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1. 发明授权

US08528556B2 Ventilatory assistance for treatment of cardiac failure and cheyne-stokes breathing 有权
标题翻译：呼吸辅助治疗心力衰竭和犬蹄呼吸
公开(公告)号：US08528556B2
公开(公告)日：2013-09-10
申请号：US13114884
申请日：2011-05-24
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： A61M11/00
CPC分类号： A61M16/0003 , A61M16/00 , A61M16/0051 , A61M16/0057 , A61M16/0069 , A61M16/024 , A61M16/0858 , A61M2016/0039 , A61M2205/3303 , A61M2230/42
摘要： Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support, for example positive pressure ventilatory support using a blower and mask. Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation (for example half the absolute value of the respiratory airflow) and a measure of longterm average ventilation (for example the instantaneous ventilation low pass filtered with a 100 second time constant). A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. Clipping is typically to between half and double the degree of support that would do all the respiratory work. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject's respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.
摘要翻译：公开了用于治疗心力衰竭，Cheyne Stokes呼吸或中枢性睡眠呼吸暂停的方法和装置。受试者提供通气支持，例如使用鼓风机和面罩的正压通气支架。确定呼吸气流。从呼吸气流得出瞬时通气量（例如呼吸气流的绝对值的一半）和长期平均通气量的测量（例如，以100秒时间常数过滤的瞬时通气低通量）。目标通气量为长期平均通气量的95％。瞬时通风作为输入信号输入到夹紧积分控制器，目标通风作为参考信号。控制器的输出决定通气支持的程度。剪切通常是所有呼吸功能的一半和两倍的支持度。计算第三种通气量，例如用5秒的时间常数过滤的瞬时通风低通量。通气支持与受试者的呼吸气流同步，模糊程度是这种通气高于目标，并且以相反的预设速率。

2. 发明申请

US20130104898A1 PRESSURE SUPPORT VENTILATION OF PATIENTS 审中-公开
公开(公告)号：US20130104898A1
公开(公告)日：2013-05-02
申请号：US13540169
申请日：2012-07-02
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： A61M16/00 , A61M16/06
CPC分类号： A61M16/0057 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0021 , A61M2016/0036 , A61M2230/202
摘要： A methodology and apparatus for determining ventilator settings including an end expiratory pressure setting, pressure swing, resistive unloading and target ventilation for delivering ventilatory support based upon generalized patient ventilation characteristics and/or disease classifications. An apparatus may be programmed with the instructions to accomplish the methodology interactively by prompting the user/physician during setup and calculating settings based upon measurements or input responses. Pre-assigned values associated with ventilation characteristics or disease classifications may be combined with a base pressure value or measured values to provide patient customized settings or adjustments to determine pressure levels for the delivery of ventilatory support.

3. 发明授权

US08381722B2 Distinguishing between closed and open airway apneas and treating patients accordingly 失效
标题翻译：区分闭合和开放性气道呼吸暂停并相应地治疗患者
公开(公告)号：US08381722B2
公开(公告)日：2013-02-26
申请号：US12893449
申请日：2010-09-29
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： F16K31/02
CPC分类号： A61M16/0066 , A61B5/087 , A61B5/7257 , A61F5/56 , A61M16/0006 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0039 , A61M2230/60
摘要： Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion. One determination of patency of the airway is performed by applying an oscillatory pressure waveform of known frequency to a patient's airway, calculating the magnitude of the component of said air flow signal at the known frequency induced by the oscillatory pressure waveform and comparing the calculated magnitude with a threshold value. Alternatively, the air flow signal is analysed to detect the presence of a component due to cardiogenic activity.
摘要翻译：公开了用于确定气道呼吸暂停，通畅和/或部分阻塞的发生的方法和装置。测量来自患者的呼吸气流以产生气流信号。通过计算移动时间窗口上的空气流信号的方差并将该方差与阈值进行比较来执行呼吸暂停的确定。通过检测气流信号的吸气部分，将其缩放为单位持续时间和面积并计算中间部分上的缩放信号的幅度的指标值来执行气道部分阻塞的一个确定。或者，指数值是空气流动信号在中间部分上的平坦度的量度。通过将已知频率的振荡压力波形应用于患者的气道，计算由振荡压力波形引起的已知频率的所述空气流信号的分量的大小，并将计算出的大小与一个阈值。或者，分析空气流信号以检测由于心源性活动引起的组分的存在。

