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1. 发明申请

US20070196333A1 Composition comprising mixtures of IFN-alpha subtypes 审中-公开
标题翻译：组合物包含IFN-α亚型的混合物
公开(公告)号：US20070196333A1
公开(公告)日：2007-08-23
申请号：US11360041
申请日：2006-02-23
申请人： Fu-Yung Lin , Chih-Ping Yang , Shir-Ly Huang , Ching-Yuan Lee
发明人： Fu-Yung Lin , Chih-Ping Yang , Shir-Ly Huang , Ching-Yuan Lee
IPC分类号： A61K38/21 , A61K9/14 , C12P21/04 , A61K9/48 , A61K9/20
CPC分类号： A61K38/212
摘要： A composition of human interferon-alpha (IFN-α) subtypes produced from human lymphoblastoid cells is disclosed. These purified IFN-α composition comprise higher specific activities and may be applied in the treatment of cancers, viruses, and immuno diseases.
摘要翻译：公开了由人类淋巴母细胞细胞产生的人类干扰素-α（IFN-α）亚型的组合物。这些纯化的IFN-α组合物包含较高的比活性，可用于治疗癌症，病毒和免疫疾病。

2. 发明授权

US07527964B2 Method for cleavage of ether-linkages in polyethoxylates 失效
标题翻译：在聚乙氧基化物中裂解醚键的方法
公开(公告)号：US07527964B2
公开(公告)日：2009-05-05
申请号：US10874619
申请日：2004-06-22
申请人： Shir-Ly Huang , Gia-Luen Guo
发明人： Shir-Ly Huang , Gia-Luen Guo
IPC分类号： B09B3/00 , C02F3/34 , C12N1/20
CPC分类号： C12P7/00 , A62D2101/28 , B09C1/10 , C02F3/34 , C12N1/20 , Y10S435/874
摘要： A method for cleavage of the ether-linkage of polyethoxylates is described. A novel pure microbial culture, Pseudomonas nitroreducens TX1 (Depository No.: BCRC910228), is used under aerobic condition to cleave the ether-linkage adjacent to the carboxylated terminus or ethoxyl terminus. This method is useful to cleave sequentially ether-linkage of polyethoxylates in an aqueous buffer solution with an initial concentration of the polyethoxylates between 0.05% and 20%. This method is also effective for the cleavage of the ether-linkages in short-chain polyethoxylates with one to three ethoxyl units.
摘要翻译：描述了一种用于裂解聚乙氧基化物的醚键的方法。在需氧条件下，使用新型纯微生物培养物硝酸还原酶假单胞菌TX1（保藏号：BCRC910228）切割邻近羧基末端或乙氧基末端的醚键。该方法可用于在聚乙氧基化物的初始浓度为0.05％至20％之间的缓冲溶液中依次切割聚乙氧基化物的醚键。该方法对于用1-3个乙氧基单元裂解短链多乙氧基化物中的醚键也是有效的。

3. 发明申请

US20050075515A1 Method for cleavage of ether-linkages in polyethoxylates 失效
标题翻译：在聚乙氧基化物中裂解醚键的方法
公开(公告)号：US20050075515A1
公开(公告)日：2005-04-07
申请号：US10874619
申请日：2004-06-22
申请人： Shir-Ly Huang , Gia-Luen Guo
发明人： Shir-Ly Huang , Gia-Luen Guo
IPC分类号： C12N1/20 , A62D101/28 , B09C1/10 , C02F3/00 , C02F3/34 , C12P7/00 , D06L1/00
CPC分类号： C12P7/00 , A62D2101/28 , B09C1/10 , C02F3/34 , C12N1/20 , Y10S435/874
摘要： A method for cleavage of the ether-linkage of polyethoxylates is described. A novel pure microbial culture, Pseudomonas nitroreducens TX1 (Depository No.: BCRC910228), is used under aerobic condition to cleave the ether-linkage adjacent to the carboxylated terminus or ethoxyl terminus. This method is useful to cleave sequentially ether-linkage of polyethoxylates in an aqueous buffer solution with an initial concentration of the polyethoxylates between 0.05% and 20%. This method is also effective for the cleavage of the ether-linkages in short-chain polyethoxylates with one to three ethoxyl units.
摘要翻译：描述了一种用于裂解聚乙氧基化物的醚键的方法。在需氧条件下，使用新型纯微生物培养物硝酸还原酶假单胞菌TX1（保藏号：BCRC910228）切割邻近羧基末端或乙氧基末端的醚键。该方法可用于在聚乙氧基化物的初始浓度为0.05％至20％之间的缓冲溶液中依次切割聚乙氧基化物的醚键。该方法对于用1-3个乙氧基单元裂解短链多乙氧基化物中的醚键也是有效的。

