专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08679493B2 Immunoglobulin Fc polypeptides 有权
标题翻译：免疫球蛋白Fc多肽
公开(公告)号：US08679493B2
公开(公告)日：2014-03-25
申请号：US12827386
申请日：2010-06-30
申请人： George Georgiou , Sang Taek Jung , Sai Reddy
发明人： George Georgiou , Sang Taek Jung , Sai Reddy
IPC分类号： A61K39/395 , C12P21/08 , C12N1/21 , C12N5/02 , C12N5/10
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化的Fe结构域，其选择性地结合FcγRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

2. 发明授权

US08629245B2 Immunoglobulin Fc libraries 有权
标题翻译：免疫球蛋白Fc文库
公开(公告)号：US08629245B2
公开(公告)日：2014-01-14
申请号：US12112971
申请日：2008-04-30
申请人： George Georgiou , Sang Taek Jung
发明人： George Georgiou , Sang Taek Jung
IPC分类号： C12Q1/68 , G01N33/569 , C07K16/00 , C07H21/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/32 , C07K2317/52 , C07K2317/72 , C07K2319/035 , C07K2319/30
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
摘要翻译：用于筛选和分离糖基化抗体Fc结构域多肽的方法和组合物。例如，在某些方面，描述了用于鉴定结合Fc受体或优先结合特定Fc受体的糖基化Fc结构域的方法。此外，本发明提供以高亲和力结合Fc受体的糖基化Fc结构域。还提供了用于基于原核的相互作用筛选的增强的方法和介质。

3. 发明申请

US20100330076A1 IMMUNOGLOBULIN FC POLYPEPTIDES 有权
标题翻译：多柔比星FC多糖
公开(公告)号：US20100330076A1
公开(公告)日：2010-12-30
申请号：US12827386
申请日：2010-06-30
申请人： George Georgiou , Sang Taek Jung , Sai Reddy
发明人： George Georgiou , Sang Taek Jung , Sai Reddy
IPC分类号： A61K39/395 , C07K16/42 , C07H21/04 , C12N5/10 , C12P21/00 , C12N5/071 , G01N33/53 , A61P37/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化的Fe结构域，其选择性地结合FcγRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

4. 发明申请

US20120208238A1 ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES 有权
标题翻译：工程化免疫球蛋白FC多糖
公开(公告)号：US20120208238A1
公开(公告)日：2012-08-16
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C12P21/02 , C12N5/0784 , C12N15/13 , C12N5/10 , C07K16/40 , C12N15/63 , C12N1/21
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

5. 发明申请

US20090136936A1 IMMUNOGLOBULIN FC LIBRARIES 有权
标题翻译：免疫球蛋白图书馆
公开(公告)号：US20090136936A1
公开(公告)日：2009-05-28
申请号：US12112971
申请日：2008-04-30
申请人： George Georgiou , Sang Taek Jung
发明人： George Georgiou , Sang Taek Jung
IPC分类号： C12Q1/68 , G01N33/569 , C07K16/00 , C07H21/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/32 , C07K2317/52 , C07K2317/72 , C07K2319/035 , C07K2319/30
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
摘要翻译：用于筛选和分离糖基化抗体Fc结构域多肽的方法和组合物。例如，在某些方面，描述了用于鉴定结合Fc受体或优先结合特定Fc受体的糖基化Fc结构域的方法。此外，本发明提供以高亲和力结合Fc受体的糖基化Fc结构域。还提供了用于基于原核的相互作用筛选的增强的方法和介质。

6. 发明授权

US08952132B2 Engineered immunoglobulin FC polypeptides 有权
标题翻译：工程化的免疫球蛋白FC多肽
公开(公告)号：US08952132B2
公开(公告)日：2015-02-10
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C07K17/00 , C07K16/00 , C07K1/00 , C07K16/28 , C12P21/08
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式