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1. 发明授权

US07105170B2 Latent human tuberculosis model, diagnostic antigens, and methods of use 有权
标题翻译：潜伏人类结核病模型，诊断抗原和使用方法
公开(公告)号：US07105170B2
公开(公告)日：2006-09-12
申请号：US10250930
申请日：2002-01-07
申请人： Frederick D. Quinn , Kristin A. Birkness , Manon Deslauriers , Peter King , David S. Beall
发明人： Frederick D. Quinn , Kristin A. Birkness , Manon Deslauriers , Peter King , David S. Beall
IPC分类号： A61K39/04 , A61K49/00 , A61K39/395 , C12Q1/00 , C12N5/00 , C12N5/08
CPC分类号： G01N33/5695 , C12Q1/025 , G01N33/5047 , G01N33/56955
摘要： Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens (and antibodies thereto), such as α-crystallin, and methods of identifying and using such molecules. Also provided are immunostimulatory compositions, for instance for use in eliciting an immune response in a subject, such as an immune response to a latent tuberculosis infection. Kits for carrying out the provided methods are also described.
摘要翻译：本文提供了体外肉芽肿模型及其使用方法。也提供了在受试者中检测和/或诊断潜在结核病的方法，以及等效特异性抗原（和其抗体）如α-晶状蛋白，以及鉴定和使用这些分子的方法。还提供了免疫刺激组合物，例如用于在受试者中引发免疫应答，例如对潜伏性结核感染的免疫应答。还描述了用于实施所提供的方法的套件。

2. 发明授权

US5750329A Methods and compositions for an artificial lung organ culture system 失效
公开(公告)号：US5750329A
公开(公告)日：1998-05-12
申请号：US679081
申请日：1996-07-12
申请人： Frederick D. Quinn , Kristin A. Birkness
发明人： Frederick D. Quinn , Kristin A. Birkness
IPC分类号： C12N5/071 , G01N33/50 , C12N5/00 , C12N5/02 , C12N5/08 , C12N5/12
CPC分类号： C12M21/08 , C12M25/02 , C12M35/08 , C12N5/0688 , C12N5/0697 , G01N33/5005 , G01N33/5088 , C12N2502/27 , C12N2502/28 , C12N2502/30 , C12N2503/04 , C12N2533/40
摘要： The present invention provides an artificial organ system comprising an endothelial cell layer, an epithelial cell layer and an artificial microporous membrane, having pores therein, disposed between and in direct contact with the endothelial cell layer and the epithelial cell layer such that the membrane has an endothelial side and an epithelial side. The present invention also provides an artificial organ system contained in a vessel comprising an upper chamber into which the epithelial side faces and containing the epithelial cell layer, and a lower chamber into which the endothelial side faces and containing the endothelial cells. The present invention also provides an artificial lung system comprising an endothelial cell layer, an alveolar epithelial cell layer and an artificial microporous membrane, having pores therein, disposed between and in direct contact with the endothelial cell layer and the alveolar epithelial cell layer such that the membrane has an endothelial side and an epithelial side. A method is also provided for constructing an artificial lung system, comprising placing an artificial microporous membrane, having pores therein, into a vessel having a bottom and supporting the membrane a distance from the bottom of the vessel to create an upper and lower chamber in the vessel such that the membrane has an endothelial side facing into the lower chamber of the vessel and an opposite epithelial side facing into the upper chamber of the vessel; placing endothelial cells into the upper chamber of the vessel under conditions such that the endothelial cells form a confluent layer of cells on the epithelial side of the membrane; and placing alveolar epithelial cells into the upper chamber of the vessel under conditions such that the endothelial cells migrate through the pores in the membrane and attach to the endothelial side of the membrane to form a confluent layer of the endothelial cells on the endothelial side of the membrane in the lower chamber and the alveolar epithelial cells form a confluent layer of the epithelial cells on the epithelial side of the membrane in the upper chamber.

3. 发明授权

US5695996A Artificial organ culture system 失效
标题翻译：人造器官培养系统
公开(公告)号：US5695996A
公开(公告)日：1997-12-09
申请号：US311762
申请日：1994-09-23
申请人： Frederick D. Quinn , Kristin A. Birkness
发明人： Frederick D. Quinn , Kristin A. Birkness
IPC分类号： C12N5/071 , G01N33/50 , C12N5/08
CPC分类号： C12M21/08 , C12M25/02 , C12M35/08 , C12N5/0688 , C12N5/0697 , G01N33/5005 , G01N33/5088 , C12N2502/27 , C12N2502/28 , C12N2502/30 , C12N2503/04 , C12N2533/40
摘要： The present invention provides an artificial organ system comprising an endothelial cell layer, an epithelial cell layer and an artificial microporous membrane disposed between and indirect contact with the endothelial cell layer and epithelial cell layer such that the membrane has an endothelial side and an epithelial side. Also provided is a method of constructing an artificial organ system, comprising the steps of placing an artificial microporous membrane into a tissue culture well and supporting the membrane a selected distance from a bottom of the well to create an upper and lower chamber in the well such that the membrane has an endothelial side facing the bottom of the well and an opposite epithelial side; placing endothelial cells into the upper chamber of the well under conditions such that the endothelial cells form a confluent layer of cells on the epithelial side of the membrane; and placing epithelial cells into the upper chamber of the well under conditions such that the endothelial cells migrate through pores in the membrane and attach to the endothelial side of the membrane to form a confluent layer of endothelial cells on the endothelial side of the membrane and the epithelial cells form a confluent layer of epithelial cells on the epithelial side of the membrane.
摘要翻译：本发明提供了一种人造器官系统，其包括内皮细胞层，上皮细胞层和设置在内皮细胞层和上皮细胞层之间间接接触的人造微孔膜，使得膜具有内皮侧和上皮侧。还提供了一种构建人造器官系统的方法，包括以下步骤：将人造微孔膜放置在组织培养井中，并且从孔的底部向选定距离支撑膜，以在井中形成上室和下室，膜具有面向井的底部和相对的上皮侧的内皮侧; 在使得内皮细胞在膜的上皮侧上形成汇合层的细胞的条件下将内皮细胞置于孔的上室中; 并将上皮细胞置于孔的上腔室中，使得内皮细胞迁移穿过膜中的孔并附着于膜的内皮侧，以在膜的内皮侧形成融合层的内皮细胞，上皮细胞在膜的上皮侧形成上皮细胞的汇合层。

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