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1. 发明授权

US07635513B1 Heat resistant microporous film 有权
标题翻译：耐热微孔膜
公开(公告)号：US07635513B1
公开(公告)日：2009-12-22
申请号：US10110186
申请日：2000-10-20
申请人： Izumi Hoshuyama , Fujiharu Nagoya , Ichiro Koguma
发明人： Izumi Hoshuyama , Fujiharu Nagoya , Ichiro Koguma
IPC分类号： B32B3/26 , B05B3/00
CPC分类号： B32B27/08 , B01D67/003 , B01D69/02 , B01D71/34 , B01D2323/20 , B01D2325/02 , B01D2325/22 , B32B3/26 , B32B5/32 , B32B27/00 , B32B27/22 , B32B27/304 , B32B38/0036 , B32B2305/026 , B32B2307/306 , B32B2307/54 , H01M2/1653 , H01M2/1686 , H01M2300/0025 , Y10T428/249953 , Y10T428/249978 , Y10T428/249981
摘要： A heat resistant microporous membrane containing a thermoplastic resin having a crystalline melting point of 140-300° C. and having a layer structure formed in the direction of membrane thickness, said layer structure containing 5-100% of a layer defined by the following (A) and 95-0% of a layer defined by the following (B):(A) a layer in which the micropores are intra-spherulitic voids, and(B) a layer in which the micropores are intra-spherulitic voids and inter-spherulitic voids.
摘要翻译：一种耐热微孔膜，其含有结晶熔点为140-300℃，具有沿膜厚度方向形成的层结构的热塑性树脂，所述层结构含有5-100％以下的层（由 A）和95-0％由以下（B）限定的层：（A）其中微孔是球内空隙的层，（B）其中微孔是球内空隙和相间的层花岗岩空隙。

2. 发明申请

US20060016748A1 Microporous hydrophilic membrane 有权
标题翻译：微孔亲水膜
公开(公告)号：US20060016748A1
公开(公告)日：2006-01-26
申请号：US10531568
申请日：2003-10-17
申请人： Ichiro Koguma , Fujiharu Nagoya
发明人： Ichiro Koguma , Fujiharu Nagoya
IPC分类号： B01D71/06
CPC分类号： B01D67/0088 , B01D67/003 , B01D67/0093 , B01D69/02 , B01D71/34 , B01D2323/02 , B01D2323/385 , B01D2325/022 , B01D2325/36 , Y10T428/249954 , Y10T428/249957 , Y10T428/249961
摘要： A hydrophilic microporous membrane comprising a thermoplastic resin, having been subjected to hydrophilizing treatment and having a maximum pore size of 10 to 100 nm, wherein when 3 wt % bovine immunoglobulin having a monomer ratio of 80 wt % or more is filtered at a constant pressure of 0.3 MPa, an average permeation rate (liter/m2/h) for 5 minutes from the start of filtration (briefly referred to as globulin permeation rate A) satisfies the following formula (1) and an average permeation rate (liter/m2/h) for 5 minutes from the time point of 55 minutes after the start of filtration (briefly referred to as globulin permeation rate B) satisfies the following formula (2): Globulin permeation rate A>0.0015×maximum pore size (nm)2.75 (1) Globulin permeation rate B/globulin permeation rate A>0.2 (2).
摘要翻译：一种亲水性微孔膜，其特征在于，具有热可塑性树脂，其进行了亲水处理，最大孔径为10〜100nm，其中，当以恒定压力过滤具有80重量％以上的单体比例的3重量％ 0.3MPa，从开始过滤（简称为球蛋白渗透速率A）开始5分钟的平均渗透速度（升/ m 2 SUP / h）满足下式（1）和平均渗透速度（升/米2 /小时）从开始过滤后55分钟的时间点（简称球蛋白渗透速率B）5分钟满足下式（2）球形蛋白渗透速率A> 0.0015×最大孔径（nm）2.75（1）<α在线公式描述=“直线公式”end =“铅” line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？>球蛋白渗透率B /球渗透速率A> 0.2（2）。 <？in-line-formula description =“In-line Formulas”end =“tail”？>

3. 发明授权

US07459085B2 Microporous hydrophilic membrane 有权
标题翻译：微孔亲水膜
公开(公告)号：US07459085B2
公开(公告)日：2008-12-02
申请号：US10531568
申请日：2003-10-17
申请人： Ichiro Koguma , Fujiharu Nagoya
发明人： Ichiro Koguma , Fujiharu Nagoya
IPC分类号： B01D11/00 , B01D39/00 , B01D39/14
CPC分类号： B01D67/0088 , B01D67/003 , B01D67/0093 , B01D69/02 , B01D71/34 , B01D2323/02 , B01D2323/385 , B01D2325/022 , B01D2325/36 , Y10T428/249954 , Y10T428/249957 , Y10T428/249961
摘要： A hydrophilic microporous membrane comprising a thermoplastic resin, having been subjected to hydrophilizing treatment and having a maximum pore size of 0 to 100 nm, wherein when 3 wt % bovine immunoglobulin having a monomer ratio of 80 wt % or more is filtered at a constant pressure of 0.3 MPa, an average permeation rate (liter/m2/h) for 5 minutes from the start of filtration (briefly referred to as globulin permeation rate A) satisfies the following formula (1) and an average permeation rate (liter/m2/h) for 5 minutes from the time point of 55 minutes after the start of filtration (briefly referred to as globulin permeation rate B) satisfies the following formula (2): Globulin permeation rate A>0.0015 ×maximum pore size (nm)2.75 (1) Globulin permeation rate B/globulin permeation rate A>0.2 . (2)
摘要翻译：一种亲水性微孔膜，其特征在于，具有经过亲水处理且最大孔径为0〜100nm的热塑性树脂，其中，当以恒定压力过滤具有80重量％以上的单体比例的3重量％ 0.3ml，从过滤开始5分钟（简称球蛋白渗透速度A）的平均渗透速度（升/ m 2 / h）满足下式（1），平均渗透速度（升/ m 2 / h）从开始过滤后55分钟的时间点（简称为球蛋白渗透速度B）5分钟满足下式（2）：<？在线式描述=“在线式” 结束=“铅”？>球蛋白渗透速率A> 0.0015×最大孔径（nm）2.75（1）<？在线公式描述=“在线公式”end =“tail”？> <？in-line -formulae description =“In-line Formulas”end =“lead”？>球蛋白渗透速率B /球蛋白渗透速率A> 0.2。（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>

