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1. 发明申请

US20120158153A1 TRAPEZIUM PROSTHESIS 审中-公开
公开(公告)号：US20120158153A1
公开(公告)日：2012-06-21
申请号：US13380284
申请日：2010-06-23
申请人： Frederick H. Hardenbrook , Seth D. Dodds , Mark Mellon
发明人： Frederick H. Hardenbrook , Seth D. Dodds , Mark Mellon
IPC分类号： A61F2/42
CPC分类号： A61F2/4261 , A61B17/842 , A61F2/30965 , A61F2002/30014 , A61F2002/30069 , A61F2002/30075 , A61F2002/3023 , A61F2002/30677 , A61F2002/30878 , A61F2002/4258 , A61F2002/4276 , A61F2210/0061 , A61F2230/0069 , A61F2250/0018
摘要： A trapezium prosthesis is provided which includes a body having a frustocylindrical shape, the frustocylindrical shape including a frustum and an oppositely disposed planar base, the frustum being canted relative to a planar base. The prosthesis may be made of a swellable fluid absorbing polymer which imparts flexibility and/or resiliency to the prosthesis. The swellable fluid absorbing polymer may also provide the surface of the prosthesis with lubricity. In embodiments, the prosthesis has a first configuration and a second configuration, the first configuration being of reduced size relative to the second configuration. The prosthesis may also include a reinforcement member. In embodiments, the prosthesis includes a stem projecting outwardly from the frustum.
摘要翻译：提供了一种梯形假体，其包括具有截头圆柱形状的主体，截头圆柱体形状包括平截头体和相对设置的平面基部，平截头体相对于平面基部倾斜。假体可由可膨胀的流体吸收聚合物制成，其向假体赋予柔性和/或弹性。可膨胀的流体吸收聚合物还可以为假体的表面提供润滑性。在实施例中，假体具有第一配置和第二配置，第一配置相对于第二配置具有减小的尺寸。假体还可以包括加强构件。在实施例中，假体包括从平截头体向外突出的杆。

2. 发明授权

US11193274B2 Protective divider 有权
公开(公告)号：US11193274B2
公开(公告)日：2021-12-07
申请号：US16140928
申请日：2018-09-25
申请人： Mark Mellon
发明人： Mark Mellon
IPC分类号： E01F15/10 , E06B9/00 , E04B2/74 , E01F13/02 , E04H6/42
摘要： A protective barrier device adapted for placement within a structure with a particular use adjacent to a vehicle. The device includes a pair of base members comprised of a hollow housing having a cavity for the addition of a weighted material. The device including a top rail and a bottom rail assembled from sections and coupled to the base members to define a perimeter of the device. A central portion generally comprising a panel is shaped for receipt within the perimeter and coupled to the rails in a cohesive assembly. The device is configured for assembly from a collapsed to an extended position for easily transport and shipping.

3. 发明授权

US09102955B2 Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose 有权
标题翻译：酵母表达纤维素酶用于同时糖化和发酵使用纤维素
公开(公告)号：US09102955B2
公开(公告)日：2015-08-11
申请号：US13130549
申请日：2009-11-23
申请人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
IPC分类号： C12N1/19 , C12P7/10 , C12N15/80 , C12P7/14 , C12P39/00 , C12N9/42
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes.
摘要翻译：包含表达异源纤维素酶的克氏杆菌的宿主细胞从纤维素产生乙醇此外，可以将表达不同杂种纤维素酶的多个宿主细胞共同共培养并用于从纤维素产生乙醇可以使用酵母菌株的重组酵母菌株和共培养物自己生产乙醇，也可以与外加纤维素酶组合使用，以提高发酵和发酵过程的效率。

4. 发明授权

US5954202A Paperboard blank for a self-contained, reclosable package 失效
标题翻译：纸板空白，用于独立的，可重新封闭的包装
公开(公告)号：US5954202A
公开(公告)日：1999-09-21
申请号：US34953
申请日：1998-03-04
申请人： Mark Mellon
发明人： Mark Mellon
IPC分类号： B65D75/14 , B65D83/04
CPC分类号： B65D83/0463 , B65D75/14 , B65D2583/0418
摘要： This invention relates to paperboard blanks which are used to form self-contained, reclosable packages. Such structures of this type, generally, are comprised of one piece of paperboard that when folded acts as an outer package when sealed and an innovative reclosable package after being opened.
摘要翻译：本发明涉及用于形成自包含可再封闭包装的纸板坯料。这种类型的这种结构通常由一片纸板组成，当折叠时，当被折叠时用作外包装并且在打开之后具有创新的可再封闭包装。

