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1. 发明申请

US20050181463A1 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US20050181463A1
公开(公告)日：2005-08-18
申请号：US10780399
申请日：2004-02-17
申请人： Galla Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon Terstappen , Shawn O'Hara , Steven Gross
发明人： Galla Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon Terstappen , Shawn O'Hara , Steven Gross
IPC分类号： G01N33/53 , G01N33/543 , G01N33/567 , G01N33/574
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞仪和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

2. 发明授权

US07863012B2 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US07863012B2
公开(公告)日：2011-01-04
申请号：US10780399
申请日：2004-02-17
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： A01N1/02 , G01N33/574 , G01N33/553 , G01N33/00
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

3. 发明授权

US08329422B2 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US08329422B2
公开(公告)日：2012-12-11
申请号：US12917630
申请日：2010-11-02
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： G01N33/574 , G01N33/553 , G01N1/18
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTER® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CELLSPOTTER®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

4. 发明申请

US20110104718A1 Analysis of Circulating Tumor Cells, Fragments, and Debris 有权
标题翻译：循环肿瘤细胞，片段和碎片的分析
公开(公告)号：US20110104718A1
公开(公告)日：2011-05-05
申请号：US12917630
申请日：2010-11-02
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W.M.M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W.M.M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： G01N33/574 , G01N33/566
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

5. 发明申请

US20130085723A1 METHOD FOR DETERMINING ARTICULAR BONE DEFORMITY RESECTION USING MOTION PATTERNS 有权
标题翻译：使用运动模式确定骨骼畸形检测的方法
公开(公告)号：US20130085723A1
公开(公告)日：2013-04-04
申请号：US13704063
申请日：2011-07-16
申请人： Laurence Chabanas , Stéphane Lavallee , Jerome Tonetti , Thomas Byrd , Bryan Talmadge Kelly , Christopher Larson
发明人： Laurence Chabanas , Stéphane Lavallee , Jerome Tonetti , Thomas Byrd , Bryan Talmadge Kelly , Christopher Larson
IPC分类号： G06F19/26
CPC分类号： G16B45/00 , G06T17/00 , G06T19/20 , G06T2210/21 , G06T2210/41 , G06T2219/2021
摘要： The invention relates to a method for real-time determination an optimal corrected surface of a first bone and/or a second bone forming together an articulation, the first and/or second bones presenting an overgrowth deformation, said corrected surface providing a greater range of motion of the articulation, the method comprising the following steps: i) constructing from acquired images of the articulation 3D voxel models of the first bone and the second bone; ii) for each of first and second bone voxel models, constructing a coordinate system defmed by a center and three axes; iii) applying a motion pattern on the coordinate system of the second bone with respect to the coordinate system of the first bone, a motion pattern being a set of contiguous positions of the first or second bone coordinate systems with respect to the other bone coordinate system, the contiguous positions defining a movement of one bone with respect to the other, wherein said motion pattern is initially loaded from a data base of pre-defined motion patterns; iv) determining a resection volume from said motion pattern as being the union of interpenetration volumes of the first or second bone voxel model with the other bone voxel model for each position of the motion pattern; v) determining the optimal corrected surface by virtually removing said resection volume from the first and/or the second bone voxel model.
摘要翻译：本发明涉及一种用于实时确定第一骨骼和/或第二骨骼的最佳校正表面的方法，所述第一骨骼和/或第二骨骼一起形成关节，第一和/或第二骨骼呈现过度生长变形，所述校正表面提供更大范围的所述方法包括以下步骤：i）从所述第一骨骼和所述第二骨骼的关节3D体素模型的获取图像构建; ii）对于第一和第二骨骼体素模型中的每一个，构造由中心和三个轴定义的坐标系; iii）相对于第一骨骼的坐标系在第二骨骼的坐标系上施加运动模式，运动模式是第一或第二骨坐标系相对于另一骨坐标系的一组连续位置所述连续位置限定一个骨骼相对于另一个骨骼的运动，其中所述运动模式最初从预先定义的运动模式的数据库加载; iv）将所述运动模式的切除体积确定为所述运动模式的每个位置的所述第一或第二骨骼体素模型与所述另一骨体素模型的相互渗透体积的联合; v）通过从第一和/或第二骨骼体素模型中虚拟去除所述切除体积来确定最佳校正表面。

6. 发明申请

US20100273797A1 ALPHA-KETOAMIDES AND DERIVATIVES THEREOF 审中-公开
标题翻译：阿尔法 - 卡特敏胺及其衍生物
公开(公告)号：US20100273797A1
公开(公告)日：2010-10-28
申请号：US12829701
申请日：2010-07-02
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。

7. 发明申请

US20060134162A1 Methods for fabricating a drug delivery device 审中-公开
标题翻译：药物输送装置的制造方法
公开(公告)号：US20060134162A1
公开(公告)日：2006-06-22
申请号：US11013769
申请日：2004-12-16
申请人： Christopher Larson
发明人： Christopher Larson
IPC分类号： A61K6/083 , B05D3/02
CPC分类号： A61K9/0051
摘要： A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The device includes a layer of material permeable to passage of the active agent. This invention provides improved methods that do not require the use of adhesives to form the drug delivery device.
摘要翻译：用于放置在眼睛中的药物递送装置包括包含药物活性剂的药物核心和保持药物核心的保持器。保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其通过眼组织的开口。该装置包括可渗透活性剂通过的材料层。本发明提供了不需要使用粘合剂形成药物递送装置的改进方法。

8. 发明申请

US20100093734A1 CYTOKINE INHIBITORS 有权
标题翻译：细胞因子抑制剂
公开(公告)号：US20100093734A1
公开(公告)日：2010-04-15
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5375 , C07D295/14
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。

9. 发明申请

US20070005009A1 Catheter with spiral cut transition member 有权
标题翻译：导管与螺旋切割过渡构件
公开(公告)号：US20070005009A1
公开(公告)日：2007-01-04
申请号：US11516062
申请日：2006-09-06
申请人： Christopher Larson , Angela Volk
发明人： Christopher Larson , Angela Volk
IPC分类号： A61M25/00
CPC分类号： A61M25/104 , A61M25/0054 , A61M25/1006 , A61M2025/0063 , A61M2025/0081 , A61M2025/0098
摘要： A tubular transition member having an annular wall with at least one cut extending through the annular wall is disclosed for controlling a transition in stiffness of a catheter from a stiffer more pushable proximal section to a more flexible and trackable distal section and increasing kink resistance. The transition member may extend across the junction formed between the stiffer proximal section and the more flexible distal section. The transition member may be used in conjunction with any type of catheter including single-operator-exchange type catheters, over-the wire type catheters, and/or fixed-wire type catheters.
摘要翻译：公开了一种具有环形壁的管状过渡构件，其具有延伸穿过环形壁的至少一个切口，用于控制导管刚性从较刚性更可推的近端区段向更柔性和可跟踪的远侧区段的过渡，并增加扭结阻力。过渡构件可以延伸穿过更硬的近端部分和更柔性的远端部分之间形成的连接点。过渡构件可以与任何类型的导管结合使用，包括单一操作者交换型导管，线型导管和/或固定线型导管。

10. 发明申请

US20050107399A1 Cytokine inhibitors 失效
标题翻译：细胞因子抑制剂
公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。

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