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1. 发明授权

US4645775A Positive inotropic 3-nitro-5-substituted ester and thioester-1,4-dihydropyridines 失效
标题翻译：正性收缩性3-硝基-5-取代酯和硫酯-1,4-二氢吡啶
公开(公告)号：US4645775A
公开(公告)日：1987-02-24
申请号：US734502
申请日：1985-05-15
申请人： Jurgen Stoltefuss , Fred R. Heiker , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Jurgen Stoltefuss , Fred R. Heiker , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/04 , A61P9/12 , C07D211/90 , C07D401/12 , C07D413/04
CPC分类号： C07D401/12 , C07D211/90 , C07D413/04
摘要： Novel 3-nitro-dihydropyridine derivatives of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## Z is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring form the ring ##STR3## X is oxygen or sulphur, A is a hydrocarbon radical with up to 12 C atoms which optionally contains one or two identical or different chain members from the group comprising O, S and CO and/or which is optionally substituted by hydroxyl or aliphatic acyloxy with up to 4 C atoms,R.sub.3 is --O--COR.sub.6, --S--CO--R.sub.6, SH, OH , NH.sub.2, ##STR4## NH--COR.sub.6, COOR.sub.6, NR.sub.7 R.sub.8 or CONR.sub.7 R.sub.8, R.sub.6 is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical, andR.sub.7 and R.sub.8 each independently is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical,or a physiologically acceptable salts thereof, which are active in circulation and exhibit positive inotropic activity.
摘要翻译：其中R 1和R 2各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 12 - 烷氧基，C 1 -C 4 - 卤代烷氧基，卤素，硝基，C 1 -C 4 - 卤代烷基的新颖的3-硝基 - 二氢吡啶衍生物，C 1 -C 4卤代烷基巯基，Z为氧或硫，R 4和R 5各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，卤素，C 1 -C 4 - 卤代烷基，C 1 -C 4卤代烷氧基或硝基或R1和R2与苯环的2 C原子一起形成环，X是氧或硫，A是具有至多12个C原子的烃基，其任选地含有一个或两个相同或不同的链成员由包含O，S和CO的基团和/或其任选被具有至多4个C原子的羟基或脂族酰氧基取代，R 3是-O-COR 6，-S-CO-R 6，SH，OH，NH 2， > NH-COR 6，COOR 6，NR 7 R 8或CONR 7 R 8，R 6是氢或具有至多6个C原子或苯基的脂族基团，并且R 7和R 8各自独立地为氢或至多6个碳原子的脂族基团 oms或苯基或其生理上可接受的盐，其在循环中具有活性并表现出正性肌力活性。

2. 发明授权

US4537881A 5-Nitro 1,4-dihydropyridines having a positive inotropic effect 失效
标题翻译：具有正性肌力作用的5-硝基1,4-二氢吡啶类
公开(公告)号：US4537881A
公开(公告)日：1985-08-27
申请号：US627596
申请日：1984-07-03
申请人： Fred R. Heiker , Jurgen Stoltefuss , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Fred R. Heiker , Jurgen Stoltefuss , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： A61K31/70 , A61K31/7028 , A61P3/08 , A61P9/04 , A61P9/12 , C07H15/04 , C07H15/06 , C07H15/12 , C07H15/14 , C07H15/26 , A61K31/41 , A61K31/395 , C07D405/12
CPC分类号： C07H15/06 , C07H15/04 , C07H15/14 , C07H15/26
摘要： Novel 1,4-dihydropyridines of the fomula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## in which Z is oxygen or sulphur, andR.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring, form the ring ##STR3## X is oxygen, sulphur or the radical NR.sub.6, R.sub.6 is a C.sub.1 -C.sub.6 -alkyl group,A is a C.sub.2 -C.sub.10 -alkylene group, it being necessary that at least two C atoms are located in the alkylene chain which connects the carbonyloxy group to X, andR.sub.3 is a monosaccharide or disaccharide moiety or a protected monosaccharide or disaccharide moiety,or pharmaceutically acceptable addition salts thereof, which exhibit positive inotropic activity and are useful in treating circulatory disorders.
摘要翻译： R1和R2各自独立地为氢，C1-C4-烷基，C1-C12-烷氧基，C1-C4-卤代烷氧基，卤素，硝基，C1-C4-卤代烷基， C1-C4卤代烷基巯基，其中Z是氧或硫，R4和R5各自独立地是氢，C1-C4-烷基，C1-C6-烷氧基，卤素，C1-C4-卤代烷基，C1-C4-卤代烷基，卤代烷氧基或硝基，或R 1和R 2与苯环的2 C原子一起形成环，X为氧，硫或基团NR 6，R 6为C 1 -C 6 - 烷基，A为C 2 - C10亚烷基，必须至少两个C原子位于将羰氧基连接到X的亚烷基链中，R3是单糖或二糖部分或受保护的单糖或二糖部分，或其药学上可接受的加成盐，其表现出正性肌力活性并且可用于治疗循环障碍。

