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1. 发明申请

US20090124514A1 SELECTION PROBE AMPLIFICATION 审中-公开
标题翻译：选择探头放大
公开(公告)号：US20090124514A1
公开(公告)日：2009-05-14
申请号：US12258244
申请日：2008-10-24
申请人： Glenn Fu , Laura Stuve , Julie Montgomery , John Sheehan , Charit Pethiyagoda , Amy Ollmann , Naiping Shen , Michael Kennemer , Andrew B. Sparks , Dennis Ballinger
发明人： Glenn Fu , Laura Stuve , Julie Montgomery , John Sheehan , Charit Pethiyagoda , Amy Ollmann , Naiping Shen , Michael Kennemer , Andrew B. Sparks , Dennis Ballinger
IPC分类号： C40B30/04
CPC分类号： C12Q1/6806 , C12Q2600/156 , C12Q2539/101 , C12Q2537/143 , C12Q2521/131
摘要： Multiple unique selection probes are provided in a single medium. Each selection probe has a sequence that is complementary to a unique target sequence that may be present in a sample under consideration. For example, each selection probe may be complementary to a sequence that includes one of the SNPs used to genotype an organism. Single-stranded selection probes anneal or hybridize with sample sequences having the unique target sequences specified by the selection probe sequences. Sequences from the sample that do not anneal or hybridize with the selection probes are separated from the bound sequences by an appropriate technique. The bound sequences can then be freed to provide a mixture of isolated target sequences, which can be used as needed for the application at hand.
摘要翻译：在单个介质中提供多个独特的选择探针。每个选择探针具有与所考虑的样品中可能存在的唯一靶序列互补的序列。例如，每个选择探针可以与包括用于基因型生物体的一个SNP的序列互补。单链选择探针与具有由选择探针序列指定的唯一靶序列的样品序列退火或杂交。来自不退火或与选择探针杂交的样品的序列通过适当的技术与结合的序列分离。然后可以释放结合的序列以提供分离的靶序列的混合物，其可根据需要用于手边的应用。

2. 发明申请

US20060183132A1 Selection probe amplification 审中-公开
标题翻译：选择探针扩增
公开(公告)号：US20060183132A1
公开(公告)日：2006-08-17
申请号：US11058432
申请日：2005-02-14
申请人： Glenn Fu , Laura Stuve , John Sheehan , Amy Ollmann , Naiping Shen , Andrew Sparks , Dennis Ballinger
发明人： Glenn Fu , Laura Stuve , John Sheehan , Amy Ollmann , Naiping Shen , Andrew Sparks , Dennis Ballinger
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q2600/156 , C12Q2521/119 , C12Q2537/143 , C12Q2539/101
摘要： Multiple unique selection probes are provided in a single medium. Each selection probe has a sequence that is complementary to a unique target sequence that may be present in a sample under consideration. For example, each selection probe may be complementary to a sequence that includes one of the SNPs used to genotype an organism. Single-stranded selection probes anneal or hybridize with sample sequences having the unique target sequences specified by the selection probe sequences. Sequences from the sample that do not anneal or hybridize with the selection probes are separated from the bound sequences by an appropriate technique. The bound sequences can then be freed to provide a mixture of isolated target sequences, which can be used as needed for the application at hand.
摘要翻译：在单个介质中提供多个独特的选择探针。每个选择探针具有与可能存在于所考虑的样品中的唯一靶序列互补的序列。例如，每个选择探针可以与包括用于基因型生物体的一个SNP的序列互补。单链选择探针与具有由选择探针序列指定的唯一靶序列的样品序列退火或杂交。来自不退火或与选择探针杂交的样品的序列通过适当的技术与结合的序列分离。然后可以释放结合的序列以提供分离的靶序列的混合物，其可根据需要用于手边的应用。

3. 发明申请

US20050019787A1 Apparatus and methods for analyzing and characterizing nucleic acid sequences 审中-公开
标题翻译：用于分析和表征核酸序列的装置和方法
公开(公告)号：US20050019787A1
公开(公告)日：2005-01-27
申请号：US10768788
申请日：2004-01-30
申请人： Anthony Berno , Karel Konvicka , David Hinds , Nila Patil , Naiping Shen , David Stern , John Sheehan
发明人： Anthony Berno , Karel Konvicka , David Hinds , Nila Patil , Naiping Shen , David Stern , John Sheehan
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F20060101 , G06F19/00
CPC分类号： G16B20/00 , G16B25/00 , G16B40/00
摘要： Computer-implemented methods, data processing apparatus and computer program codes for characterizing an interrogation position, such as a SNP position, in a nucleic acid sequence are provided herein. Computer-implemented methods involving various statistical analyses are provided for characterizing an interrogation position as being associated with a phenotypic trait of interest.
摘要翻译：本文提供了用于表征核酸序列中的询问位置（例如SNP位置）的计算机实现的方法，数据处理设备和计算机程序代码。提供涉及各种统计分析的计算机实现的方法，用于将询问位置表征为与感兴趣的表型性状相关联。

