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1. 发明授权

US08323305B2 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US08323305B2
公开(公告)日：2012-12-04
申请号：US10718504
申请日：2003-11-19
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley , Zia Yassinzadeh , Glenn Foy
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley , Zia Yassinzadeh , Glenn Foy
IPC分类号： A61M29/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12136 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开装置。

2. 发明授权

US06656207B2 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US06656207B2
公开(公告)日：2003-12-02
申请号：US10272508
申请日：2002-10-15
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
IPC分类号： A61B1708
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开装置。

3. 发明授权

US06464712B1 Expansile device for use in blood vessels and tracts in the body and method 有权
标题翻译：用于血管和体内的扩张装置和方法
公开(公告)号：US06464712B1
公开(公告)日：2002-10-15
申请号：US09528574
申请日：2000-03-20
申请人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
发明人： Gordon H. Epstein , Todd E. Lempert , Brian B. Martin , David M. Taylor , Richard M. Romley
IPC分类号： A61B1708
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00641
摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment tool is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment tools.
摘要翻译：一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。该装置包括具有近端和远端并具有纵向轴线的细长管状构件。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开工具由细长管状构件的近端承载并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到所述展开工具。

4. 发明授权

US4756595A Optical fiber connector for high pressure environments 失效
标题翻译：用于高压环境的光纤连接器
公开(公告)号：US4756595A
公开(公告)日：1988-07-12
申请号：US854224
申请日：1986-04-21
申请人： Steve W. Braun , Richard M. Romley
发明人： Steve W. Braun , Richard M. Romley
IPC分类号： G02B6/38 , G02B6/44 , G02B6/36
CPC分类号： G02B6/3893 , G02B6/3816 , G02B6/3874 , G02B6/4428
摘要： A pressure compensated, fiber optic coupler for use underwater includes a water impermeable housing have first and second apertures to receive the respective optical fibers. One fiber is permanently held by the seal to the first aperture. The other fiber is inserted through the second aperture which is sealed by a conformable seal which is biased closed when no fiber is inserted through it. An incompressible, refraction of index matched fluid fills the interior of the housing to provide pressure compensation. The conformable seal is conveniently constructed of flexible neoprene and the housing is preferably titanium.
摘要翻译：用于水下的压力补偿的光纤耦合器包括不透水的壳体，具有用于接收相应的光纤的第一和第二孔。一根纤维被密封件永久地保持在第一孔口上。另一根光纤通过第二孔插入，该密封通过合适的密封件密封，当没有纤维插入其中时，它被偏置关闭。指数匹配流体的不可压缩折射填充壳体的内部以提供压力补偿。合适的密封件由柔性氯丁橡胶构成，并且外壳优选为钛。

5. 发明授权

US5911702A Methods and devices for cannulating a patient's blood vessel 失效
标题翻译：插入患者血管的方法和装置
公开(公告)号：US5911702A
公开(公告)日：1999-06-15
申请号：US965273
申请日：1997-11-06
申请人： Richard M. Romley , Brian S. Donlon , Timothy J. Corvi , Sylvia W. Fan , Jan Komtebedde , Keke J. Lepulu , Sylvester B. Lucatero
发明人： Richard M. Romley , Brian S. Donlon , Timothy J. Corvi , Sylvia W. Fan , Jan Komtebedde , Keke J. Lepulu , Sylvester B. Lucatero
IPC分类号： A61M25/08 , A61B17/00 , A61B17/34 , A61M25/00 , A61M25/06 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0662 , A61B17/3439 , A61M25/0023 , A61B2017/00243 , A61M25/005
摘要： A method and device for introduction of a catheter and/or delivering a fluid, such as oxygenated blood, to a patient's vascular system includes a cannula having an expandable portion. The expandable portion is movable from a collapsed position to an expanded position. The expandable portion is inserted into the patient in the collapsed position which facilitates introduction and advancement of the cannula through the patient's blood vessel. After introduction into the patient, the expandable portion is moved to the expanded position. The expandable portion protects the blood vessel against fluid forces when flowing a fluid through the cannula and protects the vessel from contact with the catheter advanced through the cannula.
摘要翻译：用于引入导管和/或将诸如充氧血液的流体递送到患者血管系统的方法和装置包括具有可扩张部分的套管。可扩展部分可以从折叠位置移动到展开位置。可膨胀部分在折叠位置插入患者体内，有利于套管穿过患者血管的引入和前进。在引入到患者体内之后，可扩张部分移动到扩张位置。可膨胀部分在使流体流过套管时防止血液抵抗流体力，并保护血管免受通过插管推进的导管的接触。