4. 发明申请

US20090311768A1 Thermostable superoxide dismutase 审中-公开
标题翻译：耐热超氧化物歧化酶
公开(公告)号：US20090311768A1
公开(公告)日：2009-12-17
申请号：US12316724
申请日：2008-12-15
申请人： Shir-Ly Huang
发明人： Shir-Ly Huang
IPC分类号： C12N9/02 , C12N15/11
CPC分类号： C12N9/0089
摘要： The present invention provides a thermostable superoxide dismutase from a thermophile. The thermostable superoxide dismutase that is able to catalyze the conversion of superoxide ions or radicals under the moderate to high temperature environments.
摘要翻译：本发明提供了来自嗜热菌的热稳定超氧化物歧化酶。能够在中等至高温环境下催化超氧化物离子或自由基转化的热稳定超氧化物歧化酶。

5. 发明申请

US20080093218A1 Method for screening thermal stable proteins 审中-公开
标题翻译：筛选热稳定蛋白的方法
公开(公告)号：US20080093218A1
公开(公告)日：2008-04-24
申请号：US11790830
申请日：2007-04-27
申请人： Shir-Ly Huang , Zhang-yan Huang
发明人： Shir-Ly Huang , Zhang-yan Huang
IPC分类号： G01N27/26 , G01N33/68
CPC分类号： G01N33/6842 , G01N33/6848
摘要： The present invention screens a number of thermal stable proteins at a time. And the proteins are rapidly identified by using a mass spectrometry. The proteins obtained after screening can be gene cloned to determine its soluble temperature. By using the present invention, time, cost and human resource can be saved.
摘要翻译：本发明一次筛选出许多热稳定蛋白质。并且通过使用质谱快速鉴定蛋白质。筛选后得到的蛋白质可以进行基因克隆以确定其可溶性温度。通过使用本发明，可以节省时间，成本和人力资源。

6. 发明授权

US07405067B2 Bacterial strain for degradation of organic polymers and environmental hormones 有权
标题翻译：有机聚合物和环境激素降解的细菌菌株
公开(公告)号：US07405067B2
公开(公告)日：2008-07-29
申请号：US10984534
申请日：2004-11-08
申请人： Shir-Ly Huang , Hsiao-Cheng Hsieh
发明人： Shir-Ly Huang , Hsiao-Cheng Hsieh
IPC分类号： C12N1/20 , A01N63/00
CPC分类号： C12R1/40 , C12N1/20
摘要： A Gram-negative bacterial strain, Pseudomonas putida TX2 (PTA-6169 and BCRC 910232), was isolated from farmland, which had received frequent applications of a various pesticides and surfactants. This strain was demonstrated to have the capacity to grow on alkylphenol polyethoxylates (0.05% to 20%) or alkylphenol (0.001% to 0.01%) as sole source of carbon and energy. The metabolic activity of this strain can be applied in the degradation of organic polymers containing ethoxylate units, alkylphenol and alkylphenol derivatives.
摘要翻译：从农田中分离出革兰阴性菌株，恶臭假单胞菌（Pseudomonas putida）TX2（PTA-6169和BCRC 910232），经常应用各种农药和表面活性剂。证明该菌株具有在烷基酚聚乙氧基化物（0.05％至20％）或烷基酚（0.001％至0.01％）上生长的能力，作为碳和能量的唯一来源。该菌株的代谢活性可用于含有乙氧基化物单元，烷基酚和烷基酚衍生物的有机聚合物的降解。

7. 发明授权

US07332325B2 Biological method for removing organic polymers 有权
标题翻译：去除有机聚合物的生物学方法
公开(公告)号：US07332325B2
公开(公告)日：2008-02-19
申请号：US10979076
申请日：2004-10-29
申请人： Shir-Ly Huang , Dy-Hwa Tseng , His-Jien Chen
发明人： Shir-Ly Huang , Dy-Hwa Tseng , His-Jien Chen
IPC分类号： B09B3/00 , C12N1/00 , C12N1/20
CPC分类号： B09C1/10 , Y10S435/874
摘要： A biological method for removing organic polymers is provided. The method includes the cultivation of a bacterial strain Pseudomonas nitroreducens TX1. The deposit numbers are PTA-6168 at ATCC and BCRC910228 at Bioresources Collection and Research Center in Taiwan (Republic of China). A nitrogen source and inorganic salts are required for bacterial growth. Moreover, the method also provides the information of the supply of air and the water content in soils when this invention is applied to the removal of organic polymers in soils. In addition, the viability of cultivated bacteria is not affected by endogenous bacteria in soils and able to maintain the capacity of degrading organic polymers in the method. The present invention is able to remove the organic polymers in a wide range of amounts effectively and useful in the bioremediation of contamination from organic polymers in both soils and water.
摘要翻译：提供了一种去除有机聚合物的生物方法。该方法包括培养细菌菌株硝酸还原酶TX1。保藏号为ATCC的PTA-6168，台湾的生物资源收集和研究中心的BCRC910228（中华民国）。细菌生长需要氮源和无机盐。此外，当本发明应用于土壤中有机聚合物的去除时，该方法还提供了土壤中空气供应和含水量的信息。此外，培养细菌的生存力不受土壤中的内源性细菌影响，能够维持该方法中有机聚合物降解的能力。本发明能够有效地除去有效聚合物的有效聚合物，并可用于生物修复土壤和水中有机聚合物的污染物。

