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1. 发明申请

US20050148624A1 Jnk inhibitor 失效
标题翻译： Jnk抑制剂
公开(公告)号：US20050148624A1
公开(公告)日：2005-07-07
申请号：US10504132
申请日：2003-02-12
申请人： Fumio Itoh , Hiroyuki Kimura , Hideki Igata , Tomohiro Kawamoto , Mitsuru Sasaki , Shuji Kitamura
发明人： Fumio Itoh , Hiroyuki Kimura , Hideki Igata , Tomohiro Kawamoto , Mitsuru Sasaki , Shuji Kitamura
IPC分类号： A61K31/472 , A61K31/4725 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07D217/24 , C07D217/26 , A61K31/4709 , A61K31/47 , C07D217/22 , C07D45/02
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/5377 , C07D217/24 , C07D217/26
摘要： A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.
摘要翻译：含有异喹啉骨架或其盐的化合物的JNK抑制剂，例如下式表示的化合物，其中环A和环B各自为任选取代的苯环，X为-O-，-N-，-NR- SO 3 - 或-CHR 3 - ，R 2是酰基，任选酯化或硫酯化羧基，任选取代的氨基甲酰基或任选取代的氨基等，虚线表示单键或双键，R 1是氢原子，任选取代的烃基，任选取代的杂环基等，等等。

2. 发明授权

US07402595B2 JNK inhibitor 失效
标题翻译： JNK抑制剂
公开(公告)号：US07402595B2
公开(公告)日：2008-07-22
申请号：US10504132
申请日：2003-02-12
申请人： Fumio Itoh , Hiroyuki Kimura , Hideki Igata , Tomohiro Kawamoto , Mitsuru Sasaki , Shuji Kitamura
发明人： Fumio Itoh , Hiroyuki Kimura , Hideki Igata , Tomohiro Kawamoto , Mitsuru Sasaki , Shuji Kitamura
IPC分类号： C07D217/02 , A61K31/47
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/5377 , C07D217/24 , C07D217/26
摘要： A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.
摘要翻译：含有异喹啉骨架或其盐的化合物的JNK抑制剂，例如下式表示的化合物，其中环A和环B各自为任选取代的苯环，X为-O-，-N-，-NR- SO 3 - 或-CHR 3 - ，R 2是酰基，任选酯化或硫酯化羧基，任选取代的氨基甲酰基或任选取代的氨基等，虚线表示单键或双键，R 1是氢原子，任选取代的烃基，任选取代的杂环基等，等等。

3. 发明授权

US08492378B2 GSK-3β inhibitor 失效
标题翻译： GSK-3β抑制剂
公开(公告)号：US08492378B2
公开(公告)日：2013-07-23
申请号：US12309906
申请日：2007-08-02
申请人： Fumio Itoh , Jun Kunitomo , Hiromi Kobayashi , Eiji Kimura , Morihisa Saitoh , Tomohiro Kawamoto , Hiroki Iwashita , Katsuhito Murase
发明人： Fumio Itoh , Jun Kunitomo , Hiromi Kobayashi , Eiji Kimura , Morihisa Saitoh , Tomohiro Kawamoto , Hiroki Iwashita , Katsuhito Murase
IPC分类号： A61K31/535
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
摘要： For the purpose of providing a GSK-3β inhibitor containing an oxadiazole compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.
摘要翻译：为了提供含有恶二唑化合物或其盐的GSK-3β抑制剂或其用作预防或治疗GSK-3β相关病理或疾病的药物的前药，本发明提供了GSK-3β 含有由式（I）表示的化合物的抑制剂：其中每个符号如说明书中所定义，或其盐或其前药。

4. 发明授权

US07199124B2 JNK inhibitor 失效
标题翻译： JNK抑制剂
公开(公告)号：US07199124B2
公开(公告)日：2007-04-03
申请号：US10470751
申请日：2002-02-01
申请人： Shigenori Ohkawa , Kenichi Naruo , Seiji Miwatashi , Hiroyuki Kimura , Tomohiro Kawamoto
发明人： Shigenori Ohkawa , Kenichi Naruo , Seiji Miwatashi , Hiroyuki Kimura , Tomohiro Kawamoto
IPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , A61K31/4439
CPC分类号： C07D417/04 , C07D403/14 , C07D417/14
摘要： The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.
摘要翻译：本发明涉及含有被具有取代基的含氮芳香族基团取代的唑类化合物（I）的c-Jun N-末端激酶抑制剂（除了下式所示的化合物：