4. 发明授权

US08360060B2 Distinguishing between closed and open airway apneas and treating patients accordingly 失效
公开(公告)号：US08360060B2
公开(公告)日：2013-01-29
申请号：US12789976
申请日：2010-05-28
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： F16K31/02 , A61M16/00 , A62B7/00
CPC分类号： A61M16/0066 , A61B5/087 , A61B5/7257 , A61F5/56 , A61M16/0006 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0039 , A61M2230/60
摘要： Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion. One determination of patency of the airway is performed by applying an oscillatory pressure waveform of known frequency to a patient's airway, calculating the magnitude of the component of said air flow signal at the known frequency induced by the oscillatory pressure waveform and comparing the calculated magnitude with a threshold value. Alternatively, the air flow signal is analysed to detect the presence of a component due to cardiogenic activity.

5. 发明申请

US20110162644A1 METHODS AND APPARATUS FOR SUPPLYING CLEAN BREATHABLE GAS 审中-公开
标题翻译：供应清洁可呼吸气体的方法和装置
公开(公告)号：US20110162644A1
公开(公告)日：2011-07-07
申请号：US13030488
申请日：2011-02-18
申请人： Anthony John Ujhazy , Jonathan Caldwell Wright , Joanne Elizabeth Drew , Michael Berthon-Jones
发明人： Anthony John Ujhazy , Jonathan Caldwell Wright , Joanne Elizabeth Drew , Michael Berthon-Jones
IPC分类号： A61M16/00 , A61M16/10
CPC分类号： A61M16/0633 , A61M15/00 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0611 , A61M16/107 , A61M16/14 , A61M2016/0021 , A61M2016/0039 , A61M2205/52 , A61M2205/707
摘要： The invention features methods and apparatus for the treatment of asthma patients. A controlled supply of breathable air delivered to a patient interface or mask (4) is controlled for patient comfort to maintain a steady pressure level in a range 2 to 4 cm H2O to accommodate patient respiration. The breathable air is cleaned by a high efficiency particulate arresting filter (10) to remove allergens from the air supply. The apparatus may be programmed to automatically detect asthma-related symptoms such as an asthma attack by analyzing the respiratory flow of the patient. In response to the detection of such an attack, the apparatus may provide an audible warning or if configured with a treatment delivery module (14A, 14B), the device may administer a therapeutically effective dose of a drug or substance, for example, a broncho-dilator, to alleviate the patient's breathing difficulty. Preferred mask designs allow for proper CO2 washout to accommodate the low pressures supplied to the mask and prevent asphyxia.
摘要翻译：本发明的特征在于治疗哮喘患者的方法和装置。控制供应到患者接口或面罩（4）的可呼吸空气的受控供应，以使患者舒适度保持在2至4cm H 2 O范围内的稳定压力水平以适应患者呼吸。透气空气被高效颗粒捕集过滤器（10）清洁，以从空气源中除去过敏原。该装置可以被编程为通过分析患者的呼吸流量来自动检测哮喘相关症状，例如哮喘发作。响应于这种攻击的检测，该装置可以提供听觉警告，或者如果配置有治疗传递模块（14A，14B），该装置可以施用治疗有效剂量的药物或物质，例如支气管减轻患者的呼吸困难。优选的面罩设计允许适当的CO2冲洗以适应供应到面罩的低压并防止窒息。

