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1. 发明授权

US07894891B2 Diffusion-based magnetic resonance methods for characterizing bone structure 有权
标题翻译：用于表征骨骼结构的基于扩散的磁共振方法
公开(公告)号：US07894891B2
公开(公告)日：2011-02-22
申请号：US11478033
申请日：2006-06-29
申请人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
发明人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
IPC分类号： A61B5/04
CPC分类号： A61B5/4509 , A61B5/055 , A61B5/4504 , G01R33/5617 , G01R33/56341
摘要： A method of in vitro or in vivo nuclear magnetic resonance and/or magnetic resonance imaging, to determine bone properties by measuring the effects of molecular diffusion inside the bone specimen to derive parameters that are related to the structure of the trabecular bones. The method is a non-invasive probe that provides topological information on trabecular bone without requiring a full high-resolution image of its structure, and is compatible with clinical use.
摘要翻译：体外或体内核磁共振和/或磁共振成像的方法，通过测量骨样本内的分子扩散的影响来确定与骨小梁骨结构相关的参数来测定骨性质。该方法是一种非侵入式探针，可在骨小梁上提供拓扑学信息，无需其结构完整的高分辨率图像，与临床使用相兼容。

2. 发明授权

US08473046B2 Diffusion-based magnetic resonance methods for characterizing bone structure 有权
标题翻译：用于表征骨骼结构的基于扩散的磁共振方法
公开(公告)号：US08473046B2
公开(公告)日：2013-06-25
申请号：US12985793
申请日：2011-01-06
申请人： Yi-Qiao Song , Eric E Sigmund , HyungJoon Cho
发明人： Yi-Qiao Song , Eric E Sigmund , HyungJoon Cho
IPC分类号： A61B5/04
CPC分类号： A61B5/4509 , A61B5/055 , A61B5/4504 , G01R33/5617 , G01R33/56341
摘要： A method of in vitro or in vivo nuclear magnetic resonance and/or magnetic resonance imaging, to determine bone properties by measuring the effects of molecular diffusion inside the bone specimen to derive parameters that are related to the structure of the trabecular bones. The method is a non-invasive probe that provides topological information on trabecular bone without requiring a full high-resolution image of its structure, and is compatible with clinical use.
摘要翻译：体外或体内核磁共振和/或磁共振成像的方法，通过测量骨样本内的分子扩散的影响来确定与骨小梁骨结构相关的参数来测定骨性质。该方法是一种非侵入式探针，可在骨小梁上提供拓扑学信息，无需其结构完整的高分辨率图像，与临床使用相兼容。

3. 发明申请

US20110105886A1 DIFFUSION-BASED MAGNETIC RESONANCE METHODS FOR CHARACTERIZING BONE STRUCTURE 有权
标题翻译：用于表征骨结构的基于扩散的磁共振方法
公开(公告)号：US20110105886A1
公开(公告)日：2011-05-05
申请号：US12985793
申请日：2011-01-06
申请人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
发明人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
IPC分类号： A61B5/055
CPC分类号： A61B5/4509 , A61B5/055 , A61B5/4504 , G01R33/5617 , G01R33/56341
摘要： A method of in vitro or in vivo nuclear magnetic resonance and/or magnetic resonance imaging, to determine bone properties by measuring the effects of molecular diffusion inside the bone specimen to derive parameters that are related to the structure of the trabecular bones. The method is a non-invasive probe that provides topological information on trabecular bone without requiring a full high-resolution image of its structure, and is compatible with clinical use.
摘要翻译：体外或体内核磁共振和/或磁共振成像的方法，通过测量骨样本内的分子扩散的影响来确定与骨小梁骨结构相关的参数来测定骨性质。该方法是一种非侵入式探针，可在骨小梁上提供拓扑学信息，无需其结构完整的高分辨率图像，与临床使用相兼容。