5. 发明授权

US06723522B1 Sodium bicarbonate cotransporter protein 失效
标题翻译：碳酸氢钠协同转运蛋白
公开(公告)号：US06723522B1
公开(公告)日：2004-04-20
申请号：US09868572
申请日：2001-06-20
申请人： Hiroyuki Kimura , Tomohiro Kawamoto , Hidekazu Sawada
发明人： Hiroyuki Kimura , Tomohiro Kawamoto , Hidekazu Sawada
IPC分类号： C07N1400
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to a protein having a Na+—HCO3− cotransporter activity and a DNA encoding it. The present protein and the present DNA can be used as or for [1] obtaining an antibody and antiserum, [2] constructing an expression system for the present protein, [3] development of a system for measuring the activity of a Na+—HCO3− cotransporter and screening of a drug candidate compound using the same expression system, [4] performing drug design based on the steric structure of a Na+—HCO3− cotransporter protein, [5] a reagent for making a probe or a PCR primer in gene diagnosis, [6] making a transgenic animal, or [7] a composition for gene prevention and/or treatment.
摘要翻译：本发明涉及具有Na + HCO 3 - 共转运蛋白活性的蛋白质和编码其的DNA。本发明的蛋白质和本发明的DNA可用作[1]获得抗体和抗血清[2 ]构建本发明蛋白质的表达系统，[3]开发用于测量Na + -HCO 3 - 共转运蛋白活性的系统，并使用相同的表达系统筛选候选药物[4] 基于Na + - HCO 3 - 共转运蛋白的空间结构的药物设计，[5]用于在基因诊断中制备探针或PCR引物的试剂，[6]制备转基因动物，或[7] 用于基因预防和/或治疗的组合物。

6. 发明授权

US08441174B2 Multilayer piezoelectric element and injector using the same 有权
标题翻译：多层压电元件和注射器使用相同
公开(公告)号：US08441174B2
公开(公告)日：2013-05-14
申请号：US11917747
申请日：2006-06-15
申请人： Takeshi Okamura , Masaki Terazono , Tomohiro Kawamoto , Takafumi Tsurumaru , Shigenobu Nakamura , Ken Yamamoto
发明人： Takeshi Okamura , Masaki Terazono , Tomohiro Kawamoto , Takafumi Tsurumaru , Shigenobu Nakamura , Ken Yamamoto
IPC分类号： H01L41/083
CPC分类号： H01L41/0838 , B05B17/0653 , F02M51/0603 , H01L41/0471 , H01L41/0477
摘要： In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers are stacked alternately, the plurality of metal layers include a plurality of low-filled metal layers having a lower filling rate of metal composing the metal layers than oppositely disposed metal layers adjacent to each other in a stacking direction. In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers are stacked alternately, the plurality of metal layers include a plurality of thin metal layers having a smaller thickness than oppositely disposed metal layers adjacent to each other in a stacking direction. In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers composed mainly of an alloy are stacked alternately, the plurality of metal layers include a plurality of high-ratio metal layers having a higher ratio of a component constituting the alloy than oppositely disposed metal layers adjacent to each other in a stacking direction.
摘要翻译：在其中多个压电层和多个金属层交替堆叠的多层压电元件中，多个金属层包括多个低填充金属层，其中构成金属层的金属填充率低于相对设置的金属层在层叠方向上彼此相邻的金属层。在其中多个压电层和多个金属层交替堆叠的多层压电元件中，多个金属层包括多个薄金属层，其厚度相对于彼此相邻布置的金属层的厚度小于堆叠方向。在其中多个压电层和主要由合金构成的多个金属层交替堆叠的多层压电元件中，多个金属层包括多个高比例的金属层，其中构成合金比层叠方向上彼此相邻的相对设置的金属层。

