专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5344944A Circulation-active dioxyalkylenearyl-dihydropyridines 失效
标题翻译：循环活性二氧杂环己烯基 - 二氢吡啶
公开(公告)号：US5344944A
公开(公告)日：1994-09-06
申请号：US116414
申请日：1993-09-03
申请人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
发明人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
IPC分类号： C07D317/46 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61P3/08 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , C07D319/20 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/044 , C07D491/048 , C07D317/62
CPC分类号： C07D405/04 , C07D405/14 , C07D491/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7,R.sup.7 is H, alkyl or various other radicals,R.sup.2 and R.sup.4 each independently is alkyl or other radicals,R.sup.3 is H or optionally substituted alkyl, andR.sup.5 completes a keto or ester group,and physiologically acceptable salts thereof. Also the aldehyde intermediate therefor of the formula ##STR2##
摘要翻译：其中R 1是H，CN，NO 2或-COOR 7，R 7是H，烷基或各种其它基团，R 2和R 4各自独立地是烷基或其它基团，R 3是H或任选被取代的具有通式“IMAGE”的循环活性二氢吡啶烷基和R 5完成酮基或酯基团及其生理上可接受的盐。也可以使用式为“IMAGE”的醛中间体

2. 发明授权

US4753936A Circulation-active substituted 1,4-dihydropyridine-3-carboxylic acid piperazides 失效
标题翻译：循环活性的取代的1,4-二氢吡啶-3-羧酸哌嗪
公开(公告)号：US4753936A
公开(公告)日：1988-06-28
申请号：US002094
申请日：1987-01-12
申请人： Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Rainer Gross , Martin Bechem
发明人： Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Rainer Gross , Martin Bechem
IPC分类号： C07D335/00 , A61K31/4433 , A61K31/455 , A61P3/08 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D409/04 , C07D413/04 , A61K31/495 , C07D401/06 , C07D401/14 , C07D413/14
CPC分类号： C07D413/04 , C07D211/90
摘要： 1,4-Dihydropyridine-3-carboxylic acid piperazides of the formula ##STR1## in which R.sup.1 is CN or alkyl, preferably methyl,R.sup.2 is H, CN, NO.sub.2 or preferably carboxyalkyl,R.sup.3 is aryl or heterocyclic, andR.sup.4 is alkyl, cycloalkyl, aryl or an acyl radical,and physiologically acceptable salts thereof, are circulation active. Novel intermediates are also provided.
摘要翻译：其中R1是CN或烷基，优选甲基，R2是H，CN，NO2或优选羧基烷基，R3是芳基或杂环，R4是烷基，环烷基，环烷基，芳基或酰基及其生理上可接受的盐是循环活性的。还提供了新的中间体。

3. 发明授权

US5008279A Circulation-active fluoromethoxyphenyl dihydropyridine compounds 失效
标题翻译：循环活性氟甲氧基苯基二氢吡啶化合物
公开(公告)号：US5008279A
公开(公告)日：1991-04-16
申请号：US263671
申请日：1988-10-27
申请人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
发明人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
IPC分类号： A61K31/445 , A61K31/451 , A61P9/08 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine andR stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted(a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or(b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or(c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms,and salts thereof.
摘要翻译：式（I）的循环活性氟甲氧基苯基二氢吡啶，其中X代表氢或氟，R代表可被1至2个氧中断的具有2至12个碳原子的直链，支链或环状烷基或链烯基和/或链中的硫原子，并且其可以被羟基，具有6至12个碳原子的芳基，具有6至12个碳原子的芳氧基单取代或多取代（a），其中芳基再次被具有至多 4个碳原子，具有至多4个碳原子的烷氧基或卤素，取代基相同或不同，或（b）由羧基，具有至多6个碳原子的烷氧基羰基，吡啶基，哌啶基，嘧啶基，具有至多7个碳原子的酰氧基，氨基甲酰基，氨基甲酰基，卤素或氰基，取代基相同或不同，或（c）氨基，其中氨基可以带有一个或两个相同或不同的取代基，由至多6个碳原子的烷基 ms，苄基，苯基或具有至多7个碳原子的酰基及其盐。

