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1. 发明申请

US20090176234A1 Efficient base determination in sequencing reactions 有权
标题翻译：测序反应中有效的碱基测定
公开(公告)号：US20090176234A1
公开(公告)日：2009-07-09
申请号：US12335188
申请日：2008-12-15
申请人： Radoje Drmanac , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
发明人： Radoje Drmanac , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6855 , C12Q2531/125 , C12Q2521/313 , C12Q2521/125 , C12Q2537/163 , C12Q2525/191 , C12Q2521/531 , C12Q2521/501 , C12Q2525/307 , C12Q2525/151
摘要： The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.
摘要翻译：本发明涉及用于核酸鉴定和检测的组合物和方法。本发明的组合物和方法包括从样品中提取和分离靶核酸，使用片段化的靶核酸产生靶核酸模板，并使这些靶核酸模板进行扩增方法以形成核酸纳米棒。本发明还包括使用各种测序应用检测和鉴定序列的方法，包括通过连接方法测序。

2. 发明申请

US20090176652A1 Methods and Oligonucleotide Designs for Insertion of Multiple Adaptors into Library Constructs 有权
标题翻译：将多个适配器插入到库构造中的方法和寡核苷酸设计
公开(公告)号：US20090176652A1
公开(公告)日：2009-07-09
申请号：US12266385
申请日：2008-11-06
申请人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
发明人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
IPC分类号： C40B30/00 , C12Q1/68 , C12N15/66 , C40B50/06
CPC分类号： C12N15/66 , C12N15/10 , C12N15/64
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译：在此描述和要求保护的方面提供了将多个DNA适配器插入到相对于彼此的限定位置和取向的圆形靶DNA群中的方法。然后将所得多连接体构建体用于大规模并行核酸测序技术。

3. 发明授权

US07901890B2 Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation 有权
标题翻译：使用选择性甲基化插入多个适配器的方法和寡核苷酸设计
公开(公告)号：US07901890B2
公开(公告)日：2011-03-08
申请号：US12265593
申请日：2008-11-05
申请人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
发明人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6855 , C12Q1/6874 , C12Q2531/125 , C12Q2521/313 , C12Q2521/125 , C12Q2537/163 , C12Q2525/191 , C12Q2521/531 , C12Q2521/501
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译：在此描述和要求保护的方面提供了将多个DNA适配器插入到相对于彼此的限定位置和取向的圆形靶DNA群中的方法。然后将所得多连接体构建体用于大规模并行核酸测序技术。

4. 发明申请

US20100105052A1 Nucleic acid sequencing and process 有权
标题翻译：核酸测序和过程
公开(公告)号：US20100105052A1
公开(公告)日：2010-04-29
申请号：US12573697
申请日：2009-10-05
申请人： Radoje DRMANAC , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
发明人： Radoje DRMANAC , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2533/107 , C12Q2525/185 , C12Q2525/151
摘要： The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.
摘要翻译：本发明涉及用于核酸鉴定和检测的组合物和方法。本发明的组合物和方法包括从样品中提取和分离靶核酸，使用片段化的靶核酸产生靶核酸模板，并使这些靶核酸模板进行扩增方法以形成核酸纳米棒。本发明还包括使用各种测序应用检测和鉴定序列的方法，包括通过连接方法测序。

5. 发明授权

US07897344B2 Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs 有权
标题翻译：用于将多个适配器插入库构建体的方法和寡核苷酸设计
公开(公告)号：US07897344B2
公开(公告)日：2011-03-01
申请号：US12266385
申请日：2008-11-06
申请人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
发明人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/66 , C12N15/10 , C12N15/64
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译：在此描述和要求保护的方面提供了将多个DNA适配器插入到相对于彼此的限定位置和取向的圆形靶DNA群中的方法。然后将所得多连接体构建体用于大规模并行核酸测序技术。

6. 发明申请

US20120100534A1 EFFICIENT BASE DETERMINATION IN SEQUENCING REACTIONS 有权
标题翻译：顺序反应中有效的碱基测定
公开(公告)号：US20120100534A1
公开(公告)日：2012-04-26
申请号：US12329365
申请日：2008-12-05
申请人： Radoje Drmanac , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
发明人： Radoje Drmanac , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6855 , C12Q2531/125 , C12Q2521/313 , C12Q2521/125 , C12Q2537/163 , C12Q2525/191 , C12Q2521/531 , C12Q2521/501 , C12Q2525/307 , C12Q2525/151
摘要： The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.
摘要翻译：本发明涉及用于核酸鉴定和检测的组合物和方法。本发明的组合物和方法包括从样品中提取和分离靶核酸，使用片段化的靶核酸产生靶核酸模板，并使这些靶核酸模板进行扩增方法以形成核酸纳米棒。本发明还包括使用各种测序应用检测和鉴定序列的方法，包括通过连接方法测序。

