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1. 发明授权

US4951016A Polarized electromagnetic multi-contact relay 失效
标题翻译：极化电磁多点继电器
公开(公告)号：US4951016A
公开(公告)日：1990-08-21
申请号：US328958
申请日：1989-03-27
申请人： Gerhard Furtwaengler , Ulrich Kobler , Heinz Stadler , Josef Weiser
发明人： Gerhard Furtwaengler , Ulrich Kobler , Heinz Stadler , Josef Weiser
IPC分类号： H01H50/22 , H01H51/22
CPC分类号： H01H51/2254
摘要： A relay includes a coil member having two through extending contact spaces parallel to the axis of the coil member. The contact tongues are arranged in the contact spaces and are anchored in common in a first coil flange to form working air gaps with pole pieces in the region of a second coil flange. The pole pieces are arranged in pairs and lie perpendicularly in a plane at an end face of the second coil flange. A permanent magnet arrangement having a plurality of magnetic poles corresponding to twice the number of pole pieces polarized the pole pieces. The permanent magnet poles facing away from the pole pieces are coupled to the bearing side of the contact tongues via flux guidance plates. The permanent magnet regions allow individual independent balancing of each and every pole piece to achieve synchronous switching of the two contact tongues.
摘要翻译：继电器包括具有平行于线圈构件的轴线的两个延伸的接触空间的线圈构件。接触舌片布置在接触空间中并且共同锚固在第一线圈凸缘中以在第二线圈凸缘的区域中形成具有极片的工作气隙。极片成对布置，并且垂直地位于第二线圈凸缘的端面处的平面中。一种永久磁铁装置，其具有对应于极片极化极数数量的两倍的多个磁极。远离极片的永久磁极通过助焊剂引导板联接到接触舌的轴承侧。永磁体区域允许每个极片的独立平衡以实现两个接触舌的同步切换。

2. 发明授权

US4517537A Electromagnetic miniature relay and method of manufacture 失效
标题翻译：电磁微型继电器及制造方法
公开(公告)号：US4517537A
公开(公告)日：1985-05-14
申请号：US609305
申请日：1984-05-11
申请人： Josef Weiser , Alfred Heinzl , Heinz Stadler
发明人： Josef Weiser , Alfred Heinzl , Heinz Stadler
IPC分类号： H01H49/00 , H01H50/04 , H01H50/24 , H01H50/44 , H01H50/60 , H01H3/00
CPC分类号： H01H50/60 , H01H50/043 , Y10T29/49105
摘要： An electromagnetic miniature relay of a narrow structure characterized by a flat core being embedded in a body and extending outside of the ends of the coil to form pole pieces, a stationary contact element being embedded in the body adjacent each of the pole pieces, a flat armature extending parallel to the flat coil and having ends forming air gaps with the pole pieces, said armature carrying flat spring-like contact portions secured to the center of the armature and engaging the stationary contacts when the coil is energized to attract the armature into contact with the pole pieces.
摘要翻译：一种窄结构的电磁小型继电器，其特征在于扁平芯体嵌入在主体中并延伸到线圈的端部外部以形成极片，固定接触元件嵌入在与每个极片相邻的本体中，平坦的电枢平行于扁平线圈延伸并且具有与极片形成气隙的端部，所述电枢承载平板弹簧状接触部分固定到电枢的中心并且当线圈通电以接合固定触点以吸引电枢接触时与极片。

3. 发明授权

US08957213B2 Ethynyl compounds 有权
公开(公告)号：US08957213B2
公开(公告)日：2015-02-17
申请号：US13452973
申请日：2012-04-23
申请人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Heinz Stadler , Eric Vieira
发明人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Heinz Stadler , Eric Vieira
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4439 , A61K31/444 , C07D403/04
CPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , Y02T10/7011
摘要： The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.