6. 发明授权

US6102845A Ventricular assist device with minimal blood contacting surfaces 失效
标题翻译：心室辅助装置具有最小的血液接触表面
公开(公告)号：US6102845A
公开(公告)日：2000-08-15
申请号：US192894
申请日：1994-02-07
申请人： John C. Woodard , Ronald A. Ness , Richard M. Romley , Than Nguyen , Herbert Chen
发明人： John C. Woodard , Ronald A. Ness , Richard M. Romley , Than Nguyen , Herbert Chen
IPC分类号： A61F2/06 , A61F2/24 , A61M1/10 , A61M1/12 , A61M1/36
CPC分类号： A61M1/1037 , A61M1/1098 , A61M1/122 , A61M1/3659 , A61F2/2412 , Y10S623/90
摘要： A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses. However, the sinuses of the inner wall member are configured to provide effective valve action by the formation of vigorous vortices in the blood flow downstream of these valves, and to avoid the formation of clots on the blood-contacting surfaces of the valved conduits.
摘要翻译：心室辅助装置包括一对带阀的导管和通过这些导管连接到宿主患者的循环系统中的泵送部分。泵送部分和带阀的导管被构造和构造成最小化血液在流过装置时必须穿过的材料 - 表面转变的数量。此外，带阀的导管包括猪异种移植瓣膜，其外部由位于装置的血液接触流动路径外部的支架结构支撑。阀门导管的柔性形状保持内壁构件不透血，但限定了可形成稳定的生物界面的多孔内表面。此外，该内壁构件成形为不复制取出异种移植物瓣的猪窦或人主动脉窦的鼻窦。然而，内壁构件的鼻窦构造成通过在这些瓣膜下游的血液流中形成剧烈旋涡来提供有效的瓣膜作用，并且避免在带阀导管的血液接触表面上形成凝块。

7. 发明授权

US5810708A Ventricular assist conduit with externally supported tissue valve 失效
标题翻译：室外辅助导管，带有外部支撑的组织瓣膜
公开(公告)号：US5810708A
公开(公告)日：1998-09-22
申请号：US471438
申请日：1995-06-06
申请人： John C. Woodard , Ronald A. Ness , Richard M. Romley , Than Nguyen , Herbert Chen
发明人： John C. Woodard , Ronald A. Ness , Richard M. Romley , Than Nguyen , Herbert Chen
IPC分类号： A61F2/06 , A61F2/24 , A61M1/10 , A61M1/12 , A61M1/36
CPC分类号： A61M1/1037 , A61M1/1098 , A61M1/122 , A61M1/3659 , A61F2/2412 , Y10S623/90
摘要： A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses. However, the sinuses of the inner wall member are configured to provide effective valve action by the formation of vigorous vortices in the blood flow downstream of these valves, and to avoid the formation of clots on the blood-contacting surfaces of the valved conduits.
摘要翻译：心室辅助装置包括一对带阀的导管和通过这些导管连接到宿主患者的循环系统中的泵送部分。泵送部分和带阀的导管被构造和构造成最小化血液在流过装置时必须穿过的材料 - 表面转变的数量。此外，带阀的导管包括猪异种移植瓣膜，其外部由位于装置的血液接触流动路径外部的支架结构支撑。阀门导管的柔性形状保持内壁构件不透血，但限定了可形成稳定的生物界面的多孔内表面。此外，该内壁构件成形为不复制取出异种移植物瓣的猪窦或人主动脉窦的鼻窦。然而，内壁构件的鼻窦构造成通过在这些瓣膜下游的血液流中形成剧烈旋涡来提供有效的瓣膜作用，并且避免在带阀管道的血液接触表面上形成凝块。

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