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1. 发明授权

US06448299B1 Regeneration of strong-base anion-exchange resins by sequential chemical displacement 有权
标题翻译：通过连续化学位移再生强碱阴离子交换树脂
公开(公告)号：US06448299B1
公开(公告)日：2002-09-10
申请号：US09491242
申请日：2000-01-25
申请人： Gilbert M. Brown , Baohua Gu , Bruce A. Moyer , Peter V. Bonnesen
发明人： Gilbert M. Brown , Baohua Gu , Bruce A. Moyer , Peter V. Bonnesen
IPC分类号： B01J4900
CPC分类号： B01J49/57
摘要： A method for regenerating strong-base anion exchange resins utilizing a sequential chemical displacement technique with new regenerant formulation. The new first regenerant solution is composed of a mixture of ferric chloride, a water-miscible organic solvent, hydrochloric acid, and water in which tetrachloroferrate anion is formed and used to displace the target anions on the resin. The second regenerant is composed of a dilute hydrochloric acid and is used to decompose tetrachloroferrate and elute ferric ions, thereby regenerating the resin. Alternative chemical displacement methods include: (1) displacement of target anions with fluoroborate followed by nitrate or salicylate and (2) displacement of target anions with salicylate followed by dilute hydrochloric acid. The methodology offers an improved regeneration efficiency, recovery, and waste minimization over the conventional displacement technique using sodium chloride (or a brine) or alkali metal hydroxide.
摘要翻译：利用具有新的再生剂配方的连续化学位移技术再生强碱阴离子交换树脂的方法。新的第一再生剂溶液由氯化铁，水混溶性有机溶剂，盐酸和水的混合物组成，其中形成四氯铁酸盐阴离子并用于置换树脂上的目标阴离子。第二再生剂由稀盐酸组成，用于分解四氯铁酸盐并洗脱三价铁离子，从而再生树脂。替代化学位移方法包括：（1）用氟硼酸盐，硝酸盐或水杨酸盐置换目标阴离子，和（2）用水杨酸盐置换目标阴离子，然后用稀盐酸置换。与使用氯化钠（或盐水）或碱金属氢氧化物的常规置换技术相比，该方法提供了改进的再生效率，回收率和废物最小化。

2. 发明授权

US06800203B2 Catalytic destruction of perchlorate in ferric chloride and hydrochloric acid solution with control of temperature, pressure and chemical reagents 失效
标题翻译：氯化铁和盐酸溶液中高氯酸盐的催化破坏，控制温度，压力和化学试剂
公开(公告)号：US06800203B2
公开(公告)日：2004-10-05
申请号：US10157407
申请日：2002-05-29
申请人： Baohua Gu , David R. Cole , Gilbert M. Brown
发明人： Baohua Gu , David R. Cole , Gilbert M. Brown
IPC分类号： C02F128
CPC分类号： B01J49/57 , C02F1/42 , C02F2101/12 , C02F2303/16 , C02F2303/18 , Y10S210/902
摘要： A method is described to decompose perchlorate in a FeCl3/HCl aqueous solution such as would be used to regenerate an anion exchange resin used to remove perchlorate. The solution is mixed with a reducing agent, preferably an organic alcohol and/or ferrous chloride, and can be heated to accelerate the decomposition of perchlorate. Lower temperatures may be employed if a catalyst is added.
摘要翻译：描述了一种方法来分解FeCl 3 / HCl水溶液中的高氯酸盐，例如用于再生用于除去高氯酸盐的阴离子交换树脂。将溶液与还原剂，优选有机醇和/或氯化亚铁混合，并且可以加热以加速高氯酸盐的分解。如果加入催化剂，可以采用较低的温度。

3. 发明授权

US06358396B1 Regeneration of anion exchange resins by catalyzed electrochemical reduction 有权
标题翻译：通过催化电化学还原再生阴离子交换树脂
公开(公告)号：US06358396B1
公开(公告)日：2002-03-19
申请号：US09566036
申请日：2000-05-08
申请人： Baohua Gu , Gilbert M. Brown
发明人： Baohua Gu , Gilbert M. Brown
IPC分类号： C02F128
CPC分类号： B01J49/57 , B01J49/07 , C02F1/42 , C02F2101/12 , C02F2103/06
摘要： Anion exchange resins sorbed with perchlorate may be regenerated by a combination of chemical reduction of perchlorate to chloride using a reducing agent and an electrochemical reduction of the oxidized reducing agent. Transitional metals including Ti, Re, and V are preferred chemical reagents for the reduction of perchlorate to chloride. Complexing agents such as oxalate are used to prevent the precipitation of the oxidized Ti(IV) species, and ethyl alcohol may be added to accelerate the reduction kinetics of perchlorate. The regeneration may be performed by continuously recycling the regenerating solution through the resin bed and an electrochemical cell so that the secondary waste generation is minimized.
摘要翻译：用高氯酸盐吸附的阴离子交换树脂可以通过使用还原剂化学还原高氯酸盐与氯化物的组合和氧化还原剂的电化学还原来再生。包括Ti，Re和V的过渡金属是用于将高氯酸盐还原成氯化物的优选化学试剂。使用诸如草酸盐的络合剂来防止氧化的Ti（IV）物质的沉淀，并且可以加入乙醇以加速高氯酸盐的还原动力学。再生可以通过将再生溶液通过树脂床和电化学电池连续循环来进行，使得二次废物产生最小化。