6. 发明申请

US20100242965A1 DISTINGUISHING BETWEEN CLOSED AND OPEN AIRWAY APNEAS AND TREATING PATIENTS ACCORDINGLY 失效
标题翻译：关闭和开放的航空人员和治疗患者之间的差异
公开(公告)号：US20100242965A1
公开(公告)日：2010-09-30
申请号：US12789976
申请日：2010-05-28
申请人： Michael BERTHON-JONES
发明人： Michael BERTHON-JONES
IPC分类号： A61M16/00
CPC分类号： A61M16/0066 , A61B5/087 , A61B5/7257 , A61F5/56 , A61M16/0006 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0039 , A61M2230/60
摘要： Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion. One determination of patency of the airway is performed by applying an oscillatory pressure waveform of known frequency to a patient's airway, calculating the magnitude of the component of said air flow signal at the known frequency induced by the oscillatory pressure waveform and comparing the calculated magnitude with a threshold value. Alternatively, the air flow signal is analysed to detect the presence of a component due to cardiogenic activity.
摘要翻译：公开了用于确定气道呼吸暂停，通畅和/或部分阻塞的发生的方法和装置。测量来自患者的呼吸气流以产生气流信号。通过计算移动时间窗口上的空气流信号的方差并将该方差与阈值进行比较来执行呼吸暂停的确定。通过检测气流信号的吸气部分，将其缩放为单位持续时间和面积并计算中间部分上的缩放信号的幅度的指标值来执行气道部分阻塞的一个确定。或者，指数值是空气流动信号在中间部分上的平坦度的量度。通过将已知频率的振荡压力波形应用于患者的气道，计算由振荡压力波形引起的已知频率的所述空气流信号的分量的大小，并将计算出的大小与一个阈值。或者，分析空气流信号以检测由于心源性活动引起的组分的存在。

7. 发明申请

US20100037895A1 DETERMINING SUITABLE VENTILATOR SETTINGS FOR PATIENTS WITH ALVEOLAR HYPOVENTILATION DURING SLEEP 有权
标题翻译：在睡眠期间确定患有异常呼吸困难的患者的适用通气设置
公开(公告)号：US20100037895A1
公开(公告)日：2010-02-18
申请号：US12575029
申请日：2009-10-07
申请人： Michael Berthon-Jones , Peter Bateman , David Bassin , Gordon Malouf
发明人： Michael Berthon-Jones , Peter Bateman , David Bassin , Gordon Malouf
IPC分类号： A61M16/00
CPC分类号： A61M16/0066 , A61M16/00 , A61M16/0069 , A61M16/026 , A61M16/06 , A61M16/0858 , A61M2016/0021 , A61M2016/0036
摘要： A method and apparatus for determining suitable settings for a servo-ventilator to be used during sleep. Respiratory characteristics of a patient are measured during an awake learning period. With these measured characteristics, a target ventilation setting may be calculated by alternative methods. The calculated setting may then be used for enforcing a minimum ventilation during a treatment period where ventilatory support is provided with a servo-controlled ventilator.
摘要翻译：一种用于确定在睡眠期间使用的伺服通气机的合适设置的方法和装置。在清醒学习期间测量患者的呼吸特征。利用这些测量特征，可以通过替代方法来计算目标通气设置。然后，计算出的设置可用于在具有伺服控制的呼吸机的通气支架的治疗期间执行最小通气。