5. 发明授权

US09315833B2 Yeast cells expressing an exogenous cellulosome and methods of using the same 有权
标题翻译：表达外源性纤维素酶的酵母细胞及其使用方法
公开(公告)号：US09315833B2
公开(公告)日：2016-04-19
申请号：US13201257
申请日：2010-02-18
申请人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
发明人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
IPC分类号： C12P7/10 , C07K14/33 , C12N15/81 , C12N9/24 , C12N9/42
CPC分类号： C12P7/10 , C07K14/33 , C07K2319/035 , C07K2319/70 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N15/81 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
摘要翻译：本发明涉及在微生物中异源纤维素酶体的工程和表达，以促进生物质转化为有用的产物。在一些实施方案中，本发明涉及形成纤维素酶的核的骨架蛋白的表达。纤维素酶或其他生物降解酶可以通过泊松特蛋白结构域 - 凝聚素结构域相互作用而非共价连接至支架蛋白。

6. 发明申请

US20130323822A1 Yeast Expressing Saccharolytic Enzymes for Consolidated Bioprocessing Using Starch and Cellulose 审中-公开
标题翻译：酵母表达糖酵解酶用于固体生物处理使用淀粉和纤维素
公开(公告)号：US20130323822A1
公开(公告)日：2013-12-05
申请号：US13701652
申请日：2011-06-03
申请人： Elena Brevnova , John E. McBride , Erin Wiswall , Kevin S. Wenger , Nicky Caiazza , Heidi Hau , Aaron Argyros , Frank Agbogbo , Charles F. Rice , Trisha Barrett , John S. Bardsley , Abigail S. Foster , Anne K. Warner , Mark Mellon , Ryan Skinner , Indraneel Shikhare , Riaan Den Haan , Chhayal V. Gandhi , Alan Belcher , Vineet B. Rajgarhia , Allan C. Froehlich , Kristen M. Deleault , Emily Stonehouse , Shital A. Tripathi , Jennifer Gosselin , Yin-Ying Chiu , Haowen Xu
发明人： Elena Brevnova , John E. McBride , Erin Wiswall , Kevin S. Wenger , Nicky Caiazza , Heidi Hau , Aaron Argyros , Frank Agbogbo , Charles F. Rice , Trisha Barrett , John S. Bardsley , Abigail S. Foster , Anne K. Warner , Mark Mellon , Ryan Skinner , Indraneel Shikhare , Riaan Den Haan , Chhayal V. Gandhi , Alan Belcher , Vineet B. Rajgarhia , Allan C. Froehlich , Kristen M. Deleault , Emily Stonehouse , Shital A. Tripathi , Jennifer Gosselin , Yin-Ying Chiu , Haowen Xu
IPC分类号： C12N15/81
CPC分类号： C12N15/81 , C12N9/2405 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N9/2482 , C12N15/52 , C12P7/06 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01091 , Y02E50/17
摘要： The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.
摘要翻译：本发明涉及分泌全套或全套的酶的酵母菌株或菌株，以水解玉米淀粉，玉米纤维，木质纤维素（包括水解纤维素中的连接酶，半纤维素和木质素和碳水化合物之间）并利用戊糖（木糖和阿拉伯糖）。本发明还涉及在酵母中对于各种酶活性良好表达的蛋白质组。所得菌株或菌株可以同时水解淀粉和纤维素。所产生的菌株或菌株也可以代谢工程化以产生较少的甘油和吸收乙酸盐。所得的菌株或菌株也可用于从颗粒淀粉生产乙醇而不液化。所得到的菌株或菌株可以进一步用于减少在同时糖化和发酵（SSF）过程中水解生物质原料所需的外部酶的量，或者在当前蔗糖分解酶负载下在SSF期间提高乙醇的产率。此外，本发明的多种酶可以在本发明的细胞中共表达以提供对生物质原料的协同消化作用。在一些方面，表达不同异源糖分解酶的宿主细胞也可以共同共培养并用于从生物质原料生产乙醇。

