专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4898865A [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates 失效
标题翻译： [4-（6-氧代-1,4,5,6-四氢-3-哒嗪基）苯胺基己基1,4-二氢-2,6-二甲基-5-硝基4芳基吡啶3-羧酸酯
公开(公告)号：US4898865A
公开(公告)日：1990-02-06
申请号：US218759
申请日：1988-07-13
申请人： Gerhard Franckowiak , Martin Bechem , Michael Kayser , Rainer Gross , Matthias Schramm , Friedel Seuter , Elisabeth Perzborn , Gunther Thomas
发明人： Gerhard Franckowiak , Martin Bechem , Michael Kayser , Rainer Gross , Matthias Schramm , Friedel Seuter , Elisabeth Perzborn , Gunther Thomas
IPC分类号： A61K31/50 , A61P3/00 , A61P3/08 , A61P9/00 , C07D237/04 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D237/04
摘要： Circulation active nitrodihydropyridines of the formula ##STR1## in which R represents aryl which has 6 to 12 carbon atoms and can be substituted up to 4 times, identically or differently, by halogen, nitro, cyano, alkyl, alkoxy, alkylthio, in each case having up to 6 carbon atoms, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio, difluoromethylenedioxy, trifluoroethylenedioxy or tetrafluoroethylenedioxy or by benzyl, benzyloxy or benzylthio, each of which is optionally substituted by halogen, nitro, cyano, trifuoromethyl, alkyl having up to 4 carbon atoms or alkoxy having up to 4 carbon atoms, or represents a heterocycle which is optionally substituted by halogen, phenyl or alkyl having up to 4 carbon atoms and is from the group consisting of pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyrimidyl, pyridazinyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl, andn represents a number from 1 to 12,and physiologically acceptable salts thereof.
摘要翻译：具有式“IMAGE”的循环活性硝基二氢吡啶，其中R表示具有6至12个碳原子并且可以相同或不同地被卤素，硝基，氰基，烷基，烷氧基，烷硫基取代至多4次的芳基，具有至多6个碳原子，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基，二氟亚甲二氧基，三氟亚乙二氧基或四氟亚乙二氧基或苄基，苄氧基或苄硫基，其各自任选被卤素，硝基，氰基，三氟甲基，具有至多4个碳原子的烷基或具有至多4个碳原子的烷氧基，或表示任选被卤素，苯基或具有至多4个碳原子的烷基取代的杂环，并且是由吡咯基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基，吡啶基，嘧啶基，哒嗪基，喹啉基，苯并二唑基，苯并二唑基，色烯基或硫代色烯基，n表示1〜12的数，生理学上可接受的其盐。

2. 发明授权

US4707479A Circulation active dihydropyridine-3-carboxamides 失效
标题翻译：循环活性二氢吡啶-3-甲酰胺
公开(公告)号：US4707479A
公开(公告)日：1987-11-17
申请号：US806057
申请日：1985-12-05
申请人： Horst Meyer , Gerhard Franckowiak , Ulrich Rosentreter , Rainer Gross , Gunter Thomas , Matthias Schramm , Michael Kayser , Friedel Seuter , Elisabeth Perzborn , Martin Bechem
发明人： Horst Meyer , Gerhard Franckowiak , Ulrich Rosentreter , Rainer Gross , Gunter Thomas , Matthias Schramm , Michael Kayser , Friedel Seuter , Elisabeth Perzborn , Martin Bechem
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/50 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , C07D211/90 , C07D237/00 , C07D237/04 , C07D333/00 , C07D335/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/048 , C07D495/04 , C07D401/06
CPC分类号： C07D401/12 , C07D211/90 , C07D237/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04
摘要： 1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the blood-sugar level and the circulation and as coronary therapeutic agents and anti-arrhythmic agents.
摘要翻译：具有式“IMAGE”及其盐的1,4-二氢吡啶甲酰胺及其盐对于治疗心功能不全，血栓形成，血栓栓塞和间皮瘤有效，用于影响血糖水平和循环以及作为冠状动脉治疗剂和抗心律不齐剂。