8. 发明申请

US20080185002A1 ADJUSTMENT OF VENTILATOR PRESSURE-TIME PROFILE TO BALANCE COMFORT AND EFFECTIVENESS 有权
标题翻译：通风机压力调节平衡舒适性和有效性
公开(公告)号：US20080185002A1
公开(公告)日：2008-08-07
申请号：US12100051
申请日：2008-04-09
申请人： Michael BERTHON-JONES , Peter BATEMAN , Gordon MALOUF
发明人： Michael BERTHON-JONES , Peter BATEMAN , Gordon MALOUF
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61M16/024 , A61M16/0858 , A61M2016/0036 , A61M2205/15 , A61M2205/3344
摘要： The invention is a ventilator whose servo-controller adjusts the degree of support by adjusting the profile of the pressure waveform as well as the pressure modulation amplitude. As the servo-controller increases the degree of support by increasing the pressure modulation amplitude, it also generates a progressively more square, and therefore efficient, pressure waveform; when the servo-controller decreases the degree of support by decreasing the pressure modulation amplitude, it also generates a progressively more smooth and therefore comfortable pressure waveform.
摘要翻译：本发明是一种呼吸机，其伺服控制器通过调节压力波形的轮廓以及压力调制幅度来调节支撑度。由于伺服控制器通过增加压力调制幅度来增加支撑度，因此它还产生逐渐更平方的因此有效的压力波形; 当伺服控制器通过降低压力调制幅度来降低支撑度时，它也产生逐渐更平滑且因此舒适的压力波形。

9. 发明授权

US07270128B2 Method and apparatus to counterbalance intrinsic positive end expiratory pressure 有权
标题翻译：抵消内呼吸呼吸压力的方法和装置
公开(公告)号：US07270128B2
公开(公告)日：2007-09-18
申请号：US11130460
申请日：2005-05-16
申请人： Michael Berthon-Jones , Michael David Hallett
发明人： Michael Berthon-Jones , Michael David Hallett
IPC分类号： A62B7/00
CPC分类号： A61M16/0057 , A61M16/0006 , A61M16/0069 , A61M16/024 , A61M16/0858 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039
摘要： The invention prevents dynamic airway compression during ventilatory support of a patient. The respiratory airflow is determined by measurement or calculation, and a measure of the degree of dynamic airway compression is derived from the determined airflow. This measure is servo-controlled to be zero by increasing expiratory pressure if the measure of the degree of dynamic airway compression is large or increasing, and by reducing expiratory pressure if the measure of the degree of dynamic airway compression is small or zero.
摘要翻译：本发明在患者的通气支持期间防止动态气道压迫。通过测量或计算确定呼吸气流，并且从所确定的气流导出动态气道压缩程度的量度。如果动态气道压缩程度大或增加，则通过增加呼气压力，如果动态气道压缩程度小或为零，则通过降低呼气压力，可以将该措施伺服控制为零。

10. 发明申请

US20070142741A1 Macro-control of treatment for sleep disordered breathing 有权
标题翻译：治疗睡眠呼吸障碍的宏观控制
公开(公告)号：US20070142741A1
公开(公告)日：2007-06-21
申请号：US10595917
申请日：2004-11-25
申请人： Michael Berthon-Jones , Gordon Malouf , Peter Bateman , David Bassin , Robert Frater , Steven Farrugia
发明人： Michael Berthon-Jones , Gordon Malouf , Peter Bateman , David Bassin , Robert Frater , Steven Farrugia
IPC分类号： A61B5/08
CPC分类号： A61B5/087 , A61B5/4809 , A61B5/4818 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0858 , A61M2016/0039
摘要： A method and apparatus for treating sleep disordered breathing. An arousal index is determined for use in an outer loop of a control algorithm, the arousal index being a measure of the frequency of sleep arousals. The respiratory airflow signal in an inner loop of the control algorithm is monitored to detect an airway obstruction. If the arousal index is high, then the sensitivity of obstruction detection and/or the aggressiveness of the treatment is increased, and if the arousal index is low, then the sensitivity of the obstruction detection and/or the aggressiveness of the treatment is decreased
摘要翻译：一种治疗睡眠呼吸紊乱的方法和装置。确定唤醒指数用于控制算法的外环，唤醒指数是睡眠觉醒频率的量度。监控控制算法内循环中的呼吸气流信号，以检测气道阻塞。如果觉醒指数高，则障碍物检测的敏感度和/或治疗的侵袭性增加，并且如果觉醒指数低，则治疗的障碍物检测和/或侵袭性的敏感性降低

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