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1. 发明申请

US20080306148A1 ANTI-CANCER COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗癌组合物和方法
公开(公告)号：US20080306148A1
公开(公告)日：2008-12-11
申请号：US12102629
申请日：2008-04-14
申请人： Gavin P. Robertson , Arati K. Sharma , Arun K. Sharma , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , Arati K. Sharma , Arun K. Sharma , Shantu Amin , Dhimant Desai
IPC分类号： A61K31/21 , C07C251/00 , C12N5/00 , A61P35/00
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
摘要翻译：描述了抗癌组合物和方法，包括一种或多种异硫氰酸酯和/或异硒氰酸酯。根据本发明的实施方案提供了治疗受试者的方法，其包括向具有以Akt调节为特征的病症的受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物。向受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物可检测地增加癌细胞，特别是以Akt失调为特征的癌细胞的凋亡和/或降低增殖。

2. 发明授权

US08309541B1 Anti-cancer compositions and methods 有权
标题翻译：抗癌成分和方法
公开(公告)号：US08309541B1
公开(公告)日：2012-11-13
申请号：US13107494
申请日：2011-05-13
申请人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
IPC分类号： A01N43/00 , A01N31/00 , A61K31/33 , A61K31/095 , C07C391/00 , C07C395/00
CPC分类号： C07C391/00 , A61K8/23 , A61K31/095 , A61K31/155 , A61K31/33
摘要： Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: R2-R-R1, where R is phenyl, where R1 is (CH2)nSe—C(═NH)—NH2, where R2 is (CH2)nSe—C(═NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. Compositions of the present invention inhibit Akt enzymes, iNOS, and increase MAP kinase activity such that cancer cells contacted with the compositions are inhibited.
摘要翻译：描述了抗癌组合物和方法，包括一种或多种具有结构式I的化合物：R2-R-R1，其中R是苯基，其中R1是（CH2）nSe-C（= NHN）-NH2，其中R2是（ CH2）nSe-C（= NH）-NH2或R2是H，并且其中每个n独立地是2,3,4,5,6,7或8.根据本发明的实施方案提供了治疗受试者的方法其包括将治疗有效量的包含一种或多种具有结构式I的化合物的组合物施用于具有由Akt调节异常表征的病症的受试者。向受试者施用治疗有效量的包含一种或多种具有结构式I的化合物的组合物可检测地增加癌细胞，特别是Akt失调特征的癌细胞的凋亡和/或降低增殖。本发明的组合物抑制Akt酶，iNOS，并且增加MAP激酶活性，使得与组合物接触的癌细胞被抑制。

3. 发明授权

US08003633B1 Anti-cancer compositions and methods 有权
标题翻译：抗癌成分和方法
公开(公告)号：US08003633B1
公开(公告)日：2011-08-23
申请号：US12423366
申请日：2009-04-14
申请人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
IPC分类号： A01N43/00 , A61K31/33 , C07C391/00 , C07C395/00
CPC分类号： C07C391/00 , A61K8/23 , A61K31/095 , A61K31/155 , A61K31/33
摘要： Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. Compositions of the present invention inhibit Akt enzymes, iNOS, and increase MAP kinase activity such that cancer cells contacted with the compositions are inhibited.
摘要翻译：描述了抗癌组合物和方法，其包括一种或多种具有结构式I的化合物：其中R是苯基，其中R 1是（CH 2）n-Se-C（= NH）-NH 2，其中R 2是（CH 2）n - Se-C（= NH）-NH2或R2是H，并且其中每个n独立地是2,3,4,5,6,7或8.根据本发明的实施方案提供了治疗受试者的方法，其中包括将治疗有效量的包含一种或多种具有结构式I的化合物的组合物施用于具有由Akt调节异常表征的病症的受试者。向受试者施用治疗有效量的包含一种或多种具有结构式I的化合物的组合物可检测地增加癌细胞，特别是Akt失调特征的癌细胞的凋亡和/或降低增殖。本发明的组合物抑制Akt酶，iNOS，并且增加MAP激酶活性，使得与组合物接触的癌细胞被抑制。

4. 发明授权

US08299126B2 Treatment of canine hemangiosarcoma with a histone deacetylase inhibitor 有权
标题翻译：用组蛋白脱乙酰酶抑制剂治疗犬血管肉瘤
公开(公告)号：US08299126B2
公开(公告)日：2012-10-30
申请号：US10547396
申请日：2004-02-25
申请人： Leonard A. Cohen , Shantu Amin , Dhimant Desai
发明人： Leonard A. Cohen , Shantu Amin , Dhimant Desai
IPC分类号： A61K31/16
CPC分类号： A61K31/16 , A61K31/19
摘要： The present invention is directed to a method of treating cancer, particularly canine hemangiosarcoma. The method includes the continuous and regular administration of a formulation including a histone deacetylase inhibitor as part of the standard canine diet. The preferred histone deacetylase inhibitor is SAHA. The formulation is administered following splenectomy to prevent tumor recurrence.
摘要翻译：本发明涉及一种治疗癌症的方法，特别是犬血管肉瘤。该方法包括连续和规则地施用包含作为标准犬饮食一部分的组蛋白脱乙酰酶抑制剂的制剂。优选的组蛋白脱乙酰酶抑制剂是SAHA。脾切除后施用该制剂以预防肿瘤复发。