3. 发明授权

US4876254A Circulation-active substituted 5-nitro-1,4-dihydropyridines 失效
标题翻译：循环活性取代的5-硝基-1,4-二氢吡啶
公开(公告)号：US4876254A
公开(公告)日：1989-10-24
申请号：US179102
申请日：1988-04-08
申请人： Gerhard Franckowiak , Michael Kayser , Matthias Schramm , Gunther Thomas , Rainer Gross , elisabeth Perzborn , Friedel Seuter
发明人： Gerhard Franckowiak , Michael Kayser , Matthias Schramm , Gunther Thomas , Rainer Gross , elisabeth Perzborn , Friedel Seuter
IPC分类号： A61K31/50 , A61K31/505 , A61P9/00 , C07D211/90 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D211/90 , C07D401/14 , C07D409/14 , C07D413/14
摘要： For the treatment of circulation disorders, the novel 5-nitro-1,4-dihydropyridines of the formula ##STR1## in which R represents C.sub.6 -C.sub.14 -aryl which can be mono- to pentasubstituted by identical or different substituents from the series comprising halogen, nitro, cyano, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio and benzyl, benzyloxy or benzylthio optionally substituted by nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, orrepresents a heterocycle from the series pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl optionally mono- to tetrasubstituted by halogen, phenyl or C.sub.1 -C.sub.4 -alkyl orrepresents straight-chain, branched or cyclic alkyl with up to 14 carbon atoms,and their physiologically acceptable salts.
摘要翻译：对于循环障碍的治疗，式“IMAGE”的新的5-硝基-1,4-二氢吡啶类，其中R代表C6-C14-芳基，其可以由包含卤素的系列的相同或不同的取代基单取代或五取代硝基，氰基，C 1 -C 6烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷硫基，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基和苄基，任选被硝基，氰基，或C 1 -C 4 - 烷氧基，或代表吡啶基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基，吡啶基，哒嗪基，嘧啶基，喹啉基，苯并二唑基，被卤素，苯基或C 1 -C 4烷基四取代，或代表具有至多14个碳原子的直链，支链或环状烷基，及其生理上可接受的盐。

4. 发明授权

US5344944A Circulation-active dioxyalkylenearyl-dihydropyridines 失效
标题翻译：循环活性二氧杂环己烯基 - 二氢吡啶
公开(公告)号：US5344944A
公开(公告)日：1994-09-06
申请号：US116414
申请日：1993-09-03
申请人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
发明人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
IPC分类号： C07D317/46 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61P3/08 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , C07D319/20 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/044 , C07D491/048 , C07D317/62
CPC分类号： C07D405/04 , C07D405/14 , C07D491/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7,R.sup.7 is H, alkyl or various other radicals,R.sup.2 and R.sup.4 each independently is alkyl or other radicals,R.sup.3 is H or optionally substituted alkyl, andR.sup.5 completes a keto or ester group,and physiologically acceptable salts thereof. Also the aldehyde intermediate therefor of the formula ##STR2##
摘要翻译：其中R 1是H，CN，NO 2或-COOR 7，R 7是H，烷基或各种其它基团，R 2和R 4各自独立地是烷基或其它基团，R 3是H或任选被取代的具有通式“IMAGE”的循环活性二氢吡啶烷基和R 5完成酮基或酯基团及其生理上可接受的盐。也可以使用式为“IMAGE”的醛中间体

5. 发明授权

US4753936A Circulation-active substituted 1,4-dihydropyridine-3-carboxylic acid piperazides 失效
标题翻译：循环活性的取代的1,4-二氢吡啶-3-羧酸哌嗪
公开(公告)号：US4753936A
公开(公告)日：1988-06-28
申请号：US002094
申请日：1987-01-12
申请人： Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Rainer Gross , Martin Bechem
发明人： Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Rainer Gross , Martin Bechem
IPC分类号： C07D335/00 , A61K31/4433 , A61K31/455 , A61P3/08 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D409/04 , C07D413/04 , A61K31/495 , C07D401/06 , C07D401/14 , C07D413/14
CPC分类号： C07D413/04 , C07D211/90
摘要： 1,4-Dihydropyridine-3-carboxylic acid piperazides of the formula ##STR1## in which R.sup.1 is CN or alkyl, preferably methyl,R.sup.2 is H, CN, NO.sub.2 or preferably carboxyalkyl,R.sup.3 is aryl or heterocyclic, andR.sup.4 is alkyl, cycloalkyl, aryl or an acyl radical,and physiologically acceptable salts thereof, are circulation active. Novel intermediates are also provided.
摘要翻译：其中R1是CN或烷基，优选甲基，R2是H，CN，NO2或优选羧基烷基，R3是芳基或杂环，R4是烷基，环烷基，环烷基，芳基或酰基及其生理上可接受的盐是循环活性的。还提供了新的中间体。

