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1. 发明授权

US07785347B2 Surgical procedures and instruments 有权
标题翻译：外科手术和器械
公开(公告)号：US07785347B2
公开(公告)日：2010-08-31
申请号：US10540991
申请日：2003-12-30
申请人： Fraser Harvie , Graham Smith , Philip B. Sample , Gary R. McCarthy , Adam James , Peter Richardson , Sally L. Carter
发明人： Fraser Harvie , Graham Smith , Philip B. Sample , Gary R. McCarthy , Adam James , Peter Richardson , Sally L. Carter
IPC分类号： A61B17/04
CPC分类号： A61B17/3472 , A61B17/00491 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/0642 , A61B17/0644 , A61B17/068 , A61B17/1615 , A61B17/1622 , A61B17/1637 , A61B17/1684 , A61B17/686 , A61B17/8819 , A61B17/8836 , A61B17/8869 , A61B2017/005 , A61B2017/0404 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0437 , A61B2017/0438 , A61B2017/044 , A61B2017/0446 , A61B2017/0458 , A61B2017/0462 , A61B2017/0647 , A61F2/0805 , A61F2002/0888 , A61F2210/0085
摘要： Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.
摘要翻译：提供手术器械和方法。在一个方面，提供了一种将固定装置固定在组织内的开口内的方法，包括将材料以可流动状态传送到所述开口，并且改变材料的状态，使得材料形成干涉配合，固定装置在开口。

2. 发明授权

US07144414B2 Surgical procedures and instruments 有权
公开(公告)号：US07144414B2
公开(公告)日：2006-12-05
申请号：US10335491
申请日：2002-12-31
申请人： Fraser Harvie , Graham Smith , Philip B. Sample , Gary R. McCarthy , Adam James , Peter Richardson
发明人： Fraser Harvie , Graham Smith , Philip B. Sample , Gary R. McCarthy , Adam James , Peter Richardson
IPC分类号： A61B17/04
CPC分类号： A61B17/3472 , A61B17/00491 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/0642 , A61B17/0644 , A61B17/068 , A61B17/1615 , A61B17/1622 , A61B17/1637 , A61B17/1684 , A61B17/686 , A61B17/8819 , A61B17/8836 , A61B17/8869 , A61B2017/005 , A61B2017/0404 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0437 , A61B2017/0438 , A61B2017/044 , A61B2017/0446 , A61B2017/0458 , A61B2017/0462 , A61B2017/0647 , A61F2/0805 , A61F2002/0888 , A61F2210/0085
摘要： Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.

3. 发明申请

US20060149280A1 Surgical procedures and instruments 有权
公开(公告)号：US20060149280A1
公开(公告)日：2006-07-06
申请号：US10540991
申请日：2003-12-30
申请人： Fraser Harvie , Graham Smith , Philip Sample , Gary McCarthy , Adam James , Peter Richardson , Sally Carter
发明人： Fraser Harvie , Graham Smith , Philip Sample , Gary McCarthy , Adam James , Peter Richardson , Sally Carter
IPC分类号： A61F2/34
CPC分类号： A61B17/3472 , A61B17/00491 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/0642 , A61B17/0644 , A61B17/068 , A61B17/1615 , A61B17/1622 , A61B17/1637 , A61B17/1684 , A61B17/686 , A61B17/8819 , A61B17/8836 , A61B17/8869 , A61B2017/005 , A61B2017/0404 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0437 , A61B2017/0438 , A61B2017/044 , A61B2017/0446 , A61B2017/0458 , A61B2017/0462 , A61B2017/0647 , A61F2/0805 , A61F2002/0888 , A61F2210/0085
摘要： Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.