4. 发明申请

US20130046647A1 SYSTEM FOR MANAGING CONSTRUCTION PROJECT BIDDING 审中-公开
标题翻译：管理施工工程投标制度
公开(公告)号：US20130046647A1
公开(公告)日：2013-02-21
申请号：US13210774
申请日：2011-08-16
申请人： Dave Robertson , Sharandeep Sekhon , Baohua Gu , Dariusz Czarkowski
发明人： Dave Robertson , Sharandeep Sekhon , Baohua Gu , Dariusz Czarkowski
IPC分类号： G06Q30/08
CPC分类号： G06Q30/08 , G06Q10/00
摘要： A system is disclosed that facilitates construction project bidding, document distribution, and project management over a computer network. The system enables a project supervisor to efficiently transmit new project information and associated construction project files to one or more planroom provider systems. Each planroom provider system may make project information and associated construction project files available for transfer and viewing by one or more potential bidders connected to the planroom provider system over a public or private network. The planroom provider system(s) may provide a reference or link back to the project supervisor system to enable the potential bidder to bid on the construction project once the project information and project files have been reviewed.
摘要翻译：公开了一种通过计算机网络进行项目投标，文件分发和项目管理的系统。该系统使项目主管有效地将新的项目信息和相关的建设项目文件传送到一个或多个计划供应商系统。每个计划供应商系统可以使项目信息和相关的建设项目文件可供一个或多个通过公共或私人网络连接到计划室提供者系统的潜在投标人进行转移和查看。一旦项目信息和项目文件被审查，计划供应商系统可以提供参考或链接回项目主管系统，以使潜在投标人能够对施工项目进行投标。

5. 发明授权

US09198927B2 Targeting opposite strand replication intermediates of single-stranded viruses by RNAI 有权
标题翻译：通过RNAI靶向单链病毒的反向链复制中间体
公开(公告)号：US09198927B2
公开(公告)日：2015-12-01
申请号：US12714949
申请日：2010-03-01
申请人： Daniel E. McCallus , Catherine Pachuk , Baohua Gu
发明人： Daniel E. McCallus , Catherine Pachuk , Baohua Gu
IPC分类号： C12N15/11 , A61K31/713 , C12N15/113 , C07H21/04
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/463
摘要： The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.
摘要翻译：本发明涉及通过双链RNA介导的基因沉默（RNAi）调节病毒复制的方法和组合物，其中抗病毒方法和组合物优先靶向单链RNA病毒的相反链复制中间体。

6. 发明申请

US20120267585A1 VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION 审中-公开
公开(公告)号：US20120267585A1
公开(公告)日：2012-10-25
申请号：US13489618
申请日：2012-06-06
申请人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
发明人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
IPC分类号： C09K11/04 , C09K11/06 , B82Y30/00 , B82Y40/00
CPC分类号： C09K11/06 , B82Y30/00 , B82Y40/00 , C09K2211/1007 , C09K2211/1011 , C09K2211/1088 , H01F1/0054
摘要： Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.

7. 发明申请

US20120168671A1 VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION 有权
标题翻译：体积标准的纳米颗粒及其制备方法
公开(公告)号：US20120168671A1
公开(公告)日：2012-07-05
申请号：US12981886
申请日：2010-12-30
申请人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
发明人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
IPC分类号： C09K11/04 , C09K11/08 , C09K11/02 , C09K11/06 , H01F1/00 , B82Y40/00 , B82Y30/00
CPC分类号： B82Y30/00 , B82Y40/00 , C09K11/04 , C09K11/06 , H01F1/0054
摘要： Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.
摘要翻译：包含纳米尺寸物体（即，纳米颗粒）的组合物，其中至少一个可观察标记如放射性同位素或荧光团掺入纳米尺度物体内。纳米尺寸物体包括例如金属或半金属氧化物（例如二氧化硅），量子点，贵金属，磁性金属氧化物，有机聚合物，金属盐和核 - 壳纳米颗粒，其中标记掺入纳米颗粒内或选择性地在核 - 壳纳米颗粒的金属氧化物壳中。还描述了制备体积标记的纳米颗粒的方法。