4. 发明授权

US08772300B2 Phenyl or pyridinyl-ethynyl derivatives 有权
标题翻译：苯基或吡啶基 - 乙炔基衍生物
公开(公告)号：US08772300B2
公开(公告)日：2014-07-08
申请号：US13443911
申请日：2012-04-11
申请人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
发明人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D213/56 , C07D213/57 , C07D239/28 , C07D401/06 , C07D403/06 , C07D407/12 , C07D413/06
摘要： The present invention relates to ethynyl derivatives of formula I wherein Y is N or C—R3; R3 is hydrogen, methyl, halogen or nitrile; R1 is phenyl or pyridinyl, each of which is optionally substituted by halogen, lower alkyl or lower alkoxy; R2/R2′ are each independently hydrogen, lower alkyl or lower alkyl substituted by halogen, or R2 and R2′ together with the N-atom to which they are attached form a morpholine ring, a piperidine ring or an azetidine ring, each of which is unsubstituted or substituted one or more substituents selected from lower alkoxy, halogen, hydroxy and methyl; R4/R4′ are each independently hydrogen or lower alkyl, or R4 and R4′ together form a C3-5 cycloalkyl-, tetrahydrofuran- or an oxetane-ring; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).
摘要翻译：本发明涉及式I的乙炔基衍生物，其中Y是N或C-R3; R3是氢，甲基，卤素或腈; R1是苯基或吡啶基，其各自任选被卤素，低级烷基或低级烷氧基取代; R2 / R2'各自独立地为氢，被卤素取代的低级烷基或低级烷基，或R2和R2'与它们所连接的N-原子一起形成吗啉环，哌啶环或氮杂环丁烷环，其中每个未取代或取代的一个或多个选自低级烷氧基，卤素，羟基和甲基的取代基; R 4 / R 4'各自独立地为氢或低级烷基，或者R 4和R 4'一起形成C 3-5环烷基，四氢呋喃或氧杂环丁烷环; 或其药学上可接受的酸加成盐，或其相应的对映异构体和/或其旋光异构体和/或立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂（PAM）。

5. 发明授权

US08648088B2 Ethynyl nitrogen containing heteroaryl pyrazolidin-3-one derivatives 有权
标题翻译：含炔基氮杂芳基吡唑烷-3-酮衍生物
公开(公告)号：US08648088B2
公开(公告)日：2014-02-11
申请号：US13454167
申请日：2012-04-24
申请人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
发明人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： C07D401/04 , A61K31/506 , C07D403/04 , A61K31/4439
CPC分类号： C07D401/04 , C07D403/04 , C07D487/04
摘要： The present invention relates to ethynyl derivatives of formula I wherein G, X, R1, R2, R3, R3′, R4, and R4′ are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).
摘要翻译：本发明涉及式I的乙炔基衍生物，其中G，X，R 1，R 2，R 3，R 3'，R 4和R 4'如本文所定义，或其药学上可接受的酸加成盐，涉及外消旋混合物或其相应的对映体和/或其光学异构体和/或立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂（PAM）。

6. 发明授权

US08420661B2 Arylethynyl derivatives 有权
标题翻译：甲基乙炔基衍生物
公开(公告)号：US08420661B2
公开(公告)日：2013-04-16
申请号：US13066044
申请日：2011-04-05
申请人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
发明人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： C07D211/00 , C07D213/00 , C07D215/00 , C07D217/00 , C07D219/00 , C07D221/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , A61K31/44 , A61K31/70
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D491/107 , C07D498/04
摘要： The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
摘要翻译：本发明涉及式I的乙炔基化合物，其中R 1，R 2，R 2'，R 3，R 3'，R 4，R 4'，U，V，W，Y，m和n如本文所定义，加成盐，与外消旋混合物或其相应的对映体和/或光学异构体和/或其立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的变构调节剂。

