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1. 发明申请

US20100144558A1 SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES 有权
标题翻译：使用基因表达标记生物测定生物测定的系统和方法
公开(公告)号：US20100144558A1
公开(公告)日：2010-06-10
申请号：US12438944
申请日：2007-08-24
申请人： Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
发明人： Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
IPC分类号： C40B60/12
CPC分类号： C40B60/12 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2300/0636 , B01L2300/1827 , C40B30/10 , G01T1/02
摘要： Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
摘要翻译：根据基因表达的变化，暴露于电离辐射可以产生明确的剂量依赖性特征。在本文描述的方法和装置中，可以使用这种签名来产生和使用基于例如血液手指棒的独立的辐射生物测定装置。本发明的各个方面涉及使用基因表达特征的具有完全整合的生物芯片的生物测定法。

2. 发明授权

US09255348B2 Systems and methods for biodosimetry with biochip using gene expression signatures 有权
标题翻译：使用基因表达特征的生物芯片生物测定法的系统和方法
公开(公告)号：US09255348B2
公开(公告)日：2016-02-09
申请号：US12438944
申请日：2007-08-24
申请人： Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
发明人： Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
IPC分类号： C12M1/34 , C40B60/12 , B01L3/00 , C40B30/10 , G01T1/02
CPC分类号： C40B60/12 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2300/0636 , B01L2300/1827 , C40B30/10 , G01T1/02
摘要： Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
摘要翻译：根据基因表达的变化，暴露于电离辐射可以产生明确的剂量依赖性特征。在本文描述的方法和装置中，可以使用这种签名来产生和使用基于例如血液手指棒的独立的辐射生物测定装置。本发明的各个方面涉及使用基因表达特征的具有完全整合的生物芯片的生物测定法。

3. 发明申请

US20080176755A1 SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES 审中-公开
标题翻译：使用基因表达标记生物测定生物测定的系统和方法
公开(公告)号：US20080176755A1
公开(公告)日：2008-07-24
申请号：US11844906
申请日：2007-08-24
申请人： Sally A. Amundson , Daniel Attinger , Chee Wei Wong
发明人： Sally A. Amundson , Daniel Attinger , Chee Wei Wong
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： C40B60/12 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2300/0636 , B01L2300/1827 , C40B30/10 , G01T1/02
摘要： Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
摘要翻译：根据基因表达的变化，暴露于电离辐射可以产生明确的剂量依赖性特征。在本文描述的方法和装置中，可以使用这种签名来产生和使用基于例如血液手指棒的独立的辐射生物测定装置。本发明的各个方面涉及使用基因表达特征的具有完全整合的生物芯片的生物测定法。

4. 发明授权

US07563573B2 Method for detecting radiation exposure 失效
标题翻译：辐射暴露检测方法
公开(公告)号：US07563573B2
公开(公告)日：2009-07-21
申请号：US11370079
申请日：2006-03-06
申请人： Albert J. Fornace, Jr. , Sally A. Amundson , Jeffrey M. Trent
发明人： Albert J. Fornace, Jr. , Sally A. Amundson , Jeffrey M. Trent
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/68 , C12Q1/6888 , C12Q2600/106 , C12Q2600/158 , C12Q2565/501 , C12Q2523/313
摘要： A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate biological effects, such as patterns of expression of genes after radiation exposure. Numerous genes are provided which have been found to be responsive to radiation exposure in a variety of cell lines. These genes are incorporated into probe sets, which are exposed to a labeled nucleic acid composition from a test cell, such as cDNA reverse transcribed from mRNA in the test cell, which specifically hybridizes to members of the probe set when the cell has been exposed to a biologically significant amount of ionizing radiation. Whether the nucleic acid composition hybridizes to the nucleic acid molecules representing genes that are differentially expressed is determined. The invention also includes methods for determining a dose response relationship between radiation exposure and differential expression of one or more genes, for example to determine a probable radiation dose in cells that have actually or potentially been exposed to the ionizing radiation. The invention also includes probe sets and microarrays used in this method.
摘要翻译：公开了一种用于检测生物体对生物显着或有害量的电离辐射的暴露的方法。该方法使用核酸微阵列杂交来评估生物学效应，例如辐射暴露后基因表达的模式。已经发现已经发现许多基因对多种细胞系中的辐射暴露有反应。将这些基因并入探针组中，其从测试细胞暴露于标记的核酸组合物，例如在测试细胞中从mRNA反向转录的cDNA，当细胞暴露于细胞时，该特异性与探针组的成员杂交生物显着量的电离辐射。确定核酸组合物是否与表达差异表达基因的核酸分子杂交。本发明还包括用于确定辐射暴露与一种或多种基因的差异表达之间的剂量反应关系的方法，例如确定实际上或潜在地暴露于电离辐射的细胞中的可能的辐射剂量。本发明还包括在该方法中使用的探针组和微阵列。

5. 发明授权

US07008768B1 Method for detecting radiation exposure 失效
公开(公告)号：US07008768B1
公开(公告)日：2006-03-07
申请号：US09913171
申请日：2000-02-25
申请人： Albert J. Fornace, Jr. , Sally A. Amundson , Jeffrey M. Trent
发明人： Albert J. Fornace, Jr. , Sally A. Amundson , Jeffrey M. Trent
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/68 , C12Q1/6888 , C12Q2600/106 , C12Q2600/158 , C12Q2565/501 , C12Q2523/313
摘要： A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate biological effects, such as patterns of expression of genes after radiation exposure. Numerous genes are provided which have been found to be responsive to radiation exposure in a variety of cell lines. These genes are incorporated into probe sets, which are exposed to a labeled nucleic acid composition from a test cell, such as cDNA reverse transcribed from mRNA in the test cell, which specifically hybridizes to members of the probe set when the cell has been exposed to a biologically significant amount of ionizing radiation. Whether the nucleic acid composition hybridizes to the nucleic acid molecules representing genes that are differentially expressed is determined. The invention also includes methods for determining a dose response relationship between radiation exposure and differential expression of one or more genes, for example to determine a probable radiation dose in cells that have actually or potentially been exposed to the ionizing radiation. The invention also includes probe sets and microarrays used in this method.

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