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1. 发明授权

US5597457A System and method for forming synthetic protein crystals to determine the conformational structure by crystallography 失效
标题翻译：用于形成合成蛋白质晶体的系统和方法，以通过晶体学确定构象结构
公开(公告)号：US5597457A
公开(公告)日：1997-01-28
申请号：US630711
申请日：1996-04-08
申请人： George D. Craig , Robert Glass , Bernhard Rupp
发明人： George D. Craig , Robert Glass , Bernhard Rupp
IPC分类号： C10M171/00 , C30B7/00 , C10M169/04
CPC分类号： C10M171/001 , C30B29/58 , C30B7/00
摘要： A method for forming synthetic crystals of proteins in a carrier fluid by use of the dipole moments of protein macromolecules that self-align in the Helmholtz layer adjacent to an electrode. The voltage gradients of such layers easily exceed 10.sup.6 V/m. The synthetic protein crystals are subjected to x-ray crystallography to determine the conformational structure of the protein involved.
摘要翻译：一种通过使用邻近电极的亥姆霍兹（Selfmine）层中自对准的蛋白质大分子的偶极矩在载体流体中形成蛋白质合成晶体的方法。这些层的电压梯度容易超过106V / m。对合成的蛋白质晶体进行x射线晶体学测定以确定涉及的蛋白质的构象结构。

2. 发明授权

US5525198A Electrorheological crystallization of proteins and other molecules 失效
标题翻译：蛋白质和其他分子的电流变结晶
公开(公告)号：US5525198A
公开(公告)日：1996-06-11
申请号：US376612
申请日：1995-01-23
申请人： George D. Craig , Bernhard Rupp
发明人： George D. Craig , Bernhard Rupp
IPC分类号： C10M171/00 , C30B7/00 , C10M169/04
CPC分类号： C10M171/001 , C30B29/58 , C30B7/00
摘要： An electrorheological crystalline mass of a molecule is formed by dispersing the molecule in a dispersion fluid and subjecting the molecule dispersion to a uniform electrical field for a period of time during which time an electrorheological crystalline mass is formed. Molecules that may be used to form an electrorheological crystalline mass include any organic or inorganic molecule which has a permanent dipole and/or which is capable of becoming an induced dipole in the presence of an electric field. The molecules used to form the electrorheological crystalline mass are preferably macromolecules, such as biomolecules, such as proteins, nucleic acids, carbohydrates, lipoproteins and viruses.Molecules are crystallized by a method in which an electric field is maintained for a period of time after the electrorheological crystalline mass has formed during which time at least some of the molecules making up the electrorheological crystalline mass form a crystal lattice.The three dimensional structure of a molecule is determined by a method in which an electrorheological crystalline mass of the molecule is formed, an x-ray diffraction pattern of the electrorheological crystalline mass is obtained and the three dimensional structure of the molecule is calculated from the x-ray diffraction pattern.
摘要翻译：分子的电流变结晶质量是通过将分子分散在分散液中形成的，并使分子分散体在均匀的电场中持续一段时间，在此期间形成电流变结晶团块。可用于形成电流变结晶物质的分子包括具有永久偶极子和/或能够在电场存在下成为诱导偶极子的任何有机或无机分子。用于形成电流变结晶团的分子优选为大分子，例如生物分子，如蛋白质，核酸，碳水化合物，脂蛋白和病毒。通过在形成电流变结晶物质之后电场保持一段时间的方法使分子结晶，在该时间期间，构成电流变结晶质量的至少一些分子形成晶格。分子的三维结构通过形成分子的电流变结晶质量的方法确定，获得电流变结晶团的x射线衍射图，并且从x计算分子的三维结构射线衍射图。

3. 发明授权

US06969284B2 Connector arrangement for compact servomotor 有权
标题翻译：紧凑型伺服电机的连接器布置
公开(公告)号：US06969284B2
公开(公告)日：2005-11-29
申请号：US10894791
申请日：2004-07-20
申请人： Helmut Singer , Tobias Schimmele-Brell , Gerhard Platzer , Yasar Semerci , Andreas Wyderka , Bernhard Rupp
发明人： Helmut Singer , Tobias Schimmele-Brell , Gerhard Platzer , Yasar Semerci , Andreas Wyderka , Bernhard Rupp
IPC分类号： H01R13/518 , H01R13/639 , H01R13/658 , H02K5/22 , H01R13/501
CPC分类号： H01R13/518 , H01R13/639 , H01R13/6589 , H02K5/225
摘要： A plug connector device (11, FIG. 2) for medium voltage (e.g. 220 volts) compact servomotors has a power plug unit (16) and a control signal plug unit (17), each with connectable/disconnectable outer and inner plugs (49,48 and 52,51), the units lying in a single connector housing that is supported around a wire-passing aperture (14) in a motor housing part (13) and that pivots to different angular positions.
摘要翻译：用于中等电压（例如220伏）紧凑型伺服电动机的插头连接器装置（11，图2）具有电源插头单元（16）和控制信号插头单元（17），每个具有可连接/可断开的外部和内部插头（49 ，48和52,51），所述单元位于单个连接器壳体中，所述单个连接器壳体围绕电动机容纳部分（13）中的线通孔（14）支撑并且枢转到不同的角位置。

