环中的呼吸气流信号，以检测气道阻塞。如果觉醒指数高，则障碍物检测的敏感度和/或治疗的侵袭性增加，并且如果觉醒指数低，则治疗的障碍物检测和/或侵袭性的敏感性降低

4. 发明申请

US20050005937A1 Method and apparatus for improving the comfort of CPAP 有权
标题翻译：提高CPAP舒适度的方法和装置
公开(公告)号：US20050005937A1
公开(公告)日：2005-01-13
申请号：US10871970
申请日：2004-06-18
申请人： Steven Farrugia , Matthew Alder , Andrew Price , Ron Richard
发明人： Steven Farrugia , Matthew Alder , Andrew Price , Ron Richard
IPC分类号： A61B5/08 , A61H20060101 , A61M16/00
CPC分类号： A61M16/0003 , A61B5/08 , A61B5/417 , A61M16/0051 , A61M16/0069 , A61M16/026 , A61M16/06 , A61M16/0666 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2205/3334 , A61M2205/3365 , A61M2205/3553 , A61M2205/3584 , A61M2205/502 , A61M2230/63
摘要： A low-cost CPAP apparatus in which, upon detection of the transition from inhalation to exhalation, the blower motor is de-energized to allow it to freewheel. When the pressure in the patient mask (or whatever interface is utilized) reaches a minimum pressure level during exhalation, the motor is re-energized and its speed is controlled so to maintain the pressure at a level suitable for exhalation. Upon detection of the transition from exhalation to inhalation, the motor speed is increased to provide higher pressures in the patient mask suitable for inhalation.
摘要翻译：一种低成本CPAP装置，其中，在检测到从吸入到呼气的过渡时，鼓风机马达被断电以允许其飞行。当在呼气期间患者面罩（或任何界面使用的）压力达到最小压力水平时，电动机被重新通电，并且控制其速度以将压力保持在适于呼气的水平。在检测到从呼气到吸入的过渡时，增加电动机速度以在适于吸入的患者面罩中提供更高的压力。

5. 发明授权

US08739780B2 Low cost CPAP flow generator and humidifier assembly 有权
标题翻译：低成本CPAP流量发生器和加湿器总成
公开(公告)号：US08739780B2
公开(公告)日：2014-06-03
申请号：US11988934
申请日：2006-08-15
申请人： Zhuo Ran Tang , Cem Tarakci , John Michael Snow , Kenneth Lee , Steven Farrugia , Dmitri Anotolievich Doudkine , Ian Malcolm Smith
发明人： Zhuo Ran Tang , Cem Tarakci , John Michael Snow , Kenneth Lee , Steven Farrugia , Dmitri Anotolievich Doudkine , Ian Malcolm Smith
IPC分类号： A61M11/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/1075 , A61M16/109 , A61M16/142 , A61M16/16 , A61M2205/3368 , A61M2205/3561 , A61M2205/3584
摘要： A CPAP device wherein humidification detection and/or control is performed by a microprocessor of the CPAP device without requiring a separate humidification control chip. The microprocessor may also control the flow generator motor and the flow generator display. Further, the microprocessor may include code to prevent ‘brown-out’, and/or to detect the availability (connection and/or operability) of the humidifier. Humidifier detection may be carried out using power consumption or temperature sensor signal analysis, e.g., facilitated by use of a pull-up resistor.
摘要翻译： CPAP装置，其中加湿检测和/或控制由CPAP装置的微处理器执行，而不需要单独的加湿控制芯片。微处理器还可以控制流量发生器马达和流量发生器显示器。此外，微处理器可以包括防止“欠压”和/或检测加湿器的可用性（连接和/或可操作性）的代码。可以使用功率消耗或温度传感器信号分析来执行加湿器检测，例如通过使用上拉电阻器来促进加湿器检测。