4. 发明申请

US20100134104A1 NUCLEAR MAGNETIC RESONANCE MEASUREMENT TECHNIQUES IN NON-UNIFORM FIELDS 有权
标题翻译：非均匀磁场中的核磁共振测量技术
公开(公告)号：US20100134104A1
公开(公告)日：2010-06-03
申请号：US12576307
申请日：2009-10-09
申请人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
发明人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
IPC分类号： G01R33/44
CPC分类号： G01R33/5617 , G01N24/081 , G01R33/445 , G01R33/448 , G01R33/56341
摘要： Methods and pulse sequences for facilitating nuclear magnetic resonance (NMR) measurements in grossly inhomogeneous fields. Methods and pulse sequences according to the invention may be used to accurately measure variables such as transverse relaxation time, longitudinal relaxation time, and diffusion, without the need for data at long recovery time, thereby allowing for faster measurements. In addition, methods and pulse sequences according to embodiment of the invention may allow simultaneous encoding of information in both the amplitude and the shape of echoes, so as to allow a single-shot measurement of multiple variables, e.g., both transverse relaxation time (from the decay of echo amplitudes) and longitudinal relaxation time (from the echo shape). CPMG detection may be used to overcome the often limited signal-to-noise ratio in grossly inhomogeneous fields.
摘要翻译：用于促进在非常不均匀的场中进行核磁共振（NMR）测量的方法和脉冲序列。根据本发明的方法和脉冲序列可以用于精确地测量诸如横向弛豫时间，纵向松弛时间和扩散的变量，而不需要在长恢复时间的数据，从而允许更快的测量。此外，根据本发明的实施例的方法和脉冲序列可以允许在回波的幅度和形状两者中同时编码信息，以允许单次测量多个变量，例如横向弛豫时间（从回波幅度的衰减）和纵向弛豫时间（从回波形状）。可以使用CPMG检测来克服在非常不均匀场中经常受限的信噪比。

5. 发明申请

US20080024128A1 Nuclear magnetic resonance measurement techniques in non-uniform fields 有权
标题翻译：非均匀场核磁共振测量技术
公开(公告)号：US20080024128A1
公开(公告)日：2008-01-31
申请号：US11496557
申请日：2006-07-31
申请人： Yi-Qiao Song , Nicolas Caudal , Martin Hurlimann , Eric E. Sigmund
发明人： Yi-Qiao Song , Nicolas Caudal , Martin Hurlimann , Eric E. Sigmund
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01N24/081 , G01R33/445 , G01R33/448 , G01R33/56341
摘要： Methods and pulse sequences for facilitating nuclear magnetic resonance (NMR) measurements in grossly inhomogeneous fields. Methods and pulse sequences according to the invention may be used to accurately measure variables such as transverse relaxation time, longitudinal relaxation time, and diffusion, without the need for data at long recovery time, thereby allowing for faster measurements. In addition, methods and pulse sequences according to embodiment of the invention may allow simultaneous encoding of information in both the amplitude and the shape of echoes, so as to allow a single-shot measurement of multiple variables, e.g., both transverse relaxation time (from the decay of echo amplitudes) and longitudinal relaxation time (from the echo shape). CPMG detection may be used to overcome the often limited signal-to-noise ratio in grossly inhomogeneous fields.
摘要翻译：用于促进在非常不均匀的场中进行核磁共振（NMR）测量的方法和脉冲序列。根据本发明的方法和脉冲序列可以用于精确地测量诸如横向弛豫时间，纵向松弛时间和扩散的变量，而不需要在长恢复时间的数据，从而允许更快的测量。此外，根据本发明的实施例的方法和脉冲序列可以允许在回波的幅度和形状两者中同时编码信息，以允许单次测量多个变量，例如横向弛豫时间（从回波幅度的衰减）和纵向弛豫时间（从回波形状）。可以使用CPMG检测来克服在非常不均匀场中经常受限的信噪比。

