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1. 发明申请

US20120100047A1 AUTOMATED LIQUID HANDLING DEVICE 有权
标题翻译：自动液体处理装置
公开(公告)号：US20120100047A1
公开(公告)日：2012-04-26
申请号：US13188518
申请日：2011-07-22
申请人： Zoltan Brutler , Carl Doan , Erich Fournier , Ari Kukkonen , Scott Leclerc , George Lyman , Colin Reynolds , Thomas A. Sherwin , Jonathan Kohanski , Bryan Hotaling
发明人： Zoltan Brutler , Carl Doan , Erich Fournier , Ari Kukkonen , Scott Leclerc , George Lyman , Colin Reynolds , Thomas A. Sherwin , Jonathan Kohanski , Bryan Hotaling
IPC分类号： B01L3/02
CPC分类号： G01N35/1074
摘要： A liquid handling system that is configured to receive an interchangeable pipetting head that is selected from a plurality of interchangeable pipetting heads for automated liquid handling flexibility and scalability. The system includes a housing and at least one pipetting head disposed within that housing for aspirating and dispensing a liquid. A locking mechanism interchangeably receives the at least one pipetting head and includes an adaptor plate and a support block. The adaptor plate is operably coupled to the housing and the support block is operably coupled to the at least one pipetting head. The support block is then, in turn, is configured to be operably coupled to the adaptor plate.
摘要翻译：一种液体处理系统，其被配置为接收可互换的移液头，其从多个可互换的移液头中选择，用于自动化液体处理的灵活性和可伸缩性。该系统包括壳体和设置在该壳体内的用于抽吸和分配液体的至少一个移液头。锁定机构可互换地容纳至少一个移液头，并且包括适配器板和支撑块。适配器板可操作地联接到壳体，并且支撑块可操作地联接到至少一个移液头。然后，支撑块又被配置成可操作地联接到适配器板。

2. 发明授权

US07306767B2 Method for sealing test tubes and the like 有权
标题翻译：密封试管等的方法
公开(公告)号：US07306767B2
公开(公告)日：2007-12-11
申请号：US11080071
申请日：2005-03-15
申请人： Gregory Mathus , George Lyman
发明人： Gregory Mathus , George Lyman
IPC分类号： B01L3/00
CPC分类号： B01L3/50853
摘要： A method of sealing the open mouths of an array of test tubes comprises providing a plurality of plugs with upwardly facing recesses, and a flexible carrier sheet having the same array of mutually spaced downwardly projecting pegs inserted into and frictionally retained within the recesses of respective ones of the plugs. Sealing is effected by aligning the plugs with the open mouths of the test tubes, pressing the carrier sheet towards the test tubes to seat the plugs in the open tube mouths, and peeling the carrier sheet away from the test tubes to extract the pegs from the plug recesses while allowing the plugs to remain seated in the tube mouths.
摘要翻译：密封试管阵列的开口的方法包括提供多个具有向上的凹部的塞子，以及柔性载体片，其具有插入并摩擦地保持在相应的凹槽内的相互间隔开的向下突出的钉的相同阵列的插头。密封是通过将塞子与试管的开口对准来实现的，将载体片朝向试管按压以将塞子固定在开口管口中，并将载体片材从试管上剥离，以将塞子从插头凹槽，同时允许插头保持在管口中。

3. 外观设计

USD245300S Magnetic tape wall storage unit 失效
公开(公告)号：USD245300S
公开(公告)日：1977-08-09
申请号：US672780
申请日：1976-04-01
申请人： Gregory Mathus , George Lyman , David Roche
设计人： Gregory Mathus , George Lyman , David Roche

4. 发明授权

US5139951A Culture device having a detachable cell or tissue growth surface 失效
标题翻译：具有可分离细胞或组织生长表面的培养装置
公开(公告)号：US5139951A
公开(公告)日：1992-08-18
申请号：US595305
申请日：1990-10-10
申请人： David Butz , George Lyman , David Root , Gregory Mathus
发明人： David Butz , George Lyman , David Root , Gregory Mathus
IPC分类号： C12M3/06
CPC分类号： C12M25/02 , C12M23/00 , C12M23/12
摘要： A tissue or cell growth device is described for placement within a well of a cluster dish. The device has a cell or tissue retention element detachably attached to a hanger. The hanger preferably has openings allowing access to the well without removal of the member and is capable of positioning the cell or tissue retention element a preselected distance relative to the hanger. Also described are various embodiments of the device having differently shaped hangers and the combination of the device and a cluster dish.
摘要翻译：描述了组织或细胞生长装置用于放置在簇盘的孔内。该装置具有可拆卸地附接到衣架的细胞或组织保持元件。衣架优选地具有允许进入井的开口，而不移除构件，并且能够将电池或组织保持元件相对于衣架定位成预选的距离。还描述了具有不同形状的悬挂器以及装置和簇盘的组合的装置的各种实施例。

