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1. 发明授权

US09353049B2 Preparation method for rivastigmine, intermediates thereof, and preparation method for said intermediates 有权
标题翻译：利凡斯的明的制备方法，其中间体及所述中间体的制备方法
公开(公告)号：US09353049B2
公开(公告)日：2016-05-31
申请号：US14118411
申请日：2012-05-16
申请人： Fuli Zhang , Zhezhou Yang , Chunbo Yang , Daoxin Chen , Zhiqing Yang , Rentong Sun , Hua Bai
发明人： Fuli Zhang , Zhezhou Yang , Chunbo Yang , Daoxin Chen , Zhiqing Yang , Rentong Sun , Hua Bai
IPC分类号： C07C269/04 , C07C269/06 , C07C271/44 , C07C215/66 , C07C217/58 , C07C309/04
CPC分类号： C07C271/44 , C07B2200/07 , C07C215/66 , C07C217/58 , C07C269/04 , C07C269/06 , C07C309/04
摘要： The present invention provides a preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate, preparation methods for intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, as well as a method for using (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium to prepare rivastigmine which can be used for the treatment of Alzheimer's disease.
摘要翻译：本发明提供（S）-3-（1-（二甲基氨基）乙基）苯基乙基（甲基）氨基甲酸酯的制备方法，中间体（S）-1-（3-甲氧基苯基）-N， -N - （（S）-1-苯基乙基）乙胺，（S）-1-（3-羟基苯基）-N，N-二甲基-N - （（S）-1-苯乙基）乙胺和（S）-1 - （3-（乙基（甲基）氨基甲酰氧基）苯基）-N，N-二甲基-N - （（S）-1-苯乙基）乙胺，以及使用（S）-1-（3- 乙基（甲基）氨基甲酰氧基）苯基）-N，N-二甲基-N - （（S）-1-苯基乙基）乙胺，制备可用于治疗阿尔茨海默病的利凡斯的明。

2. 发明申请

US20140073809A1 PREPARATION METHOD FOR RIVASTIGMINE, INTERMEDIATES THEREOF, AND PREPARATION METHOD FOR SAID INTERMEDIATES 有权
标题翻译： RIVASTIGMINE的制备方法及其中间体，以及用于确定中间体的制备方法
公开(公告)号：US20140073809A1
公开(公告)日：2014-03-13
申请号：US14118411
申请日：2012-05-16
申请人： Fuli Zhang , Zhezhou Yang , Chunbo Yang , Daoxin Chen , Zhiqing Yang , Rentong Sun , Hua Bai
发明人： Fuli Zhang , Zhezhou Yang , Chunbo Yang , Daoxin Chen , Zhiqing Yang , Rentong Sun , Hua Bai
IPC分类号： C07C271/44 , C07C269/04 , C07C217/58 , C07C215/66 , C07C309/04
CPC分类号： C07C271/44 , C07B2200/07 , C07C215/66 , C07C217/58 , C07C269/04 , C07C269/06 , C07C309/04
摘要： The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound), the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula VI compound), (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula IX compound), as well as the method for using above mentioned formula IX compound to prepare rivastigmine which can be used for the treatment of Alzheimer's disease. The preparation method for rivastigmine has a reasonable synthetic design with convenient source of raw materials and high total yield, and the product resulted has high chemical and optical purity, which makes it easy for large-scale. industrial production.
摘要翻译：本发明提供（S）-3-（1-（二甲基氨基）乙基）苯基乙基（甲基）氨基甲酸酯（式X化合物）的制备方法，其中间体（S）-1-（3-甲氧基苯基）-N，N-二甲基-N - （（S）-1-苯基乙基）乙胺（式VI化合物），（S）-1-（3-羟基苯基）-N，N-二甲基-N - （（S） -1-苯基乙基）乙胺（式Ⅷ化合物）和（S）-1-（3-（乙基（甲基）氨基甲酰氧基）苯基）-N，N-二甲基-N - （（S）-1-苯乙基）乙胺式IX化合物），以及使用上述式IX化合物制备可用于治疗阿尔茨海默病的利凡斯的明的方法。利伐斯的明的制备方法具有合理的合成设计，原料来源方便，总产率高，产品化学和光学纯度高，易于大规模生产。工业生产。

