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1. 发明申请

US20100218140A1 GRAPHICAL USER INTERFACE FOR MULTI-MODAL IMAGES AT INCREMENTAL ANGULAR DISPLACEMENTS 审中-公开
标题翻译：用于增量角位移的多模式图像的图形用户界面
公开(公告)号：US20100218140A1
公开(公告)日：2010-08-26
申请号：US12716331
申请日：2010-03-03
申请人： Gilbert D. Feke , Douglas O. Wood , William E. McLaughlin , Douglas L. Vizard , Warren M. Leevy , Sean Orton , Willis Morse
发明人： Gilbert D. Feke , Douglas O. Wood , William E. McLaughlin , Douglas L. Vizard , Warren M. Leevy , Sean Orton , Willis Morse
IPC分类号： G09G5/377 , G09G5/02 , G06F3/048
CPC分类号： A61B5/0059 , A61B5/0035 , A61B6/00 , A61B6/4417 , A61B6/5247
摘要： A method for forming a sequence of images of a subject obtains at least first and second image sets of the subject, each image set having a given angular displacement relative to an axis of rotation of the subject, each image set having at least a first component image of a first diagnostic modality at the given angular displacement and a second component image that is co-registered to the first component image at the given angular displacement. The first image set is selected as the selected image set for display. A synthesized image is formed by combining image data for the at least first and second component images of the selected image set and the synthesized image is displayed.
摘要翻译：用于形成被摄体图像序列的方法获得对象的至少第一和第二图像组，每个图像组相对于被摄体的旋转轴具有给定的角位移，每个图像组具有至少第一组分在给定角度位移处的第一诊断模态的图像和在给定的角位移处共同对准第一分量图像的第二分量图像。选择第一个图像集作为显示的所选图像集。通过组合所选图像组的至少第一和第二分量图像的图像数据形成合成图像，并显示合成图像。

2. 发明授权

US09113784B2 Apparatus and method for multi-modal imaging 有权
标题翻译：多模态成像装置及方法
公开(公告)号：US09113784B2
公开(公告)日：2015-08-25
申请号：US13238290
申请日：2011-09-21
申请人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
发明人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B6/00 , A61B6/5247 , A61B2562/17
摘要： An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.
摘要翻译：一种用于对固定物体进行成像的成像系统和方法。成像系统包括适于在固定状态下接收物体的支撑构件。该系统还包括用于在各种成像模式下成像固定的物体以捕获物体的图像的装置。成像系统还包括可移动荧光屏。荧光屏适于可移动而不移动固定的物体和支撑构件。

3. 发明申请

US20100220836A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：多模式成像的装置和方法
公开(公告)号：US20100220836A1
公开(公告)日：2010-09-02
申请号：US12763231
申请日：2010-04-20
申请人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
发明人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
IPC分类号： G01N23/04 , H04N5/225 , G06K9/00
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B6/00 , A61B6/5247 , A61B2562/17
摘要： An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes first means for imaging the immobilized object in a first imaging mode to capture a first image, and second means for imaging the immobilized object in a second imaging mode to capture a second image. The first imaging mode is selected from the group: x-ray mode and radio isotopic mode. The second imaging mode is selected from the group: bright-field mode and dark-field mode. The first and second means for imaging may be included in a capture system having a camera, a first mirror on a first side of the support member for reflecting light to capture the first and second images and a second mirror on a second, opposite side of the support member for reflecting light to capture a third image from an opposite side of the object. A movable phosphor screen is employed when the first image is captured and not employed when the second image is captured. The phosphor screen is adapted to be movable without moving the immobilized object and support member. The system can further include means for generating a third image comprised of the first and second images.
摘要翻译：一种用于对固定物体进行成像的成像系统和方法。成像系统包括适于在固定状态下接收物体的支撑构件。该系统还包括用于在第一成像模式下成像固定的物体以捕获第一图像的第一装置，以及用于在第二成像模式下成像固定的物体以捕获第二图像的第二装置。第一种成像模式选自x射线模式和放射同位素模式。第二种成像模式选自明场模式和暗场模式。用于成像的第一和第二装置可以包括在具有照相机的捕获系统中，在支撑构件的第一侧上的第一反射镜用于反射光以捕获第一和第二图像，并且在第二反射镜的第二相对侧用于反射光以从物体的相对侧捕获第三图像的支撑构件。当捕获第一图像时采用可移动荧光屏，并且当捕获第二图像时不采用可移动荧光屏。荧光屏适于可移动而不移动固定的物体和支撑构件。该系统还可以包括用于生成由第一和第二图像组成的第三图像的装置。

