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1. 发明申请

US20110144304A1 Chemical Modification of Proteins 有权
标题翻译：蛋白质的化学修饰
公开(公告)号：US20110144304A1
公开(公告)日：2011-06-16
申请号：US12918678
申请日：2009-01-23
申请人： Goncalo Bernardes , Justin Chalker , Benjamin Davis
发明人： Goncalo Bernardes , Justin Chalker , Benjamin Davis
IPC分类号： C07K1/107 , C07K2/00
CPC分类号： C07K1/1133 , C07K1/02 , C07K1/026 , C07K1/107 , C07K1/13
摘要： The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides.
摘要翻译：本发明涉及将肽或蛋白质中的半胱氨酸残基选择性转化为脱氢丙氨酸（Dha）残基的方法。该方法还适用于硒代半胱氨酸和取代的半胱氨酸和硒代半胱氨酸残基，导致Dha残基，其可以转化为任何天然或非天然氨基酸残基，而不改变肽或蛋白质的其余部分。本发明还允许在任何点而不是在应当存在天然存在的半胱氨酸的位点连接所需的肽，从而允许天然化学连接用于合成不含半胱氨酸的肽。该方法允许合成非常大的肽。

2. 发明授权

US09346851B2 Chemical modification of proteins 有权
标题翻译：蛋白质的化学修饰
公开(公告)号：US09346851B2
公开(公告)日：2016-05-24
申请号：US12918678
申请日：2009-01-23
申请人： Goncalo Bernardes , Justin Chalker , Benjamin Davis
发明人： Goncalo Bernardes , Justin Chalker , Benjamin Davis
IPC分类号： C07K1/107 , C07K1/113 , C07K1/02 , C07K1/13
CPC分类号： C07K1/1133 , C07K1/02 , C07K1/026 , C07K1/107 , C07K1/13
摘要： The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides.
摘要翻译：本发明涉及将肽或蛋白质中的半胱氨酸残基选择性转化为脱氢丙氨酸（Dha）残基的方法。该方法还适用于硒代半胱氨酸和取代的半胱氨酸和硒代半胱氨酸残基，导致Dha残基，其可以转化为任何天然或非天然氨基酸残基，而不改变肽或蛋白质的其余部分。本发明还允许在任何点而不是在应当存在天然存在的半胱氨酸的位点连接所需的肽，从而允许天然化学连接用于合成不含半胱氨酸的肽。该方法允许合成非常大的肽。

3. 发明授权

US09975290B2 Flexible packaging structure with built-in tamper-evidence features and method for making same 有权
公开(公告)号：US09975290B2
公开(公告)日：2018-05-22
申请号：US12043442
申请日：2008-03-06
申请人： Benjamin Davis , Scott William Huffer
发明人： Benjamin Davis , Scott William Huffer
IPC分类号： B29C59/00 , B65D75/58 , B29L9/00
CPC分类号： B29C59/007 , B29C2791/009 , B29L2009/00 , B65D75/5833 , B65D75/5855 , B65D2101/00 , Y10T156/1082
摘要： A flexible packaging laminate has built-in opening/reclose and tamper-evidence features by forming the laminate from an outer structure joined in face-to-face relation to an inner structure. Score lines are formed in both structures to enable an opening to be formed through the laminate by lifting a flap or the like out of the plane of the laminate. The score line through the outer structure defines a larger opening than the score line through the inner structure, such that a marginal region of the outer structure extends beyond the edge of the opening portion of the inner structure. A pressure-sensitive adhesive is used to re-adhere the marginal region to an underlying surface of the inner structure adjacent the opening through the laminate. The outer score line includes at least one tear portion that is torn through upon initial opening, thus indicating the package has been at least partially opened.

