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1. 发明申请

US20090148391A1 SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS 审中-公开
标题翻译：包含二苯基甲基衍生物的协同活性制剂和进一步的皮肤和/或头发亮度和/或高效减毒化合物
公开(公告)号：US20090148391A1
公开(公告)日：2009-06-11
申请号：US12159951
申请日：2007-01-05
申请人： Gerhard Schmaus , Sabine Lange , Gabriele Vielhaber , Karin Schaper , Ravikumar Pillai
发明人： Gerhard Schmaus , Sabine Lange , Gabriele Vielhaber , Karin Schaper , Ravikumar Pillai
IPC分类号： A61K8/97 , A61K31/05 , A61Q17/04 , A61K36/48
CPC分类号： A61K8/347 , A61K8/35 , A61K2800/52 , A61K2800/782 , A61Q5/08 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to specific synergistic active skin- and/or hair-lightening and/or senile keratosis-reducing (cosmetic or pharmaceutical) preparations comprising a mixture comprising or consisting of a) a tyrosinase-inhibiting amount of one or more compounds of the formula 1: wherein: R1 is hydrogen, methyl, straight-chain or branched alkyl having 2-4 C atoms, OH or halogen, R2 is hydrogen, methyl or straight-chain or branched alkyl having 2-5 C atoms, R3 is methyl or straight-chain or branched alkyl having 2-5 C atoms, and R4 and R5 are, independently of one another hydrogen, methyl, straight-chain or branched alkyl having 2-5 C atoms, OH or halogen and b) a skin- and/or hair lightening and/or senile keratosis-reducing amount of one or more compounds selected from the group consisting of (i) chelating agents, (ii) phenolic derivatives, plant extracts with an amount of phenolic derivatives and (iii) organic acid derivatives as well as uses thereof.
摘要翻译：本发明涉及具体的协同增效活性皮肤和/或发发轻度和/或老年角化病减少剂（化妆品或药物）制剂，其包含混合物，其包含或由以下组成：a）酪氨酸酶抑制量的一种或多种化合物式1：其中：R1是氢，甲基，具有2-4个C原子的直链或支链烷基，OH或卤素，R2是氢，甲基或具有2-5个C原子的直链或支链烷基，R3是甲基或具有2-5个C原子的直链或支链烷基，R 4和R 5彼此独立地为具有2-5个C原子的氢，甲基，直链或支链烷基，OH或卤素，和b）和/或毛发发光和/或老年性角化病减少量的一种或多种选自（i）螯合剂，（ii）酚衍生物，具有一定量酚衍生物的植物提取物和（iii）有机酸衍生物及其用途。

2. 发明申请

US20090130035A1 STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES 审中-公开
标题翻译：包含苯酚化合物和苯并噻唑的稳定化制剂
公开(公告)号：US20090130035A1
公开(公告)日：2009-05-21
申请号：US12159866
申请日：2007-01-05
申请人： Sabine Lange , Gerhard Schmaus , Gabriele Vielhaber , Karin Schaper
发明人： Sabine Lange , Gerhard Schmaus , Gabriele Vielhaber , Karin Schaper
IPC分类号： A61K8/35 , A61K31/12 , C07C49/215
CPC分类号： A61K8/347 , A61K8/35 , A61K2800/52 , A61K2800/782 , A61Q5/08 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The present invention relates primarily to a cosmetic and/or pharmaceutical preparation comprising of consisting of one or more phenolic compounds of the formula (I) where for formula (I) it is the case that: R1, R2, R3, R4 and R5 are independently of one another hydrogen, halogen, an OH group, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, with 1, 2 or 3 different radicals from the group R1, R2, R3, R4 and R5 simultaneously representing an OH group, R6 and R7 are independently of one another hydrogen, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, n is an integer from 0 to 20 and R8 is methyl or a linear or branched alkyl having 2 or 3 C atoms, a cycloalkyl having 3, 4, 5, 6 or 7 C atoms or a phenyl and one or more compounds of the formula (II) where for formula (II) it is the case that: R9, R10, R11 and R12 independently of one another are hydrogen, methyl, an OH group or a group —O—R13 and R13 is methyl or a linear or branched alkyl having 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, and to uses of compounds of the formula (II) for stabilizing compounds of the formula (I), and also to methods of stabilizing compounds of the formula (I).
摘要翻译：本发明主要涉及包含一种或多种式（I）的酚类化合物的化妆品和/或药物制剂，其中对于式（I），其中R1，R2，R3，R4和R5是独立于氢，卤素，OH基，甲基或具有2,3,4或5个C原子的直链或支链烷基，与R1，R2，R3，R4和R5中的1,2或3个不同的基团同时表示OH基团，R6和R7彼此独立地为氢，甲基或具有2,3,4或5个C原子的直链或支链烷基，n为0至20的整数，R8为甲基或直链或支链烷基，具有2或3个C原子的支链烷基，具有3,4,5,6或7个C原子的环烷基，或苯基和一种或多种式（II）化合物，其中式（II）的情况是：R9 R 10，R 11和R 12彼此独立地是氢，甲基，OH基或-O-R 13基，R 13是甲基或具有2,3， 4，5，6，7，8，9或10个C原子，以及式（II）化合物用于稳定式（I）化合物的用途，以及稳定式（I）化合物的方法，。

