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1. 发明授权

US09713682B2 Device for dosing and dry nebulization 有权
公开(公告)号：US09713682B2
公开(公告)日：2017-07-25
申请号：US11887513
申请日：2006-04-07
申请人： Klaus Eistetter , Wilhelm Wurst , Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Klaus Eistetter , Wilhelm Wurst , Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M15/00 , B05B7/14 , A61M11/06 , A61M16/14 , A61M16/20 , A61M16/00
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device 1 for dosing and dry nebulization of nebulizable material 12 chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel 3, which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir 10 open only towards the nebulization channel, which contains the nebulizable material 12, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

2. 发明申请

US20090211577A1 Device for Dosing and Dry Nebulization 有权
标题翻译：剂量和干雾化装置
公开(公告)号：US20090211577A1
公开(公告)日：2009-08-27
申请号：US11887513
申请日：2006-04-07
申请人： Klaus Eistetter , Wilhelm Wurst , Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Klaus Eistetter , Wilhelm Wurst , Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M15/00
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device 1 for dosing and dry nebulization of nebulizable material 12 chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel 3, which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir 10 open only towards the nebulization channel, which contains the nebulizable material 12, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.
摘要翻译：本发明涉及一种用于对可喷雾材料12进行定量和干燥雾化的装置1，其选自包含抗感染剂和免疫调节剂的组，其包括具有第一附接片和第二附接片的雾化通道3，压缩载体气体经由阀16连接到第一附接件，用于将载气压力脉冲发送到雾化通道中。该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，只有朝向雾化通道打开的储存器10，其包含可雾化材料12，连接到雾化通道，使得其是气体相对于环境，并且当阀关闭时，在雾化通道和储存器中进行压力补偿。本发明还涉及通过这种装置对这种可喷雾材料进行计量和干燥雾化的方法。

3. 发明授权

US09636470B2 Device for dosing and dry nebulization 有权
公开(公告)号：US09636470B2
公开(公告)日：2017-05-02
申请号：US11887392
申请日：2006-04-07
申请人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M11/02 , A61M15/00 , A61M16/14 , A61M11/06 , B05B7/14 , A61M16/20 , A61M16/00
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir open only towards the nebulization channel, and used for receiving the nebulizable material, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to the use of this device for inhaled administration of a powdered pharmaceutical preparation, and to a method for dosing and dry nebulization of nebulizable material by means of such a device.

4. 发明申请

US20090000615A1 Device for Dosing and Dry Nebulization 有权
标题翻译：剂量和干雾化装置
公开(公告)号：US20090000615A1
公开(公告)日：2009-01-01
申请号：US11887392
申请日：2006-04-07
申请人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M11/00 , A61M16/10
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir open only towards the nebulization channel, and used for receiving the nebulizable material, is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to the use of this device for inhaled administration of a powdered pharmaceutical preparation, and to a method for dosing and dry nebulization of nebulizable material by means of such a device.
摘要翻译：本发明涉及一种用于对可雾化材料进行计量和干燥雾化的装置（1），其包括具有第一附接件和第二附接件的雾化通道（3）和连接到第一附件的压缩载气源以通过阀门将载气压力脉冲发送到雾化通道中。该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅朝向雾化通道打开并用于接收可雾化材料的储存器连接到喷雾通道，使得其为气体相对于环境，并且当阀关闭时，在雾化通道和储存器中进行压力补偿。本发明还涉及该装置用于粉末状药物制剂的吸入施用，以及通过这种装置对可雾化材料进行给药和干燥雾化的方法。

5. 发明授权

US10252014B2 Device and system for delivery of an aerosol to a patient on ventilatory support 有权
公开(公告)号：US10252014B2
公开(公告)日：2019-04-09
申请号：US13813669
申请日：2011-08-08
申请人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Peter Iwatschenko , Wolfgang Koch , Gerhard Pohlmann , Horst Windt
发明人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Peter Iwatschenko , Wolfgang Koch , Gerhard Pohlmann , Horst Windt
IPC分类号： A61M11/00 , A61M16/06 , A61M16/14 , A61M16/12 , A61M16/10 , A61M16/16
摘要： A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact component 10 to be positioned in contact with a respiratory organ. The contact component 10 comprises a lumen 18a, 20a, 24 through which breathing gas and an aerosol are delivered to lungs of a patient.

6. 发明授权

US09693955B2 Humidified particles comprising a therapeutically active substance 有权
公开(公告)号：US09693955B2
公开(公告)日：2017-07-04
申请号：US13817173
申请日：2011-08-22
申请人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
发明人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
IPC分类号： A61K9/12 , A61K9/14 , A61K9/00 , A61M15/00 , A61M16/10 , A61M16/06 , A61M16/16 , A61M11/00 , A61M16/14
CPC分类号： A61K9/122 , A61K9/0073 , A61K9/0075 , A61K9/0082 , A61M11/002 , A61M11/003 , A61M15/00 , A61M15/009 , A61M16/0666 , A61M16/1065 , A61M16/142 , A61M16/16 , A61M2205/505 , A61M2205/7518 , Y10T137/0318
摘要： The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.

