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1. 发明授权

US08652465B2 Methods and compositions for the treatment of persistent infections 有权
标题翻译：用于治疗持续感染的方法和组合物
公开(公告)号：US08652465B2
公开(公告)日：2014-02-18
申请号：US11449919
申请日：2006-06-08
申请人： Gordon Freeman , Arlene Sharpe , David M. Dorfman , Rafi Ahmed , Daniel Barber , E. John Wherry
发明人： Gordon Freeman , Arlene Sharpe , David M. Dorfman , Rafi Ahmed , Daniel Barber , E. John Wherry
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2803 , A61K31/713 , A61K38/1709 , A61K39/39 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K16/2818 , C07K16/2827 , C07K2317/70 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/505 , G01N33/57484 , G01N33/57492 , G01N2800/26 , Y02A50/412 , Y02A50/467 , Y02A50/58
摘要： The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
摘要翻译：本发明提供用于治疗，预防或减少持续感染例如慢性感染，潜伏感染，慢感染和癌症的方法和组合物。本发明的方法和组合物还可用于缓解与这种感染和癌症相关的一种或多种症状。

2. 发明申请

US20070122378A1 Methods and compositions for the treatment of persistent infections 有权
标题翻译：用于治疗持续感染的方法和组合物
公开(公告)号：US20070122378A1
公开(公告)日：2007-05-31
申请号：US11449919
申请日：2006-06-08
申请人： Gordon Freeman , Arlene Sharpe , David Dorfman , Rafi Ahmed , Daniel Barber , E. Wherry
发明人： Gordon Freeman , Arlene Sharpe , David Dorfman , Rafi Ahmed , Daniel Barber , E. Wherry
IPC分类号： A61K39/395 , A61K38/21 , A61K38/20 , A61K38/19 , A61K48/00 , C12Q1/70 , G01N33/569 , G01N33/574 , G01N33/554
CPC分类号： C07K16/2803 , A61K31/713 , A61K38/1709 , A61K39/39 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K16/2818 , C07K16/2827 , C07K2317/70 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/505 , G01N33/57484 , G01N33/57492 , G01N2800/26 , Y02A50/412 , Y02A50/467 , Y02A50/58
摘要： The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
摘要翻译：本发明提供用于治疗，预防或减少持续感染例如慢性感染，潜伏感染，慢感染和癌症的方法和组合物。本发明的方法和组合物还可用于缓解与这种感染和癌症相关的一种或多种症状。

3. 发明申请

US20120251537A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS 审中-公开
标题翻译：用于治疗感染和肿瘤的组合物和方法
公开(公告)号：US20120251537A1
公开(公告)日：2012-10-04
申请号：US13436492
申请日：2012-03-30
申请人： Rafi Ahmed , Rama Amara , Gordon Freeman , Arlene Sharpe
发明人： Rafi Ahmed , Rama Amara , Gordon Freeman , Arlene Sharpe
IPC分类号： A61K39/12 , A61K39/21 , A61K39/245 , A61K39/25 , A61K39/29 , A61K39/235 , A61K39/23 , A61P31/14 , A61P31/22 , A61P31/20 , A61P31/18 , A61P37/04 , A61P35/00 , A61K39/00 , A61P31/00 , A61K39/395
CPC分类号： C07K16/2827 , A61K39/12 , A61K39/395 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , A61K2039/5256 , C07K16/2818 , C07K2317/64 , C12N2710/24143 , C12N2740/16011 , C12N2760/10011 , C12N2760/10034 , C12N2770/24211 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.
摘要翻译：公开了可用于降低受试者中PD-1的表达或活性的PD-1拮抗剂。使用这些PD-1拮抗剂与来自感染剂或肿瘤的抗原可以增强特异于感染剂或肿瘤细胞的免疫应答。因此，可以使用PD-1拮抗剂治疗感染的受试者，例如持续感染。此外，可以使用PD-1拮抗剂治疗具有肿瘤的受试者。在几个实例中，可以通过移植治疗有效量的识别感兴趣的抗原的活化T细胞并通过施用治疗有效量的PD-1拮抗剂来治疗受试者。

