专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090065368A1 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 有权
标题翻译：用于分析测量和免疫测定的装置和方法
公开(公告)号：US20090065368A1
公开(公告)日：2009-03-12
申请号：US12165925
申请日：2008-07-01
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/327 , G01N27/40
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

2. 发明授权

US07419821B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US07419821B2
公开(公告)日：2008-09-02
申请号：US10087730
申请日：2002-03-05
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

3. 发明申请

US20120305409A1 Apparatus and Methods for Analyte Measurement and Immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US20120305409A1
公开(公告)日：2012-12-06
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/26
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

4. 发明申请

US20110290669A1 Apparatus and Methods for Analyte Measurement and Immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US20110290669A1
公开(公告)日：2011-12-01
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/327 , G01N27/40 , G01N33/50 , G01N27/28
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

5. 发明授权

US08017382B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08017382B2
公开(公告)日：2011-09-13
申请号：US12165925
申请日：2008-07-01
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

6. 发明授权

US06379883B2 Microfabricated aperture-based sensor 有权
标题翻译：微型孔径传感器
公开(公告)号：US06379883B2
公开(公告)日：2002-04-30
申请号：US09741347
申请日：2000-12-21
申请人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
发明人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
IPC分类号： C12Q100
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
摘要翻译：化学传感器包括位于扩散层上的酶层，扩散层和分析物阻挡层。通过在分析物阻挡层中的微细加工形成孔径，以允许控制的分析物通量到扩散层。

7. 发明授权

US6030827A Microfabricated aperture-based sensor 失效
公开(公告)号：US6030827A
公开(公告)日：2000-02-29
申请号：US12579
申请日：1998-01-23
申请人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
发明人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
IPC分类号： G01N27/327 , C12Q1/00 , C12M1/40
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.

8. 发明授权

US08679827B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08679827B2
公开(公告)日：2014-03-25
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

9. 发明授权

US08222024B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08222024B2
公开(公告)日：2012-07-17
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

10. 发明授权

US5837446A Process for the manufacture of wholly microfabricated biosensors 失效
标题翻译：制造完全微生物传感器的方法
公开(公告)号：US5837446A
公开(公告)日：1998-11-17
申请号：US482517
申请日：1995-06-07
申请人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck , Randall M. Mier, deceased
发明人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck , Randall M. Mier, deceased
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00 , G01N33/53 , G01N33/68
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over he dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对其在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式