5. 发明授权

US5026649A Apparatus for growing tissue cultures in vitro 失效
标题翻译：用于体外培养组织培养物的装置
公开(公告)号：US5026649A
公开(公告)日：1991-06-25
申请号：US841562
申请日：1986-03-20
申请人： George Lyman , Gregory Mathus , David Root
发明人： George Lyman , Gregory Mathus , David Root
IPC分类号： C12M1/20 , C12M1/22 , C12M3/00 , C12M3/06
CPC分类号： C12M29/04 , C12M25/04
摘要： Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a tubular support that in turn hangs by a flange connected to its upper end on the top of a well containing the nutrients. Typically, the well is part of a tissue culture cluster dish. The flange of the support positions the support and membrane centrally in the well so as to avoid capillary action in the space between the well and support. The configuration of the support and its cooperation with the lid of the cluster dish also prevents the support and membrane from floating in the nutrient solution in the well. Openings in the support provide access for a pipette to add and withdraw fluid from the space between the well and membrane support and from the space below the membrane.
摘要翻译：用于在体外生长组织培养物的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜发育。可渗透膜附接到管状支撑件的底端，管状支撑件的底端又通过连接到容纳营养物质的孔的顶部上方的凸缘而悬挂。通常，孔是组织培养簇盘的一部分。支撑件的凸缘将支撑件和膜中心定位在井中，以避免在井和支撑件之间的空间中的毛细作用。支架的配置及其与簇盘盖的配合也可防止支撑和膜浮在井中的营养液中。支架中的开口提供移液管的通道，以从孔和膜支撑之间的空间以及膜下方的空间添加和抽出流体。

6. 发明授权

US4927764A Tissue culture flask 失效
标题翻译：组织培养瓶
公开(公告)号：US4927764A
公开(公告)日：1990-05-22
申请号：US122052
申请日：1987-11-17
申请人： George Lyman , Gregory Mathus
发明人： George Lyman , Gregory Mathus
IPC分类号： B01L3/08 , C12M1/24
CPC分类号： C12M23/32 , B01L3/08 , C12M23/08 , C12M23/22 , C12M23/38
摘要： A tissue culture flask having a flat bottom wall with optical properties on the inner surface of which cells are grown. A top wall opposite the bottom wall has a large opening therethrough which provides access to the growing surface for the removal of cells growing on the surface. The opening is closed by a flexible transparent film which is sealed to the top wall and which may be peeled off the top wall to provide access to the flask interior.
摘要翻译：一种组织培养瓶，其具有在其内表面上生长细胞的具有光学性质的平坦底壁。与底壁相对的顶壁具有穿过其的大开口，其提供进入生长表面以去除在表面上生长的细胞。开口由柔性透明膜封闭，该透明膜密封到顶壁，并且可以从顶壁剥离以提供通向烧瓶内部的通路。

7. 发明授权

US4690757A Small volume laboratory filter 失效
标题翻译：小体积实验室过滤器
公开(公告)号：US4690757A
公开(公告)日：1987-09-01
申请号：US842494
申请日：1986-03-21
申请人： Gregory Mathus , George Lyman , Kevin Looney
发明人： Gregory Mathus , George Lyman , Kevin Looney
IPC分类号： B01D29/01 , B01D35/02 , B01D46/10 , B01D46/54 , B01D61/18 , B01D63/08 , B01D13/00
CPC分类号： B01D46/543 , B01D29/012 , B01D46/0012 , B01D61/18 , B01D63/08 , B01D2277/20
摘要： A small volume laboratory filter having a thin rectangular body and coaxial inlet and outlet sleeves connected to opposite ends thereof. A very thin filter cavity is formed in the body and lies in a plane inclined slightly to the common axis of the inlet and outlet sleeves. The cavity is divided by a filter membrane into extremely thin chambers, one communicating with the inlet sleeve and the other with the outlet sleeve. A rigid package for the filter is sealed across one end by a flexible cover which when stripped from the package exposes the inlet sleeve so that it may be readily engaged by a syringe nipple or other fluid source without the user having to touch the filter. When the inlet sleeve is engaged, the filter may be withdrawn from the package.
摘要翻译：具有薄的矩形体的小体积实验室过滤器和连接到其相对端的同轴入口和出口套筒。在体内形成非常薄的过滤腔，并且位于与入口和出口套筒的公共轴线稍微倾斜的平面内。空腔被过滤膜分成非常薄的室，一个与入口套管相通，另一个与出口套管连通。用于过滤器的刚性包装通过柔性盖密封在一端上，当从包装件剥离时，柔性罩暴露入口套筒，使得其可以容易地通过注射器管接头或其它流体源接合，而用户不必接触过滤器。当入口套筒接合时，过滤器可以从包装件中取出。