7. 发明授权

US08389536B2 Positive allosteric modulators (PAM) 有权
标题翻译：正变构调节剂（PAM）
公开(公告)号：US08389536B2
公开(公告)日：2013-03-05
申请号：US12908014
申请日：2010-10-20
申请人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
发明人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： A61K31/506
CPC分类号： C07D213/74 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/505 , A61K31/506 , C07D213/64 , C07D239/34 , C07D239/42 , C07D401/06 , C07D405/12 , C07D413/06 , C07D493/08
摘要： The present invention relates to phenylethynyl compounds of formula I wherein R1, R2, X, L, R3, R4, R4′, cyc, and n are as defined in the specification and claims and to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They are useful for the treatment of schizophrenia or cognitive diseases.
摘要翻译：本发明涉及式I的苯基乙炔基化合物，其中R 1，R 2，X，L，R 3，R 4，R 4'，R c和n如说明书和权利要求中所定义，并且与药学上可接受的酸加成盐相关，混合物或其相应的对映异构体和/或其光学异构体和/或立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂（PAM）。它们可用于治疗精神分裂症或认知疾病。

8. 发明授权

US06596773B2 Phenyl substituted pyridine and benzene derivatives 失效
公开(公告)号：US06596773B2
公开(公告)日：2003-07-22
申请号：US10051699
申请日：2002-01-17
申请人： Michael Bös , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
发明人： Michael Bös , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
IPC分类号： A61K3167
CPC分类号： C07D213/75 , C07C233/29 , C07C233/33 , C07C233/44 , C07C317/40 , C07C323/41 , C07D295/135
摘要： The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK-1 receptor.

9. 发明授权

US6150526A Piperidine derivative having renin inhibiting activity 有权
标题翻译：具有肾素抑制活性的哌啶衍生物
公开(公告)号：US6150526A
公开(公告)日：2000-11-21
申请号：US456283
申请日：1999-12-07
申请人： Alfred Binggeli , Volker Breu , Daniel Bur , Walter Fischli , Rolf Guller , Georges Hirth , Hans-Peter Marki , Marcel Muller , Christian Oefner , Heinz Stadler , Eric Vieira , Maurice Wilhelm , Wolfgang Wostl
发明人： Alfred Binggeli , Volker Breu , Daniel Bur , Walter Fischli , Rolf Guller , Georges Hirth , Hans-Peter Marki , Marcel Muller , Christian Oefner , Heinz Stadler , Eric Vieira , Maurice Wilhelm , Wolfgang Wostl
IPC分类号： C07D211/18 , A61K31/439 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/4523 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P27/02 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/42 , C07D211/44 , C07D211/54 , C07D211/56 , C07D211/74 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D521/00
CPC分类号： C07D249/08 , C07D211/42 , C07D231/12 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , Y02P20/55
摘要： Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
摘要翻译：披露哌啶衍生物，其作为药物的制造和用途。本发明涉及通式I的哌啶衍生物，其中R 1，R 2，R 3，R 4，Q，X，Z，m和n如本文所述。

10. 发明授权

US6051712A Piperidine derivatives having renin inhibiting activity 有权
标题翻译：具有肾素抑制活性的哌啶衍生物
公开(公告)号：US6051712A
公开(公告)日：2000-04-18
申请号：US255185
申请日：1999-02-22
申请人： Alfred Binggeli , Volker Breu , Daniel Bur , Walter Fischli , Rolf Guller , Georges Hirth , Hans-Peter Marki , Marcel Muller , Christian Oefner , Heinz Stadler , Eric Vieira , Maurice Wilhelm , Wolfgang Wostl
发明人： Alfred Binggeli , Volker Breu , Daniel Bur , Walter Fischli , Rolf Guller , Georges Hirth , Hans-Peter Marki , Marcel Muller , Christian Oefner , Heinz Stadler , Eric Vieira , Maurice Wilhelm , Wolfgang Wostl
IPC分类号： C07D211/18 , A61K31/439 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/4523 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P27/02 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/42 , C07D211/44 , C07D211/54 , C07D211/56 , C07D211/74 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D521/00
CPC分类号： C07D249/08 , C07D211/42 , C07D231/12 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , Y02P20/55
摘要： Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
摘要翻译：公开了新的哌啶衍生物，其作为药物的制造和用途。本发明涉及通式Ⅰ的新的哌啶衍生物，其中R 1，R 2，R 3，R 4，Q，X，Z，m和n如本文所述。

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