4. 发明授权

US06963805B2 Methods for identifying the evolutionarily conserved sequences 失效
标题翻译：鉴定进化保守序列的方法
公开(公告)号：US06963805B2
公开(公告)日：2005-11-08
申请号：US09972595
申请日：2001-10-05
申请人： Kelly A. Frazer , Nila Patil , John Sheehan
发明人： Kelly A. Frazer , Nila Patil , John Sheehan
IPC分类号： C12P19/34 , C12Q1/68 , G01N31/00 , G01N33/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.
摘要翻译：本发明提供了用于确定来自第一生物体的核酸和来自第二种不同生物体的核酸之间的序列相似性（保守序列）的方法，而不必先验地知道来自第二种不同生物体的核酸序列。第一核酸可以来自任何已知核酸序列并且第二核酸可以来自任何生物体的生物体。该方法包括确定来自第二核酸的哪些碱基与第一核酸相同，并且允许确定第二核酸的部分序列。本发明可用于鉴定基因组中的推定功能区域或推定的生物体序列。

5. 发明授权

US5819837A Process and apparatus for melting and casting of metals in a mold 失效
标题翻译：模具中金属熔化和铸造的工艺和设备
公开(公告)号：US5819837A
公开(公告)日：1998-10-13
申请号：US810022
申请日：1997-03-03
申请人： Franz Hugo , Jakob Huber , Robert Y. Abramson , John Sheehan
发明人： Franz Hugo , Jakob Huber , Robert Y. Abramson , John Sheehan
IPC分类号： B22D13/06 , B22D13/10 , B22D23/00 , B22D27/13 , B22D27/15 , B22D35/04
CPC分类号： B22D27/15 , B22D13/08 , B22D23/006 , B22D27/13
摘要： Metal is melted in an induction-heated crucible (13) on which a mold (10) with a downward-facing filling opening (26) is located in the melting position. After melting the metal, the crucible (13) and the mold (10) are jointly rotated about a horizontal axis (A--A) into a tilting position in which the molten material flows from the crucible (13) into the mold (10). In order to melt reactive metals, melting is done in a crucible (13) that is surrounded by a vacuum, this crucible being surrounded by an induction coil (15) outside of the vacuum. The mold (10) is located in a vacuum-sealed casting chamber (6) which is evacuated together with the crucible (13) prior to melting and casting is carried out by a joint tilting of the crucible (13), casting chamber (6) and mold (10) by at least 180 degrees while the vacuum is maintained.
摘要翻译：金属在感应加热的坩埚（13）中熔化，其中具有向下的填充开口（26）的模具（10）位于熔化位置。在熔化金属之后，坩埚（13）和模具（10）围绕水平轴线（A-A）共同旋转到熔融材料从坩埚（13）流入模具（10）的倾斜位置。为了熔化反应性金属，在由真空包围的坩埚（13）中进行熔化，该坩埚被真空外的感应线圈（15）包围。模具（10）位于真空密封的铸造室（6）中，其在熔化之前与坩埚（13）一起抽空，并且通过坩埚（13），铸造室（6）的接合倾斜）和模具（10）至少180度，同时保持真空。

6. 发明申请

US20110239227A1 System and Method for Controlling Inter-Application Association Through Contextual Policy Control 审中-公开
标题翻译：通过上下文策略控制来控制应用程序间协会的系统和方法
公开(公告)号：US20110239227A1
公开(公告)日：2011-09-29
申请号：US13154323
申请日：2011-06-06
申请人： Stuart Schaefer , John Sheehan
发明人： Stuart Schaefer , John Sheehan
IPC分类号： G06F9/46
CPC分类号： G06F21/53 , G06F9/44505 , G06F9/545 , G06F21/62 , G06F21/6281 , G06F2209/542
摘要： A method for controlling the interoperation of a plurality of software applications and resources includes intercepting communications from a first application to a second application or resource, directing the communication to a context management system, generating a candidate list of contexts for the communication, evaluating the candidate list according to at least one policy defined for these contexts to identify the resultant action and namespace for the communication, and performing the action as defined by the policies within the identified namespace. The method further includes tracking one or more versions of the second application, as well as tracking an evolution of application and/or resource names. The method further includes identifying one or more operations associated with a context on the candidate list, and executing the identified operations prior to a further communication.
摘要翻译：用于控制多个软件应用和资源的互操作的方法包括拦截从第一应用到第二应用或资源的通信，将通信引导到上下文管理系统，生成用于通信的上下文候选列表，评估候选根据为这些上下文定义的至少一个策略来标识用于通信的合成动作和命名空间，以及执行由所标识的命名空间内的策略定义的动作。该方法还包括跟踪第二应用的一个或多个版本，以及跟踪应用和/或资源名称的演进。该方法还包括识别与候选列表上的上下文相关联的一个或多个操作，以及在进一步通信之前执行所识别的操作。

