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1. 发明授权

US5876187A Micropumps with fixed valves 失效
标题翻译：带固定阀的微型泵
公开(公告)号：US5876187A
公开(公告)日：1999-03-02
申请号：US401546
申请日：1995-03-09
申请人： Fred K. Forster , Ronald L. Bardell , Alan P. Blanchard , Martin A. Afromowitz , Nigel R. Sharma
发明人： Fred K. Forster , Ronald L. Bardell , Alan P. Blanchard , Martin A. Afromowitz , Nigel R. Sharma
IPC分类号： B81B3/00 , F04B43/04 , F04B53/10 , F15C5/00 , F16K99/00 , F04B17/00
CPC分类号： F16K99/0001 , F04B43/046 , F04B53/1077 , F15C5/00 , F16K99/0003 , F16K99/0021 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , F16K2099/0092 , F16K2099/0094 , Y10T137/212 , Y10T137/2185 , Y10T137/2224
摘要： Micropumps fabricated by micromachining techniques and employing fixed or no-moving-parts valves. As one aspect of the invention, a laser-assisted chemical etching technique is employed for providing smooth-walled, curved configuration necessary to obtain the desired flow characteristics of the valves that are used in conjunction with the micropump.
摘要翻译：通过微加工技术制造的微泵，并采用固定或不动元件阀门。作为本发明的一个方面，采用激光辅助化学蚀刻技术来提供平滑壁弯曲结构，以获得与微型泵结合使用的阀所需的流动特性。

2. 发明申请

US20090029867A1 DNA purification and analysis on nanoengineered surfaces 审中-公开
标题翻译：纳米工程表面的DNA纯化和分析
公开(公告)号：US20090029867A1
公开(公告)日：2009-01-29
申请号：US11880790
申请日：2007-07-24
申请人： Michael W. Reed , Bernhard H. Weigl , Ronald L. Bardell
发明人： Michael W. Reed , Bernhard H. Weigl , Ronald L. Bardell
IPC分类号： C40B30/04 , C40B60/00 , C40B50/14
CPC分类号： B01L3/502707 , B01L3/5027 , B01L2200/027 , B01L2300/0636 , B01L2300/0896 , B82Y30/00 , C12N15/1006 , C12Q1/6806 , C12Q1/6813 , G01N1/34 , G01N21/6428 , G01N21/645 , C12Q2565/629 , C12Q2563/173 , C12Q2563/107
摘要： A microfluidic device for isolating genomic DNA from human leukocytes, simultaneously capturing and measuring the DNA for simplifying genetic analysis. The device contains a fluid inlet port, a fluid outlet port, and a DNA binding channel in contact with the fluid inlet port wherein at least a portion of at least one surface within the DNA binding channel is modified with a binding reagent such that DNA is preferentially bound to the surface.
摘要翻译：用于从人白细胞中分离基因组DNA的微流体装置，同时捕获和测量DNA以简化遗传分析。该装置包含流体入口，流体出口和与流体入口接触的DNA结合通道，其中DNA结合通道内的至少一个表面的至少一部分用结合试剂修饰，使DNA为优先与表面结合。

3. 发明申请

US20090215125A1 DEVICES AND PROCESSES FOR NUCLEIC ACID EXTRACTION 有权
标题翻译：用于核酸提取的装置和方法
公开(公告)号：US20090215125A1
公开(公告)日：2009-08-27
申请号：US12348244
申请日：2009-01-02
申请人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
发明人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
IPC分类号： C12P19/34 , B01L11/00 , C07H1/06 , C12N1/06
CPC分类号： C12Q1/6834 , B01L3/5027 , B01L3/502715 , B01L7/525 , B01L2200/027 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , B01L2400/0688 , B01L2400/084 , C12Q1/6806 , C12Q1/6851 , C12Q2565/629 , C12Q2563/173 , C12Q2565/137
摘要： Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
摘要翻译：公开了用于从生物样品中提取核酸的装置，方法和试剂盒。这些装置包括中间并与第一端口和第二端口流体连通的第一端口，第二端口和装订室。结合室包含有效用于结合异质核酸群体的未改性平板玻璃表面。第一端口，第二端口和结合室限定基本上不含核酸特异性结合位点的连续流体通路。

