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1. 发明申请

US20150111644A1 PLAYER RANKING SYSTEM BASED ON MULTIPLE QUANTITATIVE AND QUALITATIVE SCORING TYPES 审中-公开
标题翻译：基于多个定量和定性分类的播放器排名系统
公开(公告)号：US20150111644A1
公开(公告)日：2015-04-23
申请号：US14520534
申请日：2014-10-22
申请人： Todd Christopher LARSON
发明人： Todd Christopher LARSON
IPC分类号： A63F13/798 , A63F13/46
CPC分类号： A63F13/798 , A63F13/46
摘要： A ranking system is provided. The ranking system may provide a qualitative method of ranking quantitative evaluation data of players from a plurality of player pools, wherein the plurality of player pools are a subset of the entire group of potential players. The ranking system may provide a method of transforming a plurality of two types—objective and subjective—of evaluation data for a plurality of players into a ranking for each player by standardizing both types on the same on a common scale and applying weights to prioritize specific evaluation and, separately, applying weights to indicate the relative importance between the two types—objective and subjective—of evaluation data, so as to meet the needs of a predetermined team.
摘要翻译：提供了排名系统。排名系统可以提供一种定性方法来对来自多个玩家池的玩家的定量评估数据进行排名，其中多个玩家池是整个潜在玩家组的子集。排名系统可以提供一种将多个玩家的多个评估数据的多个两种类型 - 主观评价数据变换为每个玩家的排名的方法，通过在相同的比例上标准化两种类型，并应用权重来优先化特定评估，并分别应用权重，以表明两种类型之间的相对重要性 - 客观和主观的评估数据，以满足预定团队的需求。

2. 发明授权

US07863012B2 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US07863012B2
公开(公告)日：2011-01-04
申请号：US10780399
申请日：2004-02-17
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： A01N1/02 , G01N33/574 , G01N33/553 , G01N33/00
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

3. 发明申请

US20100093734A1 CYTOKINE INHIBITORS 有权
标题翻译：细胞因子抑制剂
公开(公告)号：US20100093734A1
公开(公告)日：2010-04-15
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5375 , C07D295/14
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。

4. 发明申请

US20070005009A1 Catheter with spiral cut transition member 有权
标题翻译：导管与螺旋切割过渡构件
公开(公告)号：US20070005009A1
公开(公告)日：2007-01-04
申请号：US11516062
申请日：2006-09-06
申请人： Christopher Larson , Angela Volk
发明人： Christopher Larson , Angela Volk
IPC分类号： A61M25/00
CPC分类号： A61M25/104 , A61M25/0054 , A61M25/1006 , A61M2025/0063 , A61M2025/0081 , A61M2025/0098
摘要： A tubular transition member having an annular wall with at least one cut extending through the annular wall is disclosed for controlling a transition in stiffness of a catheter from a stiffer more pushable proximal section to a more flexible and trackable distal section and increasing kink resistance. The transition member may extend across the junction formed between the stiffer proximal section and the more flexible distal section. The transition member may be used in conjunction with any type of catheter including single-operator-exchange type catheters, over-the wire type catheters, and/or fixed-wire type catheters.
摘要翻译：公开了一种具有环形壁的管状过渡构件，其具有延伸穿过环形壁的至少一个切口，用于控制导管刚性从较刚性更可推的近端区段向更柔性和可跟踪的远侧区段的过渡，并增加扭结阻力。过渡构件可以延伸穿过更硬的近端部分和更柔性的远端部分之间形成的连接点。过渡构件可以与任何类型的导管结合使用，包括单一操作者交换型导管，线型导管和/或固定线型导管。

5. 发明申请

US20050107399A1 Cytokine inhibitors 失效
标题翻译：细胞因子抑制剂
公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。

