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    • 5. 发明授权
    • Nuclear magnetic resonance measurement techniques in non-uniform fields
    • 非均匀场核磁共振测量技术
    • US07852077B2
    • 2010-12-14
    • US12576307
    • 2009-10-09
    • Yi-Qiao SongNicolas CaudalMartin HürlimannEric E. Sigmund
    • Yi-Qiao SongNicolas CaudalMartin HürlimannEric E. Sigmund
    • G01V3/00
    • G01R33/5617G01N24/081G01R33/445G01R33/448G01R33/56341
    • Methods and pulse sequences for facilitating nuclear magnetic resonance (NMR) measurements in grossly inhomogeneous fields. Methods and pulse sequences according to the invention may be used to accurately measure variables such as transverse relaxation time, longitudinal relaxation time, and diffusion, without the need for data at long recovery time, thereby allowing for faster measurements. In addition, methods and pulse sequences according to embodiment of the invention may allow simultaneous encoding of information in both the amplitude and the shape of echoes, so as to allow a single-shot measurement of multiple variables, e.g., both transverse relaxation time (from the decay of echo amplitudes) and longitudinal relaxation time (from the echo shape). CPMG detection may be used to overcome the often limited signal-to-noise ratio in grossly inhomogeneous fields.
    • 用于促进在非常不均匀的场中进行核磁共振(NMR)测量的方法和脉冲序列。 根据本发明的方法和脉冲序列可以用于精确地测量诸如横向弛豫时间,纵向松弛时间和扩散的变量,而不需要在长恢复时间的数据,从而允许更快的测量。 此外,根据本发明的实施例的方法和脉冲序列可以允许在回波的幅度和形状两者中同时编码信息,以允许单次测量多个变量,例如横向弛豫时间(从 回波幅度的衰减)和纵向弛豫时间(从回波形状)。 可以使用CPMG检测来克服在非常不均匀场中经常受限的信噪比。
    • 6. 发明授权
    • Method and apparatus to improve NMR spectral resolution in an inhomogeneous magnetic field
    • 改善非均匀磁场中NMR光谱分辨率的方法和装置
    • US07683615B2
    • 2010-03-23
    • US11613592
    • 2006-12-20
    • Yi-Qiao Song
    • Yi-Qiao Song
    • G01V3/00
    • G01V3/14G01N24/08G01N24/081G01R33/46G01R33/485
    • A method and apparatus for improving spectral resolution of an NMR measurement in the presence of an inhomogeneous magnetic field. According to one embodiment, a method producing a high resolution nuclear magnetic resonance (NMR) spectrum for a sample in an inhomogeneous magnetic field may comprise generating a first magnetic pulse and a second magnetic pulse, the first and second magnetic pulses being separated in time by a first time period, during the first time period, generating a gradient pulse, repeating the steps of generating the first and second magnetic pulses and generating the gradient pulse N times for different values of a field strength of the gradient pulse, wherein N is an integer greater than one, after each second magnetic pulse, acquiring a signal from the sample, and producing a reconstructed high resolution NMR spectrum from the acquired signals.
    • 一种用于在存在不均匀磁场的情况下提高NMR测量的光谱分辨率的方法和装置。 根据一个实施例,在不均匀磁场中产生用于样品的高分辨率核磁共振(NMR)光谱的方法可以包括产生第一磁脉冲和第二磁脉冲,第一和第二磁脉冲在时间上由 在第一时间周期期间,产生梯度脉冲,重复产生第一和第二磁脉冲的步骤,并且对梯度脉冲的场强的不同值产生梯度脉冲N次,其中N是 在每个第二磁脉冲之后,从样本获取信号,并从所获取的信号产生重建的高分辨率NMR光谱。