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1. 发明申请

US20090140449A1 Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon made from Multi-Block Copolymers 审中-公开
标题翻译：用于生产由多嵌段共聚物制成的超弹性，高强度膨胀气球的方法
公开(公告)号：US20090140449A1
公开(公告)日：2009-06-04
申请号：US12261090
申请日：2008-10-30
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim , Tamotsu Harada
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim , Tamotsu Harada
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.
摘要翻译：描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物从名义菌株中恢复至少约30％。挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。

2. 发明授权

US07879270B2 Process for producing a hyper-elastic, high strength dilatation balloon made from multi-block copolymers 有权
标题翻译：用于生产由多嵌段共聚物制成的超弹性高强度膨胀气球的方法
公开(公告)号：US07879270B2
公开(公告)日：2011-02-01
申请号：US12869273
申请日：2010-08-26
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp transition from the first zone to the second zone.
摘要翻译：通过挤出多嵌段共聚物组合物以形成包含相分离的玻璃状，橡胶和半结晶微区的挤出物的方法，所述挤出物以垂直对准的宏观顺序排列。通过该过程形成的气球在充气过程中证明了真实应力与标称应变响应曲线，其包括代表低模量球囊的第一区域，代表高强度球囊的第二区域以及从第一区域到第第二区。

3. 发明申请

US20100320634A1 Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon Made From Multi-Block Copolymers 有权
标题翻译：用于生产由多嵌段共聚物制成的超弹性，高强度膨胀气球的方法
公开(公告)号：US20100320634A1
公开(公告)日：2010-12-23
申请号：US12869273
申请日：2010-08-26
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp transition from the first zone to the second zone.
摘要翻译：通过挤出多嵌段共聚物组合物以形成包含相分离的玻璃状，橡胶和半结晶微区的挤出物的方法，所述挤出物以垂直对准的宏观顺序排列。通过该过程形成的气球在充气过程中证明了真实应力与标称应变响应曲线，其包括代表低模量球囊的第一区域，代表高强度球囊的第二区域以及从第一区域到第第二区。

4. 发明授权

US07968226B2 Contoured battery for implantable medical devices and method of manufacture 有权
标题翻译：用于可植入医疗器械的轮廓电池和制造方法
公开(公告)号：US07968226B2
公开(公告)日：2011-06-28
申请号：US11565306
申请日：2006-11-30
申请人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
发明人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
IPC分类号： H01M2/04 , H01M2/06 , H01M2/08
CPC分类号： A61N1/3975 , B33Y80/00 , H01M2/0202 , H01M2/0207 , H01M2/0232 , H01M2/0257 , H01M2/0267 , H01M2/0275 , H01M2/0404 , H01M2/08 , H01M2/1094 , H01M2002/0205 , Y10T29/49108
摘要： A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a preferably planar, major bottom portion, an open top to receive the cover opposing the bottom portion, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device. The cover and the shallow case being substantially hermetically sealed by a laser weld technique and an insulator member disposed within the case to provide a barrier to incident laser radiation so that during welding radiation does not impinge upon radiation sensitive component(s) disposed within the case.
摘要翻译：公开了一种具有位于壳体中的电极组件的电池，其有效地利用了许多可植入医疗装置中可用的空间。电池壳体提供了一个盖子和一个浅的外壳，优选地是平面的，主要的底部部分，一个敞开的顶部，用于接收与底部相对的盖子，并且多个边缘彼此相交并且与底部相交，以允许位于可植入装置内的其他部件的紧密邻接，同时还提供电池在装置的弓形边缘内的有效定位。盖子和浅表壳通过激光焊接技术基本上气密地密封，并且设置在壳体内的绝缘体构件以对入射的激光辐射提供屏障，使得在焊接期间辐射不会撞击设置在壳体内的辐射敏感部件。