4. 发明授权

US06916455B2 Protein crystallography prescreen kit 失效
标题翻译：蛋白质晶体学预筛选试剂盒
公开(公告)号：US06916455B2
公开(公告)日：2005-07-12
申请号：US10218764
申请日：2002-08-14
申请人： Brent W. Segelke , Heike I. Krupka , Bernhard Rupp
发明人： Brent W. Segelke , Heike I. Krupka , Bernhard Rupp
IPC分类号： B01L99/00 , C30B7/00 , G01N1/40 , B01D9/00
CPC分类号： C30B7/00 , B01L9/54 , C30B29/58 , G01N2001/4027 , Y10S117/901 , Y10T117/1024
摘要： A kit for prescreening protein concentration for crystallization includes a multiplicity of vials, a multiplicity of pre-selected reagents, and a multiplicity of sample plates. The reagents and a corresponding multiplicity of samples of the protein in solutions of varying concentrations are placed on sample plates. The sample plates containing the reagents and samples are incubated. After incubation the sample plates are examined to determine which of the sample concentrations are too low and which the sample concentrations are too high. The sample concentrations that are optimal for protein crystallization are selected and used.
摘要翻译：用于结晶蛋白浓度预筛选的试剂盒包括多个小瓶，多个预先选择的试剂和多个样品板。不同浓度的溶液中的试剂和相应的蛋白质样品数量放在样品板上。将含有试剂和样品的样品板孵育。孵育后，检查样品板以确定哪个样品浓度太低，样品浓度太高。选择和使用最适合蛋白质结晶的样品浓度。

5. 发明授权

US06724782B2 Femtosecond laser-electron x-ray source 失效
标题翻译：飞秒激光电子X射线源
公开(公告)号：US06724782B2
公开(公告)日：2004-04-20
申请号：US10137262
申请日：2002-04-30
申请人： Frederic V. Hartemann , Hector A. Baldis , Chris P. J. Barty , David J. Gibson , Bernhard Rupp
发明人： Frederic V. Hartemann , Hector A. Baldis , Chris P. J. Barty , David J. Gibson , Bernhard Rupp
IPC分类号： H01G330
CPC分类号： G03F7/70008 , H05G2/00
摘要： A femtosecond laser-electron X-ray source. A high-brightness relativistic electron injector produces an electron beam pulse train. A system accelerates the electron beam pulse train. The femtosecond laser-electron X-ray source includes a high intra-cavity power, mode-locked laser and an x-ray optics system.
摘要翻译：飞秒激光电子X射线源。高亮度相对论电子注入器产生电子束脉冲串。系统加速电子束脉冲串。飞秒激光电子X射线源包括高腔体功率，锁模激光器和x射线光学系统。

6. 外观设计

USD601504S1 Connector with pins and flange 有权
标题翻译：带引脚和法兰的连接器
公开(公告)号：USD601504S1
公开(公告)日：2009-10-06
申请号：US29313916
申请日：2009-02-19
申请人： Bernhard Rupp , Andreas Zimmermann
设计人： Bernhard Rupp , Andreas Zimmermann

7. 发明授权

US07276216B2 Protein crystallography prescreen kit 失效
标题翻译：蛋白质晶体学预筛选试剂盒
公开(公告)号：US07276216B2
公开(公告)日：2007-10-02
申请号：US11084479
申请日：2005-03-17
申请人： Brent W. Segelke , Heike I. Krupka , Bernhard Rupp
发明人： Brent W. Segelke , Heike I. Krupka , Bernhard Rupp
IPC分类号： B01D9/02
CPC分类号： C30B7/00 , B01L9/54 , C30B29/58 , G01N2001/4027 , Y10S117/901 , Y10T117/1024
摘要： A kit for prescreening protein concentration for crystallization includes a multiplicity of vials, a multiplicity of pre-selected reagents, and a multiplicity of sample plates. The reagents and a corresponding multiplicity of samples of the protein in solutions of varying concentrations are placed on sample plates. The sample plates containing the reagents and samples are incubated. After incubation the sample plates are examined to determine which of the sample concentrations are too low and which the sample concentrations are too high. The sample concentrations that are optimal for protein crystallization are selected and used.
摘要翻译：用于结晶蛋白浓度预筛选的试剂盒包括多个小瓶，多个预先选择的试剂和多个样品板。不同浓度的溶液中的试剂和相应的蛋白质样品数量放在样品板上。将含有试剂和样品的样品板孵育。孵育后，检查样品板以确定哪个样品浓度太低，样品浓度太高。选择和使用最适合蛋白质结晶的样品浓度。