7. 发明申请

US20090220765A1 Method for Manufacturing Ceramic Member, and Ceramic Member, Gas Sensor Device, Fuel Cell Device, Multi-Layer Piezoelectric Device, Injection Apparatus and Fuel Injection System 有权
标题翻译：陶瓷部件制造方法，陶瓷部件，气体传感器装置，燃料电池装置，多层压电装置，注射装置和燃料喷射系统
公开(公告)号：US20090220765A1
公开(公告)日：2009-09-03
申请号：US12280768
申请日：2007-02-27
申请人： Takeshi Okamura , Shigenobu Nakamura , Tomohiro Kawamoto , Nobuyuki Ito , Takafumi Tsurumaru , Tsuyoshi Setoguchi
发明人： Takeshi Okamura , Shigenobu Nakamura , Tomohiro Kawamoto , Nobuyuki Ito , Takafumi Tsurumaru , Tsuyoshi Setoguchi
IPC分类号： B32B3/26 , C04B35/64 , H01M8/10 , H01L41/083 , H01L41/24 , B05B1/30
CPC分类号： H01L41/273 , C04B35/195 , C04B2235/3225 , C04B2235/3481 , C04B2235/36 , C04B2235/5445 , C04B2235/6025 , F02M51/0603 , G01N27/4071 , H01L41/0471 , H01L41/0477 , H01L41/0838 , H01M8/1246 , H01M2300/0077 , Y02E60/525 , Y02P70/56 , Y10T29/42 , Y10T428/24997 , Y10T428/249981 , Y10T428/24999 , Y10T428/31678
摘要： A ceramic member in which the metal layers with high void ratio are sufficiently sintered to lower a residue of resin is produced.The method for manufacturing a ceramic member which comprises a step of forming a stacked compact from a plurality of metallic paste layers containing a metal component M1 that are stacked one on another via ceramic green sheets, and a step of firing the stacked compact, wherein at least one of plural metallic paste layers is formed as a second metallic paste layer that has the mass percentage X higher than that of the metallic paste layer that adjoin therewith in the stacking direction and a ceramic powder is contained in the second metallic paste layer in the step of forming the stacked compact, the mass percentage X being the proportion of the metal component M1 to the total metal content in the metallic paste layer.
摘要翻译：产生具有高空隙率的金属层充分烧结以降低树脂残留物的陶瓷构件。一种陶瓷构件的制造方法，其特征在于，包括：通过陶瓷生片层叠而成的多个金属成分M1的金属成分M1的多个金属膏层形成层叠成形体的工序和烧成层叠成形体的工序，形成多个金属糊层中的至少一个作为第二金属膏层，其质量百分数X高于在层叠方向上与其相邻的金属膏层的质量百分比X，并且在第二金属膏层中含有陶瓷粉末形成叠层体的步骤，质量百分比X是金属成分M1与金属膏层中的总金属含量的比例。

8. 发明授权

US5648012A Piezoelectric ceramic composition 失效
标题翻译：压电陶瓷组合物
公开(公告)号：US5648012A
公开(公告)日：1997-07-15
申请号：US577204
申请日：1995-12-21
申请人： Makoto Higashibeppu , Tomohiro Kawamoto , Tomonori Eguchi , Kenichi Yoshimura , Katsuhiko Onitsuka , Harumi Hayashi
发明人： Makoto Higashibeppu , Tomohiro Kawamoto , Tomonori Eguchi , Kenichi Yoshimura , Katsuhiko Onitsuka , Harumi Hayashi
IPC分类号： C04B35/491 , H01L41/187 , C04B35/49
CPC分类号： C04B35/491 , H01L41/187
摘要： A piezoelectric ceramic composition comprising a perovskite compound which contains, as metal components, Pb, Sr, Zr, Ti, Nb, Cr, Y, Co and at least one element selected from La, Gd, Nd, Sm and Pr, and may further contain Sb or Na, wherein when the composition formula is expressed as,(Pb.sub.1-x-.alpha.-y Sr.sub.x Na.sub..alpha. M.sub.y).sub.a [(Nb.sub.b Y.sub.c Cr.sub.d Co.sub.e Sb.sub..beta.).sub.f Ti.sub.g Zr.sub.1-f-g ]O.sub.3,wherein M is at least one element selected from La, Gd, Nd, Sm and Pr, then, x, y, a, b, c, d, e, f, g, .alpha. and .beta. satisfy the following relationships, 0.005.ltoreq.x.ltoreq.0.08, 0.002.ltoreq.y.ltoreq.0.05, 0.95.ltoreq.a.ltoreq.1.05, 0.47.ltoreq.b.ltoreq.0.70, 0.02.ltoreq.c.ltoreq.0.31, 0.11.ltoreq.d.ltoreq.0.42, 0.01.ltoreq.e.ltoreq.0.12, 0.02.ltoreq.f.ltoreq.0.15, 0.46.ltoreq.g.ltoreq.0.52, 0.ltoreq..alpha..ltoreq.0.005, 0.ltoreq..beta..ltoreq.0.13, and b+c+d+e+.beta.=1.00. The piezoelectric ceramic composition of the present invention exhibits a high electromechanical coupling coefficient Kp, a low mechanical quality factor Qm, a low dielectric constant .epsilon.r, excellent heat resistance, and can be preferably used as a piezoelectric part for being mounted on the surface and, particularly, as a digital piezoelectric.
摘要翻译：一种包含钙钛矿化合物的压电陶瓷组合物，其包含Pb，Sr，Zr，Ti，Nb，Cr，Y，Co和选自La，Gd，Nd，Sm和Pr中的至少一种元素作为金属成分，并且还可以进一步含有Sb或Na，其中当组成式表示为（Pb1-x-α-ySrxNaαMy）a [（NbbYcCrdCoeBb）fTigZr1-fg] O3时，其中M为选自La，Gd， Nd，Sm和Pr，则x，y，a，b，c，d，e，f，g，α和β满足以下关系：0.005≤x≤0.08,0.002< /=0.05,0.95

