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1. 发明申请

US20120208238A1 ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES 有权
标题翻译：工程化免疫球蛋白FC多糖
公开(公告)号：US20120208238A1
公开(公告)日：2012-08-16
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C12P21/02 , C12N5/0784 , C12N15/13 , C12N5/10 , C07K16/40 , C12N15/63 , C12N1/21
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

2. 发明授权

US08952132B2 Engineered immunoglobulin FC polypeptides 有权
标题翻译：工程化的免疫球蛋白FC多肽
公开(公告)号：US08952132B2
公开(公告)日：2015-02-10
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C07K17/00 , C07K16/00 , C07K1/00 , C07K16/28 , C12P21/08
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

3. 发明申请

US20090061383A1 Dental clinical instrument 审中-公开
标题翻译：牙科临床仪器
公开(公告)号：US20090061383A1
公开(公告)日：2009-03-05
申请号：US12230230
申请日：2008-08-26
申请人： Tae Hyun Kang
发明人： Tae Hyun Kang
IPC分类号： A61C19/04
CPC分类号： A61C19/043 , A61C19/04
摘要： Disclosed is a dental clinical instrument for the diagnosis of periodontal disease. The dental clinical instrument comprises a main body held by hand to apply a force during diagnosis, a probe having a front portion bent downward to be inserted into a periodontal site to be diagnosed and a rear portion coupled to the main body to allow the front portion to be movable up and down, and a measurement indicator positioned toward the probe on the main body to display a change in the location of the probe so that a user can discern the force applied to the probe wherein the measurement indicator displays the force applied to the probe when the probe elastically moves up and down with respect to the main body in a state where the probe is positioned at the periodontal site. The measurement indicator is disposed at a front end portion of the main body. Due to this constitution, the user can easily discern the force applied to the probe upon diagnosis of periodontal disease and a diagnostic error arising from a difference in the force of users can be significantly reduced.
摘要翻译：公开了一种用于牙周病诊断的牙科临床仪器。牙科临床仪器包括手动保持的主体以在诊断期间施加力，探针具有向下弯曲以插入待诊断的牙周部位的前部，以及连接到主体的后部，以允许前部能够上下移动，以及测量指示器，其朝向主体上的探头定位，以显示探头位置的变化，使得用户可以辨别施加到探针的力，其中测量指示器显示施加到探头在探针位于牙周部位的状态下相对于主体上下弹性地移动。测量指示器设置在主体的前端部。由于这种结构，用户可以容易地辨别牙周病诊断时施加到探针的力，并且可以显着降低由用户的力的差异引起的诊断误差。

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