3. 发明申请

US20090162305A1 FORMULATIONS OF LOW OIL CONTENT COMPRISING DIPHENYLMETHANE DERIVATIVES 审中-公开
标题翻译：含有二苯甲基衍生物的低油含量的配方
公开(公告)号：US20090162305A1
公开(公告)日：2009-06-25
申请号：US12159886
申请日：2007-01-05
申请人： Gabriele Vielhaber , Gerhard Schmaus , Sabine Lange , Karin Schaper
发明人： Gabriele Vielhaber , Gerhard Schmaus , Sabine Lange , Karin Schaper
IPC分类号： A61K8/34 , A61K31/05 , A61Q19/02
CPC分类号： A61K8/347 , A61K2800/782 , A61Q5/08 , A61Q19/02
摘要： The present invention relates to specific (cosmetic) formulations for improving the bioavailability and activity of skin- or hair-lightening or senile keratosis-reducing diphenylmethane derivatives (tyrosinase inhibitors) of the following formula 1:
摘要翻译：本发明涉及用于改善下列通式1所示的皮肤或发亮剂或老年性角化病减少二苯甲烷衍生物（酪氨酸酶抑制剂）的生物利用度和活性的具体（化妆品）制剂：

4. 发明申请

US20090297468A1 Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching 审中-公开
标题翻译：包含邻氨基苯甲酰胺和冷却剂的混合物作为缓解瘙痒的化妆品和药物组合物
公开(公告)号：US20090297468A1
公开(公告)日：2009-12-03
申请号：US11917370
申请日：2006-06-14
申请人： Gabriele Vielhaber , Gerhard Schmaus , Ravikumar Pillai
发明人： Gabriele Vielhaber , Gerhard Schmaus , Ravikumar Pillai
IPC分类号： A61K8/368 , A61K31/196
CPC分类号： A61K31/196 , A61K8/42 , A61K8/445 , A61K2800/244 , A61K2800/75 , A61Q5/02 , A61Q9/02 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/08
摘要： The invention relates to a mixture comprising or consisting of: (a) one or more compounds of Formula 1: where the symbols in the compound or each compound of Formula 1 are defined as follows: m=0, 1, 2 or 3, p=0, 1 or 2, n=0, 1 or 2, where, when n=1 or 2, R1 and R2 in pairs are each H or together are another chemical bond, where, when m=1, 2 or 3, each X independently of the others is OH, Oalkyl or Oacyl, and where, when p=1 or 2, each Y independently of the others is OH, Oalkyl or Oacyl, and R3=H or alkyl, R3=H also representing the corresponding cosmetically or pharmaceutically acceptable salts and solvates; and (b) one or more cooling agents.
摘要翻译：本发明涉及包含或由以下组成的混合物：（a）一种或多种式1的化合物：其中化合物或式1的每种化合物中的符号定义如下：m = 0,1,2或3，p = 0,1或2，n = 0,1或2，其中当n = 1或2时，成对的R1和R2各自为H或一起为另一个化学键，其中当m = 1,2或3时，每个X独立地为OH，O烷基或酰基，并且其中当p = 1或2时，每个Y独立地为OH，O烷基或酰基，并且R 3 = H或烷基，R 3 = H也表示相应的化妆品或药学上可接受的盐和溶剂合物; 和（b）一种或多种冷却剂。