6. 发明申请

US20120199126A1 Modification of Sympathetic Activation and/or Respiratory Function 有权
标题翻译：改善交感激活和/或呼吸功能
公开(公告)号：US20120199126A1
公开(公告)日：2012-08-09
申请号：US13501700
申请日：2010-10-14
申请人： Steven Farrugia , Klaus Schindhelm
发明人： Steven Farrugia , Klaus Schindhelm
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61B5/0002 , A61B5/0816 , A61B5/087 , A61B5/145 , A61B5/4818 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/20 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2016/1025 , A61M2205/18 , A61M2205/3334 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/18 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61M2230/005
摘要： Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.
摘要翻译：公开了用于通过改变呼吸功能来改善患者的交感神经激活的装置，系统和方法。在一种形式中，确定用于呼吸机的子呼吸暂停通气目标，以减轻患者的慢性交感神经激活。

7. 发明申请

US20070017518A1 METHOD AND APPARATUS FOR IMPROVING THE COMFORT OF CPAP 有权
标题翻译：改善CPAP舒适的方法和装置
公开(公告)号：US20070017518A1
公开(公告)日：2007-01-25
申请号：US11535331
申请日：2006-09-26
申请人： Steven Farrugia , Matthew Alder , Andrew Price , Ron Richard
发明人： Steven Farrugia , Matthew Alder , Andrew Price , Ron Richard
IPC分类号： A61M16/00
CPC分类号： A61M16/0003 , A61B5/08 , A61B5/417 , A61M16/0051 , A61M16/0069 , A61M16/026 , A61M16/06 , A61M16/0666 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2205/3334 , A61M2205/3365 , A61M2205/3553 , A61M2205/3584 , A61M2205/502 , A61M2230/63
摘要： A low-cost CPAP apparatus in which, upon detection of the transition from inhalation to exhalation, the blower motor is de-energized to allow it to freewheel. When the pressure in the patient mask (or whatever interface is utilized) reaches a minimum pressure level during exhalation, the motor is re-energized and its speed is controlled so to maintain the pressure at a level suitable for exhalation. Upon detection of the transition from exhalation to inhalation, the motor speed is increased to provide higher pressures in the patient mask suitable for inhalation.
摘要翻译：一种低成本CPAP装置，其中，在检测到从吸入到呼气的过渡时，鼓风机马达被断电以允许其飞行。当在呼气期间患者面罩（或任何界面使用的）压力达到最小压力水平时，电动机被重新通电，并且控制其速度以将压力保持在适于呼气的水平。在检测到从呼气到吸入的过渡时，增加电动机速度以在适于吸入的患者面罩中提供更高的压力。

8. 发明申请

US20060021618A1 Administration of CPAP treatment pressure in presence of apnea 有权
标题翻译：呼吸暂停治疗CPAP治疗压力
公开(公告)号：US20060021618A1
公开(公告)日：2006-02-02
申请号：US11237278
申请日：2005-09-28
申请人： Michael Berthon-Jones , Steven Farrugia
发明人： Michael Berthon-Jones , Steven Farrugia
IPC分类号： A61M16/00 , A62B7/00
CPC分类号： A61M16/0069 , A61B5/0205 , A61B5/4818 , A61B5/4836 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0036
摘要： CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient's airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, 62, 64) is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator (34, 38) to increase the treatment pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.
摘要翻译：公开了一种CPAP治疗装置，其具有可操作的流量发生器（34,38,40），其可操作以通过耦合到具有与一个或多个连接器的连接的掩模（30）的输送管（32）在处于高于大气的处理压力下向患者产生可呼吸气体病人的气道。传感器（44,50,56,58）产生代表患者呼吸流量的信号，其提供给控制器（54,62,64）。控制器（54,62,64）可操作以从呼吸气流减少到阈值以下来确定呼吸暂停的发生，并且如果发生呼吸暂停，则确定呼吸暂停的持续时间并使流量发生器（34 ，38）以增加治疗压力。在一个优选形式中，如果呼吸暂停之前的治疗压力超过压力阈值，则压力增加为零。在压力阈值以下，压力的增加是呼吸暂停持续时间的乘积乘以压力阈值与当前治疗压力之间的差异的增加的函数。