5. 发明申请

US20060100286A1 Treatment of canine hemangiosarcoma with a histone deacetylase inhibitor 有权
标题翻译：用组蛋白脱乙酰酶抑制剂治疗犬血管肉瘤
公开(公告)号：US20060100286A1
公开(公告)日：2006-05-11
申请号：US10547396
申请日：2004-02-25
申请人： Leonard Cohen , Shantu Amin , Dhimant Desai
发明人： Leonard Cohen , Shantu Amin , Dhimant Desai
IPC分类号： A61K31/19
CPC分类号： A61K31/16 , A61K31/19
摘要： The present invention is directed to a method of treating cancer, particularly canine hemangiosarcoma. The method includes the continuous and regular administration of a formulation including a histone deacetylase inhibitor as part of the standard canine diet. The preferred histone deacetylase inhibitor is SAHA. The formulation is administered following splenectomy to prevent tumor recurrence.
摘要翻译：本发明涉及一种治疗癌症的方法，特别是犬血管肉瘤。该方法包括连续和规则地施用包含作为标准犬饮食一部分的组蛋白脱乙酰酶抑制剂的制剂。优选的组蛋白脱乙酰酶抑制剂是SAHA。脾切除后施用该制剂以预防肿瘤复发。

6. 发明申请

US20130013592A1 System for Engaging Experts and Organizing Recorded Media 审中-公开
标题翻译：聘请专家和组织记录媒体的制度
公开(公告)号：US20130013592A1
公开(公告)日：2013-01-10
申请号：US13544986
申请日：2012-07-09
申请人： Abhijeet Narvekar , Dhimant Desai
发明人： Abhijeet Narvekar , Dhimant Desai
IPC分类号： G06F17/30
CPC分类号： G06N5/04 , G06Q30/08
摘要： A system for selecting an expert and receiving expert evaluation data comprising: a computer having access to a database comprising subject matter expert data; where said computer is programmed to perform computer-implemented operations comprising: receiving user input comprising solution requirement data; accessing said database comprising subject matter expert data and comparing said solution requirement data to said subject matter expert data; selecting at least one subject matter expert; outputting solution requirement data to said subject matter expert; and receiving solution option data based on said subject matter expert's evaluation.
摘要翻译：一种用于选择专家和接收专家评估数据的系统，包括：具有访问包括主题专家数据的数据库的计算机; 其中所述计算机被编程为执行计算机实现的操作，包括：接收包括解决方案需求数据的用户输入访问包括主题专家数据的所述数据库，并将所述解决方案要求数据与所述主题专家数据进行比较; 选择至少一个主题专家; 向所述主题专家输出解决方案要求数据; 并根据所述主题专家的评估接收解决方案选项数据。

7. 发明申请

US20150149399A1 System for Engaging Experts and Organizing Recorded Media 审中-公开
标题翻译：聘请专家和组织记录媒体的制度
公开(公告)号：US20150149399A1
公开(公告)日：2015-05-28
申请号：US14548267
申请日：2014-11-19
申请人： Abhijeet Narvekar , Dhimant Desai
发明人： Abhijeet Narvekar , Dhimant Desai
IPC分类号： G06N5/04
CPC分类号： G06N5/04 , G06Q30/08
摘要： A system for selecting an expert and receiving expert evaluation data comprising: a computer having access to a database comprising subject matter expert data; where said computer is programmed to perform computer-implemented operations comprising: receiving solution requirement data; accessing said database comprising subject matter expert data and comparing said solution requirement data to said subject matter expert data; selecting at least one subject matter expert; outputting solution requirement data to said subject matter expert; receiving solution option data based on said subject matter expert's evaluation; and wherein said solution requirement data comprises job requirement data and solution option data comprises candidate evaluation data comprising interaction between said subject matter expert and a candidate.
摘要翻译：一种用于选择专家和接收专家评估数据的系统，包括：具有访问包括主题专家数据的数据库的计算机; 其中所述计算机被编程以执行计算机实现的操作，包括：接收解决方案需求数据; 访问所述数据库包括主题专家数据，并将所述解决方案需求数据与所述主题专家数据进行比较; 选择至少一个主题专家; 向所述主题专家输出解决方案要求数据; 根据所述主题专家的评价接收解决方案选项数据; 并且其中所述解决方案需求数据包括工作要求数据和解决方案选项数据包括包括所述主题专家与候选人之间的交互的候选评估数据。

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