5. 发明申请

US20080008660A1 Antimicrobially active compounds for treating bad breath 审中-公开
标题翻译：用于治疗口臭的抗微生物活性化合物
公开(公告)号：US20080008660A1
公开(公告)日：2008-01-10
申请号：US11812085
申请日：2007-06-14
申请人： Jurgen Rabenhorst , Arnold Machinek , Gerhard Schmaus , Martina Herrmann , Gabriele Vielhaber , Ravikumar Pillai
发明人： Jurgen Rabenhorst , Arnold Machinek , Gerhard Schmaus , Martina Herrmann , Gabriele Vielhaber , Ravikumar Pillai
IPC分类号： A61K8/30 , A61K31/16 , A61Q11/00
CPC分类号： A61K31/16 , A61K8/42 , A61Q11/00
摘要： The invention relates primarily to specific uses of a compound of the Formula 1 or of mixtures of two or more different compounds of the Formula 1, in particular for producing an antimicrobially acting agent and agent against bad breath, as well as the corresponding production methods. In addition the invention relates to specific products, in particular oral hygiene products, comprising or consisting of a compound of the Formula 1 or of a mixture of two or more different compounds of the Formula 1 wherein the radicals of the compound of the Formula 1 or of each compound of the Formula 1 in the mixture are as defined in the preceding description.
摘要翻译：本发明主要涉及式1化合物或两种或多种不同式1化合物的混合物的具体用途，特别是用于生产抗微生物作用剂和抗口臭药物以及相应的生产方法。此外，本发明涉及特定的产品，特别是口服卫生产品，其包含式I化合物或由式1的两种或更多种不同化合物的混合物组成或由其组成，其中式1化合物或的混合物中式1的每种化合物如前述描述中所定义。

6. 发明申请

US20070265352A1 Synergistic mixtures of at least one 1,2 alkanediol such as 1,2-hexanediol and 1,2-octanediol with a further compound having antimicrobial properties 审中-公开
标题翻译：至少一种1,2-链烷二醇如1,2-己二醇和1,2-辛二醇的协同混合物与具有抗微生物性质的其它化合物
公开(公告)号：US20070265352A1
公开(公告)日：2007-11-15
申请号：US11254346
申请日：2005-10-20
申请人： Joachim Roeding , Sabine Lange , Gerhard Schmaus , Holger Joppe , Ravikumar Pillai
发明人： Joachim Roeding , Sabine Lange , Gerhard Schmaus , Holger Joppe , Ravikumar Pillai
IPC分类号： A61K31/047 , A01N31/02 , A01P1/00 , A61P31/00 , A23L1/015
CPC分类号： A23L3/3481 , A01N31/02 , A61K31/047 , A01N35/06 , A01N37/06 , A01N37/40 , A01N37/44 , A01N47/12 , A01N49/00 , A01N2300/00
摘要： Antimicrobial active compositions and substances comprising at least one, preferably two, unbranched (straight-chain) 1,2-alkanediols and preferably a further preservative and also to products containing such mixtures in an antimicrobially effective quantity. One example of an antimicrobial mixture comprises: (a) 1,2-hexanediol and 1,2-octanediol and also optionally 1,2-pentanediol and/or 1,2-decanediol and (b) one, two or more substances selected from the group consisting of potassium sorbate, parabens and iodopropynyl butylcarbamate (IPBC).
摘要翻译：抗微生物活性组合物和包含至少一种，优选两种非支链（直链）1,2-链烷二醇，优选另外的防腐剂的物质，以及含有这些混合物的产品，其抗微生物有效量。抗微生物混合物的一个实例包括：（a）1,2-己二醇和1,2-辛二醇，以及任选的1,2-戊二醇和/或1,2-癸二醇和（b）一种，两种或更多种选自由山梨酸钾，对羟基苯甲酸酯和碘丙炔基丁基氨基甲酸酯（IPBC）组成的组。

7. 发明授权

US08647651B2 Synergistic mixtures of C6- to C12-alkanediols and tropolone (derivatives) 有权
标题翻译： C6-至C12-烷二醇与托普龙酮（衍生物）的协同混合物
公开(公告)号：US08647651B2
公开(公告)日：2014-02-11
申请号：US11460587
申请日：2006-07-27
申请人： Gerhard Schmaus , Sabine Lange , Ravikumar Pillai , William Johncock
发明人： Gerhard Schmaus , Sabine Lange , Ravikumar Pillai , William Johncock
IPC分类号： A01N31/02 , A01N35/06
CPC分类号： A01N35/06 , A01N31/02 , A01N2300/00
摘要： Antimicrobial mixtures comprising or consisting of: one or more branched or unbranched alkanediols having 6-12 carbon atoms, one, two or more compounds chosen from the group consisting of the tropolones of the formula (I) wherein the substituents R1, R2, R3, R4 and R5 independently of one another have the following meaning: H; linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; OH; OR6, wherein R6 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; COOH; COOR7, wherein R7 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; NO2; NH2; F, Cl, Br, I; are described.
摘要翻译：包含或由以下组成的抗微生物混合物：一种或多种具有6-12个碳原子的支链或非支链烷二醇，一种，两种或更多种选自式（I）的托乐酮的化合物，其中取代基R 1，R 2，R 3， R 4和R 5彼此独立地具有以下含义：H; 具有至多30个C原子的直链或支链，饱和或不饱和的脂族烃基; 哦; OR 6，其中R 6是具有至多30个C原子的直链或支链饱和或不饱和的脂族烃基; COOH; COOR 7，其中R 7是具有至多30个C原子的直链或支链饱和或不饱和的脂族烃基; NO2; NH2; F，Cl，Br，I; 被描述。