4. 发明授权

US09138378B2 Blister package and method of forming same 有权
标题翻译：吸塑包装及其形成方法
公开(公告)号：US09138378B2
公开(公告)日：2015-09-22
申请号：US13176933
申请日：2011-07-06
申请人： Donald McArthur , Benjamin Davis
发明人： Donald McArthur , Benjamin Davis
IPC分类号： B65D75/36 , A61J1/03 , B65B61/02 , B65D75/32 , B65D75/58 , B65B61/18 , B65B9/04
CPC分类号： A61J1/035 , B65B9/045 , B65B61/02 , B65B61/18 , B65D75/327 , B65D75/5833
摘要： A blister package is defined for retaining product. The package is formed from a receptacle substrate having a planer sealing flange and at least one receptacle hollow for retaining product therein. A top layer is provided, covering the receptacle hollow with a portion overlapping and sealed to the sealing flange. A score pattern is formed in the top layer for promoting propagation of a tear upon forcing product from receptacle hollow against the top layer. The score pattern is defined by a plurality of rows of parallel straight lines aligned with the receptacle hollow. In addition, a plurality of spaced curved or bowed score lines are provided. The curved or bowed score lines transversely intersect the rows of straight lines above the receptacle hollow.
摘要翻译：泡罩包装用于保留产品。包装由具有平板密封凸缘和至少一个用于保持其中的产品的至少一个容纳空心的容器基底形成。提供顶层，覆盖接收器中空部分与重叠并密封到密封凸缘的部分。在顶层中形成刻痕图案，用于促使从容器中空压制产品抵靠顶层的撕裂扩展。评分图案由与插座空心对齐的多行平行直线限定。另外，提供了多个间隔开的弯曲或弯曲的刻痕线。弯曲或弯曲的刻痕线与容器空心上方的直线行横向相交。

5. 发明申请

US20070213506A1 Reagents And Methods For The Formation Of Disulfide Bonds And The Glycosylation Of Proteins 有权
标题翻译：二硫键形成和蛋白质糖基化的试剂和方法
公开(公告)号：US20070213506A1
公开(公告)日：2007-09-13
申请号：US10562599
申请日：2004-06-24
申请人： Benjamin Davis , David Gamblin , Antony Fairbanks , Philippe Garnier
发明人： Benjamin Davis , David Gamblin , Antony Fairbanks , Philippe Garnier
IPC分类号： C07H5/10 , C07K1/00 , C07K1/107 , C07K5/02
CPC分类号： C07K1/1077 , C07H5/10
摘要： Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The methods utilise thiosulfonate or selenenylsulfide compounds as reagents or intermediates. Some proteins and peptides comprising selenenyl-sulfide groups also form part of the invention.
摘要翻译：用于形成二硫键的方法和试剂，特别是在蛋白质，肽和氨基酸中。所述方法和试剂对蛋白质，肽和氨基酸的受控糖基化特别有用。该方法利用硫代磺酸盐或硒代硫化物作为试剂或中间体。包含硒基 - 硫醚基团的一些蛋白质和肽也构成本发明的一部分。

6. 发明申请

US20060074833A1 System and method for notifying users of changes in multi-relational ontologies 审中-公开
标题翻译：用于通知用户多关系本体变化的系统和方法
公开(公告)号：US20060074833A1
公开(公告)日：2006-04-06
申请号：US11122055
申请日：2005-05-05
申请人： Stephen Gardner , Conor McMenamin , Benjamin Davis , Matthew Eldridge
发明人： Stephen Gardner , Conor McMenamin , Benjamin Davis , Matthew Eldridge
IPC分类号： G06N5/00 , G06N5/04 , G06F17/00
CPC分类号： G06N5/04 , G06N5/02
摘要： The invention relates to a system and method for electronic notification of multi-relational ontology dynamics. The system may include providing alerts to one or more users upon changes in the content of one or more ontologies. Alerts may be provided according to individual user profiles that may specify alert frequency, content, and/or format.
摘要翻译：本发明涉及一种多关系本体动态电子通知系统和方法。该系统可以包括在一个或多个本体的内容的改变时向一个或多个用户提供警报。可以根据可以指定警报频率，内容和/或格式的个人用户简档提供警报。

7. 发明申请

US20060053173A1 System and method for support of chemical data within multi-relational ontologies 审中-公开
标题翻译：支持多关系本体化学数据的系统和方法
公开(公告)号：US20060053173A1
公开(公告)日：2006-03-09
申请号：US11122067
申请日：2005-05-05
申请人： Stephen Gardner , Benjamin Davis , Juergen Harter
发明人： Stephen Gardner , Benjamin Davis , Juergen Harter
IPC分类号： G06F17/30
CPC分类号： G06F21/6245 , G06F16/353 , G06F16/358 , G06F16/367 , G06F16/38
摘要： The invention relates to a system and method for support of chemical data within multi-relational ontologies. The system may enable entry, storage, manipulation, search, and use of chemical structures within one or more multi-relational ontologies.
摘要翻译：本发明涉及一种用于支持多关系本体内的化学数据的系统和方法。该系统可以允许进入，存储，操纵，搜索和使用一个或多个多关系本体内的化学结构。