3. 发明授权

US08324429B2 Preparation method of rivastigmine, its intermediates and preparation method of the intermediates 有权
标题翻译：利凡斯的明的制备方法及其中间体及其制备方法
公开(公告)号：US08324429B2
公开(公告)日：2012-12-04
申请号：US12812347
申请日：2008-01-10
申请人： Fuli Zhang , Meng Hu , Meihua Xie , Anping Lai , Rentong Sun , Daoxin Chen , Rusheng Bao , Hua Bai
发明人： Fuli Zhang , Meng Hu , Meihua Xie , Anping Lai , Rentong Sun , Daoxin Chen , Rusheng Bao , Hua Bai
IPC分类号： C07C211/03 , C07C269/04
CPC分类号： C07C217/58 , C07B2200/07 , C07C215/50 , C07C271/44
摘要： The present invention provides N-methylethylcarbamino-3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenyl ester represented by formula (II) and its preparation method. The present invention also provides (S)-1-(3-methoxyphenyl)-N-methyl-N—[(S)-1-phenylethyl]ethylamine and 3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenol as intermediates of the compound represented by formula (II), and the use of the compound represented by formula (II) for preparing rivastigmine used for treating Alzheimer disease.
摘要翻译：本发明提供由式（II）表示的N-甲基乙基氨基甲酸氨基-3 - [（S）-1-（甲基 - [（S）-1-苯基乙基]氨基）乙基]苯酯及其制备方法。本发明还提供（S）-1-（3-甲氧基苯基）-N-甲基-N - [（S）-1-苯基乙基]乙胺和3 - [（S）-1-（甲基 - [（S） -1-苯基乙基]氨基）乙基]苯酚作为式（II）表示的化合物的中间体，以及由式（II）表示的化合物用于制备用于治疗阿尔茨海默病的利凡斯的明的用途。

4. 发明申请

US20100286437A1 PREPATATION METHOD OF RIVASTIGMINE, ITS INTERMEDIATES AND PREPARATION METHOD OF THE INTERMEDIATES 有权
标题翻译： RIVASTIGMINE的制备方法及其中间体的制备方法和中间体的制备方法
公开(公告)号：US20100286437A1
公开(公告)日：2010-11-11
申请号：US12812347
申请日：2008-01-10
申请人： Fuli Zhang , Meng Hu , Meihua Xie , Anping Lai , Rentong Sun , Daoxin Chen , Rusheng Bao , Hua Bai
发明人： Fuli Zhang , Meng Hu , Meihua Xie , Anping Lai , Rentong Sun , Daoxin Chen , Rusheng Bao , Hua Bai
IPC分类号： C07C271/44 , C07C215/50 , C07C269/04
CPC分类号： C07C217/58 , C07B2200/07 , C07C215/50 , C07C271/44
摘要： The present invention provides N-methylethylcarbamino-3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenyl ester represented by formula (II) and its preparation method. The present invention also provides (S)-1-(3-methoxyphenyl)-N-methyl-N—[(S)-1-phenylethyl]ethylamine and 3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenol as intermediates of the compound represented by formula (II), and the use of the compound represented by formula (II) for preparing rivastigmine used for treating Alzheimer disease.
摘要翻译：本发明提供由式（II）表示的N-甲基乙基氨基甲酸氨基-3 - [（S）-1-（甲基 - [（S）-1-苯基乙基]氨基）乙基]苯酯及其制备方法。本发明还提供（S）-1-（3-甲氧基苯基）-N-甲基-N - [（S）-1-苯基乙基]乙胺和3 - [（S）-1-（甲基 - [（S） -1-苯基乙基]氨基）乙基]苯酚作为式（II）表示的化合物的中间体，以及由式（II）表示的化合物用于制备用于治疗阿尔茨海默病的利凡斯的明的用途。