8. 发明申请

US20070059331A1 SYNERGISTIC MIXTURES OF C6- TO C12-ALKANEDIOLS AND TROPOLONE (DERIVATIVES) 有权
标题翻译： C6-对C12-烷烃和三聚氰胺（衍生物）的协同混合物
公开(公告)号：US20070059331A1
公开(公告)日：2007-03-15
申请号：US11460587
申请日：2006-07-27
申请人： Gerhard Schmaus , Sabine Lange , Ravikumar Pillai , William Johncock
发明人： Gerhard Schmaus , Sabine Lange , Ravikumar Pillai , William Johncock
IPC分类号： A01N35/00 , A01N31/00
CPC分类号： A01N35/06 , A01N31/02 , A01N2300/00
摘要： Antimicrobial mixtures comprising or consisting of: one or more branched or unbranched alkanediols having 6-12 carbon atoms, one, two or more compounds chosen from the group consisting of the tropolones of the formula (I) wherein the substituents R1, R2, R3, R4 and R5 independently of one another have the following meaning: H; linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; OH; OR6, wherein R6 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; COOH; COOR7, wherein R7 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; NO2; NH2; F, Cl, Br, I; are described.
摘要翻译：包含或由以下组成的抗微生物混合物：一种或多种具有6-12个碳原子的支链或非支链烷二醇，一种，两种或更多种选自式（I）的托乐酮的化合物，其中取代基R 1，R 2，R 3， R 4和R 5彼此独立地具有以下含义：H; 具有至多30个C原子的直链或支链，饱和或不饱和的脂族烃基; 哦; OR 6，其中R 6是具有至多30个C原子的直链或支链饱和或不饱和的脂族烃基; COOH; COOR 7，其中R 7是具有至多30个C原子的直链或支链饱和或不饱和的脂族烃基; NO 2 NH 2; F，Cl，Br，I; 被描述。

9. 发明授权

US09655824B2 Use of diphenylmethane derivatives as tyrosinase inhibitors 有权
公开(公告)号：US09655824B2
公开(公告)日：2017-05-23
申请号：US10558364
申请日：2004-05-24
申请人： Gerhard Schmaus , Martina Herrmann , Holger Joppe , Gabriele Vielhaber
发明人： Gerhard Schmaus , Martina Herrmann , Holger Joppe , Gabriele Vielhaber
IPC分类号： A61K8/00 , A61Q17/04 , A61Q19/00 , A61K8/34 , A61Q5/08 , A61Q19/02 , A23L5/41
CPC分类号： A61K8/347 , A23L5/41 , A61K2800/782 , A61Q5/08 , A61Q19/02
摘要： Novel uses of compounds of the Formula 1 or mixtures of substances that contain one more compounds of the Formula 1, are described. The said compounds are suitable as agents against skin and hair browning, for combating age spots and for the inhibition of the undesired browning of foods.

10. 发明申请

US20070098655A1 Use of diphenylmethane derivatives as tyrosinase inhibitors 有权
标题翻译：二苯甲烷衍生物用作酪氨酸酶抑制剂
公开(公告)号：US20070098655A1
公开(公告)日：2007-05-03
申请号：US10558364
申请日：2004-05-24
申请人： Gerhard Schmaus , Martina Herrmann , Holger Joppe , Gabriele Vielhaber
发明人： Gerhard Schmaus , Martina Herrmann , Holger Joppe , Gabriele Vielhaber
IPC分类号： A61K8/31
CPC分类号： A61K8/347 , A23L5/41 , A61K2800/782 , A61Q5/08 , A61Q19/02
摘要： Novel uses of compounds of the Formula 1 or mixtures of substances that contain one more compounds of the Formula 1, are described. The said compounds are suitable as agents against skin and hair browning, for combating age spots and for the inhibition of the undesired browning of foods.
摘要翻译：描述了式1化合物或含有另外一种式1化合物的物质混合物的新用途。所述化合物适合作为抗皮肤和毛发褐变的药剂，用于对抗老年斑和抑制食物的不期望的褐变。

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