9. 发明申请

US20050076910A1 Administration of CPAP treatment pressure in presence of apnea 有权
标题翻译：呼吸暂停治疗CPAP治疗压力
公开(公告)号：US20050076910A1
公开(公告)日：2005-04-14
申请号：US10958854
申请日：2004-10-05
申请人： Michael Berthon-Jones , Steven Farrugia
发明人： Michael Berthon-Jones , Steven Farrugia
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61B5/0205 , A61B5/4818 , A61B5/4836 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0036
摘要： CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient's airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, 62, 64) is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator (34, 38) to increase the treatment pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.
摘要翻译：公开了一种CPAP治疗装置，其具有可操作的流量发生器（34,38,40），其可操作以通过耦合到具有与一个或多个连接器的连接的掩模（30）的输送管（32）在处于高于大气的处理压力下向患者产生可呼吸气体病人的气道。传感器（44,50,56,58）产生代表患者呼吸流量的信号，其提供给控制器（54,62,64）。控制器（54,62,64）可操作以从呼吸气流减少到阈值以下来确定呼吸暂停的发生，并且如果发生呼吸暂停，则确定呼吸暂停的持续时间并使流量发生器（34 ，38）以增加治疗压力。在一个优选形式中，如果呼吸暂停之前的治疗压力超过压力阈值，则压力增加为零。在压力阈值以下，压力的增加是呼吸暂停持续时间的乘积乘以压力阈值与当前治疗压力之间的差异的增加的函数。

10. 发明授权

US5542430A Apparatus and method for discriminating between cardiac rhythms on the basis of their morphology using a neural network 失效
标题翻译：基于神经网络的形态鉴别心脏节律的装置和方法
公开(公告)号：US5542430A
公开(公告)日：1996-08-06
申请号：US306993
申请日：1994-09-16
申请人： Steven Farrugia , Hansen Yee , Peter Nickolls
发明人： Steven Farrugia , Hansen Yee , Peter Nickolls
IPC分类号： A61B5/0464 , G06F17/00 , A61B5/046
CPC分类号： A61B5/0464 , A61B5/7242 , A61B5/7264 , Y10S128/924 , Y10S128/925
摘要： An apparatus and a method are provided for coupling to a patient's heart for discriminating between tachycardias of physiological origin, and those of pathological origin having similar rates; and also for discriminating amongst those of pathological origin having similar rates. The apparatus includes transducers and/or sensing electrodes in either or both the atrium and/or ventricle. Also included are signal processing elements for determining the times of atrial and ventricular events and for extracting morphological features from the waveforms, and a neural network for classifying the heart rhythm. The method includes a step of discriminating between different types of heart rhythms having overlapping rates. The method utilizes atrial-atrial, ventricular-ventricular and atrio-ventricular intervals; integrated waveforms; sums of differences of waveform samples; rectified integrated bandpass filtered waveforms; numbers of zero crossings in the electrogram; area under the ventricular electrogram; and R wave slope, QR area and RS area of the electrogram.
摘要翻译：提供了一种装置和方法，用于耦合到患者的心脏以区分生理起源的心动过速和具有相似速率的病理来源的装置和方法; 并且还用于区分具有相似速率的病理来源的那些。该装置包括在心房和/或心室中的一个或两个中的换能器和/或感测电极。还包括用于确定心房和心室事件的时间以及用于从波形中提取形态特征的信号处理元件，以及用于分类心律的神经网络。该方法包括区分具有重叠率的不同类型的心律的步骤。该方法利用心房，心室和心房间隔; 集成波形; 波形样本差值之和; 整流滤波波形整流; 电描记图中的零交叉数; 心室电图下的面积; 和R波幅，QR区和RS区的电描记图。

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