4. 发明授权

US4904665A Benzylaminoaryl-dihydropyridinelactones and their use in medicaments 失效
标题翻译：苄基氨基芳基 - 二氢吡啶内酯及其在药物中的用途
公开(公告)号：US4904665A
公开(公告)日：1990-02-27
申请号：US158184
申请日：1988-02-18
申请人： Siegfried Goldmann , Rainer Gross , Martin Bechem , Michael Kayser , Matthias Schramm , Siegbert Hebisch
发明人： Siegfried Goldmann , Rainer Gross , Martin Bechem , Michael Kayser , Matthias Schramm , Siegbert Hebisch
IPC分类号： A61K31/44 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07D211/90 , C07D491/04 , C07D491/048
CPC分类号： C07D491/04 , C07D211/90
摘要： A benzylaminoaryl-dihydropyridinelactone compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, halogen, cyano, nitro, C.sub.6 -C.sub.12 -aryl, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, di-C.sub.1 -C.sub.5 -alkylamino, C.sub.1 -C.sub.6 -alkoxycarboxyl or C.sub.1 -C.sub.6 -alkylsulphonyl,R.sup.2 represents hydrogen, or represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical having up to 10 carbon atoms which is optionally substituted by C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphonyl, halogen, cyano, hydroxyl, pyridyl, thienyl, pyrimidyl, piperidinyl, phenyl or an amino group, where the amino group carries two identical or different substituents from the series comprising C.sub.1 -C.sub.5 -alkyl, phenyl or benzyl,R.sup.3 represents C.sub.1 -C.sub.5 -alkyl, or represents cyano, hydroxymethyl or formyl, andR.sup.4 represents hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl or trifluoromethyl,and its isomers, isomeric mixtures, racemates or optical antipodes, and physiologically acceptable salts thereof. The compound being useful to improve the contractility of the heart and the tonus of the smooth muscles.
摘要翻译：式（I）的苄基氨基芳基 - 二氢吡啶内酯化合物其中R 1表示氢，卤素，氰基，硝基，C 6 -C 12 - 芳基，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，C 1 -C 6 - 烷硫基，三氟甲基，三氟甲氧基，三氟甲硫基，二氟甲氧基，二-C 1 -C 5烷基氨基，C 1 -C 6 - 烷氧基羧基或C 1 -C 6烷基磺酰基，R 2表示氢，或表示直链，支链或环状饱和或不饱和烃具有至多10个碳原子的基团，其任选被C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷硫基，C 1 -C 6 - 烷基磺酰基，卤素，氰基，羟基，吡啶基，噻吩基，嘧啶基，哌啶基，苯基或氨基取代，其中氨基从包含C 1 -C 5 - 烷基，苯基或苄基的系列中携带两个相同或不同的取代基，R 3表示C 1 -C 5 - 烷基，或表示氰基，羟甲基或甲酰基，R 4表示氢，卤素，C 1 -C 5 - 烷基或三氟甲基，及其异构体，异构体混合物，外消旋体或光学抗体 es及其生理上可接受的盐。该化合物可用于改善心脏和平滑肌紧张的收缩性。