8. 发明申请

US20050196327A1 Method for sealing test tubes and the like 有权
标题翻译：密封试管等的方法
公开(公告)号：US20050196327A1
公开(公告)日：2005-09-08
申请号：US11080071
申请日：2005-03-15
申请人： Gregory Mathus , George Lyman
发明人： Gregory Mathus , George Lyman
IPC分类号： B01L3/14 , B01L3/00
CPC分类号： B01L3/50853
摘要： A method of sealing the open mouths of an array of test tubes comprises providing a plurality of plugs with upwardly facing recesses, and a flexible carrier sheet having the same array of mutually spaced downwardly projecting pegs inserted into and frictionally retained within the recesses of respective ones of the plugs. Sealing is effected by aligning the plugs with the open mouths of the test tubes, pressing the carrier sheet towards the test tubes to seat the plugs in the open tube mouths, and peeling the carrier sheet away from the test tubes to extract the pegs from the plug recesses while allowing the plugs to remain seated in the tube mouths.
摘要翻译：密封试管阵列的开口的方法包括提供多个具有向上的凹部的塞子，以及柔性载体片，其具有插入并摩擦地保持在相应的凹槽内的相互间隔开的向下突出的钉的相同阵列的插头。密封是通过将塞子与试管的开口对准来实现的，将载体片朝向试管按压以将塞子固定在开口管口中，并将载体片材从试管上剥离，以将塞子从插头凹槽，同时允许插头保持在管口中。

9. 发明授权

US06890488B2 Apparatus for sealing test tubes and the like 有权
标题翻译：用于密封试管等的装置
公开(公告)号：US06890488B2
公开(公告)日：2005-05-10
申请号：US10165032
申请日：2002-06-07
申请人： Gregory Mathus , George Lyman
发明人： Gregory Mathus , George Lyman
IPC分类号： B01L3/14 , B01L3/00
CPC分类号： B01L3/50853
摘要： A sealing mat for sealing the open mouths of an array of test tubes. The mat includes a flexible carrier sheet having an array of mutually spaced pegs projecting downwardly therefrom and a plurality of plugs. The plugs are externally configured and dimensioned to be inserted in and to seal the open mouths of the test tubes. Each of the plugs has an upwardly facing recess internally configured and dimensioned to receive and coact in frictional engagement with a respective one of the pegs to thereby releasably secure the plugs to the carrier sheet. The carrier sheet is separable from the thus inserted plugs by flexure to extract the pegs from the recesses.
摘要翻译：用于密封试管阵列的开口的密封垫。垫包括柔性载体片，其具有从其向下突出的相互间隔开的钉的阵列和多个塞子。插头外部配置和尺寸设计成插入并密封试管的开放口。每个插头具有内部构造的尺寸设计为上部的凹槽，其尺寸被设计成接收并与其相应的一个棘爪摩擦接合，从而将插头可释放地固定到载体片上。载体片通过挠曲与这样插入的插塞分离，以从凹部提取钉。

10. 发明授权

US4948564A Multi-well filter strip and composite assemblies 失效
标题翻译：多孔过滤条和复合组件
公开(公告)号：US4948564A
公开(公告)日：1990-08-14
申请号：US430812
申请日：1989-11-02
申请人： David Root , George Lyman
发明人： David Root , George Lyman
IPC分类号： B01D29/01 , B01D61/18 , B01L3/00 , B01L9/06 , G01N21/03
CPC分类号： B01L9/06 , B01D61/18 , B01L3/5025 , B01L3/50255 , B01L3/50855 , G01N2021/0357 , G01N2201/0446 , Y10S436/809 , Y10T436/255
摘要： A filter strip and composite assemblies for filtering microliter quantities of fluids. A linear array of wells having open top and bottom ends are connected by frangible webs in spaced-apart relation with discrete filter membranes closing the bottom ends of each well. Tabs are provided on the ends of the filter strip for holding the same and supporting the strip in a rectangular holder having alpha-numeric designations for identifying each well in a plurality of such filter strips contained within the holder. The filter strip may be used in a vacuum manifold for applying a pressure differential across the filter membrane and directing the filtrate into an aligned aperture of a closed bottom well of an array of wells held within the manifold. Alternatively, the filter strip may be used with a transfer plate for directing the filtrate from each well of the filter strip to an aligned well of a closed bottom array of wells. Another composite assembly includes a pressure manifold for applying an increased pressure above the membranes.
摘要翻译：用于过滤微量流体的过滤条和复合组件。具有开放的顶部和底部的井的线性阵列通过易碎的腹板以间隔开的关系连接，离心过滤膜封闭每个孔的底端。在过滤条的端部设置有用于保持其的突片，并将条带支撑在具有字母数字标号的矩形保持器中，用于识别容纳在保持器内的多个这种过滤条中的每个孔。过滤条可以用在真空歧管中，用于在过滤膜上施加压力差，并将滤液引导到保持在歧管内的阱阵列的封闭的底部井的对准孔。或者，过滤条可以与转移板一起使用，用于将滤液从过滤条的每个孔导向孔的封闭底部阵列的对准井。另一复合组件包括用于在膜上施加增加压力的压力歧管。

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