4. 发明授权

US06557427B2 Capillaries for fluid movement within microfluidic channels 有权
公开(公告)号：US06557427B2
公开(公告)日：2003-05-06
申请号：US09864099
申请日：2001-05-23
申请人： Bernhard H. Weigl , Gerald L. Klein , Ronald L. Bardell , C. Frederick Battrell
发明人： Bernhard H. Weigl , Gerald L. Klein , Ronald L. Bardell , C. Frederick Battrell
IPC分类号： G01N126
CPC分类号： G01N35/1097 , B01F5/0646 , B01F5/0647 , B01F13/0062 , B01F13/0093 , B01F15/0203 , B01F15/0233 , B01F2215/0431 , B01J19/0093 , B01L3/5027 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L9/527 , B01L2200/0621 , B01L2200/0636 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , B01L2400/0457 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/0688 , F15C1/14 , F16K99/0001 , F16K99/0017 , F16K99/0057 , F16K2099/0084 , G01N21/07 , G01N2035/00158 , G01N2035/00237 , G01N2035/00247 , G01N2035/00495
摘要： A capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.

5. 发明申请

US20090081771A1 SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE 有权
标题翻译：用于加热，冷却和热循环的微流控装置的系统和方法
公开(公告)号：US20090081771A1
公开(公告)日：2009-03-26
申请号：US12199613
申请日：2008-08-27
申请人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
发明人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
IPC分类号： C12M1/40
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/185 , B01L2300/1877
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

6. 发明授权

US06743399B1 Pumpless microfluidics 有权
标题翻译：无微波微流体
公开(公告)号：US06743399B1
公开(公告)日：2004-06-01
申请号：US09684094
申请日：2000-10-06
申请人： Bernhard H. Weigl , Clinton L. Williams , Jon W. Hayenga , Ronald L. Bardell , Thomas E. Schulte
发明人： Bernhard H. Weigl , Clinton L. Williams , Jon W. Hayenga , Ronald L. Bardell , Thomas E. Schulte
IPC分类号： B02L300
CPC分类号： G01N27/06 , B01F5/0646 , B01F5/0647 , B01F11/0082 , B01F13/0059 , B01F13/0093 , B01F13/0809 , B01L3/5023 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/10 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0403 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0457 , B01L2400/0466 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , F15C3/04 , F15C3/06 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/003 , F16K99/0061 , F16K2099/0078 , F16K2099/008 , G01N2035/00237 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A microfluidic device which operates without the need for an external power source. The device includes a body structure, at least one microscale channel within the structure, a port for introducing fluid into the channel, and a power source internal to the structure for propelling the fluid through the channel. Various structures are described which embody the invention.
摘要翻译：在不需要外部电源的情况下工作的微流体装置。该装置包括主体结构，结构内的至少一个微型通道，用于将流体引入通道的端口以及用于推动流体通过通道的结构内部的电源。描述了体现本发明的各种结构。

7. 发明授权

US06488896B2 Microfluidic analysis cartridge 有权
标题翻译：微流控分析盒
公开(公告)号：US06488896B2
公开(公告)日：2002-12-03
申请号：US09804777
申请日：2001-03-13
申请人： Bernhard H. Weigl , Gerald L. Klein , Ronald L. Bardell , Clinton L. Williams , Thomas H. Schulte
发明人： Bernhard H. Weigl , Gerald L. Klein , Ronald L. Bardell , Clinton L. Williams , Thomas H. Schulte
IPC分类号： G01L1100
CPC分类号： B01L3/502776 , B01L3/50273 , B01L3/502761 , B01L2200/10 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0457 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , Y10T436/15
摘要： A device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis. Single disposable cartridges for performing blood typing assays can be constructed using this technology.
摘要翻译：用于分析基于凝血和凝集的全血的样品溶液的装置，其不需要外部电源或移动部件来进行分析。可以使用该技术构建用于进行血液分型测定的单个一次性盒。