4. 发明授权

US06620185B1 Surgical procedures and instruments 有权
标题翻译：外科手术和器械
公开(公告)号：US06620185B1
公开(公告)日：2003-09-16
申请号：US09604387
申请日：2000-06-27
申请人： Fraser Harvie , Adam James , Peter Richardson , James William Huckle
发明人： Fraser Harvie , Adam James , Peter Richardson , James William Huckle
IPC分类号： A61B1704
CPC分类号： A61B17/0642 , A61B17/00491 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/0644 , A61B17/068 , A61B17/1637 , A61B17/1684 , A61B17/8836 , A61B2017/005 , A61B2017/0404 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0437 , A61B2017/0446 , A61B2017/0462 , A61B2017/0647
摘要： Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.
摘要翻译：提供手术器械和方法。在一个方面，提供了一种将固定装置固定在组织内的开口内的方法，包括将材料以可流动状态传送到所述开口，并且改变材料的状态，使得材料形成干涉配合，固定装置在开口。

5. 发明授权

US08119593B2 Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin 有权
标题翻译：二甲双胍和超速胰岛素治疗糖尿病2型的方法
公开(公告)号：US08119593B2
公开(公告)日：2012-02-21
申请号：US12539459
申请日：2009-08-11
申请人： Peter Richardson , Robert A. Baughman , Elizabeth Potocka , Anders Hasager Boss , Richard Petrucci
发明人： Peter Richardson , Robert A. Baughman , Elizabeth Potocka , Anders Hasager Boss , Richard Petrucci
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K38/28 , A61K9/0021 , A61K9/0075 , A61K47/545
摘要： Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
摘要翻译：本文公开了一种通过超快速作用的胰岛素和甘精胰岛素的组合治疗高血糖的改进方法，其包括餐前施用超级胰岛素，以及在醒来6小时内施用第一剂甘精胰岛素。

6. 发明申请

US20090112446A1 Oxygen sensor monitoring 失效
标题翻译：氧传感器监控
公开(公告)号：US20090112446A1
公开(公告)日：2009-04-30
申请号：US11976607
申请日：2007-10-25
申请人： Peter Richardson , Kenichi Fujiki
发明人： Peter Richardson , Kenichi Fujiki
IPC分类号： G06F17/00
CPC分类号： F02D41/222 , B60W2510/0638 , B60W2510/0676 , B60W2520/10 , B60W2540/10 , B60W2550/12 , F02D41/1441 , Y02T10/40
摘要： To avoid potentially erroneous results, monitoring the operation of an oxygen sensor of an internal combustion engine of a motor vehicle to detect a slow response of the oxygen sensor as indicative of an oxygen sensor fault is temporarily suspended in response to a brake operation transition of a braking system of the vehicle.
摘要翻译：为了避免潜在的错误结果，监测机动车辆的内燃机的氧传感器的操作以检测作为氧传感器故障的氧传感器的慢响应，响应于制动操作转换车辆制动系统。

7. 发明申请

US20060234975A1 Use of adenosine receptor agonists in therapy 失效
标题翻译：腺苷受体激动剂在治疗中的应用
公开(公告)号：US20060234975A1
公开(公告)日：2006-10-19
申请号：US10547454
申请日：2004-03-05
申请人： Peter Richardson
发明人： Peter Richardson
IPC分类号： A61K31/7076
CPC分类号： A61K31/7076 , Y02A50/411
摘要： Use of compounds of formula: (I) wherein R is C1-4 alkoxy and X is H or OH; for the prevention, treatment, or amelioration of cancer, inflammation, auto-immune disease, ischemia-reperfusion injury, epilepsy, sepsis, septic shock, neurode-generation (including Alzheimer's Disease), muscle fatigue or muscle cramp is described. The compounds are effective at very low doses, and so can be administered at doses at which serious side effects are not observed.
摘要翻译：使用式（I）的化合物，其中R是C 1-4烷氧基，X是H或OH; 描述了预防，治疗或改善癌症，炎症，自身免疫疾病，缺血再灌注损伤，癫痫，败血症，败血症休克，神经发生（包括阿尔茨海默病），肌肉疲劳或肌肉抽筋的预防，治疗或改善。这些化合物在非常低的剂量下是有效的，因此可以在没有观察到严重副作用的剂量下给药。