8. 发明授权

US09424758B2 Pivotable vertical ventilation training systems and apparatuses 有权
标题翻译：枢轴式立式通气训练系统及装置
公开(公告)号：US09424758B2
公开(公告)日：2016-08-23
申请号：US14146530
申请日：2014-01-02
申请人： Benjamin Davis
发明人： Benjamin Davis
IPC分类号： G09B19/00
CPC分类号： G09B19/00
摘要： The present disclosure is directed to a simulated roof vertical ventilation training apparatus configured to be pivotably attached to a simulated roof. In some examples, the vertical ventilation training apparatus includes a frame pivotably mounted to an exposed rafter of the simulated roof. The frame is moveable between an open position and a closed position. The edges of the frame are configured to engage with at least one disposable support member to maintain the frame in a closed position. The disposable support member is configured to be cut by a user with a hand tool to allow pivot of the frame into the open position.
摘要翻译：本公开涉及一种被构造成可枢转地附接到模拟屋顶的模拟屋顶垂直通风训练装置。在一些示例中，垂直通风训练装置包括可枢转地安装到模拟屋顶的暴露的椽子上的框架。框架可在打开位置和关闭位置之间移动。框架的边缘构造成与至少一个一次性支撑构件接合，以将框架保持在关闭位置。一次性支撑构件被构造成由用户用手工工具切割以允许框架的枢轴进入打开位置。

9. 发明申请

US20140220521A1 PIVOTABLE VERTICAL VENTILATION TRAINING SYSTEMS AND APPARATUSES 审中-公开
标题翻译：可供选择的垂直通风培训系统和设备
公开(公告)号：US20140220521A1
公开(公告)日：2014-08-07
申请号：US14146530
申请日：2014-01-02
申请人： Benjamin Davis
发明人： Benjamin Davis
IPC分类号： G09B19/00
CPC分类号： G09B19/00
摘要： The present disclosure is directed to a simulated roof vertical ventilation training apparatus configured to be pivotably attached to a simulated roof. In some examples, the vertical ventilation training apparatus includes a frame pivotably mounted to an exposed rafter of the simulated roof. The frame is moveable between an open position and a closed position. The edges of the frame are configured to engage with at least one disposable support member to maintain the frame in a closed position. The disposable support member is configured to be cut by a user with a hand tool to allow pivot of the frame into the open position.
摘要翻译：本公开涉及一种被构造成可枢转地附接到模拟屋顶的模拟屋顶垂直通风训练装置。在一些示例中，垂直通风训练装置包括可枢转地安装到模拟屋顶的暴露的椽子上的框架。框架可在打开位置和关闭位置之间移动。框架的边缘构造成与至少一个一次性支撑构件接合，以将框架保持在关闭位置。一次性支撑构件被构造成由用户用手工工具切割以允许框架的枢轴进入打开位置。

10. 发明申请

US20130206632A1 PACKAGE FOR STACKED PRODUCT PIECES HAVING A PATTERN OF SEVERABLE LOCATIONS 有权
标题翻译：堆叠产品的包装有一个模式的可变地点
公开(公告)号：US20130206632A1
公开(公告)日：2013-08-15
申请号：US13808621
申请日：2011-07-07
申请人： Julie Conlon , Donald McArthur , Benjamin Davis
发明人： Julie Conlon , Donald McArthur , Benjamin Davis
IPC分类号： B65D85/62
CPC分类号： B65D85/62 , B65D75/5844 , B65D75/585 , B65D75/5888
摘要： A package supports and dispenses one or more longitudinally stacked product pieces (18). The package includes a sheet positioned around the stacked product pieces. The sheet includes a plurality of longitudinally spaced weakened locations (120) extending transversely thereabout. The weakened locations include a pair of weakened extents (125) which are closely longitudinally spaced. Each weakened location defines a severable location for the sheet to permit dispensing of the product from the package.
摘要翻译：包装件支撑并分配一个或多个纵向堆叠的产品件（18）。该包装包括位于堆叠的产品件周围的片材。片材包括横向延伸的多个纵向间隔的弱化位置（120）。弱化位置包括一对弱化的区段（125），其沿纵向间隔开。每个弱化的位置限定片材的可分离位置，以允许从包装中分配产品。

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