6. 发明授权

US5771662A Apparatus and methods for producing shrink wrap packaging 失效
标题翻译：用于生产收缩包装的设备和方法
公开(公告)号：US5771662A
公开(公告)日：1998-06-30
申请号：US671601
申请日：1996-06-28
申请人： Mike Struges , Rodney Tebben , Kenneth Dean Paulzine , Scott Christopher Larson
发明人： Mike Struges , Rodney Tebben , Kenneth Dean Paulzine , Scott Christopher Larson
IPC分类号： B65B61/02 , B65B53/02 , B65B13/02
CPC分类号： B65B61/02
摘要： An apparatus (10) is disclosed including a web of film (20) extending between first and second pairs of pinch rollers (12-15) and onto a vacuum table (18). A rotary cutter (46) positioned before the first pair of pinch rollers (12, 13) includes laterally extending and spaced knives (52) for creating cuts (54, 58) in the film (20) which expand into vent openings (54') positioned over the sides (68) of the product (72) when the film (20) is wrapped around and shrunk upon the product (72). A further rotary cutter (30) positioned between the pairs of pinch rollers (12-15) includes a cut-off knife (36) and first and second blades (44). The cut-off knife (36) creates a cut (60) in the film (20) to form a single sheet of film (20) and includes notches (38) in its cutting edge to form tie strips (62) connecting the single sheet to the web of film (20). The tie strips (62) are broken after the cut (60) leaves the second pair of pinch rollers (14, 15) since the speed of the film (20) on the vacuum table (18) is greater than the peripheral speed of the first pair of pinch rollers (12, 13) at their abutment. The blades (44) cut perforations (56) in the film (20) which extend between the bullseye openings (78) in the shrink wrapping and are positioned over the top (66) of the product (72). Thus, the shrink wrapping can be torn by pulling the film (20) between the perforations (56) to allow ease of removal of the product (72) from the shrink wrapping.
摘要翻译：公开了一种设备（10），其包括在第一和第二对夹送辊（12-15）之间延伸并到真空台（18）上的薄膜（20）。定位在第一对夹送辊（12,13）之前的旋转切割器（46）包括横向延伸和间隔开的刀片（52），用于在胶片（20）中形成膨胀成通气孔（54'）的切口（54,58））定位在产品（72）的侧面（68）上，当薄膜（20）缠绕并收缩在产品（72）上时。定位在成对的夹送辊（12-15）之间的另一旋转切割器（30）包括切断刀（36）和第一和第二刀片（44）。切割刀（36）在薄膜（20）中形成切割（60）以形成单片薄膜（20），并且在其切割边缘中包括切口（38），以形成连接条（62）片材到薄膜网（20）。由于薄膜（20）在真空工作台（18）上的速度大于第二对夹紧辊（14,15）的圆周速度，所以在切割（60）离开第二对夹送辊（14,15）之后，连接条（62）第一对压紧辊（12,13）在其邻接处。叶片（44）切割薄膜（20）中的穿孔（56），其在收缩包装中的舷窗开口（78）之间延伸并且位于产品（72）的顶部（66）上方。因此，通过拉动穿孔（56）之间的薄膜（20）可以撕裂收缩包装，以便易于从收缩包装上移除产品（72）。

7. 发明申请

US20130085723A1 METHOD FOR DETERMINING ARTICULAR BONE DEFORMITY RESECTION USING MOTION PATTERNS 有权
标题翻译：使用运动模式确定骨骼畸形检测的方法
公开(公告)号：US20130085723A1
公开(公告)日：2013-04-04
申请号：US13704063
申请日：2011-07-16
申请人： Laurence Chabanas , Stéphane Lavallee , Jerome Tonetti , Thomas Byrd , Bryan Talmadge Kelly , Christopher Larson
发明人： Laurence Chabanas , Stéphane Lavallee , Jerome Tonetti , Thomas Byrd , Bryan Talmadge Kelly , Christopher Larson
IPC分类号： G06F19/26
CPC分类号： G16B45/00 , G06T17/00 , G06T19/20 , G06T2210/21 , G06T2210/41 , G06T2219/2021
摘要： The invention relates to a method for real-time determination an optimal corrected surface of a first bone and/or a second bone forming together an articulation, the first and/or second bones presenting an overgrowth deformation, said corrected surface providing a greater range of motion of the articulation, the method comprising the following steps: i) constructing from acquired images of the articulation 3D voxel models of the first bone and the second bone; ii) for each of first and second bone voxel models, constructing a coordinate system defmed by a center and three axes; iii) applying a motion pattern on the coordinate system of the second bone with respect to the coordinate system of the first bone, a motion pattern being a set of contiguous positions of the first or second bone coordinate systems with respect to the other bone coordinate system, the contiguous positions defining a movement of one bone with respect to the other, wherein said motion pattern is initially loaded from a data base of pre-defined motion patterns; iv) determining a resection volume from said motion pattern as being the union of interpenetration volumes of the first or second bone voxel model with the other bone voxel model for each position of the motion pattern; v) determining the optimal corrected surface by virtually removing said resection volume from the first and/or the second bone voxel model.
摘要翻译：本发明涉及一种用于实时确定第一骨骼和/或第二骨骼的最佳校正表面的方法，所述第一骨骼和/或第二骨骼一起形成关节，第一和/或第二骨骼呈现过度生长变形，所述校正表面提供更大范围的所述方法包括以下步骤：i）从所述第一骨骼和所述第二骨骼的关节3D体素模型的获取图像构建; ii）对于第一和第二骨骼体素模型中的每一个，构造由中心和三个轴定义的坐标系; iii）相对于第一骨骼的坐标系在第二骨骼的坐标系上施加运动模式，运动模式是第一或第二骨坐标系相对于另一骨坐标系的一组连续位置所述连续位置限定一个骨骼相对于另一个骨骼的运动，其中所述运动模式最初从预先定义的运动模式的数据库加载; iv）将所述运动模式的切除体积确定为所述运动模式的每个位置的所述第一或第二骨骼体素模型与所述另一骨体素模型的相互渗透体积的联合; v）通过从第一和/或第二骨骼体素模型中虚拟去除所述切除体积来确定最佳校正表面。

