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1. 发明授权

US08309541B1 Anti-cancer compositions and methods 有权
标题翻译：抗癌成分和方法
公开(公告)号：US08309541B1
公开(公告)日：2012-11-13
申请号：US13107494
申请日：2011-05-13
申请人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
IPC分类号： A01N43/00 , A01N31/00 , A61K31/33 , A61K31/095 , C07C391/00 , C07C395/00
CPC分类号： C07C391/00 , A61K8/23 , A61K31/095 , A61K31/155 , A61K31/33
摘要： Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: R2-R-R1, where R is phenyl, where R1 is (CH2)nSe—C(═NH)—NH2, where R2 is (CH2)nSe—C(═NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. Compositions of the present invention inhibit Akt enzymes, iNOS, and increase MAP kinase activity such that cancer cells contacted with the compositions are inhibited.
摘要翻译：描述了抗癌组合物和方法，包括一种或多种具有结构式I的化合物：R2-R-R1，其中R是苯基，其中R1是（CH2）nSe-C（= NHN）-NH2，其中R2是（ CH2）nSe-C（= NH）-NH2或R2是H，并且其中每个n独立地是2,3,4,5,6,7或8.根据本发明的实施方案提供了治疗受试者的方法其包括将治疗有效量的包含一种或多种具有结构式I的化合物的组合物施用于具有由Akt调节异常表征的病症的受试者。向受试者施用治疗有效量的包含一种或多种具有结构式I的化合物的组合物可检测地增加癌细胞，特别是Akt失调特征的癌细胞的凋亡和/或降低增殖。本发明的组合物抑制Akt酶，iNOS，并且增加MAP激酶活性，使得与组合物接触的癌细胞被抑制。

2. 发明申请

US20080306148A1 ANTI-CANCER COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗癌组合物和方法
公开(公告)号：US20080306148A1
公开(公告)日：2008-12-11
申请号：US12102629
申请日：2008-04-14
申请人： Gavin P. Robertson , Arati K. Sharma , Arun K. Sharma , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , Arati K. Sharma , Arun K. Sharma , Shantu Amin , Dhimant Desai
IPC分类号： A61K31/21 , C07C251/00 , C12N5/00 , A61P35/00
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
摘要翻译：描述了抗癌组合物和方法，包括一种或多种异硫氰酸酯和/或异硒氰酸酯。根据本发明的实施方案提供了治疗受试者的方法，其包括向具有以Akt调节为特征的病症的受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物。向受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物可检测地增加癌细胞，特别是以Akt失调为特征的癌细胞的凋亡和/或降低增殖。

3. 发明授权

US08003633B1 Anti-cancer compositions and methods 有权
标题翻译：抗癌成分和方法
公开(公告)号：US08003633B1
公开(公告)日：2011-08-23
申请号：US12423366
申请日：2009-04-14
申请人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
发明人： Gavin P. Robertson , SubbRao V. Madhunapantula , Shantu Amin , Dhimant Desai
IPC分类号： A01N43/00 , A61K31/33 , C07C391/00 , C07C395/00
CPC分类号： C07C391/00 , A61K8/23 , A61K31/095 , A61K31/155 , A61K31/33
摘要： Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. Compositions of the present invention inhibit Akt enzymes, iNOS, and increase MAP kinase activity such that cancer cells contacted with the compositions are inhibited.
摘要翻译：描述了抗癌组合物和方法，其包括一种或多种具有结构式I的化合物：其中R是苯基，其中R 1是（CH 2）n-Se-C（= NH）-NH 2，其中R 2是（CH 2）n - Se-C（= NH）-NH2或R2是H，并且其中每个n独立地是2,3,4,5,6,7或8.根据本发明的实施方案提供了治疗受试者的方法，其中包括将治疗有效量的包含一种或多种具有结构式I的化合物的组合物施用于具有由Akt调节异常表征的病症的受试者。向受试者施用治疗有效量的包含一种或多种具有结构式I的化合物的组合物可检测地增加癌细胞，特别是Akt失调特征的癌细胞的凋亡和/或降低增殖。本发明的组合物抑制Akt酶，iNOS，并且增加MAP激酶活性，使得与组合物接触的癌细胞被抑制。