5. 发明授权

US06881516B2 Contoured battery for implantable medical devices and method of manufacture 有权
标题翻译：用于可植入医疗器械的轮廓电池和制造方法
公开(公告)号：US06881516B2
公开(公告)日：2005-04-19
申请号：US10260966
申请日：2002-09-30
申请人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Kimberly A. Chaffin
发明人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Kimberly A. Chaffin
IPC分类号： H01M2/02 , H01M2/04 , H01M2/06 , H01M2/10 , H01M2/26 , H01M10/40
CPC分类号： H01M2/0257 , B33Y80/00 , H01M2/0207 , H01M2/0232 , H01M2/0267 , H01M2/0275 , H01M2/0404 , H01M2/1094 , Y10T29/49108
摘要： A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a planar bottom, an open top to receive the cover, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device.
摘要翻译：公开了一种具有位于壳体中的电极组件的电池，其有效地利用了许多可植入医疗装置中可用的空间。电池壳体提供了一个盖子和一个浅表壳，一个平坦的底部，一个敞开的顶部，用于接纳该盖子，并且多个边缘彼此相交并且与底部相交，以允许位于其中的其它部件的紧密邻接同时还提供电池在装置的弓形边缘内的有效定位。

6. 发明授权

US08389155B2 Contoured battery for implantable medical devices 有权
标题翻译：用于可植入医疗器械的轮廓电池
公开(公告)号：US08389155B2
公开(公告)日：2013-03-05
申请号：US13171000
申请日：2011-06-28
申请人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
发明人： Paul B. Aamodt , Franise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
IPC分类号： H01M2/02 , H01M2/08
CPC分类号： A61N1/3975 , B33Y80/00 , H01M2/0202 , H01M2/0207 , H01M2/0232 , H01M2/0257 , H01M2/0267 , H01M2/0275 , H01M2/0404 , H01M2/08 , H01M2/1094 , H01M2002/0205 , Y10T29/49108
摘要： A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a preferably planar, major bottom portion, an open top to receive the cover opposing the bottom portion, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device. The cover and the shallow case being substantially hermetically sealed by a laser weld technique and an insulator member disposed within the case to provide a barrier to incident laser radiation so that during welding radiation does not impinge upon radiation sensitive component(s) disposed within the case.
摘要翻译：公开了一种具有位于壳体中的电极组件的电池，其有效地利用了许多可植入医疗装置中可用的空间。电池壳体提供了一个盖子和一个浅的外壳，优选地是平面的，主要的底部部分，一个敞开的顶部，用于接收与底部相对的盖子，并且多个边缘彼此相交并且与底部相交，以允许位于可植入装置内的其他部件的紧密邻接，同时还提供电池在装置的弓形边缘内的有效定位。盖子和浅表壳通过激光焊接技术基本上气密地密封，并且设置在壳体内的绝缘体构件以对入射的激光辐射提供屏障，使得在焊接期间辐射不会撞击设置在壳体内的辐射敏感部件。

7. 发明申请

US20120265164A1 FLOW RESTRICTOR FOR MEDICAL DEVICES 审中-公开
标题翻译：医疗器械流量限制器
公开(公告)号：US20120265164A1
公开(公告)日：2012-10-18
申请号：US13444330
申请日：2012-04-11
申请人： Markus W. Reiterer , Dale F. Seeley , Kimberly A. Chaffin
发明人： Markus W. Reiterer , Dale F. Seeley , Kimberly A. Chaffin
IPC分类号： A61M25/14 , C08J3/28 , B82Y30/00
CPC分类号： G03F7/2053 , A61M37/00 , A61M2205/04 , A61M2205/3334
摘要： This relates to fluid delivery devices and methods and, more particularly, to implantable fluid delivery devices and methods of use. A flow restrictor for medical devices is described with particularly useful properties.
摘要翻译：这涉及流体递送装置和方法，更具体地涉及可植入流体递送装置和使用方法。用于医疗装置的限流器被描述为具有特别有用的特性。

8. 发明申请

US20120035544A1 MEDICAL DEVICES WITH PLASMA-TREATED SURFACE AND METHODS 审中-公开
标题翻译：具有等离子体处理表面的医疗装置和方法
公开(公告)号：US20120035544A1
公开(公告)日：2012-02-09
申请号：US12850278
申请日：2010-08-04
申请人： Kimberly A. Chaffin , Geetha Sethumadhavan
发明人： Kimberly A. Chaffin , Geetha Sethumadhavan
IPC分类号： A61M5/142 , A61N1/362 , B32B37/00 , A61M5/315 , A61M5/00 , A61N1/36 , A61N1/39
CPC分类号： A61M5/14276 , A61M39/0208 , A61M39/0247 , A61N1/375 , C08J3/28 , C08J2383/04
摘要： A medical device (e.g., an implantable medical device) including a sealing apparatus (sealing element, e.g., a grommet for securing a lead to the device) that includes an element (e.g., a body) having a plasma-treated surface and methods (e.g., methods of making the device).
摘要翻译：包括具有等离子体处理表面的元件（例如，主体）的密封装置（密封元件，例如用于将导线固定到装置的密封件）的医疗装置（例如，可植入医疗装置）例如制造设备的方法）。

