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1. 发明申请

US20060175739A1 Hybrid balloon mold and method of using the mold to form a balloon that is used to manufacture a medical dilatation catheter 审中-公开
标题翻译：混合气囊模具和使用模具形成用于制造医用扩张导管的气囊的方法
公开(公告)号：US20060175739A1
公开(公告)日：2006-08-10
申请号：US11053359
申请日：2005-02-08
申请人： Gerard Hession , Donagh O'Shaughnessy , Gerry Clarke , Seamus Ledwith , Michael Cummins , Noel Quinn , Ashish Varma
发明人： Gerard Hession , Donagh O'Shaughnessy , Gerry Clarke , Seamus Ledwith , Michael Cummins , Noel Quinn , Ashish Varma
IPC分类号： A21C11/00 , B29D22/00
CPC分类号： B29C33/3828 , A61M25/1029 , B29C33/40 , B29C49/14 , B29C49/48 , B29C2033/0005 , B29C2049/0089 , B29K2105/258 , B29K2905/10 , B29K2905/12 , B29K2909/02 , B29K2909/08 , B29K2995/0026 , B29K2995/0029 , B29L2031/7542
摘要： A mold for forming a balloon of a balloon catheter including a body portion defining a body region of a mold cavity and distal and proximal end caps defining tapering regions and neck regions of the mold cavity. During the molding process, the mold cavity is visible from an exterior surface of the body portion, which is transparent or translucent. The distal and proximal end caps are metal and can be precision machined in the tapering and neck regions of the mold cavity in order to achieve more accurate molded balloon dimensions. Also disclosed is a method for making a balloon of a balloon catheter using the mold and a balloon made therefrom.
摘要翻译：一种用于形成球囊导管气囊的模具，包括限定模具腔的主体区域的主体部分和限定模腔的锥形区域和颈部区域的远端和近端帽。在模制过程中，模腔从身体部分的外表面是可见的，其为透明或半透明的。远端和近端帽是金属的，并且可以在模腔的锥形和颈部区域中精密加工，以便实现更精确的模制气囊尺寸。还公开了一种使用模具制造球囊导管球囊的方法和由其制成的气囊。

2. 发明申请

US20070191767A1 Bifurcated Catheter Joints 审中-公开
标题翻译：分叉导管接头
公开(公告)号：US20070191767A1
公开(公告)日：2007-08-16
申请号：US11695697
申请日：2007-04-03
申请人： Joe Hennessy , Ashish Varma , Robert Murray , Gerry Clarke , Terry Guinan , Patrick Duane
发明人： Joe Hennessy , Ashish Varma , Robert Murray , Gerry Clarke , Terry Guinan , Patrick Duane
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61M25/0009 , A61F2/95 , A61F2240/001 , A61M25/0023 , A61M25/0029 , A61M25/0032 , A61M25/10 , A61M2025/0183 , A61M2025/1045
摘要： A rapid exchange catheter includes an exchange joint that is coupled between a proximal shaft and first and second distal shafts. The exchange joint includes a proximal end that is configured to be coupled to the proximal shaft, and a distal end that is configured to be coupled to the first distal shaft and the second distal shaft. The distal end includes a first portion that includes a first guidewire lumen, and a second portion that includes a second guidewire lumen. The exchange joint also includes a guidewire port that is configured to provide access for a first guidewire into the first distal inner lumen via the first guidewire lumen and a second guidewire into the second distal inner lumen via the second guidewire lumen.
摘要翻译：快速交换导管包括耦合在近端轴和第一和第二远端轴之间的交换接头。交换接头包括构造成联接到近侧轴的近端，以及构造成联接到第一远端轴和第二远端轴的远端。远端包括包括第一导丝管腔的第一部分和包括第二导丝管腔的第二部分。所述交换接头还包括导丝端口，所述导丝端口被构造成经由所述第一导丝管线将第一导丝提供到所述第一远端内腔中，并且经由所述第二导丝管线将第二导丝提供到所述第二远端内腔中。

3. 发明授权

US06800065B2 Catheter and guide wire exchange system 失效
标题翻译：导管和导丝交换系统
公开(公告)号：US06800065B2
公开(公告)日：2004-10-05
申请号：US10116234
申请日：2002-04-04
申请人： Patrick J. Duane , Gerry Clarke , Niall Duffy , Noel Coyle , John MacNamara , David Quinn , Declan Costello , Robert Murray , Ashish Varma , Patrick J. Carmody
发明人： Patrick J. Duane , Gerry Clarke , Niall Duffy , Noel Coyle , John MacNamara , David Quinn , Declan Costello , Robert Murray , Ashish Varma , Patrick J. Carmody
IPC分类号： A61M2900
CPC分类号： A61M25/09041 , A61M2025/0186
摘要： A catheter and guide wire exchange system including a catheter having a guide wire lumen with a guide way extending along the length of a stiffened proximal shaft portion, and a guide member slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. The guide member may be slid along the proximal shaft portion and the guide wire in zipper-like fashion so that the guide wire is contained within the guide wire lumen distal to the guide member and with the guide wire and catheter being separated proximal of the guide member.
摘要翻译：一种导管和导丝线交换系统，其包括具有导丝管腔的导管，所述导管内腔具有沿加强的近侧轴部分的长度延伸的引导方式，以及引导部件，其可滑动地设置在所述近端轴周围，用于引导导丝进入或离开引导方式和导丝管腔。引导构件可以沿着近端轴部分和导丝以拉链方式滑动，使得导丝被容纳在远离引导构件的导丝管腔内，并且导丝和导管被分离在引导件的近侧会员。

