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1. 发明授权

US5289125A Method of electron spin resonance enhanced MRI 失效
标题翻译：电子自旋共振增强MRI的方法
公开(公告)号：US5289125A
公开(公告)日：1994-02-22
申请号：US790209
申请日：1991-11-08
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： A61K49/06 , G01R33/28 , G01R33/563 , G01R33/62 , G01R33/20
CPC分类号： G01R33/62 , A61K49/06 , G01R33/563 , G01R33/281
摘要： A method of electron spin resonance enhanced magnetic resonance imaging of a paramagnetic substance-containing sample wherein an image of at least part of the sample is generated from a data set produced by manipulation of enhanced free induction decay signals detected under at least two different sets of operational parameters. The operating parameters which are varied to produce the different sets include the timing of the exposure of the sample to magnetic field gradients and spin resonance stimulating radiations and, optionally, also the amplitude and frequency distribution of the electron spin resonance stimulating radiations. The manipulation of the detected signals produces, for individual image elements, a normalized signal representative of the difference between signals for that element under the different sets of operational parameters.
摘要翻译：一种包含顺磁性物质的样品的电子自旋共振增强磁共振成像的方法，其中至少部分样品的图像是从通过操纵在至少两组不同组下的检测到的增强的自由诱导衰变信号产生的数据集产生的操作参数。变化以产生不同组的操作参数包括样品暴露于磁场梯度和自旋共振刺激辐射的时间，以及可选地还有电子自旋共振刺激辐射的振幅和频率分布。检测到的信号的操纵对于各个图像元素产生表示在不同操作参数集下的该元件的信号之间的差异的归一化信号。

2. 发明授权

US5144238A Magnetic resonance imaging apparatus 失效
标题翻译：磁共振成像装置
公开(公告)号：US5144238A
公开(公告)日：1992-09-01
申请号：US633798
申请日：1990-12-26
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： G01N24/10 , A61B5/055 , G01N24/08 , G01N24/12 , G01R33/62
CPC分类号： G01R33/62
摘要： There is provided an electron spin resonance enhanced magnetic resonance imaging (ESREMRI) apparatus having means arranged to generate a primary magnetic field of a first value during periods of nuclear spin transition excitation and magnetic resonance signal detection for the generation of ESREMRI images of a subject and means arranged to generate a primary magnetic field of a second and higher value during periods of nuclear spin transition excitation and magnetic resonance signal detection for the generation of native MR images of a subject, and preferably also means for combining, e.g. superimposing, ESREMRI and native MR images so generated.
摘要翻译：提供了一种电子自旋共振增强磁共振成像（ESREMRI）装置，其具有被布置成在核自旋跃迁激发期间产生第一值的初级磁场和用于产生受试者的ESREMRI图像的磁共振信号检测的装置，用于在用于产生对象的本机MR图像的核自旋跃迁激励和磁共振信号检测期间产生第二和更高值的初级磁场的装置，并且优选地也用于组合，例如叠加，ESREMRI和本地MR图像生成。

3. 发明申请

US20110313329A1 THERAPY SYSTEM FOR DEPOSITING ENERGY 有权
标题翻译：用于放电能量的治疗系统
公开(公告)号：US20110313329A1
公开(公告)日：2011-12-22
申请号：US13061985
申请日：2009-09-04
申请人： Max O. Kohler , Teuvo J. Vaara , Shunmugavelu Sokka , Gosta J. Ehnholm
发明人： Max O. Kohler , Teuvo J. Vaara , Shunmugavelu Sokka , Gosta J. Ehnholm
IPC分类号： A61N7/02 , A61N5/02 , A61N5/00 , A61F7/00
CPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B2017/00084 , A61B2017/00194 , A61B2018/183 , A61B2090/374
摘要： A therapy system comprises a therapy module to perform successive deposits of energy in a target zone, the therapy system being provided with a control module is configured to prior the deposits of energy produce an a priori estimate of the induced heating. For example a thermometry module is provided to measure temperature in a measurement field. The induced heating may be derived on the basis of a tissue model from the settings of the therapy module. In particular the therapy module is a high-intensity focuses ultrasound transmitter. A magnetic resonance examination system configured for thermometry is employed as the thermometry module.
摘要翻译：治疗系统包括治疗模块，以在目标区域中执行能量的连续沉积，设置有控制模块的治疗系统被配置为在能量沉积之前产生感应加热的先验估计。例如，提供测温模块以测量测量场中的温度。感应加热可以基于来自治疗模块的设置的组织模型得出。特别地，治疗模块是高强度聚焦超声发射器。采用配置用于测温的磁共振检查系统作为测温模块。