7. 发明授权

US09023769B2 cDNA library for nucleic acid sequencing 有权
标题翻译：用于核酸测序的cDNA文库
公开(公告)号：US09023769B2
公开(公告)日：2015-05-05
申请号：US12956802
申请日：2010-11-30
申请人： Radoje Drmanac , Fredrik Dahl , Evan Hurowitz , Fredrie Dahl
发明人： Radoje Drmanac , Fredrik Dahl , Evan Hurowitz , Fredrie Dahl
IPC分类号： C40B50/06 , C12Q1/68 , C12N15/10 , C40B20/00
CPC分类号： C12Q1/6869 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C12N15/10 , C12Q1/6853 , C40B20/00
摘要： The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.
摘要翻译：本发明涉及用于核酸鉴定和检测的组合物和方法。本发明的组合物和方法包括从样品中提取和分离靶核酸，使用片段化的靶核酸产生靶核酸模板，并使这些靶核酸模板进行扩增方法以形成核酸纳米棒。本发明还包括使用各种测序应用检测和鉴定序列的方法，包括通过连接方法测序。

8. 发明授权

US08579700B2 Method and apparatus for settlement of processor based tournament competition 有权
公开(公告)号：US08579700B2
公开(公告)日：2013-11-12
申请号：US13050221
申请日：2011-03-17
申请人： Malcolm B. Davis , Fredrik Dahl
发明人： Malcolm B. Davis , Fredrik Dahl
IPC分类号： G06F17/00
CPC分类号： G07F17/3276 , G07F17/3244
摘要： A method of providing or receiving value from or to a participant value in a game tournament wherein a plurality of participants play a casino-style game, includes calculating an expected value for the position of each participant in the tournament, the expected value based upon the number of wagering units held by the participant at the point in time, the number of wagering units held by each other participant in the tournament at the point in time and a payout table for the tournament.

9. 发明申请

US20150083453A1 DEVICE FOR GROUNDING 审中-公开
标题翻译：接地装置
公开(公告)号：US20150083453A1
公开(公告)日：2015-03-26
申请号：US14524951
申请日：2014-10-27
申请人： Fredrik Dahl
发明人： Fredrik Dahl
IPC分类号： H01B9/00 , H01B5/08
CPC分类号： H02G13/00 , H01R4/66
摘要： A device for establishing grounding of an installation of different types includes one or more cables, wherein a ground rail or a ground conductor, ground rails or ground conductors, or a ground point or ground points are grounded by the one or more cables including a combination of electrically conductive wires or conductors in at least one inner core and at least one outer layer which surrounds the inner core wholly or partly, and a bore extending, in at least one of ground and a rock, with a depth of more than 100 m. The one or more cables are laid in the bore. The electrically conductive wires or conductors in the at least one inner core include hundreds of thin conductors surrounded by the at least one outer layer that includes coarse conductors having a diameter at least two times more than a diameter of the thin conductors.
摘要翻译：用于建立不同类型的设备的接地的装置包括一个或多个电缆，其中接地线或接地导体，接地线或接地导体或接地点或接地点由一个或多个电缆接地，包括组合在至少一个内芯中的至少一个导电线或导体，以及至少一个外部层，其全部或部分围绕内芯，以及在至少一个地面和岩石中延伸超过100μm的深度的孔。一根或多根电缆铺设在孔中。至少一个内芯中的导电线或导体包括数百个由至少一个外层包围的薄导体，其包括直径比细导体的直径至少大两倍的粗导体。

10. 发明授权

US08878057B2 Device for grounding 有权
标题翻译：接地装置
公开(公告)号：US08878057B2
公开(公告)日：2014-11-04
申请号：US13138919
申请日：2010-04-06
申请人： Fredrik Dahl
发明人： Fredrik Dahl
IPC分类号： H01R4/66 , H01B9/00 , H01B5/08
CPC分类号： H01B9/006 , H01B5/08
摘要： Device for establishing an efficient grounding of an installation of different types includes one or more cables, wherein the ground rail or ground conductor, ground rails or ground conductors or ground point or ground points of the installation being grounded by the one or more cables including a combination of electrically conductive wires or conductors in at least one inner core and at least one outer layer which surrounds the inner core wholly or partly, and the cable or the cables are laid in one and the same or each in a separate bore in ground and/or rock of a considerable depth, preferably more than 200 m, e.g. 240 m or more.
摘要翻译：用于建立不同类型的安装的有效接地的装置包括一个或多个电缆，其中，所述设备的接地导体，接地导轨或接地导体或接地点或接地点由所述一个或多个电缆接地，所述电缆包括在至少一个内核中的导电线或导体的组合以及至少一个外部层，其完全或部分地围绕内芯，并且电缆或电缆被放置在同一个或每个内部的单独的钻孔中， /或相当深度的岩石，优选大于200米，例如 240米以上。

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