专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090178153A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20090178153A1
公开(公告)日：2009-07-09
申请号：US12243731
申请日：2008-10-01
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demitri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demitri Vassilatis , Hongkui Zeng
IPC分类号： A01K67/027 , C12Q1/68 , A61K31/7088 , G01N33/53 , C12N15/00 , C12N5/10 , A61K49/00
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

2. 发明申请

US20130247233A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
公开(公告)号：US20130247233A1
公开(公告)日：2013-09-19
申请号：US13796312
申请日：2013-03-12
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： C12Q1/68 , C07K14/705
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

3. 发明申请

US20110185439A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20110185439A1
公开(公告)日：2011-07-28
申请号：US12970094
申请日：2010-12-16
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： G01N33/48 , A01K67/027 , C12N15/87 , C12N5/10 , C07K14/47 , C07H21/04 , A61K31/7088 , A61P25/00 , A61P3/00 , C12Q1/68 , A61P9/00 , A61P17/00 , G01N33/53
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

4. 发明授权

US08999654B2 Method of identifying a compound for the treatment or prevention of obesity 有权
标题翻译：识别用于治疗或预防肥胖症的化合物的方法
公开(公告)号：US08999654B2
公开(公告)日：2015-04-07
申请号：US12916227
申请日：2010-10-29
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： G01N33/566 , C07K14/72 , C12Q1/68 , C07K14/705 , A61K38/00
CPC分类号： A01K67/0278 , A01K2217/00 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K49/0008 , C07K14/723 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5023 , G01N2333/726 , G01N2800/04 , G01N2800/28 , G01N2800/50
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

5. 发明申请

US20080260744A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20080260744A1
公开(公告)日：2008-10-23
申请号：US11940917
申请日：2007-11-15
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. Mcllwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. Mcllwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： A61K39/395 , A61K31/70 , C12Q1/68 , C12Q1/02 , A01K67/027 , G01N33/00 , C12N5/06 , G01N33/569 , A61P25/00
CPC分类号： A01K67/0278 , A01K2217/00 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K49/0008 , C07K14/723 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5023 , G01N2333/726 , G01N2800/04 , G01N2800/28 , G01N2800/50
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

6. 发明申请

US20110091388A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS 审中-公开
标题翻译：使用PDE7抑制剂治疗运动障碍
公开(公告)号：US20110091388A1
公开(公告)日：2011-04-21
申请号：US12974693
申请日：2010-12-21
申请人： John E. Bergmann , Neil S. Cutshall , Gregory A. Demopulos , Vincent A. Florio , George A. Gaitanaris , Patrick Gray , John Hohmann , Rene Onrust , Hongkui Zeng
发明人： John E. Bergmann , Neil S. Cutshall , Gregory A. Demopulos , Vincent A. Florio , George A. Gaitanaris , Patrick Gray , John Hohmann , Rene Onrust , Hongkui Zeng
IPC分类号： A61K49/00 , A61K31/197 , A61K31/519 , A61K31/517 , A61K31/433 , A61P25/14 , A61P25/16 , A61P25/00
CPC分类号： A61K31/195 , A61K31/433 , A61K31/519 , A61K31/527
摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
摘要翻译：通过施用治疗有效量的PDE7抑制剂来治疗与神经运动障碍的病理学相关的运动异常的方法，例如帕金森病或不宁腿综合症。本发明的一个方面提供了与多巴胺激动剂或前体如左旋多巴结合施用PDE和抑制剂。在本发明的另一方面，PDE7抑制剂可以相对于已知与帕金森病病理学有关的其它分子靶标（i）可能对PDE7具有选择性，或（ii）其他治疗有效的药物治疗帕金森病。

7. 发明申请

US20120115849A1 Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors 审中-公开
标题翻译：使用PDE7抑制剂治疗成瘾和脉搏控制障碍
公开(公告)号：US20120115849A1
公开(公告)日：2012-05-10
申请号：US13290868
申请日：2011-11-07
申请人： Gregory A. Demopulos , George A. Gaitanaris
发明人： Gregory A. Demopulos , George A. Gaitanaris
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/551 , A61K31/4439 , A61K31/4162 , A61K31/4178 , A61K31/485 , A61K31/454 , A61K31/44 , A61P25/30 , A61P25/36 , A61P25/32 , A61P25/34 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/08 , A61K31/519
CPC分类号： A61K31/00 , A61K31/135 , A61K31/137 , A61K31/197 , A61K31/337 , A61K31/357 , A61K31/381 , A61K31/385 , A61K31/4015 , A61K31/4025 , A61K31/4178 , A61K31/44 , A61K31/454 , A61K31/485 , A61K31/4985 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/55 , A61K2300/00
摘要： This disclosure is directed to treatment of addictions and primary impulse-control disorders using phosphodiesterase 7 (PDE7) inhibitors, alone or in combination with other therapeutic agents.
摘要翻译：本公开涉及使用磷酸二酯酶7（PDE7）抑制剂单独或与其它治疗剂组合治疗成瘾和初次冲动控制障碍。