4. 发明授权

US5570022A Power supply for MRI magnets 失效
标题翻译： MRI磁铁供电
公开(公告)号：US5570022A
公开(公告)日：1996-10-29
申请号：US293379
申请日：1994-08-19
申请人： Gosta J. Ehnholm , Seppo T. Pekonen , Juha P. Virtanen
发明人： Gosta J. Ehnholm , Seppo T. Pekonen , Juha P. Virtanen
IPC分类号： G01R33/381 , G01R33/20
CPC分类号： G01R33/381
摘要： Current supply for MRI magnet having an output impedance which has been tailored to have the desired shape by using voltage and current feedback. The impedance is small at frequencies which are large with respect to the magnet L/R and the impedance is large at very low frequencies.
摘要翻译：具有通过使用电压和电流反馈被定制成具有期望形状的输出阻抗的MRI磁体的电流供应。在相对于磁体L / R大的频率上的阻抗小，并且在非常低的频率下的阻抗很大。

5. 发明授权

US5488950A Stabilizer for MRI system 失效
标题翻译： MRI系统稳定器
公开(公告)号：US5488950A
公开(公告)日：1996-02-06
申请号：US212426
申请日：1994-03-14
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： G01R33/24 , G01R33/389 , G01R33/565 , G01R33/60 , A61B5/055
CPC分类号： G01R33/389 , G01R33/24 , G01R33/60 , G01R33/56563
摘要： An electron spin resonator (ESR) is used to compensate for temporally varying instabilities in the main magnetic field B.sub.o of a nuclear magnetic resonance imaging apparatus during the derivation of NMR imaging data from an object being imaged. The ESR monitor is placed at a point outside but close to the object such that the ESR monitor is affected by the temporally varying fields. Variances across the ESR caused by gradient fields are compensated for such that the output of the ESR is independent of the strength of the gradient fields. The ESR output is used to reduce the influence of said instabilities on the imaging data.
摘要翻译：在从成像对象的NMR成像数据推导期间，电子自旋谐振器（ESR）用于补偿核磁共振成像装置的主磁场Bo中的时间上不同的不稳定性。 ESR监视器位于外部但接近对象的点，使得ESR监视器受到时间上不同的字段的影响。由梯度场引起的ESR之间的差异被补偿，使得ESR的输出与梯度场的强度无关。 ESR输出用于减少所述不稳定性对成像数据的影响。

6. 发明授权

US5250900A NMR investigation of repeated electromagnetic events 失效
标题翻译：重复电磁事件的NMR研究
公开(公告)号：US5250900A
公开(公告)日：1993-10-05
申请号：US792782
申请日：1991-11-15
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： G01R33/54 , G01R33/62 , G01R33/20
CPC分类号： G01R33/482 , G01R33/62
摘要： A method of nuclear magnetic resonance investigation of a repeated electromagnetic event in a sample comprises modulation of the nuclear spin polarization achieved during the recovery period between the final magnetic resonance signal detection period of one cycle and the initial signal generation RF pulse of the next cycle. This modulation is performed by giving the sample a different exposure to RF radiation in the different periods, for example by exposure to a different number of 180.degree. pulses in each period or by exposure to a frequency modulated continuous wave RF signal.
摘要翻译：在样品中重复电磁事件的核磁共振研究的方法包括在一个周期的最终磁共振信号检测周期与下一个周期的初始信号产生RF脉冲之间的恢复期间实现的核自旋极化的调制。通过在不同的时间段内例如通过在每个周期中暴露于不同数量的180度脉冲或者通过暴露于调频的连续波RF信号来向样品提供与RF辐射不同的曝光来执行该调制。

7. 发明授权

US5564421A VHF applicator for magnetic resonance imaging 失效
标题翻译：用于磁共振成像的VHF施加器
公开(公告)号：US5564421A
公开(公告)日：1996-10-15
申请号：US986526
申请日：1992-12-07
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： G01R33/345 , A61B5/055
CPC分类号： G01R33/345
摘要： An applicator for coupling an electromagnetic field to a sample to be imaged by magnetic resonance imaging, comprising an electrical periodic structure constructed so as to oscillate with substantially the same phase over its whole length.
摘要翻译：一种用于通过磁共振成像将电磁场耦合到要成像的样品的施加器，包括构造成在整个长度上以基本相同的相位摆动的电周期性结构。