6. 发明授权

US4886816A Circulation-active dioxyalkylenearyl-dihydropyridines 失效
标题翻译：循环活性二氧杂环己烯基 - 二氢吡啶
公开(公告)号：US4886816A
公开(公告)日：1989-12-12
申请号：US190748
申请日：1988-05-05
申请人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
发明人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
IPC分类号： C07D317/46 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61P3/08 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , C07D319/20 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/044 , C07D491/048
CPC分类号： C07D405/04 , C07D405/14 , C07D491/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7,R.sup.7 is H, alkyl or various other radicals,R.sup.2 and R.sup.4 each independently is alkyl or other radicals,R.sup.3 is H or optionally substituted alkyl,R.sup.5 completes a keto or ester group, andR.sup.6 is a direct bond or --CF.sub.2 -- or --CHF--,and physiologically acceptable salts thereof.
摘要翻译：其中R 1是H，CN，NO 2或-COOR 7，R 7是H，烷基或各种其它基团，R 2和R 4各自独立地是烷基或其它基团，R 3是H或任选被取代的具有通式“IMAGE”的循环活性二氢吡啶烷基，R5完成酮基或酯基团，并且R 6是直接键或-CF2-或-CHF-，及其生理上可接受的盐。

7. 发明授权

US4769375A Circulation-active 1,4-dihydropyridine derivatives and use thereas 失效
标题翻译：循环活性的1,4-二氢吡啶衍生物并用于其中
公开(公告)号：US4769375A
公开(公告)日：1988-09-06
申请号：US890998
申请日：1986-07-25
申请人： Horst Meyer , Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Martin Bechem , Rainer Gross
发明人： Horst Meyer , Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Martin Bechem , Rainer Gross
IPC分类号： A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/473 , A61P3/08 , A61P9/00 , A61P9/08 , A61P9/10 , C07D215/06 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/24 , C07D215/36 , C07D215/54 , C07D221/04 , C07D311/74 , C07D311/94 , C07D335/00 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D221/04 , C07D215/14 , C07D215/18 , C07D215/24 , C07D215/36 , C07D215/54 , C07D311/74 , C07D311/94 , C07D401/04 , C07D405/04 , C07D409/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,R.sup.2 is H, NO.sub.2, CN, C.sub.1 -C.sub.8 -alkylsulphonyl, aryl or carboalkoxy,R.sup.3 is alkyl or aryl,R.sup.4 is H or alkyl,X is C.dbd.O or a direct bond, andn is a number from 1 to 20,or physiologically acceptable salts thereof. A synthesis using morpholines or thiomorpholines is also disclosed.
摘要翻译： R 1为任选取代的芳基或杂环，R 2为H，NO 2，CN，C 1 -C 8 - 烷基磺酰基，芳基或烷氧羰基，R 3为烷基或芳基，R 4为H或烷基， X为C = O或直接键，n为1〜20的数，或其生理上可接受的盐。还公开了使用吗啉或硫代吗啉的合成。