3. 发明授权

US4772611A Circulation-active 3-amino-dihydropyridines 失效
标题翻译：循环活性3-氨基 - 二氢吡啶
公开(公告)号：US4772611A
公开(公告)日：1988-09-20
申请号：US43656
申请日：1987-04-28
申请人： Jurgen Stoltefuss , Fred R. Heiker , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
发明人： Jurgen Stoltefuss , Fred R. Heiker , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/505 , A61P9/00 , C07D211/84 , C07D211/90 , C07D401/04 , C07D409/04 , C07D413/04 , C07D491/04 , C07D491/048 , A61K31/455
CPC分类号： C07D491/04 , C07D211/84 , C07D211/90
摘要： Novel cardioactive compounds of the formula ##STR1## in which R.sup.1 is alkyl, aryl or heterocyclic, preferably substituted phenyl,R.sup.2 is alkyl, preferably methyl,R.sup.3 is hydrogen, halogen, acyloxy or alkyl, preferably hydrogen, andR.sup.4 is phenyl, carbalkoxy or together with R.sup.3 forms a ring, preferably carbalkoxy,are produced by reducing the corresponding nitro compounds.
摘要翻译：式（IMAGE）的新型心脏活性化合物，其中R 1是烷基，芳基或杂环，优选取代的苯基，R 2是烷基，优选甲基，R 3是氢，卤素，酰氧基或烷基，优选氢，R 4是苯基，通过还原相应的硝基化合物与R3一起形成环，优选为烷氧基。

4. 发明授权

US4772612A Circulation-active 1,4-dihydropyridines 失效
标题翻译：循环活性1,4-二氢吡啶类
公开(公告)号：US4772612A
公开(公告)日：1988-09-20
申请号：US870042
申请日：1986-06-03
申请人： Siegfried Goldmann , Jurgen Stoltefuss , Gerhard Franckowiak , Rainer Gross , Matthias Schramm , Gunter Thomas
发明人： Siegfried Goldmann , Jurgen Stoltefuss , Gerhard Franckowiak , Rainer Gross , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/455 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , C07D211/90 , C07D333/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/04 , C07D491/048
CPC分类号： C07D409/12 , C07D211/90 , C07D491/04
摘要： Novel circulation active dihydropyridines of the formula ##STR1## in which X is CO, SO.sub.2 or CONH,R.sup.4 is H, OH, alkyl, halogen, acyloxy, alkoxyalkoxy, aralkyloxy, or together with R.sup.5 forms a heterocyclic ring, andthe other radicals are conventional in the dihydropyridine art,and pharmaceutically acceptable salts thereof.
摘要翻译：其中X为CO，SO 2或CONH，R 4为H，OH，烷基，卤素，酰氧基，烷氧基烷氧基，芳烷氧基或与R 5一起形成杂环的新型循环活性二氢吡啶类化合物，其中X为CO，SO2或CONH，在二氢吡啶领域中是常规的，及其药学上可接受的盐。

5. 发明授权

US4540684A 3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity 失效
标题翻译：具有正性肌力活性的3-硝基-5-酰胺-1,4-二氢吡啶
公开(公告)号：US4540684A
公开(公告)日：1985-09-10
申请号：US612093
申请日：1984-05-18
申请人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： A61K31/455 , A61P3/08 , A61P9/02 , A61P9/04 , C07D211/90 , C07D211/98 , A61K31/70 , C07D405/12
CPC分类号： C07D211/90
摘要： A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, andR.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.sub.1 -C.sub.8 -alkyl chain to the amide nitrogen atomor a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.
摘要翻译：其中R和R 1各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 12 - 烷氧基，C 1 -C 4卤代烷氧基，卤素，硝基，三氟甲基， X是氧或硫，R4和R5各自独立地是氢，C1-C4-烷基，C1-C6-烷氧基，卤素，三氟甲基，氨基或硝基，R2和R3各自独立地是氢，C1-C10 - 烷基，C 2 -C 10 - 烯基或C 3 -C 10 - 炔基，其任选被卤素，羟基，C 1 -C 4 - 烷氧基，氨基，单 - 和二-C 1 -C 4 - 烷基氨基，C 1 -C 6 - 和/或硝基，C3至C6元环烷基，任选被C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，卤素，氨基和/或硝基取代的苯基，或苯基-C 1 -C 3 - 烷基或通过C1-C8烷基链任选与酰胺氮原子键合的碳水化合物基团或其药学上可接受的酸加成盐，其改善心脏的收缩力，使血压升高 ure，降低血糖，减少粘膜肿胀，影响患者的盐和液体平衡。