8. 发明授权

US5315250A Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US5315250A
公开(公告)日：1994-05-24
申请号：US931770
申请日：1992-08-18
申请人： Gosta J. Ehnholm , John S. Petersson
发明人： Gosta J. Ehnholm , John S. Petersson
IPC分类号： G01R33/563 , G01R33/62 , G01V3/00
CPC分类号： G01R33/563 , G01R33/62
摘要： The invention provides method of electron spin resonance enhanced magnetic resonance imaging of a subject, for example a human, animal or inanimate body, in which said subject is exposed to radiation of a frequency selected to stimulate an esr transition in a paramagnetic species in said subject whereby to effect dynamic nuclear polarization, wherein said exposure to radiation is arranged such that within the region of said subject so exposed the capacity of said radiation to stimulate a said transition is relatively enhanced in at least one volume (a region of interest (ROI)), i.e. a method in which one or more regions-of-interest within the subject under study are selected by making it possible for an enhancement agent to act more effectively in that region than outside. The method for example also allows flow processes within a body to be monitored to provide the operator with images or data sets indicative of the spatial and/or temporal characteristics of flow from the ROI.
摘要翻译：本发明提供了一种受试者例如人，动物或无生命体的电子自旋共振增强磁共振成像的方法，其中所述受试者暴露于所选择的频率的辐射以刺激所述受试者的顺磁物质中的esr转换从而实现动态核极化，其中所述暴露于辐射被布置成使得在所述受试者的区域内暴露于所述辐射的刺激所述转变的能力在至少一个体积（感兴趣区域（ROI））中相对增强，），即通过使增强剂在该区域内比在外部更有效地起作用的方式来选择被研究对象内的一个或多个兴趣区域的方法。例如，该方法还允许对体内的流程进行监控，以向操作者提供指示来自ROI的流的空间和/或时间特征的图像或数据集。

9. 发明授权

US5296811A Magnetic resonance imaging apparatus and method 失效
标题翻译：磁共振成像装置及方法
公开(公告)号：US5296811A
公开(公告)日：1994-03-22
申请号：US970805
申请日：1992-11-03
申请人： Gosta J. Ehnholm , Ilmari Kinanen , Raimo Sepponen
发明人： Gosta J. Ehnholm , Ilmari Kinanen , Raimo Sepponen
IPC分类号： G01R33/28 , G01R33/383 , G01V3/00
CPC分类号： G01R33/383 , G01R33/28
摘要： The invention relates to a novel magnetic resonance imaging apparatus. The nuclei, protons or the paramagnetic electrons of an imaged object are cyclically polarized during a period of about one second with a permanent magnet which is then quickly shifted away from the imaged object in a permanent magnet carrier tube, so that the field of the permanent magnet would not have an interfering effect on the immediately following signal-collection for MRI-imaging. The permanent magnet can be manipulated or shifted back and forth in the tube either magnetically, pneumatically, hydraulically or mechanically. The apparatus also includes another permanent magnet or a resistive magnet coil couple, which is located in the tube near the opposite end of the tube, and which generates a homogeneous magnetic field within the imaged area. The apparatus includes a gradient coil system for generating a time-dependent magnetic field gradient necessary for imaging, as well as a coil system for producing an electromagnetic radio-frequency excitation signal to be linked with the nuclei or paramagnetic electrons of an imaged object as well as for registering the response of the nuclei or electrons to said signal. A control unit is used to control the above coils and to receive the information therefrom for producing an image or some other representation thereof.
摘要翻译：本发明涉及一种新型的磁共振成像装置。成像对象的核，质子或顺磁性电子在大约一秒钟的周期内被周期性地极化，永久磁铁在永磁体载体管中迅速地从成像对象中移开，从而永久磁场磁体对于立即跟踪的MRI成像信号收集不会产生干扰。永久磁铁可以在磁力，气动，液压或机械上在管中进行操纵或前后移动。该装置还包括另一个永磁体或电阻性磁体线圈对，其位于管的相对端附近的管中，并且在成像区域内产生均匀的磁场。该装置包括用于产生成像所需的时间依赖磁场梯度的梯度线圈系统，以及用于产生要与成像对象的核或顺磁性电子连接的电磁射频激励信号的线圈系统用于记录核或电子对所述信号的响应。控制单元用于控制上述线圈并从其接收信息以产生图像或其他一些表示。

10. 发明授权

US5023555A Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US5023555A
公开(公告)日：1991-06-11
申请号：US459453
申请日：1990-01-02
申请人： Gosta J. Ehnholm
发明人： Gosta J. Ehnholm
IPC分类号： G01R33/48
CPC分类号： G01R33/445
摘要： The invention provides a magnetic resonance imaging apparatus having a primary field generating means for generating a substantially uniform magnetic field, wherein that said primary field generating means is arranged in use to generate a magnetic field the field direction of which varies with time, e.g. a rotating field. The varying field operates to average out from the magnetic field experienced by the sample being imaged at least some of the external perturbing magnetic fields so reducing the sensitivity of the apparatus to such external fields.
摘要翻译：本发明提供了一种磁共振成像装置，其具有用于产生基本上均匀的磁场的主场产生装置，其中所述主场产生装置被布置成在使用中产生其场方向随时间变化的磁场，例如，旋转场。变化的场操作以从由正在对至少一些外部扰动磁场成像的样品所经历的磁场进行平均化，从而降低装置对这种外部场的灵敏度。

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