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    • 5. 发明授权
    • Pyrazolothiazole compound
    • 吡唑并噻唑化合物
    • US08530504B2
    • 2013-09-10
    • US12900026
    • 2010-10-07
    • Kogyoku ShinTaro TerauchiYoshinori TakahashiMinako HashizumeKunitoshi TakedaKodo ShikataAkira Inomata
    • Kogyoku ShinTaro TerauchiYoshinori TakahashiMinako HashizumeKunitoshi TakedaKodo ShikataAkira Inomata
    • A61K31/429A61P25/24
    • C07D513/04
    • A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.; and R7 is a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkylthio group.
    • 由式(I)表示的化合物或其药理学上可接受的盐表现出优异的CRF受体拮抗作用,其中X为氮原子或CH; R1为-A11-A12; A11是单键或C1-6亚烷基; A12是氢原子,C1-6烷基或C3-6环烷基等; R2为-A21-A22; A21是单键或C1-6亚烷基; A22为氢原子,C1-6烷基,C3-6环烷基,非芳族杂环基或杂芳基等; R3是C1-6烷基,C3-6环烷基,C1-6烷氧基,C3-6环烷氧基C1-6烷基,二C1-6烷基氨基,卤素原子,氰基 ,甲酰基或羧基等; R4是氢原子或C1-6烷氧基; R5是卤素原子,C1-6烷基或C1-6烷氧基; R6是氢原子,C1-6烷基,C1-6烷氧基,C1-6烷硫基或C1-6烷基亚磺酰基等; 且R 7为C 1-6烷基,C 1-6烷氧基或C 1-6烷硫基。
    • 10. 发明申请
    • Hearing processing method and hearing aid using the same
    • 听力处理方法和助听器
    • US20060222193A1
    • 2006-10-05
    • US11388244
    • 2006-03-23
    • Mikio TohyamaMichiko KazamaYoshinori TakahashiKiyoaki TeradaShinichi SakamotoKeisuke WatanukiTakeshi Nakaichi
    • Mikio TohyamaMichiko KazamaYoshinori TakahashiKiyoaki TeradaShinichi SakamotoKeisuke WatanukiTakeshi Nakaichi
    • H04R25/00
    • H04R25/505H04R2430/03
    • A hearing aid device for processing an input sound signal via a microphone so as to output a sound signal from an earphone comprises a signal processing element, a couple of acoustic nerve excitation pattern calculation elements, a couple of acoustic filter shape memory elements, a comparison element, a correction processing element, etc. The couple of acoustic nerve excitation pattern calculation elements calculate acoustic nerve excitation patterns of a normal hearing person and a hearing impaired person based on an output signal of the signal processing element and acoustic filter shapes of the normal hearing person and the hearing impaired person which are stored in the couple of acoustic filter shape memory elements. Each of the acoustic nerve excitation patterns is compared via the comparison element. Then, the correction processing element corrects the input sound signal such that the acoustic nerve excitation pattern of the hearing impaired person is identical with the acoustic nerve excitation pattern of the normal hearing person, so as to generate an output sound signal.
    • 一种用于经由麦克风处理输入声音信号以便从耳机输出声音信号的助听器装置包括信号处理元件,一对声音神经激励图案计算元件,一对声学滤波器形状记忆元件,比较 元件,校正处理元件等。声学神经激励图案计算元件根据信号处理元件的输出信号和正常的声学滤波器形状来计算正常听力者和听力受损者的声学神经激励模式 听力人和听力障碍者,其被存储在声学滤波器形状的存储元件中。 通过比较元件比较每个声神经激励图案。 然后,校正处理元件校正输入声音信号,使得听力受损者的声神经激励模式与正常听力者的声音神经激励模式相同,以产生输出声音信号。