7. 发明申请

US20130152925A1 DEVICE AND SYSTEM FOR DELIVERY OF AN AEROSOL TO A PATIENT ON VENTILATORY SUPPORT 审中-公开
标题翻译：航空器向航空器运送航空器的装置和系统
公开(公告)号：US20130152925A1
公开(公告)日：2013-06-20
申请号：US13813669
申请日：2011-08-08
申请人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Peter Iwatschenko , Wolfgang Koch , Gerhard Pohlmann , Horst Windt
发明人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Peter Iwatschenko , Wolfgang Koch , Gerhard Pohlmann , Horst Windt
IPC分类号： A61M16/06 , A61M16/12
CPC分类号： A61M16/0666 , A61M11/00 , A61M16/0683 , A61M16/1065 , A61M16/12 , A61M16/14 , A61M16/16 , A61M2202/0208 , A61M2240/00
摘要： A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact component 10 to be positioned in contact with a respiratory organ. The contact component 10 comprises a lumen 18a, 20a, 24 through which breathing gas and an aerosol are delivered to lungs of a patient.
摘要翻译：用于在通气支架上向患者输送气溶胶的装置和系统包括与呼吸器官接触定位的接触部件10。接触部件10包括管腔18a，20a，24，呼吸气体和气溶胶通过其流入患者的肺部。

8. 发明申请

US20120090606A1 APPARATUS FOR THE AEROSOLIZATION OF LARGE VOLUMES OF DRY POWDER 有权
标题翻译：用于大容量干粉的气化装置
公开(公告)号：US20120090606A1
公开(公告)日：2012-04-19
申请号：US13264422
申请日：2010-04-22
申请人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
发明人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
IPC分类号： A61M16/10
CPC分类号： A61M16/0069 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/0005 , A61M15/0006 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/0086 , A61M16/0003 , A61M16/0666 , A61M16/0808 , A61M16/0833 , A61M16/085 , A61M16/1005 , A61M16/1065 , A61M16/107 , A61M16/202 , A61M16/208 , A61M2016/003 , A61M2016/1025 , A61M2202/064 , A61M2205/07 , A61M2205/3334 , A61M2205/42 , A61M2240/00 , B05B7/1413 , B05B7/1422
摘要： The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device comprises: a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.
摘要翻译：所要求保护的主题涉及可雾化材料的计量和雾化装置。该装置包括：具有雾化通道的主体，其具有可连接到载气源的远端连接部分，其向气雾化通道提供压力脉冲; 用于输出气雾化材料的近端附接部分和用于接收可雾化材料的储存器。储存器包括壁并且以气密的方式连接到主体并与雾化通道流体连接。装置的壁的至少一部分是自激振膜，可通过压力脉冲进入振荡。

9. 发明授权

US08910627B2 Apparatus for the aerosolization of large volumes of dry powder 有权
标题翻译：用于雾化大量干粉的装置
公开(公告)号：US08910627B2
公开(公告)日：2014-12-16
申请号：US13264422
申请日：2010-04-22
申请人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
发明人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
IPC分类号： A61M16/10 , A61M11/02 , A61M11/06 , A61M15/00 , A61M11/00 , A61M16/20 , B05B7/14 , A61M16/08
CPC分类号： A61M16/0069 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/0005 , A61M15/0006 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/0086 , A61M16/0003 , A61M16/0666 , A61M16/0808 , A61M16/0833 , A61M16/085 , A61M16/1005 , A61M16/1065 , A61M16/107 , A61M16/202 , A61M16/208 , A61M2016/003 , A61M2016/1025 , A61M2202/064 , A61M2205/07 , A61M2205/3334 , A61M2205/42 , A61M2240/00 , B05B7/1413 , B05B7/1422
摘要： The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device comprises: a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.
摘要翻译：所要求保护的主题涉及可雾化材料的计量和雾化装置。该装置包括：具有雾化通道的主体，其具有可连接到载气源的远端连接部分，其向气雾化通道提供压力脉冲; 用于输出气雾化材料的近端附接部分和用于接收可雾化材料的储存器。储存器包括壁并且以气密的方式连接到主体并与雾化通道流体连接。装置的壁的至少一部分是自激振膜，可通过压力脉冲进入振荡。

10. 发明申请

US20130142782A1 HUMIDIFIED PARTICLES COMPRISING A THERAPEUTICALLY ACTIVE SUBSTANCE 有权
标题翻译：包含治疗活性物质的湿润颗粒物
公开(公告)号：US20130142782A1
公开(公告)日：2013-06-06
申请号：US13817173
申请日：2011-08-22
申请人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
发明人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
IPC分类号： A61K9/12 , A61M15/00
CPC分类号： A61K9/122 , A61K9/0073 , A61K9/0075 , A61K9/0082 , A61M11/002 , A61M11/003 , A61M15/00 , A61M15/009 , A61M16/0666 , A61M16/1065 , A61M16/142 , A61M16/16 , A61M2205/505 , A61M2205/7518 , Y10T137/0318
摘要： The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.
摘要翻译：本发明涉及雾化和加湿的颗粒，其包含治疗活性物质，其可以通过将干燥的可吸入颗粒悬浮在载体气体中，加入水蒸气并使水在颗粒上冷凝而获得。本发明还涉及产生这些颗粒的方法以及用于实施这些方法的装置。

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