6. 发明授权

US4895855A Mixture of different dihydropyridines 失效
标题翻译：不同二氢吡啶的混合物
公开(公告)号：US4895855A
公开(公告)日：1990-01-23
申请号：US806160
申请日：1985-12-06
申请人： Siegfried Goldmann , Horst Boshagen , Friedrich Bossert , Gerhard Franckowiak , Horst Meyer , Jurgen Stoltefuss , Rainer Gross , Matthias Schramm , Gunter Thomas
发明人： Siegfried Goldmann , Horst Boshagen , Friedrich Bossert , Gerhard Franckowiak , Horst Meyer , Jurgen Stoltefuss , Rainer Gross , Matthias Schramm , Gunter Thomas
IPC分类号： C07D211/90 , A61K31/435 , A61K31/44 , A61K31/455 , A61P9/08 , A61P9/10 , A61P43/00 , C07D491/044 , C07D491/048 , C07D495/04
CPC分类号： A61K31/44
摘要： A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinforcing.
摘要翻译：有效治疗循环障碍的组合物包含（I）和（II）的混合物，其中变量可以有不同的会议。我是变力和II是血管舒张，但是组合中的成分预计是对抗性的，它们是加强的。

7. 发明授权

US5008279A Circulation-active fluoromethoxyphenyl dihydropyridine compounds 失效
标题翻译：循环活性氟甲氧基苯基二氢吡啶化合物
公开(公告)号：US5008279A
公开(公告)日：1991-04-16
申请号：US263671
申请日：1988-10-27
申请人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
发明人： Gerhard Franckowiak , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Michael Kayser , Siegbert Hebisch , Matthias Schramm
IPC分类号： A61K31/445 , A61K31/451 , A61P9/08 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine andR stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted(a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or(b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or(c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms,and salts thereof.
摘要翻译：式（I）的循环活性氟甲氧基苯基二氢吡啶，其中X代表氢或氟，R代表可被1至2个氧中断的具有2至12个碳原子的直链，支链或环状烷基或链烯基和/或链中的硫原子，并且其可以被羟基，具有6至12个碳原子的芳基，具有6至12个碳原子的芳氧基单取代或多取代（a），其中芳基再次被具有至多 4个碳原子，具有至多4个碳原子的烷氧基或卤素，取代基相同或不同，或（b）由羧基，具有至多6个碳原子的烷氧基羰基，吡啶基，哌啶基，嘧啶基，具有至多7个碳原子的酰氧基，氨基甲酰基，氨基甲酰基，卤素或氰基，取代基相同或不同，或（c）氨基，其中氨基可以带有一个或两个相同或不同的取代基，由至多6个碳原子的烷基 ms，苄基，苯基或具有至多7个碳原子的酰基及其盐。

8. 发明授权

US5420142A Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical composition and use 失效
标题翻译：某些3-甲酰基-1,4-二氢吡啶及其药物组成和用途
公开(公告)号：US5420142A
公开(公告)日：1995-05-30
申请号：US166671
申请日：1993-12-14
申请人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding , Matthias Schramm
发明人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding , Matthias Schramm
IPC分类号： A61K31/435 , A61K31/47 , A61P9/00 , A61P9/12 , C07D211/90 , C07D401/04
CPC分类号： C07D401/04 , C07D211/90
摘要： The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation.
摘要翻译：本发明涉及3-甲酰基-1,4-二氢吡啶衍生物作为药物用于控制心血管疾病，特别是病理改变的血压和心功能不全的新用途及其制备方法。

