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1. 发明授权

US08323305B2 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US08323305B2
公开(公告)日：2012-12-04
申请号：US10718504
申请日：2003-11-19
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley , Zia Yassinzadeh , Glenn Foy
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley , Zia Yassinzadeh , Glenn Foy
IPC分类号： A61M29/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12136 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开装置。

2. 发明授权

US06656207B2 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US06656207B2
公开(公告)日：2003-12-02
申请号：US10272508
申请日：2002-10-15
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
IPC分类号： A61B1708
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开装置。

3. 发明授权

US06464712B1 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US06464712B1
公开(公告)日：2002-10-15
申请号：US09528574
申请日：2000-03-20
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
IPC分类号： A61B1708
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment tool is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment tools.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开工具由细长管状构件的近端承载并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开工具。

4. 发明授权

US6056769A Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method 失效
标题翻译：用于体内的血管和束的膨胀装置和与其一起使用的张力施加装置和方法
公开(公告)号：US6056769A
公开(公告)日：2000-05-02
申请号：US126969
申请日：1998-07-31
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00637 , A61B2017/00641 , A61B2017/00654 , A61B2017/00867
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. A first elongate tubular member has proximal and distal extremities and has a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member is and movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member, and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. A deployment mechanism is carried by the proximal extremity of the first elongate tubular member and is adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions. A deployment mechanism includes a push-pull wire with proximal and distal extremities and extends through the first elongate tubular member and is coupled to the expansile member.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。第一细长管状构件具有近端和远端，并且具有纵向轴线。膨胀构件由第一细长管状构件的远端承载并且在收缩和膨胀位置之间移动。膨胀构件在扩展位置具有预定构造。可变形膜覆盖膨胀构件，并且其尺寸设计成能够在膨胀位置上覆盖并膨胀膨胀构件。展开机构由第一细长管状构件的近端承载，并且适于由人手操作，以控制膨胀构件在收缩位置和扩展位置之间的移动。展开机构包括具有近端和远端四肢的推拉线，并且延伸穿过第一细长管状构件并且联接到膨胀构件。

5. 发明授权

US6056770A Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US6056770A
公开(公告)日：2000-05-02
申请号：US241680
申请日：1999-02-01
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B17/08
CPC分类号： A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B2017/00495 , A61B2017/00867
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane at least partially covers the expansile member and is sized so as to be capable of expanding as the expansile member moves from the contracted configuration to the expanded configuration. Deployment members are carried by the proximal extremity of the elongated tubular member and are coupled to the expansile member. The deployment members are adapted to be capable of moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to the deployment members.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。可变形膜至少部分地覆盖膨胀构件，并且其尺寸设计成随着膨胀构件从收缩构型移动到膨胀构型而能够膨胀。展开构件由细长管状构件的近端承载并且联接到膨胀构件。展开构件适于能够在伸缩构件之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到展开构件。

6. 发明授权

US5951589A Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method 失效
标题翻译：用于体内的血管和束的膨胀装置和与其一起使用的张力施加装置和方法
公开(公告)号：US5951589A
公开(公告)日：1999-09-14
申请号：US126963
申请日：1998-07-31
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00637 , A61B2017/00641 , A61B2017/00654 , A61B2017/00867
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. A first elongate tubular member has proximal and distal extremities and has a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member and is movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. A deployment mechanism is carried by the proximal extremity of the first elongate tubular member and is adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions. A biological sealant introducer is connected to the first elongate tubular member for introducing a biological sealant into the body proximal to the expansile member and external to the lumen of the vessel. The biological sealant introducing means includes a second elongate tubular member with proximal and distal extremities. A longitudinal axis and a first lumen extend from the proximal to the distal extremity of the second elongate tubular member. The distal extremity of the second elongate tubular member terminates proximal to the distal extremity of the first elongate tubular member and adjacent to said expansile member. The first elongate tubular member is carried by the second elongate tubular member.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。第一细长管状构件具有近端和远端，并且具有纵向轴线。膨胀构件由第一细长管状构件的远端承载并且可在收缩和膨胀位置之间移动。膨胀构件在扩展位置具有预定构造。可变形膜覆盖膨胀构件，并且其尺寸设计成能够在膨胀位置上覆盖并膨胀膨胀构件。展开机构由第一细长管状构件的近端承载，并且适于由人手操作，以控制膨胀构件在收缩位置和扩展位置之间的移动。生物密封剂引入器连接到第一细长管状构件，用于将生物密封剂引入靠近膨胀构件的体内并且在容器的内腔外部。生物密封剂引入装置包括具有近端和远端的第二细长管状构件。纵向轴线和第一内腔从第二细长管状构件的近端延伸到远端。第二细长管状构件的远端终止于第一细长管状构件的远端并且邻近所述膨胀构件终止。第一细长管状构件由第二细长管状构件承载。