8. 发明授权

US06860940B2 Automated macromolecular crystallization screening 失效
标题翻译：自动化大分子结晶筛选
公开(公告)号：US06860940B2
公开(公告)日：2005-03-01
申请号：US10253130
申请日：2002-09-23
申请人： Brent W. Segelke , Bernhard Rupp , Heike I. Krupka
发明人： Brent W. Segelke , Bernhard Rupp , Heike I. Krupka
IPC分类号： B01J19/00 , C30B7/00 , C40B40/06 , C40B40/10 , C40B50/08 , C40B70/00 , C30B25/02
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00542 , B01J2219/00585 , B01J2219/00599 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , C30B7/00 , C30B29/58 , C40B40/06 , C40B40/10 , C40B50/08 , C40B70/00 , Y10S117/90 , Y10T117/1068 , Y10T117/1072 , Y10T117/1088
摘要： An automated macromolecular crystallization screening system wherein a multiplicity of reagent mixes are produced. A multiplicity of analysis plates is produced utilizing the reagent mixes combined with a sample. The analysis plates are incubated to promote growth of crystals. Images of the crystals are made. The images are analyzed with regard to suitability of the crystals for analysis by x-ray crystallography. A design of reagent mixes is produced based upon the expected suitability of the crystals for analysis by x-ray crystallography. A second multiplicity of mixes of the reagent components is produced utilizing the design and a second multiplicity of reagent mixes is used for a second round of automated macromolecular crystallization screening. In one embodiment the multiplicity of reagent mixes are produced by a random selection of reagent components.
摘要翻译：一种自动化的大分子结晶筛选系统，其中产生多种试剂混合物。使用与样品组合的试剂混合物产生多个分析板。孵育分析板以促进晶体的生长。制作晶体的图像。关于通过X射线晶体学分析晶体的适用性来分析图像。基于通过X射线晶体学分析晶体的预期适用性产生试剂混合物的设计。使用该设计产生第二多种试剂组分的混合物，并且将第二多种试剂混合物用于第二轮自动化大分子结晶筛选。在一个实施方案中，多种试剂混合物通过试剂组分的随机选择产生。

9. 发明授权

US06803689B2 Stator 失效
标题翻译：定子
公开(公告)号：US06803689B2
公开(公告)日：2004-10-12
申请号：US10130113
申请日：2002-08-05
申请人： Bernhard Rupp , Anton Paweletz
发明人： Bernhard Rupp , Anton Paweletz
IPC分类号： H02K500
CPC分类号： H02K3/50 , H02K9/22 , H02K2203/03
摘要： A stator according to the invention has an elastoplastic element, which is disposed between the winding and the pole cog and which secures the winding firmly to the pole cog, thus preventing vibrations.
摘要翻译：根据本发明的定子具有弹性塑料元件，其设置在绕组和极齿轮之间，并且将线圈牢固地固定到杆齿轮，从而防止振动。

10. 发明授权

US06225722B1 Electric machine with a rotor that rotates around a stator 失效
标题翻译：具有绕定子旋转的转子的电机
公开(公告)号：US06225722B1
公开(公告)日：2001-05-01
申请号：US09529949
申请日：2000-06-05
申请人： Bernhard Rupp , Gerd Knoepfel
发明人： Bernhard Rupp , Gerd Knoepfel
IPC分类号： H02K500
CPC分类号： H02K5/1675 , H02K1/14 , H02K1/187 , H02K21/22
摘要： A brushless direct current electric machine, comprising a stator with a hub and first stator pole teeth, which extend radially outward from this hub and have excitation coils, and with second stator pole teeth, which do not have excitation coils, interposed the first stator pole teeth, and has a rotor equipped with permanent magnets, which can rotate around the stator. The electric machine also has a base plate in which a rotor shaft bearing is inserted directly into the hub of the stator which fastens each of the second stator teeth to the base plate. The base plate is made of sheet metal and has supporting nipples oriented toward the second stator pole teeth. The second stator pole teeth have holes through which screws extend, which are screwed into the supporting nipples. The electric machine operates as a brushless direct current motor and is manufactured inexpensively.
摘要翻译：一种无刷直流电机，包括具有毂的定子和从该毂径向向外延伸并具有励磁线圈的第一定子极齿，以及具有不具有励磁线圈的第二定子极齿，插入第一定子极齿，并且具有配备有可绕定子旋转的永磁体的转子。电机还具有基板，其中转子轴承直接插入定子的毂中，将每个第二定子齿紧固到基板。基板由金属板制成，并具有朝向第二定子极齿定位的支撑接头。第二定子极齿具有螺钉延伸的孔，螺钉拧入支撑接头中。电机作为无刷直流电动机工作，成本低廉。

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