专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07706501B2 Method and apparatus for measuring long bone density of small-animals 失效
标题翻译：测量小动物长骨密度的方法和装置
公开(公告)号：US07706501B2
公开(公告)日：2010-04-27
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/083 , G01B15/00
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

2. 发明授权

US06947142B2 Color detection in random array of microspheres 失效
标题翻译：随机阵列的微球的颜色检测
公开(公告)号：US06947142B2
公开(公告)日：2005-09-20
申请号：US10606621
申请日：2003-06-26
申请人： Samuel Chen , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard , Joaquin Calcines
发明人： Samuel Chen , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard , Joaquin Calcines
IPC分类号： G01N21/25 , G01J3/46
CPC分类号： G01N21/251
摘要： A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, at least one of which has a color characteristic; capturing the microarray with an electronic color image sensor assembly having a matrix of pixels to produce an electronic microarray image; detecting the location of a microsphere within the captured microarray image; and identifying a color characteristic of the detected microsphere.
摘要翻译：一种确定着色微球的一种或多种颜色特性的方法，包括：提供微球的微阵列，其中至少一种具有颜色特征; 用具有像素矩阵的电子彩色图像传感器组件捕获微阵列，以产生电子微阵列图像; 检测捕获的微阵列图像内的微球的位置; 并识别检测到的微球的颜色特性。

3. 发明授权

US5731425A Polypeptide surface marker for cells 失效
标题翻译：细胞多肽表面标记
公开(公告)号：US5731425A
公开(公告)日：1998-03-24
申请号：US330638
申请日：1994-10-28
申请人： Billy L. Brizzard , Darlene W. Bianca , Richard G. Chubet , Douglas L. Vizard , Thomas Patrick Hopp
发明人： Billy L. Brizzard , Darlene W. Bianca , Richard G. Chubet , Douglas L. Vizard , Thomas Patrick Hopp
IPC分类号： C07K14/00 , C12N15/11 , C07H21/04 , C12N15/85 , C12P21/02
CPC分类号： C12N15/11 , C07K14/00
摘要： This invention discloses a gene for the identification of cells comprising a selection leader segment, a cell marker segment and a transmembrane segment. The gene can be used to identify cells transfected with the gene by the steps of: inserting the gene having a selection leader segment, a cell marker segment and a transmembrane segment into the DNA or RNA of a cell, allowing the cell to express the gene, and detecting the expressed cell marker segment of the gene.
摘要翻译：本发明公开了一种用于鉴定包含选择前导片段，细胞标记片段和跨膜片段的细胞的基因。该基因可以用于鉴定通过以下步骤鉴定用该基因转染的细胞：将具有选择前导片段，细胞标记区段和跨膜区段的基因插入细胞的DNA或RNA，允许细胞表达基因并检测基因表达的细胞标志物区段。

4. 发明申请

US20100220836A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：多模式成像的装置和方法
公开(公告)号：US20100220836A1
公开(公告)日：2010-09-02
申请号：US12763231
申请日：2010-04-20
申请人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
发明人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
IPC分类号： G01N23/04 , H04N5/225 , G06K9/00
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B6/00 , A61B6/5247 , A61B2562/17
摘要： An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes first means for imaging the immobilized object in a first imaging mode to capture a first image, and second means for imaging the immobilized object in a second imaging mode to capture a second image. The first imaging mode is selected from the group: x-ray mode and radio isotopic mode. The second imaging mode is selected from the group: bright-field mode and dark-field mode. The first and second means for imaging may be included in a capture system having a camera, a first mirror on a first side of the support member for reflecting light to capture the first and second images and a second mirror on a second, opposite side of the support member for reflecting light to capture a third image from an opposite side of the object. A movable phosphor screen is employed when the first image is captured and not employed when the second image is captured. The phosphor screen is adapted to be movable without moving the immobilized object and support member. The system can further include means for generating a third image comprised of the first and second images.
摘要翻译：一种用于对固定物体进行成像的成像系统和方法。成像系统包括适于在固定状态下接收物体的支撑构件。该系统还包括用于在第一成像模式下成像固定的物体以捕获第一图像的第一装置，以及用于在第二成像模式下成像固定的物体以捕获第二图像的第二装置。第一种成像模式选自x射线模式和放射同位素模式。第二种成像模式选自明场模式和暗场模式。用于成像的第一和第二装置可以包括在具有照相机的捕获系统中，在支撑构件的第一侧上的第一反射镜用于反射光以捕获第一和第二图像，并且在第二反射镜的第二相对侧用于反射光以从物体的相对侧捕获第三图像的支撑构件。当捕获第一图像时采用可移动荧光屏，并且当捕获第二图像时不采用可移动荧光屏。荧光屏适于可移动而不移动固定的物体和支撑构件。该系统还可以包括用于生成由第一和第二图像组成的第三图像的装置。

5. 发明申请

US20100208348A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：US20100208348A1
公开(公告)日：2010-08-19
申请号：US12709156
申请日：2010-02-19
申请人： Gilbert D. Feke , Douglas L. Vizard
发明人： Gilbert D. Feke , Douglas L. Vizard
IPC分类号： G02B5/28 , G02B5/22
CPC分类号： A61B5/0059 , A61B6/00
摘要： A tunable spectral filtration device comprises at least one optical filter for intersecting a first path of converging or diverging light comprising an axis at a first angle of incidence and at least one device positioned to enable a second path of the converging or diverging light to pass through the at least one optical filter at a second angle of incidence. The optical filter comprises at least one coating and is tiltable over a plurality of angles with respect to the axis. The first angle of incidence is opposite in sign to the second angle of incidence, such that the positioning of the at least one optical filter and the at least one device substantially cancels angle-of-incidence dependent spectral broadening and/or polarization dependent spectral broadening of the converging or diverging light.
摘要翻译：可调谐光谱过滤装置包括至少一个光学滤光器，用于与会聚或发散光的第一路径交叉，该第一路径包括第一入射角的轴线和至少一个装置，其定位成使得会聚或发散光的第二路径能够通过所述至少一个滤光器处于第二入射角。光学滤波器包括至少一个涂层并且可相对于轴线在多个角度上倾斜。第一入射角与第二入射角相反，使得至少一个滤光器和至少一个器件的定位基本上抵消入射角依赖的光谱展宽和/或偏振相关光谱展宽的会聚光或发散光。