7. 发明授权

US5922009A Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method 失效
标题翻译：用于体内的血管和束的膨胀装置和与其一起使用的张力施加装置和方法
公开(公告)号：US5922009A
公开(公告)日：1999-07-13
申请号：US972383
申请日：1997-11-18
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00637 , A61B2017/00641 , A61B2017/00659 , A61B2017/00867
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises a first elongate tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member and is movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. Deployment means are carried by the proximal extremity of the first elongate tubular member and are adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的第一细长管状构件。膨胀构件由第一细长管状构件的远端承载并且可在收缩和膨胀位置之间移动。膨胀构件在扩展位置具有预定构造。可变形膜覆盖膨胀构件，并且其尺寸设计成能够在膨胀位置上覆盖并膨胀膨胀构件。展开装置由第一细长管状构件的近端承载，并且适于由人手操作，以控制膨胀构件在收缩位置和膨胀位置之间的运动。

8. 发明授权

US6045570A Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method 有权
标题翻译：生物密封剂混合物和用于人体穿刺部位和束的经皮闭塞的系统和方法
公开(公告)号：US6045570A
公开(公告)日：2000-04-04
申请号：US161193
申请日：1998-09-25
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin
IPC分类号： A61B17/00 , A61L24/04 , A61L24/10 , A61K17/08
CPC分类号： A61B17/00491 , A61B17/0057 , A61L24/043 , A61L24/104 , A61B2017/00495 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065 , A61B2017/00654 , A61B2017/00659 , A61B2017/00663
摘要： A biological sealant comprising a gelatin slurry. The slurry contains gelatin, saline or water and thrombin.
摘要翻译：包含明胶浆料的生物密封剂。浆液含有明胶，盐水或水和凝血酶。

9. 发明授权

US5782860A Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method 失效
标题翻译：人体穿刺部位和经皮穿刺闭塞装置及方法
公开(公告)号：US5782860A
公开(公告)日：1998-07-21
申请号：US798870
申请日：1997-02-11
申请人： Gordon H. Epstein , Todd E. Lempert
发明人： Gordon H. Epstein , Todd E. Lempert
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00637 , A61B2017/00641 , A61B2017/00659 , A61B2017/00867
摘要： A closure device for percutaneously forming a closure of a puncture in the tissue of human body. The device comprises a flexible elongate tubular member having proximal and distal extremities and a longitudinal axis. The flexible elongate tubular member has a first lumen extending from the proximal extremity to the distal extremity. A closure assembly is carried by the distal extremity of the flexible elongate tubular member and is movable between contracted and expanded positions. The closure assembly includes a closure mechanism covered by an impermeable membrane. A handle is carried by the proximal extremity of the flexible elongate tubular member and is adapted to be grasped by the human hand. A deployment mechanism is carried by the handle and extends through the flexible elongate tubular member and is coupled to the closure assembly for moving the closure assembly from the contracted position to the expanded position.
摘要翻译：一种用于经皮形成人体组织中穿刺闭合的闭合装置。该装置包括具有近端和远端以及纵向轴线的柔性细长管状构件。柔性细长管状构件具有从近端延伸到远端的第一内腔。闭合组件由柔性细长管状构件的远端承载并且可在收缩和膨胀位置之间移动。闭合组件包括由不透水膜覆盖的封闭机构。手柄由柔性细长管状构件的近端支撑并且适于被人的手抓住。展开机构由手柄承载并延伸穿过柔性细长管状构件并且联接到封闭组件，用于将封闭组件从收缩位置移动到扩展位置。

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