4. 发明申请

US20100040614A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS 审中-公开
标题翻译：用于治疗感染和肿瘤的组合物和方法
公开(公告)号：US20100040614A1
公开(公告)日：2010-02-18
申请号：US12521302
申请日：2007-12-26
申请人： Rafi Ahmed , Rama Amara , Gordon Freeman , Arlene Sharpe
发明人： Rafi Ahmed , Rama Amara , Gordon Freeman , Arlene Sharpe
IPC分类号： A61K39/395 , A61K39/00 , A61P31/12
CPC分类号： C07K16/2827 , A61K39/12 , A61K39/395 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , A61K2039/5256 , C07K16/2818 , C07K2317/64 , C12N2710/24143 , C12N2740/16011 , C12N2760/10011 , C12N2760/10034 , C12N2770/24211 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.
摘要翻译：公开了可用于降低受试者中PD-1的表达或活性的PD-1拮抗剂。使用这些PD-1拮抗剂与来自感染剂或肿瘤的抗原可以增强特异于感染剂或肿瘤细胞的免疫应答。因此，可以使用PD-1拮抗剂治疗感染的受试者，例如持续感染。此外，可以使用PD-1拮抗剂治疗具有肿瘤的受试者。在几个实例中，可以通过移植治疗有效量的识别感兴趣的抗原的活化T细胞并通过施用治疗有效量的PD-1拮抗剂来治疗受试者。

5. 发明授权

US09598491B2 Methods for the treatment of infections and tumors 有权
公开(公告)号：US09598491B2
公开(公告)日：2017-03-21
申请号：US12626848
申请日：2009-11-27
申请人： Rafi Ahmed , Rama Amara , Vijayakumar Velu , Kehmia Titanji , Gordon Freeman
发明人： Rafi Ahmed , Rama Amara , Vijayakumar Velu , Kehmia Titanji , Gordon Freeman
IPC分类号： C12Q1/02 , C07K16/28 , A61K31/7105 , A61K39/39 , A61K39/395 , G01N33/50 , G01N33/569 , A61K39/00
CPC分类号： G01N33/5052 , A61K31/7105 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/24 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2760/10034 , G01N33/5088 , G01N33/56966 , G01N2333/52 , G01N2800/26 , Y02A50/41 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist.

6. 发明申请

US20100151492A1 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS 有权
标题翻译：治疗感染和肿瘤的方法
公开(公告)号：US20100151492A1
公开(公告)日：2010-06-17
申请号：US12626848
申请日：2009-11-27
申请人： Rafi Ahmed , Rama Amara , Vijayakumar Velu , Kehmia Titanji , Gordon Freeman
发明人： Rafi Ahmed , Rama Amara , Vijayakumar Velu , Kehmia Titanji , Gordon Freeman
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/5052 , A61K31/7105 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/24 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2760/10034 , G01N33/5088 , G01N33/56966 , G01N2333/52 , G01N2800/26 , Y02A50/41 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist.
摘要翻译：公开了可用于降低受试者中PD-1的表达或活性的PD-1拮抗剂。使用这些PD-1拮抗剂与来自感染剂或肿瘤的抗原可以增强特异于感染剂或肿瘤细胞的免疫应答。因此，可以使用PD-1拮抗剂治疗感染的受试者，例如持续感染。此外，可以使用PD-1拮抗剂治疗具有肿瘤的受试者。在几个实例中，可以通过移植治疗有效量的识别感兴趣的抗原的活化T细胞并通过施用治疗有效量的PD-1拮抗剂来治疗受试者。还公开了用于测定施用PD-1拮抗剂的受试者中PD-1拮抗剂的功效的方法。在一些实施方案中，这些方法包括测量来自施用PD-1拮抗剂的受试者的样品中记忆B细胞的增殖。

7. 发明授权

US10726010B2 Optimization technique of generalized disjunctive semi/anti join 有权
公开(公告)号：US10726010B2
公开(公告)日：2020-07-28
申请号：US13603302
申请日：2012-09-04
申请人： Rafi Ahmed , Chun-Chieh Lin , Mohamed Zait
发明人： Rafi Ahmed , Chun-Chieh Lin , Mohamed Zait
IPC分类号： G06F16/2453
摘要： A method, apparatus, and stored instructions are provided for transforming a query representation by unnesting a predicate condition that is based on whether or not a result exists for a subquery of the predicate condition. An initial query representation is received. The initial query representation represents an initial query that includes an EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate and at least one other predicate in a disjunction. The initial query representation is transformed into a semantically equivalent transformed query representation that represents a transformed query. The transformed query includes, instead of the EXISTS-equivalent predicate or a NOT-EXISTS-equivalent predicate, a join operator that references the data object. The transformed query representation, when used for execution, causes the at least one other predicate to be applied separately from a join operation caused by the join operator such that execution of the initial representation is semantically equivalent to execution of the transformed representation.