9. 发明申请

US20110318635A1 CONTOURED BATTERY FOR IMPLANTABLE MEDICAL DEVICES AND METHOD OF MANUFACTURE 有权
标题翻译：用于可植入医疗装置的轮廓电池及其制造方法
公开(公告)号：US20110318635A1
公开(公告)日：2011-12-29
申请号：US13171000
申请日：2011-06-28
申请人： Paul B. Aamodt , Frannise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
发明人： Paul B. Aamodt , Frannise D. Bartley , Steve M. Bruesehoff , Kurt J. Casby , David P. Haas , Karl E. Hokanson , Thomas M. Nutzman , Andrew J. Ries , Scott J. Robinson , Randy S. Roles , Sonja K. Somdahl , Walter C. Sunderland , Jason T. Papenfuss , William J. Farrell , Kimberly A. Chaffin
IPC分类号： H01M2/10 , H01M10/00 , H01M2/04
CPC分类号： A61N1/3975 , B33Y80/00 , H01M2/0202 , H01M2/0207 , H01M2/0232 , H01M2/0257 , H01M2/0267 , H01M2/0275 , H01M2/0404 , H01M2/08 , H01M2/1094 , H01M2002/0205 , Y10T29/49108
摘要： A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a preferably planar, major bottom portion, an open top to receive the cover opposing the bottom portion, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device. The cover and the shallow case being substantially hermetically sealed by a laser weld technique and an insulator member disposed within the case to provide a barrier to incident laser radiation so that during welding radiation does not impinge upon radiation sensitive component(s) disposed within the case.
摘要翻译：公开了一种具有位于壳体中的电极组件的电池，其有效地利用了许多可植入医疗装置中可用的空间。电池壳体提供了一个盖子和一个浅的外壳，优选地是平面的，主要的底部部分，一个敞开的顶部，用于接收与底部相对的盖子，并且多个边缘彼此相交并且与底部相交，以允许位于可植入装置内的其他部件的紧密邻接，同时还提供电池在装置的弓形边缘内的有效定位。盖子和浅表壳通过激光焊接技术基本上气密地密封，并且设置在壳体内的绝缘体构件以对入射的激光辐射提供屏障，使得在焊接期间辐射不会撞击设置在壳体内的辐射敏感部件。

10. 发明申请

US20100196439A1 Angiogenesis Mechanism and Method, and Implantable Device 审中-公开
标题翻译：血管生成机制与方法及植入装置
公开(公告)号：US20100196439A1
公开(公告)日：2010-08-05
申请号：US12520035
申请日：2007-12-20
申请人： Michael Theodore Beck , Deon Bezuidenhout , Kelvin Bonnema , Kimberly A. Chaffin , Neil Davies , Brian C.A. Fernandes , Eric J. Fogt , Eric A. Grovender , Robert Cushing Hamlen , Matthew Jolly , Eamonn J. McAndrew , Syamasundar V. Pakala , William P. VanAntwerp , Peter P. Zilla , Edouard A. Koullick
发明人： Michael Theodore Beck , Deon Bezuidenhout , Kelvin Bonnema , Kimberly A. Chaffin , Neil Davies , Brian C.A. Fernandes , Eric J. Fogt , Eric A. Grovender , Robert Cushing Hamlen , Matthew Jolly , Eamonn J. McAndrew , Syamasundar V. Pakala , William P. VanAntwerp , Peter P. Zilla , Edouard A. Koullick
IPC分类号： A61K9/00 , A61K38/18 , A61K35/12 , A61P3/10
CPC分类号： A61L27/38 , A61F2/022 , A61L27/3616 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/434
摘要： Various methods and devices are provided for providing therapy to a living body. In one embodiment, an implanted permeable container has living cells provided therein, and various nutrients and/or agents are provided into the container to promote cell life.
摘要翻译：提供用于向生物体提供治疗的各种方法和装置。在一个实施例中，植入的可渗透容器具有设置在其中的活细胞，并且向容器提供各种营养物和/或试剂以促进细胞寿命。

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