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1. 发明授权

US4766151A Ethers and oxime ethers of alkylamino alcohols as medicaments and novel products, and processes for their preparation 失效
标题翻译：烷基氨基醇的醚和肟醚作为药物和新产品，及其制备方法
公开(公告)号：US4766151A
公开(公告)日：1988-08-23
申请号：US788694
申请日：1985-10-21
申请人： Gerard Leclerc , Mohammed Bouzoubaa , Guy Andermann , Georges de Burlet , Catherine Cannet , Jacques Himber
发明人： Gerard Leclerc , Mohammed Bouzoubaa , Guy Andermann , Georges de Burlet , Catherine Cannet , Jacques Himber
IPC分类号： A61K31/13 , A61K31/15 , A61P9/12 , A61P27/02 , A61P27/06 , C07C67/00 , C07C213/00 , C07C217/28 , C07C239/00 , C07C249/08 , C07C249/12 , C07C251/50 , C07C251/58 , C07C131/02 , C07C131/04
CPC分类号： A61K31/15 , A61K31/13 , Y10S514/913
摘要： Glaucoma can be treated by the application to the eye of a physiologically active amount of a compound of the formula ##STR1## in which: each of R.sub.3 and R.sub.4 is selected from hydrogen, and alkyl, alkenyl and cycloalkyl radicals, or R.sub.3 and R.sub.4 together with the carbon between them are a cycloalkylidene radical,R.sub.2 is a lower alkyl radical, and the salts thereof with pharmaceutically acceptable acids, in an opthamologically accepted carrier therefor, which when liquid and an isotonic agent is present can have the form of an eye lotion. The 1-N-tert.-butylamino derivatives of 3-(cyclopropyl-methyl-ketone-oximino)-propan-2-ol, 3-(dicyclopropyl-ketone-oximino)-propan-2-ol, and 3-(3,3,5-trimethylcyclohexane-1-ketone-oximino)-propan-2-ol are novel compounds within such formula specifically useful for such treatment.
摘要翻译：青光眼可以通过应用于生理活性量的式“IMAGE”化合物的眼睛进行治疗，其中：R 3和R 4各自选自氢，烷基，烯基和环烷基，或R 3和R 4一起其中它们之间的碳是环烷叉基，R2是低级烷基，以及其与药学上可接受的酸的盐，在光学上可接受的载体中，当存在液体和等渗剂时，其可以具有眼液的形式。 3-（环丙基 - 甲基 - 酮 - 肟基） - 丙-2-醇，3-（二环丙基 - 肟基） - 丙-2-醇和3-（3 ，3,5-三甲基环己烷-1-酮 - 肟基） - 丙-2-醇是在此类化合物中特别可用于这种处理的新化合物。

2. 发明授权

US4952573A Compounds having GABA like activity, and use of same in tissue irrigating solutions 失效
标题翻译：具有GABA活性的化合物，以及在组织冲洗溶液中的用途
公开(公告)号：US4952573A
公开(公告)日：1990-08-28
申请号：US172047
申请日：1988-03-23
申请人： Gerard LeClerc , Beatrice Ruhland , Guy Andermann , Georges de Burlet , Michel Dietz
发明人： Gerard LeClerc , Beatrice Ruhland , Guy Andermann , Georges de Burlet , Michel Dietz
IPC分类号： C07D215/50 , C07D223/16 , C07D498/04
CPC分类号： C07D223/16 , C07D215/50
摘要： Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.
摘要翻译：描述了提高角膜内皮液泵效率的化合物，从而促进角膜功能的正常作用和肿胀角膜的脱皮，以及化合物合成的方法。此外，还讨论了包括一种或多种化合物的手术冲洗溶液及其使用方法。

3. 发明授权

US4837021A Two part tissue irrigating solution 失效
标题翻译：两部分组织冲洗液
公开(公告)号：US4837021A
公开(公告)日：1989-06-06
申请号：US948188
申请日：1986-12-31
申请人： Guy Andermann , Georges de Burlet , Michel Dietz , Joseph Spittler
发明人： Guy Andermann , Georges de Burlet , Michel Dietz , Joseph Spittler
IPC分类号： A61K33/14 , A61K33/42
CPC分类号： A61K33/14 , A61K33/42 , Y10S514/912
摘要： A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium calcium chloride, and bicarbonate ions as well as dextrose, glutathione, and gamma-amino butyric acid (GABA) or functional analogue(s) of GABA, or a mixture of GABA and such analogue(s) in proportions consistent with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.
摘要翻译：在手术过程中，用于冲洗动物组织如眼组织和神经组织的组织冲洗溶液含有钠，钾，镁氯化钙和碳酸氢根离子以及右旋糖，谷胱甘肽和γ-氨基丁酸（GABA）或 GABA的功能类似物，或GABA和这种类似物的混合物，其比例与组织细胞的渗透稳定性和持续代谢一致。冲洗溶液通过混合提供碳酸氢盐的第一碱性溶液和提供钙，镁，葡萄糖和谷胱甘肽的第二酸性溶液来制备。第一溶液和第二溶液可以作为稳定的无菌溶液长时间储存，并在使用24小时内混合。

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