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1. 发明授权

US08642548B2 Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome 有权
标题翻译： Val（8）GLP-1组合物和治疗功能性消化不良和/或肠易激综合征的方法
公开(公告)号：US08642548B2
公开(公告)日：2014-02-04
申请号：US13389410
申请日：2010-08-05
申请人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
发明人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605
CPC分类号： C07K14/605 , A61K9/0075 , A61K9/1682 , A61K31/357 , A61K31/496 , A61K31/513 , A61K38/10 , A61K38/12 , A61K38/26 , A61K2300/00
摘要： A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
摘要翻译：本文公开了治疗需要治疗的哺乳动物中的功能性消化不良和/或肠易激综合征的方法。该方法包括通过吸入向哺乳动物施用制剂，其中所述制剂避免了活性成分的第一次通过代谢。该方法包括通过肺吸入施用包含二酮哌嗪和胰高血糖素样肽（GLP-1），类似物ROSE-010的制剂。

2. 发明申请

US20120252728A1 Val (8) GLP-1 Composition and Method for Treating Functional Dyspepsia and/or Irritable Bowel Syndrome 有权
标题翻译： Val（8）GLP-1治疗功能性消化不良和/或肠易激综合征的组合物和方法
公开(公告)号：US20120252728A1
公开(公告)日：2012-10-04
申请号：US13389410
申请日：2010-08-05
申请人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
发明人： Peter Richardson , Enda Kenny , Per Hellstrom , Marshall L. Grant , Grayson W. Stowell , Scott Daniels , Anthony Smithson , Stephanie Greene
IPC分类号： A61K38/26 , A61P1/00 , B29B9/12 , A61P1/04
CPC分类号： C07K14/605 , A61K9/0075 , A61K9/1682 , A61K31/357 , A61K31/496 , A61K31/513 , A61K38/10 , A61K38/12 , A61K38/26 , A61K2300/00
摘要： A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
摘要翻译：本文公开了治疗需要治疗的哺乳动物中的功能性消化不良和/或肠易激综合征的方法。该方法包括通过吸入向哺乳动物施用制剂，其中所述制剂避免了活性成分的第一次通过代谢。该方法包括通过肺吸入施用包含二酮哌嗪和胰高血糖素样肽（GLP-1），类似物ROSE-010的制剂。

3. 发明申请

US20190301740A1 OUTDOOR PATIO HEATER ACCESSORY AND METHOD OF USE 审中-公开
公开(公告)号：US20190301740A1
公开(公告)日：2019-10-03
申请号：US16368411
申请日：2019-03-28
申请人： Scott Daniels
发明人： Scott Daniels
IPC分类号： F24C1/12 , F23C3/00
摘要： An accessory for a patio heater includes a bracket to secure to a pole of the patio heater; two arms attached to and extending away from the bracket in an upward direction; and two concave shields attached to the arms to bend around a heating element of the patio heater; the concave shields reflect heat in a desired direction.

4. 发明申请

US20100093011A1 AMINE-CONTAINING COMPOUND ANALYSIS METHODS 有权
标题翻译：含胺化合物分析方法
公开(公告)号：US20100093011A1
公开(公告)日：2010-04-15
申请号：US12555319
申请日：2009-09-08
申请人： Subodh B. NIMKAR , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
发明人： Subodh B. NIMKAR , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
IPC分类号： C12Q1/26 , G01N33/00 , G01N33/68
CPC分类号： G01N33/6848 , Y10T436/142222 , Y10T436/173845 , Y10T436/24
摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.
摘要翻译：本教导提供了使用等压标记和亲 - 子离子跃迁监测（PDITM）在一个或多个样品中分析一种或多种含胺化合物的方法。在各种实施方案中，所述方法包括以下步骤：（a）从一组等压标签组合标记具有不同等压标签的一种或多种含胺化合物，每个同量异位标签包含报告离子部分; （b）将每个等压标记的含胺化合物的至少一部分合并以产生组合的样品; （c）使组合样品的至少一部分经受PDITM; （d）测量一个或多个所传递的报道离子的离子信号; 至少基于相应报道离子的测量离子信号与标准化合物的一个或多个测量离子信号的比较来确定一种或多种等压标记的含胺化合物的浓度。

5. 发明授权

US08569071B2 Amine-containing compound analysis methods 有权
标题翻译：含胺化合物分析方法
公开(公告)号：US08569071B2
公开(公告)日：2013-10-29
申请号：US12555319
申请日：2009-09-08
申请人： Subodh B. Nimkar , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
发明人： Subodh B. Nimkar , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , Y10T436/142222 , Y10T436/173845 , Y10T436/24
摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.
摘要翻译：本教导提供了使用等压标记和亲 - 子离子跃迁监测（PDITM）在一个或多个样品中分析一种或多种含胺化合物的方法。在各种实施方案中，所述方法包括以下步骤：（a）从一组等压标签组合标记具有不同等压标签的一种或多种含胺化合物，每个同量异位标签包含报告离子部分; （b）将每个等压标记的含胺化合物的至少一部分合并以产生组合的样品; （c）使组合样品的至少一部分经受PDITM; （d）测量一个或多个所传递的报道离子的离子信号; 至少基于相应报道离子的测量离子信号与标准化合物的一个或多个测量离子信号的比较来确定一种或多种等压标记的含胺化合物的浓度。

6. 发明申请

US20060183238A1 Amine-containing compound analysis methods 审中-公开
公开(公告)号：US20060183238A1
公开(公告)日：2006-08-17
申请号：US11350147
申请日：2006-02-08
申请人： Subodh Nimkar , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
发明人： Subodh Nimkar , Subhasish Purkayastha , Darryl Pappin , Scott Daniels
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , Y10T436/142222 , Y10T436/173845 , Y10T436/24
摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.

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