5. 发明授权

US09315166B2 Techniques for synchronous rectification control of DC-DC converters in electrified vehicles 有权
标题翻译：电气化车辆中DC-DC转换器的同步整流控制技术
公开(公告)号：US09315166B2
公开(公告)日：2016-04-19
申请号：US14323563
申请日：2014-07-03
申请人： Zhong Nie , Mengyang Zhang , Dennis Krozek , Fred A Householder , Hua Bai , Wei Guo , Chen Duan
发明人： Zhong Nie , Mengyang Zhang , Dennis Krozek , Fred A Householder , Hua Bai , Wei Guo , Chen Duan
IPC分类号： B60L9/00 , B60R16/03 , B60L11/18 , H02M3/335 , B60L1/00 , B60L11/08 , H02J7/00 , H02J1/00 , H02M3/337 , H02M1/00
CPC分类号： B60R16/03 , B60L1/00 , B60L11/08 , B60L11/1803 , B60L11/1868 , B60L2210/12 , B60L2240/526 , B60L2240/527 , B60L2240/529 , B60L2250/16 , H02J7/0054 , H02J2001/002 , H02M3/33592 , H02M3/3376 , H02M2001/0048 , Y02T10/70 , Y02T10/7005 , Y02T10/7066 , Y02T10/7077 , Y02T10/7233 , Y02T10/92
摘要： Techniques are presented for synchronous rectification control (SRC) of a DC-DC converter in an electrified vehicle (EV) can include determining a required output current for the DC-DC converter based on a secondary voltage of a secondary battery system of the EV, the DC-DC converter being configured to convert a primary voltage from a primary battery system of the EV to the secondary voltage. The techniques can include determining, at the controller, a switching frequency for the DC-DC converter that causes the DC-DC converter to output the required output current. The techniques can include determining turn-on and turn-off delays of the DC-DC converter based on the required output current and the switching frequency using one or more look-up tables. The techniques can also include controlling the DC-DC converter efficiency based on the turn-on and turn-off delays.
摘要翻译：呈现用于电气化车辆（EV）中的DC-DC转换器的同步整流控制（SRC）的技术可以包括基于EV的二次电池系统的次级电压确定DC-DC转换器的所需输出电流， DC-DC转换器被配置为将来自EV的一次电池系统的初级电压转换为次级电压。这些技术可以包括在控制器处确定使DC-DC转换器输出所需输出电流的DC-DC转换器的开关频率。这些技术可以包括基于所需的输出电流和使用一个或多个查找表的开关频率来确定DC-DC转换器的导通和关断延迟。这些技术还可以包括基于导通和关断延迟来控制DC-DC转换器的效率。

6. 发明授权

US08980362B2 Powdered beverage comprising fruit or vegetable pulp 有权
标题翻译：包含水果或蔬菜浆的粉状饮料
公开(公告)号：US08980362B2
公开(公告)日：2015-03-17
申请号：US13805790
申请日：2011-03-25
申请人： Si-Ze Du , Yongcheng Liao , Hua Bai
发明人： Si-Ze Du , Yongcheng Liao , Hua Bai
IPC分类号： A23L1/212 , A23L2/02 , A23L2/39 , A23L2/52 , A23L2/60 , A23L2/395
CPC分类号： A23L2/02 , A23L2/39 , A23L2/395 , A23L2/52 , A23L2/60 , A23L19/09
摘要： The present invention relates generally to the field of food and beverages. In particular, the present invention relates to a powdered beverage comprising fruit or vegetable pulp. Embodiments of the present invention relate to compositions comprising dry fruit or vegetable pulp and sugar powder, wherein the size of the sugar powder particles and pulp particles is selected in a way that, e.g., segregation of low density pulp particles is avoided during transportation and storage time.
摘要翻译：本发明一般涉及食品和饮料领域。特别地，本发明涉及包含水果或植物纸浆的粉末饮料。本发明的实施方案涉及包含干果或植物纸浆和糖粉的组合物，其中以如下方式选择糖粉颗粒和纸浆颗粒的尺寸，即在运输和储存期间避免低密度纸浆颗粒的偏析时间。