4. 发明申请

US20160045437A1 COMPOSITIONS AND METHODS INCLUDING CELECOXIB AND PLUMBAGIN RELATING TO TREATMENT OF CANCER 有权
标题翻译：包括与治疗癌症相关的CELECOXIB和PLUMBAGIN的组合物和方法
公开(公告)号：US20160045437A1
公开(公告)日：2016-02-18
申请号：US14777160
申请日：2013-03-15
申请人： Gavin P. ROBERTSON , Chandagalu D. ENDRAGOWDA , Arati K. SHARMA , Gregory KARDOS , Sanjay SINGH , THE PENN STATE RESEARCH FOUNDATION
发明人： Gavin P. Robertson , Chandagalu D. Raghavendra , Arati K. Sharma , Gregory Kardos , Sanjay Singh
IPC分类号： A61K9/127 , G01N33/574 , A61K45/06 , A61K9/14 , A61K31/122 , A61K31/415
CPC分类号： A61K9/1271 , A61K9/14 , A61K31/122 , A61K31/415 , A61K45/06 , G01N33/57496 , G01N2333/4703 , G01N2333/90216 , A61K2300/00
摘要： The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and plumbagin in combination; methods for treatment of a proliferative disease including administration of celecoxib and plumbagin in a subject in need thereof; and particularly methods for treatment of skin cancer including administration of celecoxib and plumbagin in a subject in need thereof.
摘要翻译：本发明涉及用于治疗增殖性疾病的组合物和方法。在具体方面，本发明涉及组合物，其包含塞来考昔和扁桃酸的组合; 用于治疗增殖性疾病的方法，包括在有需要的受试者中施用塞来昔布和铅松蛋白; 特别是用于治疗皮肤癌的方法，包括在有需要的受试者中施用塞来昔布和铅丹。

5. 发明授权

US08785502B2 Compositions and methods relating to proliferative diseases 有权
标题翻译：与增殖性疾病有关的组成和方法
公开(公告)号：US08785502B2
公开(公告)日：2014-07-22
申请号：US13312682
申请日：2011-12-06
申请人： Gavin P. Robertson , Chandagalu D. Raghavendragowda , SubbaRao V. Madhunapantula , Omer F. Kuzu , Gajanan S. Inamdar
发明人： Gavin P. Robertson , Chandagalu D. Raghavendragowda , SubbaRao V. Madhunapantula , Omer F. Kuzu , Gajanan S. Inamdar
IPC分类号： A61K31/135 , A61K9/127
CPC分类号： A61K31/135 , A61K9/0019 , A61K9/1271 , A61K31/136 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/26 , A61K45/06 , C07C61/29 , C07C211/31 , C07C229/38 , C07C265/08 , C07C275/24 , C07C279/04 , C07C331/24 , C07C335/02
摘要： Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
摘要翻译：本文描述了抗癌组合物和方法。特别地，描述了包含莱美胺，莱美胺衍生物，胺基胺，丙二胺衍生物和松香酸衍生物中的一种或多种的组合物。在本文中描述了使用一种或多种莱美胺，莱美胺衍生物，普利亚胺，丙二胺衍生物和松果酸衍生物的受试者中治疗病理状况尤其是癌症的方法。

6. 发明申请

US20120141578A1 COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES 有权
标题翻译：与增殖性疾病有关的组合物和方法
公开(公告)号：US20120141578A1
公开(公告)日：2012-06-07
申请号：US13312682
申请日：2011-12-06
申请人： Gavin P. Robertson , Chandagalu D. Raghavendragowda , SubbaRao V. Madhunapantula , Omer F. Kuzu , Gajanan S. Inamdar
发明人： Gavin P. Robertson , Chandagalu D. Raghavendragowda , SubbaRao V. Madhunapantula , Omer F. Kuzu , Gajanan S. Inamdar
IPC分类号： A61K9/127 , A61P35/00 , A61K31/235 , C07C211/31 , A61K31/135
CPC分类号： A61K31/135 , A61K9/0019 , A61K9/1271 , A61K31/136 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/26 , A61K45/06 , C07C61/29 , C07C211/31 , C07C229/38 , C07C265/08 , C07C275/24 , C07C279/04 , C07C331/24 , C07C335/02
摘要： Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
摘要翻译：本文描述了抗癌组合物和方法。特别地，描述了包含莱美胺，莱美胺衍生物，胺基胺，丙二胺衍生物和松香酸衍生物中的一种或多种的组合物。在本文中描述了使用一种或多种莱美胺，莱美胺衍生物，普利亚胺，丙二胺衍生物和松果酸衍生物的受试者中治疗病理状况尤其是癌症的方法。

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