5. 发明授权

US4898865A [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates 失效
标题翻译： [4-（6-氧代-1,4,5,6-四氢-3-哒嗪基）苯胺基己基1,4-二氢-2,6-二甲基-5-硝基4芳基吡啶3-羧酸酯
公开(公告)号：US4898865A
公开(公告)日：1990-02-06
申请号：US218759
申请日：1988-07-13
申请人： Gerhard Franckowiak , Martin Bechem , Michael Kayser , Rainer Gross , Matthias Schramm , Friedel Seuter , Elisabeth Perzborn , Gunther Thomas
发明人： Gerhard Franckowiak , Martin Bechem , Michael Kayser , Rainer Gross , Matthias Schramm , Friedel Seuter , Elisabeth Perzborn , Gunther Thomas
IPC分类号： A61K31/50 , A61P3/00 , A61P3/08 , A61P9/00 , C07D237/04 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D237/04
摘要： Circulation active nitrodihydropyridines of the formula ##STR1## in which R represents aryl which has 6 to 12 carbon atoms and can be substituted up to 4 times, identically or differently, by halogen, nitro, cyano, alkyl, alkoxy, alkylthio, in each case having up to 6 carbon atoms, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio, difluoromethylenedioxy, trifluoroethylenedioxy or tetrafluoroethylenedioxy or by benzyl, benzyloxy or benzylthio, each of which is optionally substituted by halogen, nitro, cyano, trifuoromethyl, alkyl having up to 4 carbon atoms or alkoxy having up to 4 carbon atoms, or represents a heterocycle which is optionally substituted by halogen, phenyl or alkyl having up to 4 carbon atoms and is from the group consisting of pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyrimidyl, pyridazinyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl, andn represents a number from 1 to 12,and physiologically acceptable salts thereof.
摘要翻译：具有式“IMAGE”的循环活性硝基二氢吡啶，其中R表示具有6至12个碳原子并且可以相同或不同地被卤素，硝基，氰基，烷基，烷氧基，烷硫基取代至多4次的芳基，具有至多6个碳原子，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基，二氟亚甲二氧基，三氟亚乙二氧基或四氟亚乙二氧基或苄基，苄氧基或苄硫基，其各自任选被卤素，硝基，氰基，三氟甲基，具有至多4个碳原子的烷基或具有至多4个碳原子的烷氧基，或表示任选被卤素，苯基或具有至多4个碳原子的烷基取代的杂环，并且是由吡咯基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基，吡啶基，嘧啶基，哒嗪基，喹啉基，苯并二唑基，苯并二唑基，色烯基或硫代色烯基，n表示1〜12的数，生理学上可接受的其盐。

6. 发明授权

US4886816A Circulation-active dioxyalkylenearyl-dihydropyridines 失效
标题翻译：循环活性二氧杂环己烯基 - 二氢吡啶
公开(公告)号：US4886816A
公开(公告)日：1989-12-12
申请号：US190748
申请日：1988-05-05
申请人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
发明人： Gerhard Franckowiak , Albrecht Marhold , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunther Thomas
IPC分类号： C07D317/46 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61P3/08 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , C07D319/20 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/044 , C07D491/048
CPC分类号： C07D405/04 , C07D405/14 , C07D491/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7,R.sup.7 is H, alkyl or various other radicals,R.sup.2 and R.sup.4 each independently is alkyl or other radicals,R.sup.3 is H or optionally substituted alkyl,R.sup.5 completes a keto or ester group, andR.sup.6 is a direct bond or --CF.sub.2 -- or --CHF--,and physiologically acceptable salts thereof.
摘要翻译：其中R 1是H，CN，NO 2或-COOR 7，R 7是H，烷基或各种其它基团，R 2和R 4各自独立地是烷基或其它基团，R 3是H或任选被取代的具有通式“IMAGE”的循环活性二氢吡啶烷基，R5完成酮基或酯基团，并且R 6是直接键或-CF2-或-CHF-，及其生理上可接受的盐。

7. 发明授权

US4772611A Circulation-active 3-amino-dihydropyridines 失效
标题翻译：循环活性3-氨基 - 二氢吡啶
公开(公告)号：US4772611A
公开(公告)日：1988-09-20
申请号：US43656
申请日：1987-04-28
申请人： Jurgen Stoltefuss , Fred R. Heiker , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
发明人： Jurgen Stoltefuss , Fred R. Heiker , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/505 , A61P9/00 , C07D211/84 , C07D211/90 , C07D401/04 , C07D409/04 , C07D413/04 , C07D491/04 , C07D491/048 , A61K31/455
CPC分类号： C07D491/04 , C07D211/84 , C07D211/90
摘要： Novel cardioactive compounds of the formula ##STR1## in which R.sup.1 is alkyl, aryl or heterocyclic, preferably substituted phenyl,R.sup.2 is alkyl, preferably methyl,R.sup.3 is hydrogen, halogen, acyloxy or alkyl, preferably hydrogen, andR.sup.4 is phenyl, carbalkoxy or together with R.sup.3 forms a ring, preferably carbalkoxy,are produced by reducing the corresponding nitro compounds.
摘要翻译：式（IMAGE）的新型心脏活性化合物，其中R 1是烷基，芳基或杂环，优选取代的苯基，R 2是烷基，优选甲基，R 3是氢，卤素，酰氧基或烷基，优选氢，R 4是苯基，通过还原相应的硝基化合物与R3一起形成环，优选为烷氧基。