8. 发明授权

US07115411B2 Bacterial strain for degradation of organic polymers 有权
标题翻译：用于有机聚合物降解的细菌菌株
公开(公告)号：US07115411B2
公开(公告)日：2006-10-03
申请号：US10875006
申请日：2004-06-22
申请人： Shir-Ly Huang
发明人： Shir-Ly Huang
IPC分类号： C12N1/20
CPC分类号： C12R1/38 , B09C1/10 , C12P7/00
摘要： A Gram-negative bacterial strain, Pseudomonas nitroreducens TX1 (BCRC910228) isolated from the surfactant-contaminated drainage sediment is described. This strain is shown to have the capacity in utilizing alkylphenol polyethoxylates as a sole source of carbon and energy to grow. Furthermore, it can be grown on a high concentration of alkylphenol polyethoxylates in an aqueous environment. This strain can be applied in the remediation of organic polymers-contaminated water and soil.
摘要翻译：描述了从表面活性剂污染的排水沉积物中分离的革兰氏阴性菌菌株硝酸还原酶TX1（BCRC910228）。该菌株显示出具有利用烷基酚聚乙氧基化物作为生长碳和能量的唯一来源的能力。此外，它可以在含水环境中在高浓度的烷基酚聚乙氧基化物上生长。该菌株可用于有机聚合物污染的水和土壤的修复。

9. 发明申请

US20050095694A1 Biological method for removing organic polymers 有权
标题翻译：去除有机聚合物的生物学方法
公开(公告)号：US20050095694A1
公开(公告)日：2005-05-05
申请号：US10979076
申请日：2004-10-29
申请人： Shir-Ly Huang , DY-Hwa Tseng , His-Jien Chen
发明人： Shir-Ly Huang , DY-Hwa Tseng , His-Jien Chen
IPC分类号： C12N1/20 , B09C1/10 , C02F3/34 , C02F11/02 , C12S1/00
CPC分类号： B09C1/10 , Y10S435/874
摘要： A biological method for removing organic polymers is provided. The method includes the cultivation of a bacterial strain Pseudomonas nitroreducens TX1. The deposit numbers are PTA-6168 at ATCC and BCRC910228 at Bioresources Collection and Research Center in Taiwan (Republic of China). A nitrogen source and inorganic salts are required for bacterial growth. Moreover, the method also provides the information of the supply of air and the water content in soils when this invention is applied to the removal of organic polymers in soils. In addition, the viability of cultivated bacteria is not affected by endogenous bacteria in soils and able to maintain the capacity of degrading organic polymers in the method. The present invention is able to remove the organic polymers in a wide range of amounts effectively and useful in the bioremediation of contamination from organic polymers in both soils and water.
摘要翻译：提供了一种去除有机聚合物的生物方法。该方法包括培养细菌菌株硝酸还原酶TX1。保藏号为ATCC的PTA-6168，台湾的生物资源收集和研究中心的BCRC910228（中华民国）。细菌生长需要氮源和无机盐。此外，当本发明应用于土壤中有机聚合物的去除时，该方法还提供了土壤中空气供应和含水量的信息。此外，培养细菌的生存力不受土壤中的内源性细菌影响，能够维持该方法中有机聚合物降解的能力。本发明能够有效地除去有效聚合物的有效聚合物，并可用于生物修复土壤和水中有机聚合物的污染物。

10. 发明申请

US20050063963A1 Bacterial strain for degradation of organic polymers 有权
标题翻译：用于有机聚合物降解的细菌菌株
公开(公告)号：US20050063963A1
公开(公告)日：2005-03-24
申请号：US10875006
申请日：2004-06-22
申请人： Shir-Ly Huang
发明人： Shir-Ly Huang
IPC分类号： C12N1/20 , B09C1/10 , C02F3/34 , C12N1/00 , C12P7/00
CPC分类号： C12R1/38 , B09C1/10 , C12P7/00
摘要： A Gram-negative bacterial strain, Pseudomonas nitroreducens TX1 (BCRC910228) isolated from the surfactant-contaminated drainage sediment is described. This strain is shown to have the capacity in utilizing alkylphenol polyethoxylates as a sole source of carbon and energy to grow. Furthermore, it can be grown on a high concentration of alkylphenol polyethoxylates in an aqueous environment. This strain can be applied in the remediation of organic polymers-contaminated water and soil.
摘要翻译：描述了从表面活性剂污染的排水沉积物中分离的革兰氏阴性菌菌株硝酸还原酶TX1（BCRC910228）。该菌株显示出具有利用烷基酚聚乙氧基化物作为生长碳和能量的唯一来源的能力。此外，它可以在含水环境中在高浓度的烷基酚聚乙氧基化物上生长。该菌株可用于有机聚合物污染的水和土壤的修复。

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