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1. 发明申请

US20100074916A1 AVIAN INFLUENZA VACCINE 审中-公开
公开(公告)号：US20100074916A1
公开(公告)日：2010-03-25
申请号：US12443964
申请日：2007-10-10
申请人： Gary J. Nabel , Zhi-yong Yang , Chih-jen Wei , Wing-pui Kong , Lan Wu
发明人： Gary J. Nabel , Zhi-yong Yang , Chih-jen Wei , Wing-pui Kong , Lan Wu
IPC分类号： A61K39/145 , C07K14/005 , C07K16/00 , C07H21/04 , C07H21/02 , C12P21/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/15043 , C12N2760/16122 , C12N2760/16134 , C12N2810/6072
摘要： H5 hemagglutinin (HA) polypeptides are provided that are adapted to humans through mutations that change receptor specificity in the H1 serotype, and related polynucleotides, methods, compositions, and vaccines.
摘要翻译：提供H5血凝素（HA）多肽，其通过改变H1血清型中的受体特异性的突变以及相关的多核苷酸，方法，组合物和疫苗适应人类。

2. 发明申请

US20110177122A1 DNA PRIME/ACTIVATED VACCINE BOOST IMMUNIZATION TO INFLUENZA VIRUS 审中-公开
标题翻译： DNA PRIME / ACTIVATED VACCINE加强免疫对流感病毒
公开(公告)号：US20110177122A1
公开(公告)日：2011-07-21
申请号：US13121004
申请日：2009-09-25
申请人： Gary J. Nabel , Chih-jen Wei , Zhi-Yong Yang
发明人： Gary J. Nabel , Chih-jen Wei , Zhi-Yong Yang
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/545 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to a combination of a priming composition and a boosting composition to prime and boost an immune response in a subject whereby the immune response resulting from administration of the priming composition to the subject is capable of being boosted. The priming composition comprises a DNA plasmid that comprises a nucleic acid molecule encoding an influenza virus hemagglutinin (HA) or an epitope-bearing domain thereof. The boosting composition comprises an influenza vaccine. The present invention also relates to a method to use such a combination to vaccinate a subject and to enhance an immune response to an influenza vaccine administered alone. Such a combination can elicit an immune response not only against at least one influenza virus strain from which the priming composition or boosting composition is derived but also to at least one heterologous influenza virus strain.
摘要翻译：本发明涉及引发组合物和促进组合物的组合以引发和增强受试者中的免疫应答，由此将引发组合物施用于受试者的免疫应答能够被增强。引发组合物包含DNA质粒，其包含编码流感病毒血凝素（HA）或其表位承载结构域的核酸分子。助推组合物包含流感疫苗。本发明还涉及使用这种组合来接种受试者并增强对单独施用的流感疫苗的免疫应答的方法。这种组合可以引起免疫应答，不仅针对起源组合物或促进组合物得自其中的至少一种流感病毒株，而且还可引发至少一种异源流感病毒株。

3. 发明申请

US20110171260A1 INFLUENZA DNA VACCINATION AND METHODS OF USE THEREOF 审中-公开
标题翻译：流感病毒DNA疫苗及其使用方法
公开(公告)号：US20110171260A1
公开(公告)日：2011-07-14
申请号：US12838292
申请日：2010-07-16
申请人： SRINIVAS RAO , GARY J. NABEL , ZHI-YONG YANG , CHIH-JEN WEI , WING-PUI KONG
发明人： SRINIVAS RAO , GARY J. NABEL , ZHI-YONG YANG , CHIH-JEN WEI , WING-PUI KONG
IPC分类号： A61K39/145 , C12N15/63 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to an influenza immunogen that includes one or more DNA constructs encoding at least two divergent influenza HAs, wherein each of such one or more DNA constructs encodes one or more of the at least two divergent influenza HAs. Such an immunogen, when administered to a subject, induces an immune response to a plurality of strains of influenza virus, wherein at least one strain of the plurality of strains does not encode any of the divergent influenza HAs encoded by the immunogen. The divergent influenza HAs can be swine influenza HAs or equine influenza HAs, such as influenza H1 HAs or influenza H3 HAs. The invention also relates to a method to use such an immunogen to induce such an immune response as well as to DNA constructs comprising such divergent influenza HAs. Such an immunogen can provide a heterologous as well as a homologous immune response. Such an immunogen can be used to induce an immune response against evolving influenza virus.
摘要翻译：本发明涉及一种流感免疫原，其包含编码至少两种不同的流感HAs的一种或多种DNA构建体，其中每种这样的一种或多种DNA构建体编码所述至少两种分歧流感HAs中的一种或多种。当免疫原被施用于受试者时，这种免疫原诱导对多种流感病毒株的免疫应答，其中多个菌株中的至少一个菌株不编码由免疫原编码的任何发散性流感病毒HA。不同的流感病毒可以是猪流感HAs或马流感HAs，例如H1N1流感或H3A流感HAs。本发明还涉及使用这种免疫原诱导这种免疫应答的方法以及包含这种不同的流感HAs的DNA构建体。这样的免疫原可以提供异源和同源免疫应答。这种免疫原可用于诱导针对进化型流感病毒的免疫应答。

4. 发明申请

US20120219584A1 PROTECTION AGAINST PANDEMIC AND SEASONAL STRAINS OF INFLUENZA 审中-公开
标题翻译：保护大流行和季节性流感病毒
公开(公告)号：US20120219584A1
公开(公告)日：2012-08-30
申请号：US13500421
申请日：2010-10-05
申请人： Gary J. Nabel , Chih-Jen Wei , Zhi-Yong Yang , Jeffrey Boyington
发明人： Gary J. Nabel , Chih-Jen Wei , Zhi-Yong Yang , Jeffrey Boyington
IPC分类号： A61K39/145 , C07K14/11 , A61P37/04 , C12Q1/70 , A61P31/16 , C12N15/63 , C12N15/44
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： Immunogens and compositions are provided that encode a protein comprising an influenza A subtype H1 hemagglutinin glycan-shielded receptor binding domain A (RBD A) region and at least one influenza A subtype H1 hemagglutinin antigenic site wherein the antigenic site is not within the RBD-A region. Also provided are immunogens and compositions that encode an immunogenic protein comprising at least one epitope of the RBD-A region of a pandemic influenza A subtype H1 hemagglutinin antigen. Also provided are such proteins, nucleic acids that encode such proteins, and antibodies against such proteins. Also provided are methods to use such immunogens and compositions to elicit a neutralizing antibody immune response against influenza A subtype H1 virus.
摘要翻译：提供免疫原和组合物，其编码包含A型亚型H1血凝素聚糖屏蔽受体结合结构域A（RBD A）区域和至少一种甲型H1亚型H1血凝素抗原位点的蛋白质，其中抗原位点不在RBD-A 地区。还提供了编码包含大流行性甲型H1亚型H1血凝素抗原的RBD-A区域的至少一个表位的免疫原性蛋白质的免疫原和组合物。还提供了这样的蛋白质，编码这种蛋白质的核酸和针对这种蛋白质的抗体。还提供了使用这样的免疫原和组合物引发针对甲型H1亚型H1型病毒的中和抗体免疫应答的方法。

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