6. 发明申请

US20090080608A1 METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS 失效
标题翻译：用于测量小动物长骨密度的方法和装置
公开(公告)号：US20090080608A1
公开(公告)日：2009-03-26
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/06
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

7. 发明授权

US5945292A Method of identifying cells with polypeptide surface marker 失效
标题翻译：用多肽表面标记鉴定细胞的方法
公开(公告)号：US5945292A
公开(公告)日：1999-08-31
申请号：US906746
申请日：1997-08-06
申请人： Billy L. Brizzard , Darlene W. Bianca , Richard G. Chubet , Douglas L. Vizard , Thomas Patrick Hopp
发明人： Billy L. Brizzard , Darlene W. Bianca , Richard G. Chubet , Douglas L. Vizard , Thomas Patrick Hopp
IPC分类号： C07K14/00 , C12N15/11 , G01N33/567 , C12Q1/02 , C12Q1/04
CPC分类号： C12N15/11 , C07K14/00
摘要： This invention discloses a gene for the identification of cells comprising a secretion leader segment, a cell marker segment and a transmembrane segment. The gene can be used to identify cells transfected with the gene by the steps of: inserting the gene having a secretion leader segment, a cell marker segment and a transmembrane segment into the DNA or RNA of a cell, allowing the cell to express the gene, and detecting the expressed cell marker segment of the gene.
摘要翻译：本发明公开了一种用于鉴定包含分泌前导片段，细胞标志物片段和跨膜片段的细胞的基因。该基因可以通过以下步骤来鉴定用基因转染的细胞：将具有分泌前导片段，细胞标记区段和跨膜区段的基因插入细胞的DNA或RNA，允许细胞表达基因并检测基因表达的细胞标志物区段。

8. 发明授权

US5830629A Autoradiography assemblage using transparent screen 失效
标题翻译：放射自显影装置采用透明屏幕
公开(公告)号：US5830629A
公开(公告)日：1998-11-03
申请号：US652401
申请日：1996-05-23
申请人： Douglas L. Vizard , David J. Steklenski
发明人： Douglas L. Vizard , David J. Steklenski
IPC分类号： G03C1/725 , C09K11/00 , G01T1/29 , G03C1/73 , G03C1/76
CPC分类号： G01T1/2942
摘要： An assemblage useful for autoradiography comprising, in order, a sample layer containing a radioactively labeled biological sample in contact with a phosphor layer, a film layer and a reflector layer. The phosphor layer is preferably a gadolinium oxysulfide containing layer and the film is preferably a photographic film containing a tabular grain emulsion.
摘要翻译：一种用于放射自显影的组合物，其顺序为包含与磷光体层接触的放射性标记的生物样品的样品层，膜层和反射层。荧光体层优选为含硫氧化硫的层，并且膜优选为含有片状颗粒乳剂的照相胶片。

9. 发明申请

US20120029346A1 METHOD AND APPARATUS FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：用于多模式成像的方法和装置
公开(公告)号：US20120029346A1
公开(公告)日：2012-02-02
申请号：US13270471
申请日：2011-10-11
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于对受试动物进行成像的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

10. 发明申请

US20120026588A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：US20120026588A1
公开(公告)日：2012-02-02
申请号：US13188562
申请日：2011-07-22
申请人： Gilbert Feke , Douglas L. Vizard
发明人： Gilbert Feke , Douglas L. Vizard
IPC分类号： G02B26/00
CPC分类号： G02B5/285 , G02B26/002 , G02B26/008 , G02B26/023
摘要： A tunable spectral filtration device is disclosed that includes one or more pairs of interference filters in series, wherein each element of each pair is independently selected from one or more options, independently positioned to intersect a path of converging or diverging light, and independently tilted with respect to the light path. Each filter may be either of a bandpass type, a shortpass type, a longpass type, a notch type, or multiple combinations thereof. Each filter in the series may be independently selected and tilted to tune the net spectral output of the series. The elements in a pair of filters may be tilted in opposite directions so as to cancel angle-of incidence dependent broadening of the spectral output of the individual filters for noncollimated light, as well as cancel translational shift of the transmitted light rays. The elements in a pair of filters may be tilted through orthogonal tilt axes so as to cancel polarization dependent broadening of the spectral output of the individual filters for light whose polarization state is a superposition of nonzero parallel and perpendicular components relative to the tilt axes.
摘要翻译：公开了一种可调谐光谱过滤装置，其包括一对或多对串联的干涉滤光器，其中每对的每个元件独立地选自一个或多个选项，独立地定位成与会聚光或发散光相交，并独立地倾斜与尊重光路。每个滤光器可以是带通型，短通型，长通型，凹口型或其多种组合中的任一种。可以独立地选择和倾斜系列中的每个滤光片以调节该系列的净光谱输出。一对滤波器中的元件可以在相反的方向上倾斜，以便消除入射角依赖于非准直光的各个滤光器的光谱输出的变宽，以及消除透射光线的平移移动。一对滤波器中的元件可以通过正交的倾斜轴倾斜，从而抵消偏振状态是相对于倾斜轴的非零平行和垂直分量的叠加的光的各个滤光器的光谱输出的偏振相关的加宽。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式