6. 发明授权

US07622919B2 Nuclear magnetic resonance measurement techniques in non-uniform fields 有权
标题翻译：非均匀场核磁共振测量技术
公开(公告)号：US07622919B2
公开(公告)日：2009-11-24
申请号：US11496557
申请日：2006-07-31
申请人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
发明人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01N24/081 , G01R33/445 , G01R33/448 , G01R33/56341
摘要： Methods and pulse sequences for facilitating nuclear magnetic resonance (NMR) measurements in grossly inhomogeneous fields. Methods and pulse sequences according to the invention may be used to accurately measure variables such as transverse relaxation time, longitudinal relaxation time, and diffusion, without the need for data at long recovery time, thereby allowing for faster measurements. In addition, methods and pulse sequences according to embodiment of the invention may allow simultaneous encoding of information in both the amplitude and the shape of echoes, so as to allow a single-shot measurement of multiple variables, e.g., both transverse relaxation time (from the decay of echo amplitudes) and longitudinal relaxation time (from the echo shape). CPMG detection may be used to overcome the often limited signal-to-noise ratio in grossly inhomogeneous fields.
摘要翻译：用于促进在非常不均匀的场中进行核磁共振（NMR）测量的方法和脉冲序列。根据本发明的方法和脉冲序列可以用于精确地测量诸如横向弛豫时间，纵向松弛时间和扩散的变量，而不需要在长恢复时间的数据，从而允许更快的测量。此外，根据本发明的实施例的方法和脉冲序列可以允许在回波的幅度和形状两者中同时编码信息，以允许单次测量多个变量，例如横向弛豫时间（从回波幅度的衰减）和纵向弛豫时间（从回波形状）。可以使用CPMG检测来克服在非常不均匀场中经常受限的信噪比。

7. 发明授权

US07852077B2 Nuclear magnetic resonance measurement techniques in non-uniform fields 有权
标题翻译：非均匀场核磁共振测量技术
公开(公告)号：US07852077B2
公开(公告)日：2010-12-14
申请号：US12576307
申请日：2009-10-09
申请人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
发明人： Yi-Qiao Song , Nicolas Caudal , Martin Hürlimann , Eric E. Sigmund
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01N24/081 , G01R33/445 , G01R33/448 , G01R33/56341
摘要： Methods and pulse sequences for facilitating nuclear magnetic resonance (NMR) measurements in grossly inhomogeneous fields. Methods and pulse sequences according to the invention may be used to accurately measure variables such as transverse relaxation time, longitudinal relaxation time, and diffusion, without the need for data at long recovery time, thereby allowing for faster measurements. In addition, methods and pulse sequences according to embodiment of the invention may allow simultaneous encoding of information in both the amplitude and the shape of echoes, so as to allow a single-shot measurement of multiple variables, e.g., both transverse relaxation time (from the decay of echo amplitudes) and longitudinal relaxation time (from the echo shape). CPMG detection may be used to overcome the often limited signal-to-noise ratio in grossly inhomogeneous fields.
摘要翻译：用于促进在非常不均匀的场中进行核磁共振（NMR）测量的方法和脉冲序列。根据本发明的方法和脉冲序列可以用于精确地测量诸如横向弛豫时间，纵向松弛时间和扩散的变量，而不需要在长恢复时间的数据，从而允许更快的测量。此外，根据本发明的实施例的方法和脉冲序列可以允许在回波的幅度和形状两者中同时编码信息，以允许单次测量多个变量，例如横向弛豫时间（从回波幅度的衰减）和纵向弛豫时间（从回波形状）。可以使用CPMG检测来克服在非常不均匀场中经常受限的信噪比。

8. 发明申请

US20070238969A1 Diffusion-based magnetic resonance methods for characterizing bone structure 有权
标题翻译：用于表征骨骼结构的基于扩散的磁共振方法
公开(公告)号：US20070238969A1
公开(公告)日：2007-10-11
申请号：US11478033
申请日：2006-06-29
申请人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
发明人： Yi-Qiao Song , Eric E. Sigmund , HyungJoon Cho
IPC分类号： A61B5/05
CPC分类号： A61B5/4509 , A61B5/055 , A61B5/4504 , G01R33/5617 , G01R33/56341
摘要： A method of in vitro or in vivo nuclear magnetic resonance and/or magnetic resonance imaging, to determine bone properties by measuring the effects of molecular diffusion inside the bone specimen to derive parameters that are related to the structure of the trabecular bones. The method is a non-invasive probe that provides topological information on trabecular bone without requiring a full high-resolution image of its structure, and is compatible with clinical use.
摘要翻译：体外或体内核磁共振和/或磁共振成像的方法，通过测量骨样本内的分子扩散的影响来确定与骨小梁骨结构相关的参数来测定骨性质。该方法是一种非侵入式探针，可在骨小梁上提供拓扑学信息，无需其结构完整的高分辨率图像，与临床使用相兼容。

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