4. 发明申请

US20080039784A1 Multi-Lumen Catheter System 审中-公开
标题翻译：多腔导管系统
公开(公告)号：US20080039784A1
公开(公告)日：2008-02-14
申请号：US11877222
申请日：2007-10-23
申请人： David Quinn , Ashish Varma
发明人： David Quinn , Ashish Varma
IPC分类号： A61M25/10
CPC分类号： A61M25/0029 , A61M25/0023 , A61M25/0032 , A61M25/0051 , A61M25/0053 , A61M2025/0036
摘要： A multi-lumen catheter with a generally circular cross-section having a central guidewire lumen, partially circumscribed by an inflation lumen having a generally C-shaped cross-section defining a web and a guidewire access cut extending radially through that web from the outer surface of the multi-lumen catheter to the central guidewire lumen. The guidewire access cut allowing access to an indwelling guidewire for direct control over axial translation, or ingress and egress of the guidewire.
摘要翻译：具有大致圆形横截面的多腔导管，其具有中心导丝管腔，部分地由具有限定腹板的大致C形横截面的充气腔内接，以及从外表面径向穿过该腹板的导丝通路切口的多腔导管连接到中心导丝管腔。引导线进入切割允许访问留置导丝，以直接控制轴向平移，或导丝的进入和流出。

5. 发明申请

US20050069452A1 Method of sterilizing balloon with ionizing radiation 有权
标题翻译：用电离辐射消毒气球的方法
公开(公告)号：US20050069452A1
公开(公告)日：2005-03-31
申请号：US10671946
申请日：2003-09-29
申请人： Ashish Varma , Frank Clarke
发明人： Ashish Varma , Frank Clarke
IPC分类号： A61L2/08 , A61L29/14 , B65B55/16 , A61L2/00 , A61M31/00
CPC分类号： A61L2/087 , A61L2/081 , A61L29/14 , A61L2202/24 , B32B27/12 , B32B27/34 , B32B27/36 , B32B2250/40 , B32B2307/74 , B32B2439/80 , B65B55/16
摘要： A sterilization process that preserves the mechanical properties of dilatation balloons and balloon catheters manufactured from polymers susceptible to the degradation reactions induced by ionizing radiation. The advantages of the sterilization process contemplated by this invention results from a reduced oxygen environment during sterilization, thereby preventing the degeneration process initiated in polymers during irradiation. Additionally, a balloon or balloon dilatation catheter sterilized by the process of the invention is provided.
摘要翻译：一种灭菌方法，其保持由对由电离辐射引起的降解反应敏感的聚合物制造的膨胀气囊和球囊导管的机械性能。本发明考虑的灭菌方法的优点是由于灭菌过程中的氧气环境减少，从而防止在照射期间在聚合物中引发的退化过程。另外，提供了通过本发明的方法消毒的球囊或球囊扩张导管。

6. 发明申请

US20060135948A1 Multi-exchange catheter guide member with improved seal 审中-公开
标题翻译：多重交换导管导向件具有改进的密封
公开(公告)号：US20060135948A1
公开(公告)日：2006-06-22
申请号：US11015272
申请日：2004-12-16
申请人： Ashish Varma
发明人： Ashish Varma
IPC分类号： A61M25/00
CPC分类号： A61M25/09041 , A61M25/0029 , A61M25/0032 , A61M2025/09116 , A61M2025/09125
摘要： A catheter and a guidewire exchange system includes a catheter and a guide member. The catheter includes a lumen extending through the shaft and sized to receive the guidewire, and a longitudinal guideway enabling transverse access from the shaft exterior surface to the lumen. The guide member includes a housing, a catheter passageway extending through the housing and adapted to slidably receive the catheter, a guidewire passageway extending from one end of the housing into the catheter passageway and including a tube adapted to merge the guidewire transversely through the guideway and into the first lumen, and a user-activated device positioned in the guidewire passageway and including a clamping body adapted to clamp the guidewire and thereby secure the guidewire in the guidewire passageway.
摘要翻译：导管和导丝交换系统包括导管和引导构件。导管包括延伸穿过轴并且尺寸适于接纳导丝的腔，以及能够从轴外表面到内腔的横向进入的纵向导轨。引导构件包括壳体，延伸穿过壳体并适于滑动地容纳导管的导管通道，从壳体的一端延伸到导管通道中并且包括适于将导丝横穿导轨并入导管的导管，以及位于导丝通道中的用户激活的装置，并且包括适于夹紧导丝的夹持主体，从而将导丝固定在导丝通道中。