7. 发明授权

US6047829A Unit dose packaging system (UDPS) having a child resistant locking feature 有权
标题翻译：单位剂量包装系统（UDPS）具有防儿童锁定功能
公开(公告)号：US6047829A
公开(公告)日：2000-04-11
申请号：US157292
申请日：1998-09-18
申请人： Scott Bowen Johnstone , Brad Allen Jones , Mark Mellon , William Roger Rigby
发明人： Scott Bowen Johnstone , Brad Allen Jones , Mark Mellon , William Roger Rigby
IPC分类号： B65D5/00 , B65D5/38 , B65D83/04
CPC分类号： B65D5/38 , B65D83/0463 , B65D2215/04 , B65D2583/0454
摘要： This invention relates to a two piece paperboard package that houses a unit dose product on an internal slide card within an outer paperboard shell. This package may have one or more internal or external lock(s) that prevent the slide card from being pulled out without triggering some type of lock release mechanism. This package is focused around providing a child resistant, senior-friendly unit dose package that can be opened and closed numerous times and then finally disposed of.
摘要翻译：本发明涉及一种两片纸板包装，其在外部纸板外壳内的内部滑动卡上容纳单位剂量产品。该包可能具有一个或多个内部或外部锁定，以防止滑动卡被拉出而不触发某种类型的锁定释放机构。这个包装集中在提供一个耐小孩，高级友好的单位剂量包，可以多次打开和关闭，然后最终处理。

8. 发明申请

US20190093346A1 Protective Divider 审中-公开
公开(公告)号：US20190093346A1
公开(公告)日：2019-03-28
申请号：US16140928
申请日：2018-09-25
申请人： Mark Mellon
发明人： Mark Mellon
IPC分类号： E04B2/74
摘要： A protective barrier device adapted for placement within a structure with a particular use adjacent to a vehicle. The device includes a pair of base members comprised of a hollow housing having a cavity for the addition of a weighted material. The device including a top rail and a bottom rail assembled from sections and coupled to the base members to define a perimeter of the device. A central portion generally comprising a panel is shaped for receipt within the perimeter and coupled to the rails in a cohesive assembly. The device is configured for assembly from a collapsed to an extended position for easily transport and shipping.

9. 发明授权

US5927595A Multi-use envelope 失效
标题翻译：多用信封
公开(公告)号：US5927595A
公开(公告)日：1999-07-27
申请号：US118966
申请日：1998-07-20
申请人： Mark Mellon , William R. Rigby , Arthur J. Thomas
发明人： Mark Mellon , William R. Rigby , Arthur J. Thomas
IPC分类号： B65D27/06 , B65D27/34
CPC分类号： B65D27/34 , B65D27/06
摘要： A multi-use envelope for at least two mailings comprises opposed front and rear panels foldably connected together at their bottom edges and secured together at their side edges by side closure flaps to form an envelope structure. The improvement comprises a pair of closure flaps foldably attached respectively to the top edges of each of the front and rear panels wherein each closure flap has an independent means for sealing and opening the envelope. A first closure flap is folded inside the envelope for the first mailing while the other closure flap is used to close the envelope. Upon receipt, the first closure flap is folded outside the envelope for use in closing the envelope for the second mailing.
摘要翻译：用于至少两个邮件的多用途信封包括在其底部边缘处可折叠地连接在一起的相对的前面板和后面板，并且通过侧面闭合折片在其侧边缘处固定在一起以形成包络结构。改进包括一对可折叠地分别附接到每个前板和后板的顶部边缘的闭合翼片，其中每个闭合翼片具有用于密封和打开信封的独立装置。第一封闭翼片折叠在信封内用于第一次邮寄，而另一个封闭翼片用于封闭信封。收到后，将第一封闭舌片折叠在信封外面，用于封闭第二邮寄信封。

10. 发明授权

US08658398B2 Heterologous expression of termite cellulases yeast 有权
标题翻译：白蚁纤维素酶酵母的异源表达
公开(公告)号：US08658398B2
公开(公告)日：2014-02-25
申请号：US13003200
申请日：2009-07-07
申请人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John McBride , Chhayal Gandhi , Erin Wiswall
发明人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John McBride , Chhayal Gandhi , Erin Wiswall
IPC分类号： C12P19/14
CPC分类号： C12N9/2437 , C12N15/81 , C12N15/815 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells of the termite and termite-associated symbiont cellulases, and variants and combinations thereof, result in yeast with improved cellulosic activity. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
摘要翻译：本发明提供白蚁和白蚁相关共生体纤维素酶的异源表达。纤维素酶可以例如密码子优化并在酵母宿主细胞中表达，例如酵母酿酒酵母（Saccharomyces cerevisiae）。纤维素酶也可以与其他纤维素酶在宿主细胞中共表达。在白蚁和白蚁相关共生体纤维素酶的这种宿主细胞中的表达及其变体和组合导致具有改善的纤维素活性的酵母。因此，这些基因和表达系统对于有效和成本有效的整合生物处理系统是有用的。

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