7. 发明申请

US20090133013A1 Creating Virtual Applications 有权
标题翻译：创建虚拟应用程序
公开(公告)号：US20090133013A1
公开(公告)日：2009-05-21
申请号：US11941292
申请日：2007-11-16
申请人： Jefferson B. Criddle , Anthony Douglas Krueger , John Sheehan , Joe Yap
发明人： Jefferson B. Criddle , Anthony Douglas Krueger , John Sheehan , Joe Yap
IPC分类号： G06F17/30 , G06F9/445
CPC分类号： G06F8/60
摘要： Embodiments are provided to create a virtual application or suite of virtual applications. In an embodiment, a system is configured to create a virtual package which includes information that can be used in a hosted virtual application environment. The system can provide bits of a virtual package based in part on user demand for an application or certain application functionality. In one embodiment, a system includes a sequencer component which can create a virtual package which includes information associated with setup-time and run-time changes made to a computing device. The sequencer component can use a number of extensible markup language (XML) files to create the virtual package. Other embodiments are available.
摘要翻译：提供实施例以创建虚拟应用程序或虚拟应用程序套件。在一个实施例中，系统被配置为创建包括可以在托管虚拟应用环境中使用的信息的虚拟包。该系统可以部分地基于用户对应用程序的需求或某些应用功能来提供虚拟包的位。在一个实施例中，系统包括定序器组件，其可以创建包括与对计算设备进行的建立时间和运行时间改变相关联的信息的虚拟包。定序器组件可以使用多个可扩展标记语言（XML）文件来创建虚拟包。其他实施例是可用的。

8. 外观设计

USD537137S1 Golf club head 有权
公开(公告)号：USD537137S1
公开(公告)日：2007-02-20
申请号：US29232479
申请日：2005-06-20
申请人： John Sheehan
设计人： John Sheehan

9. 发明授权

US10229265B2 System and method for controlling inter-application association through contextual policy control 有权
公开(公告)号：US10229265B2
公开(公告)日：2019-03-12
申请号：US13154323
申请日：2011-06-06
申请人： Stuart Schaefer , John Sheehan
发明人： Stuart Schaefer , John Sheehan
IPC分类号： G06F21/53 , G06F9/54 , G06F9/445 , G06F21/62
摘要： A method for controlling the interoperation of a plurality of software applications and resources includes intercepting communications from a first application to a second application or resource, directing the communication to a context management system, generating a candidate list of contexts for the communication, evaluating the candidate list according to at least one policy defined for these contexts to identify the resultant action and namespace for the communication, and performing the action as defined by the policies within the identified namespace. The method further includes tracking one or more versions of the second application, as well as tracking an evolution of application and/or resource names. The method further includes identifying one or more operations associated with a context on the candidate list, and executing the identified operations prior to a further communication.

10. 发明授权

US09290337B2 Grain buggy assembly 有权
标题翻译：粮食车组装
公开(公告)号：US09290337B2
公开(公告)日：2016-03-22
申请号：US13255469
申请日：2010-03-15
申请人： John Sheehan , Glen Picone
发明人： John Sheehan , Glen Picone
IPC分类号： B65F1/00 , B65G69/04 , B60P1/36
CPC分类号： B65G69/0433 , B60P1/36
摘要： The present invention relates to a grain buggy assembly. The grain buggy assembly includes a grain buggy and a conveyor for movably mounting to the buggy. In use, the conveyor can be moved from a retracted configuration in which the conveyor is retracted relative to the buggy to a grain loading configuration. In the grain loading configuration, the conveyor can extend from the buggy to receive grain for conveyance to the buggy. In one embodiment, the conveyor is pivotally mounted to the grain buggy.
摘要翻译：本发明涉及谷物车辆组件。谷物车组件包括谷物车和用于可移动地安装到越野车的输送机。在使用中，输送机可以从其中输送机相对于越野车收回的缩回配置移动到谷物装载配置。在谷物装载配置中，输送机可以从货车延伸以接收粮食以便运输到越野车。在一个实施例中，输送机枢转地安装在谷物车上。

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