4. 发明授权

US07140496B2 Multilayer microporous membrane 有权
标题翻译：多层微孔膜
公开(公告)号：US07140496B2
公开(公告)日：2006-11-28
申请号：US10343691
申请日：2002-07-31
申请人： Fujiharu Nagoya , Ichiro Koguma
发明人： Fujiharu Nagoya , Ichiro Koguma
IPC分类号： B01D29/01
CPC分类号： B01D67/0083 , B01D67/0011 , B01D67/0016 , B01D67/0018 , B01D67/003 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/34 , B01D2323/385 , B01D2325/02 , B01D2325/022 , Y10T428/249958 , Y10T428/249961 , Y10T428/249964 , Y10T428/249978 , Y10T428/249979
摘要： A multilayer microporous membrane containing a thermoplastic resin, comprising a coarse structure layer with a higher open pore ratio and a fine structure layer with a lower open pore ratio, wherein said coarse structure layer is present at least in one membrane surface having a thickness of not less than 5.0 μm, a thickness of said fine structure layer is not less than 50% of the whole membrane thickness, and said coarse structure layer and said fine structure layer are formed in one-piece.
摘要翻译：一种含有热塑性树脂的多孔微孔膜，其包含具有较高开孔率的粗结构层和具有较低开孔率的精细结构层，其中所述粗结构层至少存在于不厚度的膜表面中小于5.0μm时，所述精细结构层的厚度不小于整个膜厚度的50％，并且所述粗糙结构层和所述精细结构层形成为一体。

5. 发明申请

US20130317172A1 METHOD FOR IMMOBILIZING TEMPERATURE RESPONSIVE PROTEIN A 审中-公开
标题翻译：用于固定温度反应蛋白A的方法
公开(公告)号：US20130317172A1
公开(公告)日：2013-11-28
申请号：US13996385
申请日：2011-12-26
申请人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Satoshi Sato
发明人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Satoshi Sato
IPC分类号： C07K14/31
CPC分类号： C07K14/31 , B01D15/3809 , B01D15/3876 , B01J20/261 , B01J20/286 , B01J20/321 , B01J20/3219 , B01J20/3274 , B01J2220/86
摘要： A method for manufacturing a carrier having temperature responsive protein A, which is protein A mutated such that a binding property to an antibody changes depending upon temperature, immobilized thereto, wherein the temperature responsive protein A has the binding property to the antibody in a first temperature region and no binding property to the antibody in a second temperature region; and the method comprises a step of immobilizing the temperature responsive protein A to a carrier surface at a temperature within the first temperature region in which the temperature responsive protein A has the binding property to the antibody.
摘要翻译：一种制造具有温度敏感性蛋白A的载体的方法，其是蛋白A突变，使得与抗体的结合性随固化的温度而变化，其中温度敏感性蛋白A在第一温度下具有与抗体的结合性并且在第二温度区域中与抗体没有结合性; 并且该方法包括在温度响应蛋白A具有与抗体结合性的第一温度区域内的温度下将温度响应蛋白A固定在载体表面上的步骤。

6. 发明授权

US09643173B2 Temperature responsive adsorbent having a strong cation exchange group and method for producing the same 有权
公开(公告)号：US09643173B2
公开(公告)日：2017-05-09
申请号：US13994255
申请日：2011-12-19
申请人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Teruo Okano , Yoshikatsu Akiyama , Kenichi Nagase
发明人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Teruo Okano , Yoshikatsu Akiyama , Kenichi Nagase
IPC分类号： B01J39/20 , C07K1/18 , B01J39/26 , C08F293/00 , B01J20/285 , B01J20/32 , B01J39/05 , B01J39/19
CPC分类号： B01J39/20 , B01J20/285 , B01J20/3276 , B01J20/3278 , B01J39/05 , B01J39/19 , B01J39/26 , C07K1/18 , C08F293/005 , C08F2438/01
摘要： Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.

7. 发明申请

US20130317129A1 TEMPERATURE RESPONSIVE ADSORBENT HAVING A STRONG CATION EXCHANGE GROUP AND METHOD FOR PRODUCING THE SAME 有权
公开(公告)号：US20130317129A1
公开(公告)日：2013-11-28
申请号：US13994255
申请日：2011-12-19
申请人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Teruo Okano , Yoshikatsu Akiyama , Kenichi Nagase
发明人： Ichiro Koguma , Hiroki Shigematsu , Kazuo Okuyama , Teruo Okano , Yoshikatsu Akiyama , Kenichi Nagase
IPC分类号： B01J39/20 , C07K1/18
CPC分类号： B01J39/20 , B01J20/285 , B01J20/3276 , B01J20/3278 , B01J39/05 , B01J39/19 , B01J39/26 , C07K1/18 , C08F293/005 , C08F2438/01
摘要： Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.

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