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1. 发明申请

US20120065277A1 MICROFLUIDIC CHEMOSTAT 有权
标题翻译：微血管化学
公开(公告)号：US20120065277A1
公开(公告)日：2012-03-15
申请号：US13197654
申请日：2011-08-03
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： A01N61/00 , A01P1/00 , C12M1/00
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

2. 发明申请

US20090018195A1 MICROFLUIDIC CHEMOSTAT 有权
标题翻译：微血管化学
公开(公告)号：US20090018195A1
公开(公告)日：2009-01-15
申请号：US12182088
申请日：2008-07-29
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： A01N37/02 , A01P1/00
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

3. 发明申请

US20140141497A1 MICROFLUIDIC CHEMOSTAT 有权
标题翻译：微血管化学
公开(公告)号：US20140141497A1
公开(公告)日：2014-05-22
申请号：US13850988
申请日：2013-03-26
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： C12M1/00
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

4. 发明授权

US08426159B2 Microfluidic chemostat 有权
标题翻译：微流控恒化器
公开(公告)号：US08426159B2
公开(公告)日：2013-04-23
申请号：US13197654
申请日：2011-08-03
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： C12P1/00 , C12Q1/28
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

5. 发明授权

US08017353B2 Microfluidic chemostat 有权
标题翻译：微流控恒化器
公开(公告)号：US08017353B2
公开(公告)日：2011-09-13
申请号：US12182088
申请日：2008-07-29
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： C12P1/00 , C12M1/36 , C12M3/00 , C12M3/08 , C12M1/33
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

6. 发明授权

US07407799B2 Microfluidic chemostat 有权
标题翻译：微流控恒化器
公开(公告)号：US07407799B2
公开(公告)日：2008-08-05
申请号：US11012852
申请日：2004-12-14
申请人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
发明人： Frederick Balagadde , Carl L. Hansen , Emil Kartalov , Stephen R. Quake
IPC分类号： C12P19/04 , C12M1/00
CPC分类号： C12P19/04 , B01L3/5027 , B01L3/502738 , B01L2300/0861 , B01L2300/0877 , B01L2300/10 , B01L2300/163 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34 , C12M39/00 , C12P1/00
摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
摘要翻译：描述了一种恒温器，其包括具有多个室的生长室。每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。另外，描述了在恒化器的生长室中防止生物膜形成的方法。该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

7. 发明授权

US08709153B2 Microfludic protein crystallography techniques 失效
标题翻译：微氟蛋白晶体学技术
公开(公告)号：US08709153B2
公开(公告)日：2014-04-29
申请号：US13280276
申请日：2011-10-24
申请人： Carl L. Hansen , Stephen R. Quake , James M. Berger
发明人： Carl L. Hansen , Stephen R. Quake , James M. Berger
IPC分类号： C30B7/14
CPC分类号： C30B7/14 , F17D5/005 , F17D5/06 , Y10T137/0318 , Y10T137/0391
摘要： The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
摘要翻译：本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。

8. 发明授权

US08021480B2 Microfluidic free interface diffusion techniques 有权
标题翻译：微流体界面扩散技术
公开(公告)号：US08021480B2
公开(公告)日：2011-09-20
申请号：US12762170
申请日：2010-04-16
申请人： Carl L. Hansen , Stephen R. Quake , James M. Berger
发明人： Carl L. Hansen , Stephen R. Quake , James M. Berger
IPC分类号： C30B29/02
CPC分类号： C30B7/14 , B01F5/00 , B01F13/0093 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502738 , B01L3/502746 , B01L3/502769 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B1/00 , C30B29/02 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T117/1004 , Y10T117/1008 , Y10T117/1012 , Y10T137/0318 , Y10T137/0324 , Y10T137/2224 , Y10T436/25
摘要： A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays.
摘要翻译：将静态流体和第二流体沿微流体界面放置接触，并允许通过扩散混合而不对流流过该界面。根据本发明的一个实施例，流体是静态的，并且最初位于微流体通道中的封闭阀结构的任一侧上，该微流体通道的宽度被紧紧地约束在至少一个维度上。然后打开阀门，并且微流体通道两侧的防滑层抑制沿着所得界面的两种流体之间的对流混合。根据本发明的实施方案的用于微流体自由界面的应用包括但不限于蛋白质结晶研究，蛋白质溶解度研究，流体系统的性质的确定以及各种生物测定如扩散免疫测定，底物转换测定和竞争性结合测定。

9. 发明授权

US07413712B2 Microfluidic rotary flow reactor matrix 有权
标题翻译：微流控旋流反应器基体
公开(公告)号：US07413712B2
公开(公告)日：2008-08-19
申请号：US10837025
申请日：2004-04-30
申请人： Jian Liu , Carl L. Hansen , Stephen R. Quake
发明人： Jian Liu , Carl L. Hansen , Stephen R. Quake
IPC分类号： C12Q1/68 , F16K11/10 , F15C1/04
CPC分类号： B81B3/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00833 , B01J2219/00891 , B01J2219/0095 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/088 , B01L2300/123 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , C12Q1/68 , F04B43/043 , G01N2035/00158
摘要： A microfluidic device comprises a matrix of rotary flow reactors. The microfluidic matrix device offers a solution to the “world-to-chip” interface problem by accomplishing two important goals simultaneously: an economy of scale in reagent consumption is achieved, while simultaneously minimizing pipetting steps. N2 independent assays can be performed with only 2N+1 pipetting steps, using a single aliquot of enzyme amortized over all reactors. The chip reduces labor relative to conventional fluid handling techniques by using an order of magnitude less pipetting steps, and reduces cost by consuming two to three orders of magnitude less reagents per reaction. A PCR format has immediate applications in medical diagnosis and gene testing. Beyond PCR, the microfluidic matrix chip provides a universal and flexible platform for biological and chemical assays requiring parsimonious use of precious reagents and highly automated processing.
摘要翻译：微流体装置包括旋转流反应器的基质。微流体矩阵器件通过同时实现两个重要目标来提供“世界到芯片”接口问题的解决方案：实现了试剂消耗的规模经济，同时最大限度地减少了移液步骤。使用在所有反应器中摊销的酶的单等分试样，可以仅使用2N + 1移液步骤进行N 2 - 2独立测定。该芯片相对于常规流体处理技术通过使用少量的移液步骤来减少劳动，并且通过每次反应消耗两到三个数量级的试剂来降低成本。 PCR格式可以在医学诊断和基因检测中立即应用。除了PCR之外，微流体芯片芯片为生物和化学测定提供了通用和灵活的平台，需要简约地使用贵重的试剂和高度自动化的处理。

10. 发明申请

US20080173365A1 MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS 有权
公开(公告)号：US20080173365A1
公开(公告)日：2008-07-24
申请号：US11932107
申请日：2007-10-31
申请人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
发明人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
IPC分类号： F15C1/06
CPC分类号： B05D3/04 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/06 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B65B31/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6832 , C12Q1/6874 , C30B29/54 , F04B43/043 , F15C1/06 , F15C3/00 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T137/0379 , Y10T137/0424 , Y10T137/206 , Y10T137/2082 , Y10T137/2164 , Y10T137/2169 , Y10T137/2174 , Y10T137/2202 , Y10T137/2224 , Y10T137/3084 , Y10T137/7837 , Y10T137/86027 , Y10T156/10 , Y10T428/24479 , Y10T428/24612 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

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