8. 发明授权

US4808622A Circulation active methionine-substituted 1,4-dihydropyridines 失效
标题翻译：循环活性甲硫氨酸取代的1,4-二氢吡啶类
公开(公告)号：US4808622A
公开(公告)日：1989-02-28
申请号：US1496
申请日：1987-01-07
申请人： Gunther Kinast , Eckhard Schwenner , Stanislav Kazda , Andreas Knorr , Michael Kayser
发明人： Gunther Kinast , Eckhard Schwenner , Stanislav Kazda , Andreas Knorr , Michael Kayser
IPC分类号： A61K31/455 , A61P9/10 , A61P9/12 , C07D211/90 , C07D413/04 , C07D211/86
CPC分类号： C07D413/04 , C07D211/90
摘要： Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.
摘要翻译：循环活跃，例如其中R1是苯基或杂环基的式“IMAGE”的抗高血压新型甲硫氨酸取代的二氢吡啶或其生理上可接受的盐。

9. 发明申请

US20060156053A1 A GROUND-BASED SOFTWARE TOOL FOR CONTROLLING REDUNDANCY MANAGEMENT SWITCHING OPERATIONS 有权
标题翻译：一种基于地面的软件工具，用于控制冗余管理切换操作
公开(公告)号：US20060156053A1
公开(公告)日：2006-07-13
申请号：US10905608
申请日：2005-01-12
申请人： Thomas Judd , Michael Kayser
发明人： Thomas Judd , Michael Kayser
IPC分类号： G06F11/00
CPC分类号： G06F11/2023 , G06F11/2038 , G06F11/2048
摘要： Systems, methods, and computer program products for easily altering redundancy management data values associated with redundancy management logic that is executed by redundant data processing systems. The redundancy management data values are altered on a computer device remote from the system that includes the redundant data processing systems.
摘要翻译：用于容易地改变由冗余数据处理系统执行的冗余管理逻辑相关联的冗余管理数据值的系统，方法和计算机程序产品。冗余管理数据值在远离包括冗余数据处理系统的系统的计算机设备上被改变。

10. 发明授权

US4876255A Substituted 1,4-dihydropyridines for control of circulation and thromboses 失效
标题翻译：用于控制循环和血栓形成的取代的1,4-二氢吡啶
公开(公告)号：US4876255A
公开(公告)日：1989-10-24
申请号：US178710
申请日：1988-04-07
申请人： Gerhard Franckowiak , Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter , Michael Kayser , Gunther Thomas
发明人： Gerhard Franckowiak , Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter , Michael Kayser , Gunther Thomas
IPC分类号： A61K31/50 , A61K31/505 , A61P7/02 , A61P9/00 , C07D211/90 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D211/90 , C07D401/14 , C07D409/14 , C07D413/14
摘要： For the control of coronary diseases and thromboses there are provided the novel compounds ##STR1## in which R.sup.1 is an optionally substituted phenyl or heterocyclic radical,R.sup.2 is a cyano, keto, carboxy, ester or amide group, andX is from 0 to 6,and physiologically acceptable salts thereof.
摘要翻译：为了控制冠状动脉疾病和血栓形成，提供了新的化合物（I），其中R 1是任选取代的苯基或杂环基，R 2是氰基，酮基，羧基，酯或酰胺基，X是 0至6，及其生理上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式