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1. 发明授权

US07706501B2 Method and apparatus for measuring long bone density of small-animals 失效
标题翻译：测量小动物长骨密度的方法和装置
公开(公告)号：US07706501B2
公开(公告)日：2010-04-27
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/083 , G01B15/00
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

2. 发明申请

US20120029346A1 METHOD AND APPARATUS FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：用于多模式成像的方法和装置
公开(公告)号：US20120029346A1
公开(公告)日：2012-02-02
申请号：US13270471
申请日：2011-10-11
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于对受试动物进行成像的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

3. 发明申请

US20120026588A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：US20120026588A1
公开(公告)日：2012-02-02
申请号：US13188562
申请日：2011-07-22
申请人： Gilbert Feke , Douglas L. Vizard
发明人： Gilbert Feke , Douglas L. Vizard
IPC分类号： G02B26/00
CPC分类号： G02B5/285 , G02B26/002 , G02B26/008 , G02B26/023
摘要： A tunable spectral filtration device is disclosed that includes one or more pairs of interference filters in series, wherein each element of each pair is independently selected from one or more options, independently positioned to intersect a path of converging or diverging light, and independently tilted with respect to the light path. Each filter may be either of a bandpass type, a shortpass type, a longpass type, a notch type, or multiple combinations thereof. Each filter in the series may be independently selected and tilted to tune the net spectral output of the series. The elements in a pair of filters may be tilted in opposite directions so as to cancel angle-of incidence dependent broadening of the spectral output of the individual filters for noncollimated light, as well as cancel translational shift of the transmitted light rays. The elements in a pair of filters may be tilted through orthogonal tilt axes so as to cancel polarization dependent broadening of the spectral output of the individual filters for light whose polarization state is a superposition of nonzero parallel and perpendicular components relative to the tilt axes.
摘要翻译：公开了一种可调谐光谱过滤装置，其包括一对或多对串联的干涉滤光器，其中每对的每个元件独立地选自一个或多个选项，独立地定位成与会聚光或发散光相交，并独立地倾斜与尊重光路。每个滤光器可以是带通型，短通型，长通型，凹口型或其多种组合中的任一种。可以独立地选择和倾斜系列中的每个滤光片以调节该系列的净光谱输出。一对滤波器中的元件可以在相反的方向上倾斜，以便消除入射角依赖于非准直光的各个滤光器的光谱输出的变宽，以及消除透射光线的平移移动。一对滤波器中的元件可以通过正交的倾斜轴倾斜，从而抵消偏振状态是相对于倾斜轴的非零平行和垂直分量的叠加的光的各个滤光器的光谱输出的偏振相关的加宽。

4. 发明申请

US20090324048A1 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US20090324048A1
公开(公告)日：2009-12-31
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： G06K9/00 , G01N23/04 , G01N23/223
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

5. 发明申请

US20090114860A1 APPARATUS AND METHOD FOR IMAGING IONIZING RADIATION 有权
标题翻译：用于成像离子辐射的装置和方法
公开(公告)号：US20090114860A1
公开(公告)日：2009-05-07
申请号：US12324092
申请日：2008-11-26
申请人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
发明人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
IPC分类号： G01N23/04
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

6. 发明申请

US20080314114A1 FLUORESCENCE CALIBRATOR FOR MULTIPLE BAND FLAT FIELD CORRECTION 有权
标题翻译：荧光校正器用于多条平面场校正
公开(公告)号：US20080314114A1
公开(公告)日：2008-12-25
申请号：US11765618
申请日：2007-06-20
申请人： Gilbert Feke , Douglas L. Vizard
发明人： Gilbert Feke , Douglas L. Vizard
IPC分类号： G01N3/62
CPC分类号： G01N21/6456 , G01N21/278 , Y10T428/24942
摘要： A fluorescence reference plate for a fluorescence spectroscopic instrument is arranged with fluorescent layers having different excitation and emission characteristics. The fluorescent layers are ordered in the form of a stack for providing a flat-field calibration standard over multiple bands of wavelengths.
摘要翻译：布置具有不同激发和发射特性的荧光层的荧光分光仪的荧光基准板。荧光层以堆叠的形式排列，以在多个波长带上提供平坦场校准标准。

7. 发明申请

US20090080608A1 METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS 失效
标题翻译：用于测量小动物长骨密度的方法和装置
公开(公告)号：US20090080608A1
公开(公告)日：2009-03-26
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/06
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

8. 发明授权

US07630072B2 Fluorescence calibrator for multiple band flat field correction 有权
标题翻译：用于多波段平场校正的荧光校准器
公开(公告)号：US07630072B2
公开(公告)日：2009-12-08
申请号：US11765618
申请日：2007-06-20
申请人： Gilbert Feke , Douglas L. Vizard
发明人： Gilbert Feke , Douglas L. Vizard
IPC分类号： G01J1/10
CPC分类号： G01N21/6456 , G01N21/278 , Y10T428/24942
摘要： A fluorescence reference plate for a fluorescence spectroscopic instrument is arranged with fluorescent layers having different excitation and emission characteristics. The fluorescent layers are ordered in the form of a stack for providing a flat-field calibration standard over multiple bands of wavelengths.
摘要翻译：布置具有不同激发和发射特性的荧光层的荧光分光仪的荧光基准板。荧光层以堆叠的形式排列，以在多个波长带上提供平坦场校准标准。

9. 发明授权

US08203132B2 Apparatus and method for imaging ionizing radiation 有权
标题翻译：用于成像电离辐射的装置和方法
公开(公告)号：US08203132B2
公开(公告)日：2012-06-19
申请号：US12324092
申请日：2008-11-26
申请人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
发明人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
IPC分类号： G01N23/04
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

10. 发明授权

US08041409B2 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US08041409B2
公开(公告)日：2011-10-18
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

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