8. 发明授权

US08552154B2 Anti-PD-L1 antibodies and uses therefor 有权
标题翻译：抗PD-L1抗体及其用途
公开(公告)号：US08552154B2
公开(公告)日：2013-10-08
申请号：US13120406
申请日：2009-09-25
申请人： Gordon J. Freeman , Rafi Ahmed , Timothy D. Jones , Francis J. Carr , James P. Gregson
发明人： Gordon J. Freeman , Rafi Ahmed , Timothy D. Jones , Francis J. Carr , James P. Gregson
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412
摘要： The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.
摘要翻译：本发明部分基于新型人抗PD-1，PD-L1和PD-L2抗体的鉴定。因此，本发明涉及用于诊断，预后和治疗将受益于调节PD-1，PD-L1和/或PD-L2活性（例如持续感染性疾病，自身免疫性疾病，哮喘，移植物）的病症的组合物和方法排斥，炎性疾病和肿瘤），使用本文所述的新的人抗PD-1，PD-L1和PD-L2抗体。

9. 发明授权

US08438152B2 Techniques for bushy tree execution plans for snowstorm schema 有权
标题翻译：用于暴雪模式的丛林执行计划的技术
公开(公告)号：US08438152B2
公开(公告)日：2013-05-07
申请号：US11927324
申请日：2007-10-29
申请人： Rafi Ahmed
发明人： Rafi Ahmed
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30498
摘要： Methods for transforming a query to simulate a bushy tree execution plan for queries containing joins in series are provided. Left deep tree execution plans are supported by most relational database systems but are inefficient at processing queries directed to databases with snowstorm schema. A snowstorm schema contains several large fact tables and many smaller dimension tables, which make reference to one another. Bushy tree execution plans can be much more efficient for processing queries to snowstorm schema. The decision to choose between left-deep and bushy tree execution plans are based on the relative costs of the two execution plans. The methods provided transform queries which are otherwise executed with left deep tree execution plans into queries which are executed with simulated bushy tree execution plans.
摘要翻译：提供了用于转换查询以模拟包含串联连接的查询的丛树执行计划的方法。左深树执行计划是大多数关系数据库系统支持的，但在处理针对具有暴风雪模式的数据库的查询时效率低下。暴风雪模式包含几个大事实表和许多较小的维度表，这些表彼此引用。布什树执行计划可以更有效地处理对暴风雪模式的查询。选择左深和深树执行计划的决定是基于两个执行计划的相对成本。所提供的方法转换了查询，否则这些查询将使用左深树执行计划执行到使用模拟丛林执行计划执行的查询中。

10. 发明授权

US08150865B2 Techniques for coalescing subqueries 有权
标题翻译：合并子查询的技术
公开(公告)号：US08150865B2
公开(公告)日：2012-04-03
申请号：US12182002
申请日：2008-07-29
申请人： Rafi Ahmed , Srikanth Bellamkonda
发明人： Rafi Ahmed , Srikanth Bellamkonda
IPC分类号： G06F17/30
CPC分类号： G06F17/30448
摘要： Methods for transforming queries that contain EXISTS and NOT EXISTS subqueries are provided. The methods provided transform original queries that contain EXISTS and/or NOT EXISTS subqueries in conjunctive or disjunctive combinations into transformed queries that coalesce the original EXISTS and/or NOT EXISTS subqueries into a reduced number of EXISTS and/or NOT EXISTS subqueries, thereby eliminating duplicative table accesses and join operations.
摘要翻译：提供了用于转换包含EXISTS和NOT EXISTS子查询的查询的方法。所提供的方法将包含EXISTS和/或NOT EXISTS子查询的原始查询以联合或分离的组合转换为将原始EXISTS和/或NOT EXISTS子查询合并到减少数量的EXISTS和/或NOT EXISTS子查询中的转换查询，从而消除重复表访问和连接操作。

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