9. 发明授权

US4764516A Mixtures of optically active nitrodihydropyridines active on the circulatory system 失效
标题翻译：在循环系统上活跃的光学活性硝基二氢吡啶的混合物
公开(公告)号：US4764516A
公开(公告)日：1988-08-16
申请号：US806071
申请日：1985-12-06
申请人： Gerhard Franckowiak , Rolf Grosser , Gunter Thomas , Matthias Schramm , Rainer Gross
发明人： Gerhard Franckowiak , Rolf Grosser , Gunter Thomas , Matthias Schramm , Rainer Gross
IPC分类号： A61K31/4427 , A61K31/455 , A61K31/505 , A61P9/04 , A61P9/06 , A61P9/08 , C07D211/90 , C07D401/04
CPC分类号： C07D401/04 , C07D211/90
摘要： Pure enantiomers of 5-nitrodihydropyridine of the formula ##STR1## are mixed, wherein one of the enantiomers has a high vasodilative action and a low negative inotropic activity on heart muscle, the other enantiomer has a low vasoconstrictive action and a high positive inotropic activity on heart muscle, the mixture being high in vasodilative activity and in positive inotropic activity on heart muscle.
摘要翻译：混合式为“IMAGE”的5-硝基二氢吡啶的纯对映异构体，其中一种对映异构体对心肌具有高血管扩张作用和低负性肌力活性，另一种对映异构体具有低的血管收缩作用和高的正性肌力活性心脏肌肉，混合物具有高血管扩张活性和心脏肌肉正性肌力活动。

10. 发明授权

US4628107A Intermediate 8-carboxaldehyde-(-chromone and -thiochromone) derivatives 失效
标题翻译：中间体8-甲醛 - （ - 色酮和硫代色酮）衍生物
公开(公告)号：US4628107A
公开(公告)日：1986-12-09
申请号：US750571
申请日：1985-06-28
申请人： Siegfried Goldmann , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Siegfried Goldmann , Gerhard Franckowiak , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： C07D211/90 , C07D311/22 , C07D311/24 , C07D311/30 , C07D335/06 , C07D405/04 , C07D409/04 , C07D409/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
CPC分类号： C07D335/06 , C07D211/90 , C07D311/22 , C07D311/24 , C07D311/30 , C07D405/04 , C07D409/04 , C07D409/14
摘要： Novel chromone-8-aldehydes and thiochromone-8-aldehydes, useful in making pharmaceutically active dihydropyridines, of the formula ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1 -C.sub.10 aliphatic hydrocarbon radical, a C.sub.1 -C.sub.10 alkyl carboxylate, or an aromatic or heteroaromatic ring which optionally has 1-5 identical or different halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, cyano, hydroxyl, nitro, C.sub.1 -C.sub.5 -monofluoroalkyl or polyfluoroalkyl, C.sub.1 -C.sub.5 monofluoroalkoxy or polyfluoroalkoxy, C.sub.1 -C.sub.6 monofluoroalkylthio or polyfluoroalkylthio, amino, C.sub.1 -C.sub.5 -monoalkylamino or C.sub.1 -C.sub.5 dialkylamino substituents,R.sub.2 represents hydrogen or 1 to 3 halogen atoms, A represents a single bond, a C.sub.1 -C.sub.20 alkylene chain or a C.sub.2 -C.sub.20 alkylene chain which can optionally be interrupted by oxygen or sulphur, andX represents oxygen or sulphur,are made from corresponding compounds which in 8-position carry an ester or olefinic radical.
摘要翻译：可用于制备药物活性二氢吡啶的新颖的色酮-8-醛和硫色酮-8-醛，其具有式“IMAGE”，其中R 1表示氢，C 1 -C 10脂族烃基，C 1 -C 10烷基羧酸酯或芳族或任选具有1-5个相同或不同的卤素，C 1 -C 10 - 烷基，C 1 -C 10 - 烷氧基，C 1 -C 10 - 烷硫基，C 1 -C 10 - 烷基亚磺酰基，氰基，羟基，硝基，C 1 -C 5 - 单氟烷基或多氟烷基，C 1 -C 5单氟烷氧基或多氟烷氧基，C 1 -C 6单氟烷硫基或多氟烷硫基，氨基，C 1 -C 5单烷基氨基或C 1 -C 5二烷基氨基取代基，R 2表示氢或1至3个卤素原子，A表示单键，亚烷基链或可任选被氧或硫中断的C 2 -C 20亚烷基链，X表示氧或硫，由相应的8-位带有酯或烯基的化合物制成。

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