8. 发明授权

US06228639B1 Vectors and methods for the mutagenesis of mammalian genes 失效
标题翻译：用于哺乳动物基因突变的载体和方法
公开(公告)号：US06228639B1
公开(公告)日：2001-05-08
申请号：US09002046
申请日：1997-12-31
申请人： George A. Gaitanaris
发明人： George A. Gaitanaris
IPC分类号： C12N500
CPC分类号： C12N15/86 , C12N15/102 , C12N2740/13043 , C12N2800/30 , C12N2830/003 , C12N2840/203 , C12N2840/44
摘要： Disclosed herein are methods for mutagenizing a mammalian gene, the methods involving introducing into a mammalian cell a retroviral vector which includes a splice acceptor sequence, a transcription termination sequence, and retroviral packaging and integration sequences, the introducing step being carried out under conditions which allow the vector to integrate into the genome of the cell. Also disclosed are retroviral vectors for use in these methods as well as methods for the use of mutagenized cells.
摘要翻译：本文公开了诱变哺乳动物基因的方法，所述方法包括向哺乳动物细胞中引入包含剪接受体序列，转录终止序列和逆转录病毒包装和整合序列的逆转录病毒载体，所述引入步骤在允许该载体整合到细胞的基因组中。还公开了用于这些方法的逆转录病毒载体以及使用诱变细胞的方法。

9. 发明授权

US6027881A Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence 失效
标题翻译：突变体Aequorea维多利亚荧光蛋白具有增加的细胞荧光
公开(公告)号：US6027881A
公开(公告)日：2000-02-22
申请号：US646538
申请日：1996-05-08
申请人： George N. Pavlakis , George A. Gaitanaris , Roland H. Stauber , John N. Vournakis
发明人： George N. Pavlakis , George A. Gaitanaris , Roland H. Stauber , John N. Vournakis
IPC分类号： C12N15/09 , C07K14/435 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/91 , C07H21/04 , C07K1/00 , C12N1/20
CPC分类号： C07K14/43595 , C07K2319/00
摘要： The present invention is directed to mutants of the jellyfish Aequorea victoria green fluorescent protein (GFP) having at least 5 and preferably greater than 20 times the specific green fluorescence of the wild type protein. In other embodiments, the invention comprises mutant blue fluorescent proteins (BFPs) that emit an enhanced blue fluorescence. The invention also encompasses the expression of nucleic acids that encode a mutant GFP or BFP in a wide variety of engineered host cells, and the isolation of engineered proteins having increased fluorescent activity. The novel mutants of the present invention allow for a significantly more sensitive detection of fluorescence in engineered host cells than is possible with GFP or with its known mutants. Thus, the mutant fluorescent proteins provided herein can be used as sensitive reporter molecules to detect the cell and tissue-specific expression and subcellular compartmentalization of GFP or BFP mutants, or of chimeric proteins comprising GFP or BFP mutants fused to a regulatory sequence or to a second protein sequence.
摘要翻译：本发明涉及具有野生型蛋白质的特定绿色荧光的至少5倍，优选大于20倍的水母Aequorea维多利亚绿色荧光蛋白（GFP）的突变体。在其它实施方案中，本发明包括发射增强的蓝色荧光的突变蓝色荧光蛋白（BFP）。本发明还包括在多种工程化宿主细胞中编码突变型GFP或BFP的核酸的表达，以及具有增加的荧光活性的工程蛋白的分离。与GFP或其已知突变体相比，本发明的新突变体允许在工程化宿主细胞中显着更灵敏地检测荧光。因此，本文提供的突变荧光蛋白可用作敏感的报道分子，以检测GFP或BFP突变体或融合至调节序列的GFP或BFP突变体的嵌合蛋白的细胞和组织特异性表达和亚细胞区室化第二个蛋白质序列。

10. 发明授权

US06265548B1 Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence 有权
标题翻译：突变体Aequorea维多利亚荧光蛋白具有增加的细胞荧光
公开(公告)号：US06265548B1
公开(公告)日：2001-07-24
申请号：US09503222
申请日：2000-02-11
申请人： George N. Pavlakis , George A. Gaitanaris , Roland H. Stauber , John N. Vournakis
发明人： George N. Pavlakis , George A. Gaitanaris , Roland H. Stauber , John N. Vournakis
IPC分类号： C07K14435
CPC分类号： C07K14/43595 , C07K2319/00
摘要： The present invention is directed to mutants of the jellyfish Aequorea victoria green fluorescent protein (GFP) having at least 5 and preferably greater than 20 times the specific green fluorescence of the wild type protein. In other embodiments, the invention comprises mutant blue fluorescent proteins (BFPs) that emit an enhanced blue fluorescence. The invention also encompasses the expression of nucleic acids that encode a mutant GFP or BFP in a wide variety of engineered host cells, and the isolation of engineered proteins having increased fluorescent activity. The novel mutants of the present invention allow for a significantly more sensitive detection of fluorescence in engineered host cells than is possible with GFP or with its known mutants. Thus, the mutant fluorescent proteins provided herein can be used as sensitive reporter molecules to detect the cell and tissue-specific expression and subcellular compartmentalization of GFP or BFP mutants, or of chimeric proteins comprising GFP or BFP mutants fused to a regulatory sequence or to a second protein sequence.
摘要翻译：本发明涉及具有野生型蛋白质的特定绿色荧光的至少5倍，优选大于20倍的水母Aequorea维多利亚绿色荧光蛋白（GFP）的突变体。在其它实施方案中，本发明包括发射增强的蓝色荧光的突变蓝色荧光蛋白（BFP）。本发明还包括在多种工程化宿主细胞中编码突变型GFP或BFP的核酸的表达，以及具有增加的荧光活性的工程蛋白的分离。与GFP或其已知突变体相比，本发明的新突变体允许在工程化宿主细胞中显着更灵敏地检测荧光。因此，本文提供的突变荧光蛋白可用作敏感的报道分子，以检测GFP或BFP突变体或融合至调节序列的GFP或BFP突变体的嵌合蛋白的细胞和组织特异性表达和亚细胞区室化第二个蛋白质序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式