8. 发明申请

US20120237939A1 DEVICES AND PROCESSES FOR NUCLEIC ACID EXTRACTION 审中-公开
标题翻译：用于核酸提取的装置和方法
公开(公告)号：US20120237939A1
公开(公告)日：2012-09-20
申请号：US13452689
申请日：2012-04-20
申请人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
发明人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： C12Q1/6834 , B01L3/5027 , B01L3/502715 , B01L7/525 , B01L2200/027 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , B01L2400/0688 , B01L2400/084 , C12Q1/6806 , C12Q1/6851 , C12Q2565/629 , C12Q2563/173 , C12Q2565/137
摘要： Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
摘要翻译：公开了用于从生物样品中提取核酸的装置，方法和试剂盒。这些装置包括中间并与第一端口和第二端口流体连通的第一端口，第二端口和装订室。结合室包含有效用于结合异质核酸群体的未改性平板玻璃表面。第一端口，第二端口和结合室限定基本上不含核酸特异性结合位点的连续流体通路。

9. 发明授权

US07011791B2 Microfluidic devices for rotational manipulation of the fluidic interface between multiple flow streams 有权
标题翻译：用于旋转操纵多个流动之间的流体界面的微流体装置
公开(公告)号：US07011791B2
公开(公告)日：2006-03-14
申请号：US09956467
申请日：2001-09-18
申请人： Bernhard H. Weigl , Ronald L. Bardell , Andrew Kamholz , Matthew Munson , Eric Schilling , Kenneth Hawkins
发明人： Bernhard H. Weigl , Ronald L. Bardell , Andrew Kamholz , Matthew Munson , Eric Schilling , Kenneth Hawkins
IPC分类号： G01N21/00 , G01N31/22 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： F15C1/14 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/0093 , B01F15/0203 , B01F15/0233 , B01F2005/0031 , B01F2215/0431 , B01J19/0093 , B01L3/502776 , B01L2200/0621 , B01L2200/0636 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/161 , B01L2400/0406 , B01L2400/0457 , B01L2400/0655 , B01L2400/0688 , F16K99/0001 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , G01N21/07 , G01N2035/00237 , G01N2035/00495 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/2575
摘要： Microfluidic devices and methods are provided for enhancing detection of a diffusion pattern formed by particles diffusing between at least two fluid streams in parallel laminar flow such that an interface is formed between them by increasing the dimension of the streams in the diffusion direction. This may be accomplished by flowing the streams through a transforming turn, or by flowing the streams through a channel having diverging walls. Devices and methods are also provided for enhancing diffusion between two streams comprising changing the interface between said streams from a narrow interface to a broad interface.
摘要翻译：提供了微流体装置和方法，用于增强由在平行层流中的至少两个流体流之间扩散的颗粒形成的扩散图案的检测，使得通过增加流在扩散方向上的尺寸而在它们之间形成界面。这可以通过使流流经转化回转，或者使流流过具有发散壁的通道来实现。还提供了用于增强两个流之间的扩散的装置和方法，包括将所述流之间的界面从窄界面改变为宽界面。

10. 发明授权

US08163535B2 Devices and processes for nucleic acid extraction 有权
标题翻译：用于核酸提取的装置和方法
公开(公告)号：US08163535B2
公开(公告)日：2012-04-24
申请号：US12348244
申请日：2009-01-02
申请人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
发明人： Michael W. Reed , Oliver Z. Nanassy , Paul V. Haydock , Nigel Rudra Sharma , Ronald L. Bardell , Perry Hargrave
IPC分类号： C12M1/00 , C12M1/36 , G01N15/06 , C07H21/04
CPC分类号： C12Q1/6834 , B01L3/5027 , B01L3/502715 , B01L7/525 , B01L2200/027 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , B01L2400/0688 , B01L2400/084 , C12Q1/6806 , C12Q1/6851 , C12Q2565/629 , C12Q2563/173 , C12Q2565/137
摘要： Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
摘要翻译：公开了用于从生物样品中提取核酸的装置，方法和试剂盒。这些装置包括中间并与第一端口和第二端口流体连通的第一端口，第二端口和装订室。结合室包含有效用于结合异质核酸群体的未改性平板玻璃表面。第一端口，第二端口和结合室限定基本上不含核酸特异性结合位点的连续流体通路。

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