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1. 发明申请

US20120219584A1 PROTECTION AGAINST PANDEMIC AND SEASONAL STRAINS OF INFLUENZA 审中-公开
标题翻译：保护大流行和季节性流感病毒
公开(公告)号：US20120219584A1
公开(公告)日：2012-08-30
申请号：US13500421
申请日：2010-10-05
申请人： Gary J. Nabel , Chih-Jen Wei , Zhi-Yong Yang , Jeffrey Boyington
发明人： Gary J. Nabel , Chih-Jen Wei , Zhi-Yong Yang , Jeffrey Boyington
IPC分类号： A61K39/145 , C07K14/11 , A61P37/04 , C12Q1/70 , A61P31/16 , C12N15/63 , C12N15/44
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： Immunogens and compositions are provided that encode a protein comprising an influenza A subtype H1 hemagglutinin glycan-shielded receptor binding domain A (RBD A) region and at least one influenza A subtype H1 hemagglutinin antigenic site wherein the antigenic site is not within the RBD-A region. Also provided are immunogens and compositions that encode an immunogenic protein comprising at least one epitope of the RBD-A region of a pandemic influenza A subtype H1 hemagglutinin antigen. Also provided are such proteins, nucleic acids that encode such proteins, and antibodies against such proteins. Also provided are methods to use such immunogens and compositions to elicit a neutralizing antibody immune response against influenza A subtype H1 virus.
摘要翻译：提供免疫原和组合物，其编码包含A型亚型H1血凝素聚糖屏蔽受体结合结构域A（RBD A）区域和至少一种甲型H1亚型H1血凝素抗原位点的蛋白质，其中抗原位点不在RBD-A 地区。还提供了编码包含大流行性甲型H1亚型H1血凝素抗原的RBD-A区域的至少一个表位的免疫原性蛋白质的免疫原和组合物。还提供了这样的蛋白质，编码这种蛋白质的核酸和针对这种蛋白质的抗体。还提供了使用这样的免疫原和组合物引发针对甲型H1亚型H1型病毒的中和抗体免疫应答的方法。

2. 发明申请

US20110177122A1 DNA PRIME/ACTIVATED VACCINE BOOST IMMUNIZATION TO INFLUENZA VIRUS 审中-公开
标题翻译： DNA PRIME / ACTIVATED VACCINE加强免疫对流感病毒
公开(公告)号：US20110177122A1
公开(公告)日：2011-07-21
申请号：US13121004
申请日：2009-09-25
申请人： Gary J. Nabel , Chih-jen Wei , Zhi-Yong Yang
发明人： Gary J. Nabel , Chih-jen Wei , Zhi-Yong Yang
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/545 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to a combination of a priming composition and a boosting composition to prime and boost an immune response in a subject whereby the immune response resulting from administration of the priming composition to the subject is capable of being boosted. The priming composition comprises a DNA plasmid that comprises a nucleic acid molecule encoding an influenza virus hemagglutinin (HA) or an epitope-bearing domain thereof. The boosting composition comprises an influenza vaccine. The present invention also relates to a method to use such a combination to vaccinate a subject and to enhance an immune response to an influenza vaccine administered alone. Such a combination can elicit an immune response not only against at least one influenza virus strain from which the priming composition or boosting composition is derived but also to at least one heterologous influenza virus strain.
摘要翻译：本发明涉及引发组合物和促进组合物的组合以引发和增强受试者中的免疫应答，由此将引发组合物施用于受试者的免疫应答能够被增强。引发组合物包含DNA质粒，其包含编码流感病毒血凝素（HA）或其表位承载结构域的核酸分子。助推组合物包含流感疫苗。本发明还涉及使用这种组合来接种受试者并增强对单独施用的流感疫苗的免疫应答的方法。这种组合可以引起免疫应答，不仅针对起源组合物或促进组合物得自其中的至少一种流感病毒株，而且还可引发至少一种异源流感病毒株。