4. 发明申请

US20120008742A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 有权
标题翻译：多模式成像的装置和方法
公开(公告)号：US20120008742A1
公开(公告)日：2012-01-12
申请号：US13238290
申请日：2011-09-21
申请人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
发明人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
IPC分类号： G01N23/04 , G06K9/00 , G01T1/164
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B6/00 , A61B6/5247 , A61B2562/17
摘要： An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.
摘要翻译：一种用于对固定物体进行成像的成像系统和方法。成像系统包括适于在固定状态下接收物体的支撑构件。该系统还包括用于在各种成像模式下成像固定的物体以捕获物体的图像的装置。成像系统还包括可移动荧光屏。荧光屏适于可移动而不移动固定的物体和支撑构件。

5. 发明授权

US07706501B2 Method and apparatus for measuring long bone density of small-animals 失效
标题翻译：测量小动物长骨密度的方法和装置
公开(公告)号：US07706501B2
公开(公告)日：2010-04-27
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/083 , G01B15/00
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

6. 发明申请

US20090080608A1 METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS 失效
标题翻译：用于测量小动物长骨密度的方法和装置
公开(公告)号：US20090080608A1
公开(公告)日：2009-03-26
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/06
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

7. 发明申请

US20110293529A1 FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION 有权
标题翻译：用于疾病检测的荧光近红外激活探针
公开(公告)号：US20110293529A1
公开(公告)日：2011-12-01
申请号：US13101370
申请日：2011-05-05
申请人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
发明人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
IPC分类号： A61K49/00 , C12Q1/68 , C12Q1/37 , G01N33/53 , B82Y15/00
CPC分类号： G01N33/587 , A61K49/0485 , B82Y5/00 , B82Y15/00 , C12Q1/34 , G01N33/542
摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
摘要翻译：用于成像生物过程和体外和体内疾病检测的荧光可激活探针。还描述了检测酶的存在的方法。将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。可切割间隔物的一端连接到纳米颗粒。至少两种类型包括能量供体类型和能量受体类型。至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。通过将样品暴露于光源并用检测器检测发射光来检测荧光。

8. 发明申请

US20100022866A1 TORSIONAL SUPPORT APPARATUS AND METHOD FOR CRANIOCAUDAL ROTATION OF ANIMALS 有权
标题翻译：扭转支撑装置和动物旋转旋转的方法
公开(公告)号：US20100022866A1
公开(公告)日：2010-01-28
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

9. 发明授权

US08834846B2 Fluorescent NIRF activatable probes for disease detection 有权
标题翻译：用于疾病检测的荧光NIRF可激活探针
公开(公告)号：US08834846B2
公开(公告)日：2014-09-16
申请号：US13101370
申请日：2011-05-05
申请人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
发明人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
IPC分类号： A61B5/00
CPC分类号： G01N33/587 , A61K49/0485 , B82Y5/00 , B82Y15/00 , C12Q1/34 , G01N33/542
摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
摘要翻译：用于成像生物过程和体外和体内疾病检测的荧光可激活探针。还描述了检测酶的存在的方法。将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。可切割间隔物的一端连接到纳米颗粒。至少两种类型包括能量供体类型和能量受体类型。至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。通过将样品暴露于光源并用检测器检测发射光来检测荧光。

10. 发明授权

US08660631B2 Torsional support apparatus and method for craniocaudal rotation of animals 有权
标题翻译：扭转支撑装置和动物头部旋转的方法
公开(公告)号：US08660631B2
公开(公告)日：2014-02-25
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

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