8. 发明授权

US5008279A Circulation-active fluoromethoxyphenyl dihydropyridine compounds 失效
标题翻译：循环活性氟甲氧基苯基二氢吡啶化合物
公开(公告)号：US5008279A
公开(公告)日：1991-04-16
申请号：US263671
申请日：1988-10-27
申请人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
发明人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
IPC分类号： A61K31/445 , A61K31/451 , A61P9/08 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine andR stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted(a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or(b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or(c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms,and salts thereof.
摘要翻译：式（I）的循环活性氟甲氧基苯基二氢吡啶，其中X代表氢或氟，R代表可被1至2个氧中断的具有2至12个碳原子的直链，支链或环状烷基或链烯基和/或链中的硫原子，并且其可以被羟基，具有6至12个碳原子的芳基，具有6至12个碳原子的芳氧基单取代或多取代（a），其中芳基再次被具有至多 4个碳原子，具有至多4个碳原子的烷氧基或卤素，取代基相同或不同，或（b）由羧基，具有至多6个碳原子的烷氧基羰基，吡啶基，哌啶基，嘧啶基，具有至多7个碳原子的酰氧基，氨基甲酰基，氨基甲酰基，卤素或氰基，取代基相同或不同，或（c）氨基，其中氨基可以带有一个或两个相同或不同的取代基，由至多6个碳原子的烷基 ms，苄基，苯基或具有至多7个碳原子的酰基及其盐。

9. 发明授权

US4710501A Circulation active pyrimidinyl-dihydropyridines 失效
标题翻译：循环活性嘧啶基 - 二氢吡啶
公开(公告)号：US4710501A
公开(公告)日：1987-12-01
申请号：US862869
申请日：1986-05-13
申请人： Gerhard Franckowiak , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
发明人： Gerhard Franckowiak , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/505 , A61K31/70 , A61K31/7028 , A61P9/02 , A61P9/04 , A61P9/08 , C07D401/04 , C07D401/14 , C07H15/06 , C07H15/26 , A61K31/44 , C07D239/24
CPC分类号： C07D401/04 , C07D401/14 , C07H15/26
摘要： Novel compounds of the formula ##STR1## in which R.sup.2 is hydrogen or a substituent, andR.sup.1 is optionally substituted alkyl or alkenyl,exhibit positive inotropic activity on the cardiac muscle, intensifying the contraction power.
摘要翻译：式中，R 2为氢或取代基，R 1为任选取代的烷基或烯基的新颖化合物“IMAGE”表现出对心肌的正性肌力活性，增强收缩力。

10. 发明授权

US5162338A Circulation active 4-aminoaryldihydropryidine lactones 失效
标题翻译：循环活性4-氨基芳基二氢化丙酸内酯
公开(公告)号：US5162338A
公开(公告)日：1992-11-10
申请号：US782748
申请日：1991-10-18
申请人： Siegfried Goldmann , Matthias Schramm , Rainer Gross , Gunther Thomas , Martin Bechem , Michael Kayser
发明人： Siegfried Goldmann , Matthias Schramm , Rainer Gross , Gunther Thomas , Martin Bechem , Michael Kayser
IPC分类号： C07D491/04 , C07D491/048
CPC分类号： C07D491/04
摘要： 4 Aminoaryldihydropyridines of the formula ##STR1## in which R.sup.1 is hydrogen or an organic radical, preferably methyl or ethyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.5 - alkyl, --CN, --NH.sub.2, --CH.sub.2 or --CH.sub.2 OH, preferably methyl,R.sup.3 is hydrogen or alkyl, preferably hydrogen,Y is --CO-- or --SO.sub.2 --, andR.sup.4 is an organic radical, orY-R.sup.4 is hydrogen,and physiologically acceptable salts thereof, are circulation-active and effective for improving myocardial contractility, for raising blood pressure, for lowering blood sugar, for reducing mucosal swelling and for controlling the salt and fluid balance.
摘要翻译： 4，其中R 1是氢或有机基团，优选甲基或乙基的氨基芳基二氢吡啶，其中R 2是氢，C 1 -C 5 - 烷基，-CN，-NH 2，-CH 2或-CH 2 OH，优选甲基，R 3是氢或烷基，优选氢，Y是-CO-或-SO 2 - ，并且R 4是有机基团，或Y-R 4是氢，并且其生理上可接受的盐是循环活性的并且对于提高心肌收缩力是有效的，用于提高血压降低血糖，减少粘膜肿胀和控制盐和液体平衡。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式