9. 发明授权

US08520042B2 Exposure apparatus, control method thereof, and image forming apparatus 失效
标题翻译：曝光装置及其控制方法和图像形成装置
公开(公告)号：US08520042B2
公开(公告)日：2013-08-27
申请号：US13014284
申请日：2011-01-26
申请人： Tomohiro Kawamoto
发明人： Tomohiro Kawamoto
IPC分类号： B41J2/435 , B41J2/47
CPC分类号： G03G15/043 , G03G2215/0404
摘要： The invention provides an exposure apparatus having a configuration such that, when a single laser light source having a plurality of light-emitting points is driven by a plurality of laser control apparatuses, mutual monitoring of the control state of the respective laser control apparatuses is possible, thus reducing malfunctions due to the effects of noise, and also provides a method to control this exposure apparatus, and an image forming apparatus. To accomplish this, the exposure apparatus does not execute light amount control of the light source to be driven when the determination unit has determined that another driving unit is causing the light source to be driven to emit light, and executes the light amount control of the light source to be driven when the determination unit has determined that another driving unit is not causing the light source to be driven to emit light.
摘要翻译：本发明提供一种曝光装置，其具有以下结构：当具有多个发光点的单个激光光源被多个激光控制装置驱动时，可以相互监视各激光控制装置的控制状态，从而减少由噪声的影响引起的故障，并且还提供了一种控制该曝光装置的方法和图像形成装置。为了实现这一点，当确定单元确定另一个驱动单元正在使光源被驱动发光时，曝光设备不执行要驱动的光源的光量控制，并且执行当确定单元确定另一驱动单元不使光源被驱动以发光时，要驱动的光源。

10. 发明申请

US20110182603A1 EXPOSURE APPARATUS, CONTROL METHOD THEREOF, AND IMAGE FORMING APPARATUS 失效
标题翻译：曝光装置，其控制方法和图像形成装置
公开(公告)号：US20110182603A1
公开(公告)日：2011-07-28
申请号：US13014284
申请日：2011-01-26
申请人： Tomohiro Kawamoto
发明人： Tomohiro Kawamoto
IPC分类号： G03G15/043
CPC分类号： G03G15/043 , G03G2215/0404
摘要： The invention provides an exposure apparatus having a configuration such that, when a single laser light source having a plurality of light-emitting points is driven by a plurality of laser control apparatuses, mutual monitoring of the control state of the respective laser control apparatuses is possible, thus reducing malfunctions due to the effects of noise, and also provides a method to control this exposure apparatus, and an image forming apparatus. To accomplish this, the exposure apparatus does not execute light amount control of the light source to be driven when the determination unit has determined that another driving unit is causing the light source to be driven to emit light, and executes the light amount control of the light source to be driven when the determination unit has determined that another driving unit is not causing the light source to be driven to emit light.
摘要翻译：本发明提供一种曝光装置，其具有以下结构：当具有多个发光点的单个激光光源被多个激光控制装置驱动时，可以相互监视各激光控制装置的控制状态，从而减少由噪声的影响引起的故障，并且还提供了一种控制该曝光装置的方法和图像形成装置。为了实现这一点，当确定单元确定另一驱动单元正在使光源被驱动发光时，曝光设备不执行要驱动的光源的光量控制，并且执行当确定单元确定另一个驱动单元不使光源被驱动以发光时，要驱动的光源。

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