3. 发明申请

US20110274721A1 HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV 失效
标题翻译：基于艾滋病病毒多种环境的艾滋病病毒疫苗
公开(公告)号：US20110274721A1
公开(公告)日：2011-11-10
申请号：US13086884
申请日：2011-04-14
申请人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zengguang Wang , Zhi-Yong Yang , Jason G.D. Gall , C. Richter King
发明人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zengguang Wang , Zhi-Yong Yang , Jason G.D. Gall , C. Richter King
IPC分类号： A61K39/21 , A61P37/04 , A61P31/18 , A61K31/7088
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
摘要翻译：在一个实施方案中，本发明提供了多重HIV质粒DNA或病毒载体疫苗，其包括来自独立进化枝的Env（任选的Env嵌合体）和Gag-Pol-（任选地）Nef的不同进化枝的组分。本发明的疫苗还可以包括V1，V2，V3或V4缺失或其组合。在另一个实施方案中，本发明提供了多重HIV包膜免疫原。

4. 发明授权

US5650306A Recombinant nucleic acids for inhibiting HIV gene expression 失效
标题翻译：用于抑制HIV基因表达的重组核酸
公开(公告)号：US5650306A
公开(公告)日：1997-07-22
申请号：US73836
申请日：1993-06-07
申请人： Gary J. Nabel , Zhi-Yong Yang , Jinsong Liu , Clive Woffendin
发明人： Gary J. Nabel , Zhi-Yong Yang , Jinsong Liu , Clive Woffendin
IPC分类号： A61K38/00 , C07K14/16 , C12N15/11 , C07H21/04 , C12N15/63 , C12N15/86
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16322
摘要： This invention provides recombinant nucleic acid molecules for enhanced expression of genes that inhibit HIV gene expression. Cells transfected with these recombinant nucleic acids exhibit prolonged cell life. This invention also provides methods of treating individuals infected with HIV by introducing into them the transfected cells of this invention.
摘要翻译：本发明提供用于增强抑制HIV基因表达的基因表达的重组核酸分子。用这些重组核酸转染的细胞具有延长的细胞寿命。本发明还提供了通过向其中引入本发明的转染细胞来治疗感染HIV的个体的方法。

5. 发明授权

US08323961B2 HIV vaccines based on adenoviral vectors encoding Env from multiple clades of HIV 失效
标题翻译：基于编码Env的腺病毒载体的HIV疫苗来自HIV的多个进化枝
公开(公告)号：US08323961B2
公开(公告)日：2012-12-04
申请号：US13086884
申请日：2011-04-14
申请人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zengguang Wang, legal representative , Zhi-Yong Yang , Jason G. D. Gall , C. Richter King
发明人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zhi-Yong Yang , Jason G. D. Gall , C. Richter King
IPC分类号： C12N15/63 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a composition comprising four adenoviral vectors, each comprising a nucleic acid sequence encoding a clade A HIV Env protein, a clade B HIV Env protein, a clade C HIV Env protein, and a clade B HIV Gag-Pol fusion protein, respectively. The invention also provides a method of inducing an immune response against HIV-1 in an animal comprising administering the composition to the animal.
摘要翻译：本发明提供包含四种腺病毒载体的组合物，每种腺病毒载体分别包含编码进化枝A HIV Env蛋白，进化枝B HIV Env蛋白，进化枝C HIV Env蛋白和进化枝B HIV Gag-Pol融合蛋白的核酸序列。本发明还提供了一种在动物中诱导针对HIV-1的免疫应答的方法，其包括向所述动物施用所述组合物。

6. 发明申请

US20120219583A1 NUCLEIC ACID SEQUENCES ENCODING EXPANDABLE HIV MOSAIC PROTEINS 审中-公开
标题翻译：编码可扩展的HIV MOSAIC蛋白的核酸序列
公开(公告)号：US20120219583A1
公开(公告)日：2012-08-30
申请号：US13502206
申请日：2010-10-15
申请人： Gary J. Nabel , Zhi-Yong Yang , Wing-Pui Kong , Bette Korber
发明人： Gary J. Nabel , Zhi-Yong Yang , Wing-Pui Kong , Bette Korber
IPC分类号： A61K31/713 , C07K14/00 , C12N15/63 , C12N15/861 , B65D85/00 , A61P37/04 , A61P31/18 , C12N1/19 , C12N5/10 , C12N15/11 , C12N1/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K2319/00 , C12N2710/10343 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234
摘要： The invention is directed to a nucleic acid molecule encoding a HIV-1 polypeptide which comprises the nucleic acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. The invention also provides a method of inducing an immune response against HIV-1 in a mammal.
摘要翻译：本发明涉及编码HIV-1多肽的核酸分子，其包含SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3或SEQ ID NO：4的核酸序列。本发明还提供了在哺乳动物中诱导针对HIV-1的免疫应答的方法。