7. 发明授权

US08633000B2 Process for the production of L-Citrulline 有权
标题翻译：生产L-瓜氨酸的方法
公开(公告)号：US08633000B2
公开(公告)日：2014-01-21
申请号：US13470908
申请日：2012-05-14
申请人： Hua Bai , Peijie Yang , Zhengjie Chen , Chongyang Xu , Zhaorui Li , Zigang Zhao , Luyan Jiang , Zongyi Yang , Jiang Li
发明人： Hua Bai , Peijie Yang , Zhengjie Chen , Chongyang Xu , Zhaorui Li , Zigang Zhao , Luyan Jiang , Zongyi Yang , Jiang Li
IPC分类号： C12P13/10 , C07C227/40
CPC分类号： C07C275/16 , C07C273/189
摘要： Processes for producing a suitable purity grade of L-Citrulline are disclosed. The processes can include contacting crude L-Citrulline in an aqueous solution with an adsorptive medium at a temperature above approximately 50° C. and below the temperature of denaturement for the L-Citrulline for an interval sufficient to remove at least one contaminant from the L-Citrulline. The processes can also include concentrating the dissolved L-Citrulline relative to the aqueous solution.
摘要翻译：公开了生产合适纯度的L-瓜氨酸的方法。该方法可以包括使粗L-肉桂碱在水溶液中与吸附介质在高于约50℃的温度下接触并且低于L-瓜氨酸的变性温度，其间隔足以从L中除去至少一种污染物蛋白质所述方法还可以包括相对于水溶液浓缩溶解的L-瓜氨酸。

8. 发明授权

US08567099B2 Device to dry catalyst roaster conveyor belt and method of using same 有权
标题翻译：干燥催化剂烘干机输送带设备及其使用方法
公开(公告)号：US08567099B2
公开(公告)日：2013-10-29
申请号：US12912233
申请日：2010-10-26
申请人： Hua Bai , Ralph S. Kruska
发明人： Hua Bai , Ralph S. Kruska
IPC分类号： F26B13/00
CPC分类号： F26B13/10
摘要： A system and process for removing an inorganic salt from a catalyst roaster belt is disclosed. The system includes an apparatus with a drying vessel having a catalyst roaster belt inlet, a catalyst roaster belt outlet, a heating medium inlet, and a heating medium outlet, wherein the catalyst roaster belt inlet and the catalyst roaster belt outlet are spaced apart along a first direction, the heating medium inlet and the heating medium outlet are spaced apart along a second direction, the heating medium inlet is spaced apart from the catalyst roaster belt inlet in the second direction, and the catalyst roaster belt inlet is between the heating medium inlet and the heating medium outlet along the second direction. The system includes an acid bath and a moveable catalyst roaster belt extending from the acid bath through the catalyst roaster belt inlet and through the catalyst roaster belt outlet. The process includes the steps of providing a catalyst roaster belt with an inorganic salt disposed thereon and supplying a heating medium to a first side of the catalyst roaster belt such that heat from the heating medium flows through the catalyst roaster belt to a second side of the catalyst roaster belt to vaporize the inorganic salt.
摘要翻译：公开了一种从催化剂焙烧炉中除去无机盐的体系和方法。该系统包括具有干燥容器的装置，该干燥容器具有催化剂烘焙带入口，催化剂烘焙带出口，加热介质入口和加热介质出口，其中催化剂烘焙带入口和催化剂烤箱带出口沿着第一方向，加热介质入口和加热介质出口沿着第二方向间隔开，加热介质入口在第二方向上与催化剂烘焙带入口间隔开，并且催化剂烘焙带入口在加热介质入口和加热介质出口沿着第二方向。该系统包括酸浴和可移动的催化剂烘焙带，其从酸浴通过催化剂烤箱带入口并通过催化剂烤箱带出口延伸。该方法包括以下步骤：提供催化剂焙烧带，其上设置有无机盐，并将加热介质供应到催化剂烘焙带的第一侧，使得来自加热介质的热量流过催化剂烘焙带至第二侧催化剂烘焙带，以蒸发无机盐。

