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1. 发明授权

US4753911A Insoluble complex oxidation catalysts 失效
标题翻译：不溶性复合氧化催化剂
公开(公告)号：US4753911A
公开(公告)日：1988-06-28
申请号：US934014
申请日：1986-11-24
申请人： Gerald L. Goe , Thomas D. Bailey , James R. Beadle
发明人： Gerald L. Goe , Thomas D. Bailey , James R. Beadle
IPC分类号： B01J31/22 , B01J31/16 , B01J31/18 , B01J31/40 , C07C45/00 , C07C49/67 , C07C67/00 , B01J31/04 , B01J31/06
CPC分类号： B01J31/1805 , B01J31/1658 , B01J31/181 , B01J31/4015 , B01J2231/70 , B01J2531/62
摘要： Insoluble complex oxidation catalysts comprising chromium salts bound on an insoluble polymer supports having pendant pyridine groups, that are useful in oxidation reactions such as Tetralino.RTM. to .alpha.-tetralone, ethylbenzene to acetophenone, and 2-methyl-5-ethylpyridine to 2-methyl-5-acetylpyridine. Also disclosed are processes for accomplishing such oxidations utilizing such catalysts.

2. 发明授权

US4839323A Insoluble complex oxidation catalysts 失效
标题翻译：不溶性复合氧化催化剂
公开(公告)号：US4839323A
公开(公告)日：1989-06-13
申请号：US115962
申请日：1987-11-02
申请人： Gerald L. Goe , Thomas D. Bailey , James R. Beadle
发明人： Gerald L. Goe , Thomas D. Bailey , James R. Beadle
IPC分类号： B01J31/16 , B01J31/18 , B01J31/40
CPC分类号： B01J31/1658 , B01J31/181 , B01J31/4015 , B01J2231/70 , B01J2531/62
摘要： Insoluble complex oxidation catalysts comprising chromium salts bound on an insoluble polymer supports having pendant pyridine groups, that are useful in oxidation reactions such as Tetralin.RTM. to .alpha.-tetralone, ethylbenzene to acetophenone, and 2-methyl-5-ethylpyridine to 2-methyl-5-acetylpyridine. Also disclosed are processes for accomplishing such oxidations utilizing such catalysts.
摘要翻译：不溶性复合氧化催化剂，其结合在具有侧基吡啶基团的不溶性聚合物载体上，可用于氧化反应如四氢萘酮与α-四氢萘酮，乙苯至苯乙酮和2-甲基-5-乙基吡啶至2-甲基 - 5-乙酰基吡啶。还公开了利用这种催化剂完成这种氧化的方法。

3. 发明授权

US07790703B2 Phosphonate compounds 有权
公开(公告)号：US07790703B2
公开(公告)日：2010-09-07
申请号：US11715604
申请日：2007-03-07
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/52 , A61K31/505 , A61K31/665 , C07D239/22 , C07D473/00
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

4. 发明授权

US07687480B2 Phosphonate compounds 有权
标题翻译：膦酸酯化合物
公开(公告)号：US07687480B2
公开(公告)日：2010-03-30
申请号：US11925309
申请日：2007-10-26
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/675 , C07D239/70
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
摘要翻译：本发明涉及膦酸酯化合物，含有它们的组合物，获得它们的方法及其用于治疗多种医学病症，例如骨质疏松症和其他骨代谢疾病，癌症，病毒感染等的用途。

5. 发明授权

US06686462B2 Antiviral compounds and methods of administration 失效
标题翻译：抗病毒化合物和给药方法
公开(公告)号：US06686462B2
公开(公告)日：2004-02-03
申请号：US08808847
申请日：1997-02-28
申请人： Andre Rosowsky , Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini , Douglas D. Richman
发明人： Andre Rosowsky , Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini , Douglas D. Richman
IPC分类号： A61K3170
CPC分类号： C07H19/10 , C07H19/20
摘要： The invention provides lipophilic phosphonoacid/nucleoside conjugates that exhibit exceptional antiviral activity, including activity against drug-resistant HIV strains. Compounds of the invention include phosphonoacid/nucleoside conjugates where the carboxyl group and phosphonyl groups of the phosphonacid are esterified whereby the compound contains at least one lipophilic group and at least one nucleoside group.
摘要翻译：本发明提供亲油性膦酰基/核苷缀合物，其表现出非凡的抗病毒活性，包括抗药物抗性HIV株的活性。本发明的化合物包括膦酰基/核苷缀合物，其中膦酰基的羧基和膦酰基被酯化，由此化合物含有至少一个亲油基团和至少一个核苷基团。