8. 发明授权

US5752506A Ventilator system 失效
标题翻译：呼吸机系统
公开(公告)号：US5752506A
公开(公告)日：1998-05-19
申请号：US700840
申请日：1996-08-21
申请人： Peter Richardson
发明人： Peter Richardson
IPC分类号： A61M16/00 , A61M16/04 , A61M16/08 , A61H31/00
CPC分类号： A61M16/0463 , A61M16/0096 , A61M16/0858 , A61M2016/0027
摘要： A ventilation system for use in ventilating a patient includes a source of pressurized gas, a primary delivery conduit to communicate and transmit the pressurized gas, an endotracheal tube for insertion into the patient's mouth and throat, and an adapter. The adapter includes a first side aperture and a second side aperture, coupled between the primary delivery conduit and the endotracheal tube for communication pressurized gas therebetween. A pressure detector is connected to the first side aperture to detect and generate signals reflective of the pressure of gas in the adapter. An indicator associated with the pressure detector receives the signals and visually displays an indication of the detected pressure of the gas in the adapter. The second side aperture receives and communicates pulses of pressurized gas from the source of pressurized gas to the endotracheal tube. The side apertures are connected to channels that angle toward the second part. The adapter may be formed from a separate base and top joined together. A source of lung therapy material may also be included in the system.
摘要翻译：用于通气患者的通气系统包括加压气体源，用于连通和传送加压气体的主要输送导管，用于插入患者口腔和喉部的气管插管，以及适配器。适配器包括第一侧孔和第二侧孔，联接在主输送导管和气管内管之间，用于在其间连通加压气体。压力检测器连接到第一侧孔以检测并产生反映适配器中气体压力的信号。与压力检测器相关联的指示器接收信号并且在视觉上显示检测到的适配器中气体压力的指示。第二侧孔口将加压气体的脉冲从加压气体源传送到气管内管。侧孔连接到与第二部分成角度的通道。适配器可以由连接在一起的单独的基座和顶部形成。肺部治疗材料的来源也可能包括在系统中。

9. 发明授权

US08921311B2 Method for treating hyperglycemia 有权
标题翻译：治疗高血糖症的方法
公开(公告)号：US08921311B2
公开(公告)日：2014-12-30
申请号：US13235208
申请日：2011-09-16
申请人： Donald Costello , Peter Richardson , Robert A. Baughman , Mark T. Marino
发明人： Donald Costello , Peter Richardson , Robert A. Baughman , Mark T. Marino
IPC分类号： A61P3/10 , A61K38/22 , C07K14/575 , A61K9/00 , A61K38/26 , A61K38/28 , A61K31/495 , A61K9/16 , A61K38/00
CPC分类号： A61K38/26 , A61K9/0075 , A61K9/1641 , A61K9/167 , A61K9/1676 , A61K31/495 , A61K38/22 , A61K38/28 , A61K45/06 , C07K14/57545 , A61K2300/00
摘要： A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
摘要翻译：提供了一种用于治疗受试者的高血糖症和/或糖尿病的方法。特别地，该方法旨在治疗具有大于约8mM的空腹血糖浓度的2型糖尿病患者，其中通过肺吸入向患者施用包含GLP-1分子和二酮哌嗪的制剂，干粉吸入系统。

10. 发明授权

US08642548B2 Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome 有权
标题翻译： Val（8）GLP-1组合物和治疗功能性消化不良和/或肠易激综合征的方法
公开(公告)号：US08642548B2
公开(公告)日：2014-02-04
申请号：US13389410
申请日：2010-08-05
申请人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
发明人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605
CPC分类号： C07K14/605 , A61K9/0075 , A61K9/1682 , A61K31/357 , A61K31/496 , A61K31/513 , A61K38/10 , A61K38/12 , A61K38/26 , A61K2300/00
摘要： A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
摘要翻译：本文公开了治疗需要治疗的哺乳动物中的功能性消化不良和/或肠易激综合征的方法。该方法包括通过吸入向哺乳动物施用制剂，其中所述制剂避免了活性成分的第一次通过代谢。该方法包括通过肺吸入施用包含二酮哌嗪和胰高血糖素样肽（GLP-1），类似物ROSE-010的制剂。

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