8. 发明申请

US20090137039A1 TARGETING OPPOSITE STRAND REPLICATION INTERMEDIATES OF SINGLE-STRANDED VIRUSES BY RNAI 审中-公开
标题翻译： RNAI对单链病毒的针对性替代中间性
公开(公告)号：US20090137039A1
公开(公告)日：2009-05-28
申请号：US12201499
申请日：2008-08-29
申请人： Daniel E. McCALLUS , Catherine Pachuk , Baohua Gu
发明人： Daniel E. McCALLUS , Catherine Pachuk , Baohua Gu
IPC分类号： C12N5/08 , C12N5/06 , C12N15/11
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/463
摘要： The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.
摘要翻译：本发明涉及通过双链RNA介导的基因沉默（RNAi）调节病毒复制的方法和组合物，其中抗病毒方法和组合物优先靶向单链RNA病毒的相反链复制中间体。

9. 发明授权

US09011735B2 Volume-labeled nanoparticles and methods of preparation 有权
标题翻译：体积标记的纳米颗粒和制备方法
公开(公告)号：US09011735B2
公开(公告)日：2015-04-21
申请号：US12981886
申请日：2010-12-30
申请人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
发明人： Wei Wang , Baohua Gu , Scott T. Retterer , Mitchel J. Doktycz
IPC分类号： C09K11/04 , C09K11/06 , C09K11/08 , B82Y40/00 , B82Y30/00 , H01F1/00
CPC分类号： B82Y30/00 , B82Y40/00 , C09K11/04 , C09K11/06 , H01F1/0054
摘要： Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.
摘要翻译：包含纳米尺寸物体（即，纳米颗粒）的组合物，其中至少一个可观察标记如放射性同位素或荧光团掺入纳米尺度物体内。纳米尺寸物体包括例如金属或半金属氧化物（例如二氧化硅），量子点，贵金属，磁性金属氧化物，有机聚合物，金属盐和核 - 壳纳米颗粒，其中标记掺入纳米颗粒内或选择性地在核 - 壳纳米颗粒的金属氧化物壳中。还描述了制备体积标记的纳米颗粒的方法。

10. 发明授权

US07989211B1 Functionalized gold surface-enhanced raman scattering substrate for rapid and ultra-sensitive detection of anionic species in the environment 有权
标题翻译：功能化的金表面增强拉曼散射底物，用于环境中阴离子物质的快速和超灵敏检测
公开(公告)号：US07989211B1
公开(公告)日：2011-08-02
申请号：US12645017
申请日：2009-12-22
申请人： Baohua Gu , Chuanmin Ruan , Wei Wang
发明人： Baohua Gu , Chuanmin Ruan , Wei Wang
IPC分类号： G01N33/00 , G01N21/65
CPC分类号： G01N33/182 , G01N21/658 , Y10T436/153333 , Y10T436/173076 , Y10T436/19 , Y10T436/193333
摘要： This invention relates to the development of a new Raman enhancing reagent and a surface-enhanced Raman scattering (SERS) method for rapid and ultra-sensitive detection and identification of perchlorate (ClO4−) and other anions such as technetium (TcO4−), uranium and nitrate in environmental samples. The method involves the synthesis of controlled gold nanoparticles which are modified with amine functional groups such as 2-(dimethylamino)ethanethiol and N,N,N-trimethylaminethiol. These functionalized Au nanoparticles were found to be reactive with perchlorate and other anions and can be used to detect these anions by Raman spectroscopy at ultra low concentrations in complex environmental matrices. This invention overcomes the limitations of currently-available analytical techniques by offering an inexpensive, rapid, ultra-sensitive, and real-time identification and detection of perchlorate and other anions. The technique is not only sensitive but also highly specific because of the unique Raman vibrational bands of perchlorate and other anions.
摘要翻译：本发明涉及新型拉曼增强试剂和表面增强拉曼散射（SERS）方法的开发，用于快速和超灵敏检测和鉴定高氯酸盐（ClO4-）和其他阴离子如锝（TcO4-），铀和硝酸盐在环境样品中。该方法涉及用胺官能团如2-（二甲基氨基）乙硫醇和N，N，N-三甲基氨基硫醇修饰的受控金纳米颗粒的合成。发现这些官能化的Au纳米颗粒与高氯酸盐和其它阴离子反应，可用于通过拉曼光谱法在复杂环境基质中以超低浓度检测这些阴离子。本发明通过提供廉价，快速，超灵敏和实时鉴定和检测高氯酸盐和其他阴离子来克服当前可用的分析技术的局限性。由于高氯酸盐和其他阴离子的独特的拉曼振动带，该技术不仅敏感，而且具有高度的特异性。

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