7. 发明授权

US07947822B2 HIV vaccines based on Env of multiple clades of HIV 失效
标题翻译：基于Env多个艾滋病毒携带者的艾滋病毒疫苗
公开(公告)号：US07947822B2
公开(公告)日：2011-05-24
申请号：US12683844
申请日：2010-01-07
申请人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zengguang Wang, legal representative , Zhi-Yong Yang
发明人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zhi-Yong Yang
IPC分类号： C07H21/04 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a composition comprising a pharmaceutically acceptable carrier and six plasmids, each of which encodes an HIV Env, Gag, Pol, or Nef protein. The invention also provides a method of inducing an immune response in an animal using the composition.
摘要翻译：本发明提供包含药学上可接受的载体和六种质粒的组合物，每种质粒编码HIV Env，Gag，Pol或Nef蛋白质。本发明还提供了使用该组合物在动物中诱导免疫应答的方法。

8. 发明申请

US20090232841A1 Optimzed vaccines to provide protection against ebola and other viruses 有权
标题翻译：优化疫苗，以提供针对埃博拉和其他病毒的保护
公开(公告)号：US20090232841A1
公开(公告)日：2009-09-17
申请号：US11662869
申请日：2005-09-27
申请人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang
发明人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang
IPC分类号： A61K39/12 , C07H21/00 , C07K14/005 , C12N7/00 , A61K31/7088 , A61P37/04
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译：本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，其具有位于所述GP的相对保守区域中的至少一个氨基酸改变，其降低体外细胞毒性并且与体外细胞毒性相比保留免疫原性野生型病毒GP和相关修饰的病毒GP，质粒DNA，重组病毒，腺病毒，药物组合物，疫苗组合物，与修饰的病毒GP特异性反应的抗体的免疫原性及其制备和使用的相关方法。

9. 发明申请

US20080112997A1 Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo 审中-公开
标题翻译：用DNA包被支架的方法和从DNA涂层支架体内重组基因的表达
公开(公告)号：US20080112997A1
公开(公告)日：2008-05-15
申请号：US11980983
申请日：2007-10-31
申请人： Elizabeth Nabel , Gary Natel , Zhi-Yong Yang
发明人： Elizabeth Nabel , Gary Natel , Zhi-Yong Yang
IPC分类号： A61F2/82 , A61K31/711 , A61P9/00
CPC分类号： A61L31/16 , A61F2/82 , A61K9/0024 , A61K31/711 , A61K38/45 , A61K38/50 , A61K48/00 , A61L31/10 , A61L2300/252 , A61L2300/258 , A61L2300/416 , A61L2300/606 , C08L89/00
摘要： The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
摘要翻译：本发明描述了DNA涂覆的支架及其使用方法来治疗或预防血管疾病如再狭窄。

10. 发明申请

US20120156239A1 OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES 审中-公开
标题翻译：优化疫苗提供针对EBOLA和其他病毒的保护
公开(公告)号：US20120156239A1
公开(公告)日：2012-06-21
申请号：US13349917
申请日：2012-01-13
申请人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang , Maria Grazia Pau , Jaap Goudsmit , Gary Nabel
发明人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang , Maria Grazia Pau , Jaap Goudsmit , Gary Nabel
IPC分类号： A61K39/12 , C12N7/01 , A61P31/14 , C12N15/63 , C12N15/40 , A61P37/04
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译：本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，其具有位于所述GP的相对保守区域中的至少一个氨基酸改变，其降低体外细胞毒性并且与体外细胞毒性相比保留免疫原性野生型病毒GP和相关修饰的病毒GP，质粒DNA，重组病毒，腺病毒，药物组合物，疫苗组合物，与修饰的病毒GP特异性反应的抗体的免疫原性及其制备和使用的相关方法。

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