8. 发明申请

US20100273797A1 ALPHA-KETOAMIDES AND DERIVATIVES THEREOF 审中-公开
标题翻译：阿尔法 - 卡特敏胺及其衍生物
公开(公告)号：US20100273797A1
公开(公告)日：2010-10-28
申请号：US12829701
申请日：2010-07-02
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
摘要翻译：本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。

9. 发明授权

US07153561B2 Absorbent article with graphic design thereon 有权
标题翻译：具有图形设计的吸收制品
公开(公告)号：US07153561B2
公开(公告)日：2006-12-26
申请号：US10618030
申请日：2003-07-11
申请人： Todd Christopher Larson , Mark M. Mleziva , Michael Donald Sperl , Paula Mary Sosalla
发明人： Todd Christopher Larson , Mark M. Mleziva , Michael Donald Sperl , Paula Mary Sosalla
IPC分类号： B32B3/00
CPC分类号： A61F13/84 , A61F13/51496 , A61F13/5622 , A61F2013/15243 , A61F2013/8497 , B41M1/04 , B41M1/40 , B41M3/00 , B41M5/00 , B44F1/08 , Y10T428/24802 , Y10T428/24851 , Y10T428/24876 , Y10T428/24901
摘要： In a substrate having a graphic and a method for applying the graphic thereto, a non-phosphorescent material is applied to the substrate to define a non-phosphorescent region of the graphic and a phosphorescent material is applied to the substrate to define a phosphorescent region of the graphic. At least a portion of the non-phosphorescent region and at least a portion of the phosphorescent region are in overlapping relationship with each other so as to define an overlapping region of the graphic. When the overlapping region is exposed to light sufficient to cause phosphorescence of the phosphorescent region the at least a portion of the phosphorescent region phosphoresces to render the overlapping region visible in the absence of light. In another embodiment, the graphic has a non-photoluminescent region in overlapping relationship with a photoluminescent region.
摘要翻译：在具有图形的基板和应用图形的方法中，将非磷光材料施加到基板以限定图形的非磷光区域，并将磷光材料施加到基板以限定磷光发光区域的磷光区域图形。至少一部分非磷光区域和磷光区域的至少一部分彼此重叠，以便限定图形的重叠区域。当重叠区域暴露于足以引起磷光区域的磷光的光时，磷光区域的至少一部分磷酸化以使重叠区域在不存在光的情况下可见。在另一个实施方案中，该图形具有与光致发光区域重叠关系的非光致发光区域。

10. 发明申请

US20060134162A1 Methods for fabricating a drug delivery device 审中-公开
标题翻译：药物输送装置的制造方法
公开(公告)号：US20060134162A1
公开(公告)日：2006-06-22
申请号：US11013769
申请日：2004-12-16
申请人： Christopher Larson
发明人： Christopher Larson
IPC分类号： A61K6/083 , B05D3/02
CPC分类号： A61K9/0051
摘要： A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The device includes a layer of material permeable to passage of the active agent. This invention provides improved methods that do not require the use of adhesives to form the drug delivery device.
摘要翻译：用于放置在眼睛中的药物递送装置包括包含药物活性剂的药物核心和保持药物核心的保持器。保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其通过眼组织的开口。该装置包括可渗透活性剂通过的材料层。本发明提供了不需要使用粘合剂形成药物递送装置的改进方法。

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