9. 发明申请

US20130270356A1 APPARATUS AND METHOD FOR PRODUCING FREE-STANDING MATERIALS 有权
标题翻译：用于生产自由放置材料的装置和方法
公开(公告)号：US20130270356A1
公开(公告)日：2013-10-17
申请号：US13449126
申请日：2012-04-17
申请人： Heather A. G. Stern , Vincent DiFilippo , Jitendra S. Goela , Michael A. Pickering , Hua Bai , Debashis Chakraborty , Hangyao Wang
发明人： Heather A. G. Stern , Vincent DiFilippo , Jitendra S. Goela , Michael A. Pickering , Hua Bai , Debashis Chakraborty , Hangyao Wang
IPC分类号： B05B7/26
CPC分类号： B05B7/26 , B01F3/02 , B01F5/0256 , B01F13/1016 , C23C14/0629 , C23C14/228 , C23C14/564 , C23C16/01 , C23C16/306 , C23C16/403 , C23C16/4401 , C23C16/45512
摘要： An apparatus includes a manifold with a chamber for mixing multiple reactants. Gases are jetted into the manifold by a plurality of inlet injectors. The inlet injectors are arranged such that the gases passing into the manifold impinge on each other at a common point to form a mixture. The mixture passes through a plurality of holes in one side of the manifold into a deposition chamber where the mixture of gases impinges on additional gases at a common point to provide a reaction resulting in deposition of solid materials in the deposition chamber. The solid materials are free-standing.
摘要翻译：一种装置包括具有用于混合多个反应物的室的歧管。气体通过多个入口喷射器喷射到歧管中。入口喷射器被布置成使得进入歧管的气体在共同点处彼此撞击以形成混合物。混合物通过歧管一侧的多个孔进入沉积室，其中气体混合物在共同点撞击另外的气体以提供反应，从而在沉积室中沉积固体材料。固体材料是独立的。

10. 发明授权

US08558041B2 Isothermal multitube reactors and processes incorporating the same 有权
标题翻译：等温多管反应器及其结合的方法
公开(公告)号：US08558041B2
公开(公告)日：2013-10-15
申请号：US12901305
申请日：2010-10-08
申请人： Max M. Tirtowidjojo , Hua Bai , Debashis Chakraborty , Juergen Eiffler , Heinz Groenewald , Kurt F. Hirsekorn , Manfred Kokott , William J. Kruper, Jr. , Thomas U. Luebbe , Avani M. Patel , Shirley S. Sexton , Peter Wenzel , Marcus Wobser
发明人： Max M. Tirtowidjojo , Hua Bai , Debashis Chakraborty , Juergen Eiffler , Heinz Groenewald , Kurt F. Hirsekorn , Manfred Kokott , William J. Kruper, Jr. , Thomas U. Luebbe , Avani M. Patel , Shirley S. Sexton , Peter Wenzel , Marcus Wobser
IPC分类号： C07C17/00
CPC分类号： B01J19/2425 , B01J19/0026 , B01J19/006 , B01J19/2405 , B01J2219/00063 , B01J2219/00081 , B01J2219/00159 , B01J2219/00162 , B01J2219/00166 , B01J2219/00247 , B01J2219/0227 , C07C17/206 , C07C17/269 , C07C21/18 , C07C21/04
摘要： The present invention provides isothermal multitube reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors utilize a feed mixture inlet temperature at least 20° C. different from a desired reaction temperature.
摘要翻译：本发明提供了适于从氯化和/或氟化烷烃和氯化和/或氟化烯烃的反应生产氯化和/或氟化丙烯和更高级烯烃的等温多管反应器。反应器利用不同于所需反应温度的进料混合物入口温度至少20℃。

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