7. 发明申请

US20050118370A1 Hyper-elastic, high strength dilatation balloon made from multi-block copolymers 审中-公开
标题翻译：由多嵌段共聚物制成的超弹性高强度膨胀球囊
公开(公告)号：US20050118370A1
公开(公告)日：2005-06-02
申请号：US10920457
申请日：2004-08-18
申请人： Ashish Varma , Kimberly Chaffin
发明人： Ashish Varma , Kimberly Chaffin
IPC分类号： A61L29/00 , A61L29/04 , A61M25/00 , B29C47/00 , B29C55/04 , B29C55/12 , B29C71/00 , B65D1/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.
摘要翻译：描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物从名义菌株中恢复至少约30％。挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。

8. 发明申请

US20050070880A1 Transition section for a catheter 审中-公开
标题翻译：导管切片
公开(公告)号：US20050070880A1
公开(公告)日：2005-03-31
申请号：US10808440
申请日：2004-03-25
申请人： Ashish Varma , Noel Coyle , Richard Gribbons
发明人： Ashish Varma , Noel Coyle , Richard Gribbons
IPC分类号： A61M25/00 , A61M25/16 , A61M29/02
CPC分类号： A61M25/0023 , A61M25/0052 , A61M25/0053 , A61M25/0054 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A catheter having a proximal shaft defining a guidewire lumen and an inflation lumen. The inflation lumen is arcuate shaped and reinforced with a tube having an arcuate shaped cross-section or another reinforcing means. The catheter also has a distal shaft, with a greater flexibility than the proximal shaft. The catheter also has a transition section. A proximal end of the transition section communicates with the proximal shaft, and a distal end communicating with the distal shaft. The transition section has a gradually increased flexibility from its proximal end to its distal end. The transition section includes a transition means creating the increased flexibility.
摘要翻译：具有限定导丝管腔和充气腔的近端轴的导管。充气腔是弧形的，并用具有弓形截面的管或另一个加强装置加强。导管还具有远端轴，其具有比近侧轴更大的灵活性。导管还具有过渡部分。过渡部分的近端与近侧轴连通，远端与远侧轴连通。过渡部分从其近端到其远端具有逐渐增加的柔性。过渡部分包括产生增加的灵活性的过渡装置。

9. 发明申请

US20090140449A1 Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon made from Multi-Block Copolymers 审中-公开
标题翻译：用于生产由多嵌段共聚物制成的超弹性，高强度膨胀气球的方法
公开(公告)号：US20090140449A1
公开(公告)日：2009-06-04
申请号：US12261090
申请日：2008-10-30
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim , Tamotsu Harada
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim , Tamotsu Harada
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.
摘要翻译：描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物从名义菌株中恢复至少约30％。挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。

10. 发明申请

US20050149172A1 Minimal injury resorbable stent 审中-公开
标题翻译：最小损伤可吸收支架
公开(公告)号：US20050149172A1
公开(公告)日：2005-07-07
申请号：US10740805
申请日：2003-12-22
申请人： Ashish Varma
发明人： Ashish Varma
IPC分类号： A61F2/02 , A61F2/06 , A61L31/14 , D01F4/00 , D01F6/62
CPC分类号： A61F2/06 , A61F2210/0004 , A61L31/148 , D01F4/00 , D01F6/62 , D01F6/625
摘要： A minimal injury resorbable stent comprising an oriented resorbable material drawn to a ratio about 7-350 is disclosed. The drawn materials of the present invention have tensile strength of about 50-500 MPa and Young's modulus of about 2-300 GPa. The bioresorbable stents can have cylindrical shape and optionally further comprise one or more of a solvent, plasticizer, biologically active agent and modifier. Also disclosed is a method for manufacturing a minimal injury resorbable stent. The process comprises contacting a resorbable polymer with a solvent to form a polymer mixture, extruding said polymer mixture to form an extrudate, drawing said extrudate to a draw ratio in the range of about 7-350 to form a drawn extrudate and forming said stent from said drawn extrudate. The process optionally further comprises coagulating the extrudate and annealing the extrudate and/or stent.
摘要翻译：公开了一种最小损伤可再吸收支架，其包括被拉伸至约7-350的比例的定向可再吸收材料。本发明的拉伸材料具有约50-500MPa的拉伸强度和约2-300GPa的杨氏模量。生物可再吸收支架可以具有圆柱形形状，并且任选地还包含一种或多种溶剂，增塑剂，生物活性剂和改性剂。还公开了一种用于制造最小损伤可再吸收支架的方法。该方法包括使可再吸收的聚合物与溶剂接触以形成聚合物混合物，挤出所述聚合物混合物以形成挤出物，将所述挤出物拉伸至约7-350范围内的拉伸比，以形成拉伸挤出物并形成所述支架所述拉伸挤出物。该方法任选还包括使挤出物凝结并使挤出物和/或支架退火。

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