6. 发明授权

US5215591A Crystalline form of D-gulose 失效
标题翻译： D-酮糖的结晶形式
公开(公告)号：US5215591A
公开(公告)日：1993-06-01
申请号：US856638
申请日：1992-03-24
申请人： James R. Beadle , Gilbert V. Levin , Lee R. Zehner
发明人： James R. Beadle , Gilbert V. Levin , Lee R. Zehner
IPC分类号： C07H3/02 , C13K13/00
CPC分类号： C07H3/02 , C13K13/00
摘要： Free flowing, substantially pure, non-hygroscopic, crystalline .beta.-D-gulopyranose is disclosed. This crystalline form of D-gulose is characterized by a sharp melting point of 130.degree.-132.degree. C., a specific optical rotation of -40.degree. and characteristic mutarotation. A method for preparation of crystalline .beta.-D-gulopyranose from D-gulose syrup is also disclosed. This method involves dilution of the D-gulose syrup, followed by initiation of crystallization, and isolation of .beta.-D-gulopyranose crystals. Crystalline .beta.-D-gulopyranose may be used as an excipient, a chelating agent, a pharmaceutical intermediate, a cleaning agent for glass and metals, a food additive, and as an additive for detergents.
摘要翻译：公开了自由流动的，基本上纯的，非吸湿性的结晶β-D-吡喃葡萄糖。该D-形木糖的结晶形式的特征在于尖锐的熔点为130℃-132℃，比旋光度为-40度，具有特殊的旋转作用。还公开了从D-木糖糖浆制备结晶β-D-吡喃葡萄糖的方法。该方法包括稀释D-木糖糖浆，随后开始结晶，并分离β-D-吡喃葡萄糖晶体。结晶β-D-吡喃葡萄糖可用作赋形剂，螯合剂，药物中间体，玻璃和金属用清洁剂，食品添加剂和用作洗涤剂的添加剂。

7. 发明授权

US08309565B2 Phosphonate compounds 有权
标题翻译：膦酸酯化合物
公开(公告)号：US08309565B2
公开(公告)日：2012-11-13
申请号：US13220548
申请日：2011-08-29
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/506 , C07D239/22
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
摘要翻译：本发明涉及膦酸酯化合物，含有它们的组合物，获得它们的方法及其用于治疗多种医学病症，例如骨质疏松症和其他骨代谢疾病，癌症，病毒感染等的用途。

8. 发明授权

US08222257B2 Phosphono-pent-2-en-1-yl nucleosides and analogs 有权
标题翻译：膦酰 - 戊-2-烯-1-基核苷和类似物
公开(公告)号：US08222257B2
公开(公告)日：2012-07-17
申请号：US11887502
申请日：2006-03-30
申请人： Karl Y. Hostetler , James R. Beadle , Hyunah Choo
发明人： Karl Y. Hostetler , James R. Beadle , Hyunah Choo
IPC分类号： A01N43/54 , A01N43/90 , A61K31/522 , A61K31/52 , A61K31/505 , C07D245/00 , C07D225/02 , C07D487/00 , C07D239/02 , C07D475/00 , C07D473/00 , C07F9/02
CPC分类号： C07F9/65616 , C07F9/6512 , C07H19/10 , C07H19/20
摘要： Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.
摘要翻译：提供化合物和组合物用于治疗，预防或改善与病毒感染和/或细胞增殖相关的多种医学病症。本文提供的化合物是5-膦酰基 - 戊-2-烯-1-基核苷及其酯。

9. 发明授权

US07994143B2 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权
标题翻译：抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐
公开(公告)号：US07994143B2
公开(公告)日：2011-08-09
申请号：US12797327
申请日：2010-06-09
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译：本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。

10. 发明授权

US07749983B2 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权
标题翻译：抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐
公开(公告)号：US07749983B2
公开(公告)日：2010-07-06
申请号：US11736614
申请日：2007-04-18
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
IPC分类号： A01N57/00 , A61K31/675
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译：本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。

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